Prominent publications by Gerald David Weinstein

KOL Index score: 10827

BACKGROUND: Previous studies of infliximab in psoriasis have demonstrated rapid improvement with induction therapy and sustained response with regularly administered maintenance therapy.

OBJECTIVE: The efficacy and safety of continuous (every-8-week) and intermittent (as-needed) maintenance regimens were compared.

METHODS: Patients with moderate-to-severe psoriasis (n = 835) were randomized to induction therapy (weeks 0, 2, and 6) with infliximab 3 mg/kg or 5 mg/kg or placebo. ...

Known for 1 Year |  Monoclonal Arthritis |  Infliximab Maintenance |  Induction Therapy |  Illness Surveys
KOL Index score: 10245

OBJECTIVE: To determine safety and efficacy of monotherapy with etanercept.

DESIGN: Randomized, double-blind, placebo-controlled, multicenter study.

SETTING: Outpatient, ambulatory; private practice and university dermatology research centers.

PATIENTS: Patients aged at least 18 years, with plaque psoriasis involving 10% or more of body surface area; 148 were screened and 112 were randomly assigned to treatment groups and received study drug.

INTERVENTIONS: Patients received placebo or ...

Known for Patients Psoriasis |  24 Weeks |  Efficacy Etanercept |  75 Improvement |  Placebo Treated
KOL Index score: 10087

Determination of the cell types proliferating in the dermis of patients with psoriasis should identify those cells experiencing activation or responding to growth factors in the psoriatic dermal milieu. Toward that end, sections of formalin-fixed biopsies obtained from 3H-deoxyuridine (3H-dU)-injected skin of eight psoriatic patients were immunostained, followed by autoradiography. Proliferating dermal cells exhibit silver grains from tritium emissions. The identity of the proliferating ...

Known for Proliferating Cells |  Factor Xiiia |  Dendritic Cell |  Psoriatic Patients |  Psoriasis Skin
KOL Index score: 9622

BACKGROUND: Tazarotene in a gel formulation is widely used in the treatment of psoriasis.

OBJECTIVE: To determine the efficacy and safety of tazarotene 0.1% and 0.05% creams in the treatment of psoriasis.

METHODS: A total of 1303 patients participated in 2 clinical trials. Patients applied tazarotene creams 0.1% and 0.05% or vehicle once daily to all psoriatic lesions for 12 weeks followed by a 12-week posttreatment period.

RESULTS: Both creams were significantly more effective than ...

Known for 12 Weeks |  Treatment Psoriasis |  Tazarotene 01 |  Efficacy Safety |  Dermatologic Agents
KOL Index score: 9242

BACKGROUND: Topical therapy providing initial improvement and maintenance of effect after treatment of the large majority of patients with limited, mild to moderate psoriasis is not presently available. Previous topical retinoids have generally been either ineffective or too irritating for therapy of psoriasis.

OBJECTIVE: Our purpose was to evaluate a new topical retinoid, tazarotene, in the treatment of stable plaque psoriasis during treatment and posttreatment periods.

METHODS: In a ...

Known for Tazarotene Gel |  Topical Therapy |  12 Weeks |  Psoriasis Treatment |  Plaque Elevation
KOL Index score: 9025

BACKGROUND: Methotrexate remains a valuable option for the treatment of psoriasis. This report will summarize studies regarding the use of methotrexate since the last guidelines were published in 1998.

OBJECTIVE: A task force of the National Psoriasis Foundation Medical Board was convened to evaluate treatment options. Our aim was to achieve a consensus on new updated guidelines for the use of methotrexate in the treatment of psoriasis.

METHODS: Reports in the literature were reviewed ...

Known for Methotrexate Psoriasis |  Liver Biopsies |  Medical Board |  Hepatic Fibrosis |  Rheumatoid Arthritis
KOL Index score: 8342

OBJECTIVE: To determine the safety and efficacy of photodynamic therapy (PDT) using 20% wt/vol aminolevulinic acid hydrochloride (hereinafter "ALA") and visible blue light for the treatment of multiple actinic keratoses of the face and scalp.

DESIGN: Randomized, placebo-controlled, uneven parallel-group study.

INTERVENTIONS: Patients (N = 243) were randomized to receive vehicle or ALA followed within 14 to 18 hours by PDT. Follow-up visits occurred 24 hours and 1, 4, 8, and 12 weeks ...

Known for Multiple Actinic Keratoses |  Photodynamic Therapy |  Aminolevulinic Acid |  Light Treatment |  Topical Pdt
KOL Index score: 8225

BACKGROUND: Topical corticosteroids are often used in the treatment of psoriasis, but long-term use may be associated with serious adverse events such as tachyphylaxis or atrophy of the skin. Tazarotene, a new topical retinoid, has demonstrated significant clinical benefits but can cause mild to moderate local irritation.

