Haibing Chen: Influence Statistics

Haibing Chen

Haibing Chen

Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China | Department of Endocrinology and ...

Haibing Chen: Expert Impact

Concepts for which Haibing Chen has direct influence: Type 2 diabetes , Diabetic retinopathy , Diabetic nephropathy , Uric acid , Type 2 , 2 diabetes , Diabetic rats .

Haibing Chen: KOL impact

Concepts related to the work of other authors for which for which Haibing Chen has influence: Diabetic retinopathy , Type 2 diabetes , Oxidative stress , Kidney disease , Insulin resistance , Uric acid , Metabolic memory .

KOL Resume for Haibing Chen

Year
2022

Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China

2021

Department of Endocrinology and Metabolism, Shanghai 10th People’s Hospital, School of Medicine, Tongji University, 301 Yanchang Road, Shanghai 200072, China

2020

Department of Endocrinology and Metabolism, Shanghai Eighth People’s Hospital, 200233, Shanghai, China

2019

Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center of Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

2018

Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China

2017

Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600Yishan road, 200233, Shanghai, China

2016

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao tong University Affiliated Sixth People’s Hospital, Shanghai, China

2015

Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiaotong University Affiliated Sixth People's Hospital Shanghai 200233, China.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Key Laboratory of Diabetes Shanghai China

2014

Department of Endocrinology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China

2012

Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China

2011

Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, People's Republic of China

2010

Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Department of Ophthalmology, Shanghai Jiaotong University Affiliated First People’s Hospital of Shanghai, Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

2009

Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China

2008

Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai, China

2006

Shanghai Diabetic Institute, Shanghai Jiaotong University Affiliated No. 6 People Hospital, 600 Yishan Road, Shanghai 200233, China

