Valérie Vroome

Valérie Vroome

Barrier Therapeutics Nv, A Wholly Owned Subsidiary Of Stiefel Laboratories, Wiertzstraat 50, 1047 Brussel, Belgium

Direct Impact

Concepts for which Valérie Vroome has direct influence:

acne papules
seborrheic dermatitis
non-tar shampoo
miconazole nitrate
topical retinol
stratum corneum
chronic leg ulcers

External impact

Concepts related to the work of other authors for which Valérie Vroome has influence:

acne papules
endogenous reactive oxygen species
antifungal activity
seborrhoeic dermatitis
topical application
severe dandruff
irritation potential

Prominent publications by Valérie Vroome

KOL-Index: 39 A series of substituted benzylsulfanyl-phenylamines was synthesized, of which four substituted benzylsulfanyl-phenylguanidines (665, 666, 667 and 684) showed potent fungicidal activity (minimal fungicidal concentration, MFC ≤ 10 μM for Candida albicans and Candida glabrata). A benzylsulfanyl-phenyl scaffold with an unsubstituted guanidine resulted in less active compounds (MFC=50-100 μM), ...
KOL-Index: 21 To unravel the working mechanism of the fungicidal piperazine-1-carboxamidine derivative BAR0329, we found that its intracellular accumulation in Saccharomyces cerevisiae is dependent on functional lipid rafts. Moreover, BAR0329 induced caspase-dependent apoptosis in yeast, in which the mitochondrial fission machinery consisting of Fis1 (Whi2), Dnm1 and Mdv1 is involved. Our data are ...
Known for
Mitochondrial Fission | Proapoptotic Function | Working Mechanism | Intracellular Accumulation
KOL-Index: 14
Known for
Oral Antifungals
KOL-Index: 13 BackgroundCellulite occurs to varying degrees on the thighs and buttocks of many otherwise healthy women. Among the many purported treatments for cellulite, only a handful have been tested in clinical trials.ObjectiveThe aim of this study was to critically explore the reputed effect of topical retinol in the treatment of cellulite.Materials and MethodsThe study compared the effect of topical ...
Known for
Trial Topical
KOL-Index: 13 BACKGROUND: Acne is a multifactorial disease exhibiting distinct clinical presentations. Among them, the catamenial type is a matter of concern for young women. Some oral contraceptives may help without, however, clearing the skin condition. AIM: The present open study aimed at evaluating the effect of overnight applications of a paste made of petrolatum,15% zinc oxide and 0.25% miconazole ...
Known for
Autofluorescent Follicular Casts | Cyanoacrylate Follicular Biopsies | Papules | Non-Medicated Cream
KOL-Index: 12 The skin barrier function (SBF) is an important aspect of skin biology, particularly in the elicitation of inflammation. The SBF recovery rate after tape stripping and surfactant challenge can be assessed by measuring the transepidermal water loss (TEWL). Previous clinical studies have shown some inflammatory effect after topical applications of miconazole. The aim of this study was to ...
Known for
Faster Sbf Recovery Rate | 15 Zinc Oxide | 5 Sites | Pastes
KOL-Index: 12 BACKGROUND: Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE: To revisit the various aspects of action of the drug in a dermatologic setting. METHOD: Review of the current peer-reviewed publications. RESULTS/CONCLUSION: Miconazole essentially inhibits 14alpha-demethylase, an enzyme required for the biosynthesis of ergosterol, which is the main sterol ...
Known for
Biosynthesis Ergosterol | Addition Miconazole | Action Drug | Effects Skin
KOL-Index: 11 BACKGROUND: The treatment of chronic leg ulcers remains a stubborn problem in many patients. Topical 2% ketanserin ointment, a 5HT2-serotoninergic blocking agent, has been reported to improve healing of decubitus, venous, diabetic and ischaemic ulcers. METHOD: The present double-blind intra-individual comparative study was performed in 12 women with diabetes presenting with at least two ...
Known for
Ketanserin-Treated Ulcers | Double-Blind Intra-Individual | 2-Week Intervals | 5ht2-Serotoninergic Blocking Agent
KOL-Index: 10 BACKGROUND: The classical management of acne calls for prolonged oral and/or topical treatments; however, some patients request a rapid effect to make the papules disappear within a few hours or days. OBJECTIVE: To test the effect of a single overnight application of a paste containing 0.25% miconazole nitrate on acne papules, and comparison with the effect of the same but unmedicated paste. ...
Known for
Single Application | Normal Skin | Classical Management | Pretreatment Indices
KOL-Index: 9 BACKGROUND: Seborrheic dermatitis is considered to be a Malassezia-driven disease. Little objective information is available so far from biometrological quantitative assessments of this skin condition. Pramiconazole is a novel triazole with potent in vitro antifungal activity, especially against Malassezia spp. OBJECTIVE: To study the sequential effects of pramiconazole on Malassezia, ...
Known for
Biometrological | Dermatitis Density | Sebum | Pramiconazole-Treated

Barrier Therapeutics nv, a wholly owned subsidiary of Stiefel Laboratories, Wiertzstraat 50, 1047 Brussel, Belgium

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