Prominent publications by Irvin Mark Modlin

KOL Index score: 14431

The prevalence of type 2 diabetes mellitus (T2DM) and obesity in the western world is steadily increasing. Bariatric surgery is an effective treatment of T2DM in obese patients. The mechanism by which weight loss surgery improves glucose metabolism and insulin resistance remains controversial. In this review, we propose that two mechanisms participate in the improvement of glucose metabolism and insulin resistance observed following weight loss and bariatric surgery: caloric restriction ...

Known for Weight Loss |  Insulin Resistance |  Bariatric Surgery |  Fat Mass |  Caloric Restriction
KOL Index score: 13141

Ménétrier's disease is an uncommon disorder of unknown etiology characterized by enlarged gastric folds with foveolar hyperplasia and cystic dilatation of gastric glands. Biochemical features that are seen frequently include hypoproteinemia, hypochlorhydria, and increased gastric mucus. Because transforming growth factor alpha (TGF alpha) is an epithelial cell mitogen that inhibits gastric acid secretion and increases gastric mucin content, we hypothesized that its altered expression ...

Known for Transgenic Mice |  Tgf Alpha |  Growth Factor |  Gastric Mucosa |  Ménétriers Disease
KOL Index score: 12757

The fat mass participates in the regulation of glucose and insulin metabolism through the release of adipocytokines in a mechanism called the adipoinsular axis. Putative adipocytokines include leptin, adiponectin and resistin. Obesity plays an important role in the pathogenesis of insulin resistance and type 2 diabetes mellitus (T2DM). Bariatric surgery for morbidly obese patients leads to rapid and prolonged improvement in insulin resistance and T2DM in the vast majority of patients. We ...

Known for Insulin Resistance |  Bariatric Surgery |  Leptin Adiponectin |  Adipoinsular Axis |  Gastric Bypass
KOL Index score: 12190

BackgroundPeptide receptor radionuclide therapy (PRRT) is an effective method for treating neuroendocrine tumors (NETs). It is limited, however, in the prediction of individual tumor response and the precise and early identification of changes in tumor size. Currently, response prediction is based on somatostatin receptor expression and efficacy by morphological imaging and/or chromogranin A (CgA) measurement. The aim of this study was to assess the accuracy of circulating NET ...

Known for Peptide Receptor |  Neuroendocrine Tumors |  Therapeutic Efficacy |  Circulating Transcripts |  Netest Cga
KOL Index score: 12190

BACKGROUND: Proton pump inhibitors are regarded as the most effective class of acid suppressive medication for gastroesophageal reflux disease treatment. There is considerable interest regarding the dose equivalence between various proton pump inhibitors.

GOALS: To compare the efficacy of pantoprazole and esomeprazole with regard to healing and relief from gastroesophageal reflux disease-related symptoms.

STUDY: Multicenter, randomized, double-blind study. Patients with gastroesophageal ...

Known for Gastroesophageal Reflux |  Pantoprazole Esomeprazole |  Symptom Relief |  Daily 40 |  Proton Pump Inhibitors
KOL Index score: 11858

BACKGROUND: Carcinoid tumors represent an unusual and complex disease spectrum with protean clinical manifestations. This compilation of several large United States-based databases comprising patients from 1950 to 1999 examines 13,715 carcinoid tumors and provides epidemiologic information regarding the natural history and evolution of the detection and diagnosis of this entity.

METHODS: The authors evaluated 10,878 carcinoid tumors that were identified by the Surveillance, Epidemiology, ...

Known for Carcinoid Tumors |  United States |  Gastrointestinal Tract |  Authors Knowledge |  Year Survival
KOL Index score: 11647

The cyclin D1 protein is one of the cell cycle regulators required for cell cycle progression through G1 phase to S phase. The cyclin D1-cyclin-dependent kinase (CDK) system is thought to control the cell cycle through mediating extracellular signals from mitogens, such as epidermal growth factor (EGF). In this study, we attempted to examine the therapeutic effect of cyclin D1 antisense oligonucleotides (AS/D1) on cell proliferation and apoptosis of the gastric cancer cell line MKN-74, ...

Known for Cyclin D1 |  Epidermal Growth Factor |  Cell Growth |  Gastric Cancer |  Induces Apoptosis
KOL Index score: 11590

BACKGROUND: Treatment of small intestinal neuroendocrine tumors (SINETs) with mammalian target of rapamycin (mTOR) inhibitors alone or with somatostatin analogs has been proposed as effective therapy, because both agents have been reported to exhibit antiproliferative activity. Because adenocarcinomas escape mTOR inhibition, we examined whether the escape phenomenon occurred in SINETs and whether usage of somatostatin analogs with mTOR inhibitors surmounted loss of inhibition.


Known for Growth Factor |  Neuroendocrine Tumor |  Small Intestinal |  Mtor Inhibitors |  Cell Lines
KOL Index score: 11458

OBJECTIVES: Current monoanalyte blood-based biomarkers for the diagnosis and follow-up of neuroendocrine tumors (NETs) do not achieve satisfactory metrics of sensitivity and specificity. We report the sensitivity and selectivity of the PCR-based test, the NETest, to detect tumors with reference to other benign and malignant gastrointestinal diseases.

METHODS: A total of 179 cases (gastrointestinal tumors: n=81; pancreatic disease: n=98) were prospectively collected and assessed using the ...