Prominent publications by Haibing Chen

KOL-Index: 16777 . PURPOSE: Hyperglycemia-induced mitochondrial reactive oxygen species (ROS) production plays an important role in the development of complications of diabetes such as retinopathy. However, whether pigment epithelium-derived factor (PEDF) can decrease ROS production remains uncertain. The aim of this study was to clarify whether PEDF can decrease mitochondria-derived ROS generation and ...
Known for Mitochondrial Ros | Pedf Expression | Protein Ucp2 | Cultured Endothelium
KOL-Index: 14449 . OBJECTIVE: This study aimed to verify whether the decreased vascular endothelial growth factor (VEGF)-to-pigment epithelium-derived factor (PEDF) ratio can serve as an indicator for the protective effect of angiotensin-converting enzyme inhibitors (ACEIs) on diabetic retinopathy (DR) and to investigate the role of mitochondrial reactive oxygen species (ROS) in the downregulated ...
Known for Diabetic Retinopathy | Growth Factor | Vascular Endothelial | Pigment Epithelium
KOL-Index: 13579 . OBJECTIVE: Mitochondrial reactive oxygen species (ROS) plays a key role in diabetic retinopathy (DR) pathogenesis. However, whether simvastatin decreases diabetes-induced mitochondrial ROS production remains uncertain. The aim of this study was to clarify the beneficial effects and mechanism of action of simvastatin against diabetes-induced retinal vascular damage. RESEARCH DESIGN AND ...
Known for Diabetic Rats | Retinal Vascular | Oxygen Species | Peroxisome Proliferator
KOL-Index: 12698 . Nuclear factor (NF)-κB and signal transducer and activator of transcription 3 (STAT3) play a critical role in diabetic nephropathy (DN). Sirtuin-1 (SIRT1) regulates transcriptional activation of target genes through protein deacetylation. Here, we determined the roles of Sirt1 and the effect of NF-κB (p65) and STAT3 acetylation in DN. We found that acetylation of p65 and STAT3 was ...
Known for Diabetic Kidney Disease | Kidney Injury | Db Db Mice | Stat3 Sirt1
KOL-Index: 11869 . AIMS: To assess the involvement of peripheral nerve dysfunction in asymptomatic patients with latent autoimmune diabetes of adults (LADA) or type 2 diabetes (T2DM), and compare nerve conduction (NC) parameters between the two groups. METHODS: A total of 1635 patients without symptoms and signs relevant to diabetic polyneuropathy (1275 with T2DM and 360 with LADA) were included and were ...
Known for Latent Autoimmune Diabetes | Peripheral Nerve | Type 2 | Lada Patients
KOL-Index: 11689 . Cellular metabolic memory occurs in diabetic microvascular and macrovascular complications, but the underlying mechanisms remain unclear. Here, we investigate the role of sirtuin 1 (SIRT1) and metformin in this phenomenon. In bovine retinal capillary endothelial cells (BRECs) and retinas of diabetic rats, the inflammatory gene, nuclear factor-κB (NF-κB), and the proapoptotic gene, Bax, ...
Known for Cellular Metabolic Memory | Sirtuin 1 | Therapeutic Effects | Metformin Nf
KOL-Index: 11203 . AIMS: This cross-sectional study aimed to determine the prevalence and associated risk factors of chronic kidney disease (CKD) in Chinese type 2 diabetic patients. METHODS: A total of 3301 patients with type 2 diabetes were included in this study. Anthropometric parameters and biochemical indices were measured. The main outcome measures were detection of CKD, albuminuria and estimated ...
Known for Chronic Kidney Disease | Type 2 Diabetes | Prevalence Ckd | Crosssectional Study
KOL-Index: 10681 . Vascular endothelial growth factor (VEGF) plays a pivotal role in diabetic retinopathy (DR) and hypertension has been identified as an independent risk factor for DR. The aim of the present study was to: (1) explore whether beta-adrenergic blockers influence retinal VEGF expression; (2) determine the effect of angiotensin-converting enzyme inhibitors (ACEI) on retinal VEGF expression ...
Known for Diabetic Rats | Growth Factor | Vascular Endothelial | Converting Enzyme
KOL-Index: 8925 . Aims/hypothesisThe mechanisms underlying the cellular metabolic memory induced by high glucose remain unclear. Here, we sought to determine the effects of microRNAs (miRNAs) on metabolic memory in diabetic retinopathy.MethodsThe miRNA microarray was used to examine human retinal endothelial cells (HRECs) following exposure to normal glucose (N) or high glucose (H) for 1 week or transient H ...
Known for Metabolic Memory | Diabetic Retinopathy | Signalling Pathway | Sirt1 Expression
KOL-Index: 8636 . PURPOSE: To investigate the relationship of ficolin-3 with inflammatory and angiogenic factors, namely, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF), in the vitreous of eyes with proliferative diabetic retinopathy (PDR). DESIGN: Case-control study. METHODS: Vitreous fluid and serum samples were obtained at the time of vitreoretinal surgery from 21 ...
Known for Growth Factor | Diabetic Retinopathy | Vascular Endothelial | Idiopathic Macular Hole
KOL-Index: 8593 . This hospital-based, cross-sectional study investigated the effect of age of diabetes onset on the development of diabetic retinopathy (DR) among Chinese type 2 diabetes mellitus (DM) patients. A total of 5,214 patients with type 2 DM who were referred to the Department of Ophthalmology at the Shanghai First People’s Hospital from 2009 to 2013 was eligible for inclusion. Diabetic ...
Known for Diabetic Retinopathy | Type 2 | Age Diabetes | Independent Risk
KOL-Index: 8577 . The overproduction of mitochondrial reactive oxygen species (ROS) plays a key role in the pathogenesis of diabetic nephropathy (DN). However, the underlying molecular mechanism remains unclear. Our aim was to investigate the role of PGC-1α in the pathogenesis of DN. Rat glomerular mesangial cells (RMCs) were incubated in normal or high glucose medium with or without the ...
Known for Diabetic Nephropathy | Protective Role | Pgc1α Expression | Oxidative Stress
KOL-Index: 8298 . OBJECTIVE: In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined. METHODS: Serum betatrophin levels were determined using ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, ...
Known for Serum Betatrophin | Type 2 | Insulin Resistance | Glucose Tolerance
KOL-Index: 8206 . BACKGROUND: Low vitamin D levels can be associated with albuminuria, and vitamin D analogs are effective anti-proteinuric agents. The aim of this study was to investigate differences in vitamin D levels between those with micro- and those with macroalbuminuria, and to determine whether low dose cholecalciferol increases vitamin D levels and ameliorates albuminuria. METHODS: Two studies ...
Known for Type 2 | Diabetic Patients | Vitamin Levels | Longitudinal Studies
KOL-Index: 7359 . AIMS: To evaluate the prevalence and risk of diabetes based on family history in high-risk subjects and also to evaluate insulin sensitivity and insulin secretion in these subjects. METHODS: Data were analysed from 9756 participants in the Shanghai High-Risk Diabetic Screen (SHiDS) Project. Family history of diabetes was classified according to parental and sibling diabetes status. The ...
Known for Risk Diabetes | Insulin Secretion | Prevalence Rates | Glucose Tolerance

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Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, School of Medicine, Tongji University, Shanghai, China | Department of Endocrinology and Metabolism, Shanghai 10th People's Hospital, Tongji University, Shanghai, China. Ele