• Disease
  • Type
  • Type 2
  • Type 2 Diabetes
  • Alex S F Doney

    Prominent publications by Alex S F Doney

    KOL Index score: 12670

    BACKGROUND: The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets.

    METHODS: Through DNA genotyping, we tested 54,003 coding-sequence variants covering 13,715 human genes in up to 72,868 patients with coronary artery disease and 120,770 controls who did not have coronary artery disease. Through DNA sequencing, we studied the effects of loss-of-function mutations in selected genes.

    RESULTS: We ...

    Also Ranks for: Coronary Disease |  function angptl4 |  coding variation |  triglyceride levels |  mutations lpl
    KOL Index score: 10785

    To identify common variants influencing body mass index (BMI), we analyzed genome-wide association data from 16,876 individuals of European descent. After previously reported variants in FTO, the strongest association signal (rs17782313, P = 2.9 × 10−6) mapped 188 kb downstream of MC4R (melanocortin-4 receptor), mutations of which are the leading cause of monogenic severe childhood-onset obesity. We confirmed the BMI association in 60,352 adults (per-allele effect = 0.05 Z-score units; P ...

    Also Ranks for: Common Variants |  fat mass |  topic receptor |  mc4r melanocortin |  aged obesity
    KOL Index score: 10397

    BACKGROUND: Glutathione S-transferases (GSTs) modulate oxidative stress, and variation in GST genes has been associated with cardiovascular disease risk. We prospectively determined smoking-related cardiovascular morbidity by GST genotype in a large cohort of individuals with type 2 diabetes using a population-based diabetes research database (DARTS).

    METHODS AND RESULTS: We performed a cohort study of 2015 individuals with type 2 diabetes. Individuals were genotyped for the Ile105Val ...

    Also Ranks for: Type 2 Diabetes |  cardiovascular morbidity |  2 diabetic |  gstt1 gene |  glutathione transferase
    KOL Index score: 10133

    Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We report a genome-wide association study for glycemic response to metformin in 1,024 Scottish individuals with type 2 diabetes with replication in two cohorts including 1,783 Scottish individuals and 1,113 individuals from the UK Prospective Diabetes Study. In a combined meta-analysis, we identified a SNP, rs11212617, associated with treatment success (n = 3,920, P = 2.9 × 10(-9), odds ratio = 1.35, 95% CI ...

    Also Ranks for: Glycemic Response |  2 diabetes |  common variants |  atm ataxia telangiectasia |  metformin type
    KOL Index score: 9900

    OBJECTIVE: Metformin is actively transported into the liver by the organic cation transporter (OCT)1 (encoded by SLC22A1). In 12 normoglycemic individuals, reduced-function variants in SLC22A1 were shown to decrease the ability of metformin to reduce glucose excursion in response to oral glucose. We assessed the effect of two common loss-of-function polymorphisms in SLC22A1 on metformin response in a large cohort of patients with type 2 diabetes.


    Also Ranks for: Organic Cation Transporter |  glycemic response |  godarts study |  metformin patients |  slc22a1 polymorphisms
    KOL Index score: 9521

    Purpose: Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between measurements from different applications is unclear. We evaluate the agreement between retinal measures from two software applications, the Singapore "I" Vessel Assessment (SIVA) and the Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE), and examine respective associations between retinal and systemic ...

    Also Ranks for: Vampire Measurements |  retinal vascular |  vessel assessment |  cohort 1936 |  fundus camera images
    KOL Index score: 9358

    To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult waist circumference (WC) and waist-hip ratio (WHR). We selected 26 SNPs for follow-up, for which the evidence of association with measures of central adiposity (WC and/or WHR) was strong and disproportionate to that for overall adiposity or height. Follow-up studies in a maximum of 70,689 individuals ...

    Also Ranks for: Fat Distribution |  central adiposity |  wc whr |  waist circumference |  loci influencing
    KOL Index score: 8970

    Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein ...

    Also Ranks for: Plasma Triglycerides |  common variants |  artery disease |  cad risk |  hdl cholesterol
    KOL Index score: 8950

    OBJECTIVE: There is considerable interindividual variation in sulfonylurea response in type 2 diabetes. Transcription factor 7-like 2 (TCF7L2) variants have been identified to be strongly associated with type 2 diabetes risk, probably due to decreased beta-cell function. We hypothesized that variation in TCF7L2 would influence response to sulfonylureas but not metformin. We studied the effect of TCF7L2 rs12255372 and rs7903146 genotypes on glycemic response.


    Also Ranks for: Tcf7l2 Genotype |  response sulfonylureas |  2 diabetes |  treatment failure |  genetic variation
    KOL Index score: 8939

    OBJECTIVES: The LPA single-nucleotide polymorphism rs10455872 has been associated with low-density lipoprotein cholesterol (LDLc) lowering response to statins in several randomized control trials (RCTs) and is a known coronary artery disease (CAD) marker. However, it is unclear what residual risk of CAD this marker may have during statin treatment.

    METHODS: Using electronic medical records linked to the GoDARTS genotyped population, we identified over 8000 patients on statins in Tayside, ...