Known for Neuroendocrine Tumors |  Clinical Utility |  Gastrointestinal Tract |  Netest Cga |  Tumor Chromogranin
KOL Index score: 11283

Pathologic grading for prognostic stratification of neuroendocrine tumors (NETs) is critical but presents a challenging interpretive dilemma. Tumor cell proliferative rate is an important factor in the determination of prognosis, and immunohistochemical analysis with Ki67 is becoming more widely used to quantify the proliferative rate. However, Ki67 assessment has limitations due to lack of uniformity and consistency in quantification. These limitations are accentuated in ...

Known for Ki67 Proliferative |  Objective Quantification |  Neuroendocrine Tumors |  Gold Standard |  2000 Cells
KOL Index score: 11267

The modulation of enterocyte sheet migration was studied using Caco-2 cells, a well-differentiated human colonic cell line. Although Caco-2 cells attached and spread equivalently over collagen types I, III, IV, and V and laminin, migration over laminin was significantly slower than migration over the collagen types. Fibronectin was a poor substrate for attachment, spreading, and migration. Epidermal growth factor (EGF) stimulated migration over laminin but did not alter Caco-2 migration ...

Known for Epidermal Growth Factor |  Collagen Laminin |  Caco2 Cells |  Egf Treatment |  Cell Surface
KOL Index score: 11260

BACKGROUND & AIMS: Parenteral control of gastric acid hypersecretion in conditions such as Zollinger-Ellison syndrome (ZES) or idiopathic gastric acid hypersecretion is necessary perioperatively or when oral medications cannot be taken for other reasons (e.g., during chemotherapy, acute upper gastrointestinal bleeding, or in intensive care unit settings).

METHODS: We evaluated the efficacy and safety of 15-minute infusions of the proton pump inhibitor pantoprazole (80-120 mg every 8-12 ...

Known for Intravenous Pantoprazole |  Gastric Acid Hypersecretion |  Acid Output |  Ellison Syndrome |  7 Patients
KOL Index score: 11140

YF476 is a potent and highly selective cholecystokin 2 (CCK(2)) receptor antagonist of the benzodiazepine class. It inhibits gastric neuroendocrine enterochromaffin-like (ECL) cell secretion, proliferation and spontaneous formation of gastric neuroendocrine tumors (carcinoids) in cotton rats. The Mastomys rodent species exhibits a genetic predisposition to gastric ECL neuroendocrine tumor formation which can be accelerated by acid suppression and induction of hypergastrinemia. In this ...

Known for Ecl Cell |  Cck2 Receptor |  Carcinoid Tumor |  Atrophic Gastritis |  Gastric Neuroendocrine


Irvin Mark Modlin: Influence Statistics

Sample of concepts for which Irvin Mark Modlin is among the top experts in the world.
Concept World rank
kda tubulovesicle #1
sinen lymph nodes #1
pylori mastomys #1
kda histamine #1
basal pepsinogen secretion #1
university istanbul istanbul #1
ppg secretion combination #1
netest carcinoids #1
implications acid secretion #1
respective peptide #1
disease progression cga #1
nedome netest #1
prognostic accuracy netest #1
net nomogram data #1
inflammation asher winkelstein #1
fold gastrin #1
enteroglucagon increase dogs #1
safety acidsuppressing medications #1
releases motilin #1
109 vip #1
management bpnets #1
mrs1754 neca #1
cholinomimetic stimulation #1
cathepsin conversion #1
denervated intact parts #1
synthetic rabbits dmpge2 #1
pepsinogen acid secretion #1
biomarkers gepnets #1
5ht release ec50 #1
enteroglucagon levels groups #1
stomach neoplasms mastomys #1
8 27 weeks #1
cell tgfalpha #1
endoscopic criteria therapy #1
elevated cga #1
micromethod assay #1
nervism hormonal regulation #1
accuracy cga #1
serotonin carbachol #1
nrc african americans #1
define hallmarks #1
mtor somatostatin analogs #1
p005 neoplastic cells #1
controls vagotomy #1
cakt purines receptor #1
local excision carcinoids #1
yale experience #1
srs stirmri #1
mastomys loxtidine #1

Key People For Neuroendocrine Tumors

Top KOLs in the world
Kjell E Öberg
neuroendocrine tumors carcinoid syndrome telotristat ethyl
James C Yao
neuroendocrine tumors gastric cancer carcinoid syndrome
Martyn Evan Caplin
neuroendocrine tumors telotristat ethyl carcinoid syndrome
Wouter W de Herder
neuroendocrine tumors somatostatin analogs carcinoid syndrome
Guido Rindi
neuroendocrine tumors endocrine cells transgenic mice
Philippe B Ruszniewski
neuroendocrine tumors chronic pancreatitis liver metastases

Irvin Mark Modlin:Expert Impact

Concepts for whichIrvin Mark Modlinhas direct influence:Neuroendocrine tumors,  Carcinoid tumors,  Acid secretion,  Parietal cells,  Gastric carcinoids,  Neuroendocrine tumor,  19th century,  Histamine secretion.

Irvin Mark Modlin:KOL impact

Concepts related to the work of other authors for whichfor which Irvin Mark Modlin has influence:Neuroendocrine tumors,  Acute pancreatitis,  Carcinoid tumor,  Liver metastases,  Gastrointestinal tract,  Gastroesophageal reflux disease,  Acid secretion.



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Yale University School of Medicine, New Haven, CT USA, | Gastroenterological and Endoscopic Surgery, Yale University School of Medicine, New Haven, Connecticut, USA | WREN Laboratories, Branford, CT 06405, USA;,, (M.K.);, i

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