    Also Ranks for: Statin Treatment |  lipoprotein cholesterol |  coronary artery |  ldlc response |  association rs10455872
    KOL Index score: 8845

    BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or traits.

    OBJECTIVES: This study sought to systematically test if genetic variants identified for non-CAD diseases/traits also associate with CAD and to undertake a comprehensive analysis of the extent of pleiotropy of all CAD loci.

    METHODS: In discovery analyses involving ...

    Also Ranks for: Artery Disease |  cad loci |  genome wide |  genetic pleiotropy |  single nucleotide
    KOL Index score: 8602

    We performed fine mapping of 39 established type 2 diabetes (T2D) loci in 27,206 cases and 57,574 controls of European ancestry. We identified 49 distinct association signals at these loci, including five mapping in or near KCNQ1. 'Credible sets' of the variants most likely to drive each distinct signal mapped predominantly to noncoding sequence, implying that association with T2D is mediated through gene regulation. Credible set variants were enriched for overlap with FOXA2 chromatin ...

    Also Ranks for: Causal Mechanisms |  genetic fine |  2 diabetes |  single nucleotide receptor |  hepatocyte nuclear factor
    KOL Index score: 8304

    BACKGROUND: Apolipoprotein E (APOE) genotypes have been associated with variations in plasma-lipid levels and with response to statins, although the influence of APOE on the response to statins remains controversial, especially in patients with diabetes. We sought to evaluate the association of the APOE genotype with the low-density lipoprotein cholesterol (LDLc)-lowering response to statins, in a large population-based cohort of patients with diabetes.

    METHODS AND RESULTS: A total of ...

    Also Ranks for: Statin Treatment |  apoe genotype |  fatty acids |  studies diabetes |  ldlc levels
    KOL Index score: 8293

    To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest ...

    Also Ranks for: Diabetes Susceptibility |  ancestry meta |  type 2 |  genetic architecture |  directional consistency
    KOL Index score: 8175

    BACKGROUND: Considerable interindividual variation exists in cholesterol-lowering response to 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors (statins). HMGCR catalyzes the rate-limiting step in cholesterol biosynthesis, and also plays a significant role in cholesterol homeostasis. We evaluated the association of a single nucleotide polymorphism (rs17238540) in the HMGCR gene with lipid-lowering response to statins in a large population-based cohort of patients with ...

    Also Ranks for: Statin Treatment |  coa reductase |  lowering response |  total cholesterol |  hmgcr inhibitors


    Alex S F Doney: Influence Statistics

    Sample of concepts for which Alex S F Doney is among the top experts in the world.
    Concept World rank
    cost wider economy #1
    7180 8190 #1
    survey population respondents #1
    rdmp source tool #1
    slow provision #1
    ended consent respondents #1
    anonymized cohorts #1
    34 billion euro #1
    hba1c 90 95 #1
    rdmp researchers #1
    rdmp #1
    rdmp tool implementation #1
    practice lists respondents #1
    hba1c timeweighted #1
    95 hba1c 90 #1
    hba1c hba1c measurements #1
    ushaped relationship hba1c #1
    hba1c 6170 #1
    21 billion euro #1
    6170 7180 #1
    hba1c insulin sensitizers #1
    78 billion pound #1
    841 34 #1
    8190 #1
    patientspecific phenotypic data #1
    hba1c 8190 #1
    8190 95 #1
    blood routine tests #1
    cost cerebral ischaemia #1
    respondents survey population #1
    163 datasets #1
    ischaemia cerebrovascular #1
    cohorts researchers #1
    cost cerebral #1
    6170 95 #1
    insidious consequence #1
    timeweighted hba1c #1
    attitudes dna biobanks #1
    246 30 hours #1
    public attitudes storage #1
    largest extract #1

    Key People For Type 2 Diabetes

    Top KOLs in the world
    David Richard Matthews
    type 2 diabetes sri lanka growth hormone
    Frank B Hu
    type 2 diabetes cardiovascular disease physical activity
    Rury R Holman
    type 2 diabetes cardiovascular disease impaired glucose tolerance
    David Matthew Nathan
    type 2 diabetes insulin resistance cardiovascular disease
    John B Buse
    type 2 diabetes insulin degludec cardiovascular outcomes
    Tuomilehto Tuomilehto
    type 2 diabetes blood pressure north karelia

    Alex S F Doney:Expert Impact

    Concepts for whichAlex S F Doneyhas direct influence:Type 2 diabetes,  2 diabetes,  Type 2,  Blood pressure,  Heart failure,  Heart rate,  Statin treatment,  Common variants.

    Alex S F Doney:KOL impact

    Concepts related to the work of other authors for whichfor which Alex S F Doney has influence:Type 2 diabetes,  Genetic variants,  Insulin resistance,  Mendelian randomization,  Cardiovascular disease,  Metabolic syndrome,  Blood pressure.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    MEMO Research, University of Dundee, Dundee, UK | Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK | Population Health and Genomics, University of Dundee, Dundee, UK | NIHR Global Health Research Unit o