OBJECTIVE: We evaluate whether a combination treatment of topical tazarotene and a topical corticosteroid would increase efficacy while reducing the incidence of local ...

Known for Treatment Psoriasis |  Topical Tazarotene |  Local Adverse Events |  12 Weeks |  Clinical Benefits
KOL Index score: 8027

Objective: To examine the safety and efficacy of photodynamic therapy using topical 5-aminolevulinic acid (ALA) and red light to treat actinic keratoses (AKs).Design: Actinic keratoses were treated with topical ALA (concentrations of 0%, 10%, 20%, or 30%) under occlusion for 3 hours. Before photodynamic therapy, sites were examined for fluorescence. Sites were irradiated with an argon pumped dye laser (630 nm) at fluences of 10 to 150 J/cm2.Setting: Academic medical center.Patients: ...

Known for Photodynamic Therapy |  Actinic Keratosis |  Aminolevulinic Acid |  Topical 5 |  Patients Aks
KOL Index score: 8010

BACKGROUND: Biologics are widely used in the treatment of psoriasis and psoriatic arthritis.

OBJECTIVE: Our aim was to arrive at a consensus on the kind of monitoring and the vaccinations that should be performed before and during biologic therapy.

METHODS: Medical literature and data presented at meetings were reviewed and a consensus conference was held by members of the Medical Board of the National Psoriasis Foundation.

RESULTS: Consensus was established on monitoring and vaccination ...

Known for Medical Board |  Patients Psoriasis |  Biologic Therapy |  Physical Examination |  Liver Function Tests
KOL Index score: 7534

OBJECTIVE: This study was designed to evaluate the long-term safety and efficacy of 0.1% tacrolimus ointment in adult and pediatric patients with atopic dermatitis (AD).

METHODS: A total of 408 adult and 391 pediatric patients with AD who had participated in a previous clinical trial of tacrolimus ointment were enrolled in this long-term, open-label, noncomparative trial. Tacrolimus ointment 0.1% was applied twice daily either intermittently or continuously to the affected areas. ...

Known for 4 Years |  Atopic Dermatitis |  Tacrolimus Ointment |  Adverse Events Total |  1 Week
KOL Index score: 7281

The definitions of psoriasis severity and clinically significant improvement in psoriasis are used to classify treatments, obtain Food and Drug Administration approval, and determine product labeling and reimbursement. The Medical Advisory Board of the National Psoriasis Foundation has addressed these issues because of their importance in the clinical trials that are conducted to gain FDA approval of indications. Narrow indications, which are without a sound rational basis, will-in this ...

Known for Severe Psoriasis |  Bsa Involvement |  Severity Patients |  Quality Life |  Body Surface Area
KOL Index score: 7146

Normal skin and actinic keratoses were exposed to fluorouracil in order to study its effect on deoxyribonucleic acid (DNA) synthesis. Using intradermally injected tritiated deoxyuridine and autoradiography, we have demonstrated that fluorouracil blocks DNA synthesis in vivo by inhibiting thymidylate synthetase activity. Fluorouracil administered intradermally blocks DNA synthesis in both normal skin and actinic keratoses. Applied topically, and topically with occlusion, fluorouracil ...

Known for Actinic Keratoses |  Dna Synthesis |  Normal Skin |  5 Fluorouracil |  Tissue Concentration


Gerald David Weinstein: Influence Statistics

Sample of concepts for which Gerald David Weinstein is among the top experts in the world.
Concept World rank
21 patients methotrexate #1
vivo 19 patients #1
epidermopoiesis propranolol injection #1
roughness laxity #1
blood psoriatic patients #1
74 dermatol #1
methotrexate techniques #1
pigmentation flank organs #1
thiotepa fluorouracil #1
psoriasis piritrexim #1
104 105 fluorouracil #1
proliferating lymphoid #1
androstenedione flank #1
fraction psoriasis #1
program topical #1
light uva #1
chemotherapy psoriasis #1
questionnaires 20 #1
differentiated cell kinetics #1
drug penetrated #1
percutaneous penetraton #1
hpd produced #1
psoriatics animal #1
volunteers stimulation #1
doses psoriasis area #1
skin mgbg #1
mtx dna synthesis #1
flank organ growth #1
psoriasis 52000 cells #1
25000arch dermatol #1
cells cd22 cells #1
human hair root #1
normal skin volunteers #1
vaginal assay #1
cytospun preparations #1
mtx dhfr inhibitors #1
29 psoriatic patients #1
psoriasis topical methotrexate #1
cytokinetics chemotherapy #1
methotrexate reviewed #1

Key People For Tazarotene Gel

Top KOLs in the world
John Sefton
tazarotene gel acne vulgaris photodamaged skin
Deborah A Lew‐Kaya
tazarotene cream acne vulgaris photodamaged skin
Roshantha A S Chandraratna
retinoic acid retinoid receptors guinea pigs
Gerald David Weinstein
dna synthesis photodynamic therapy actinic keratoses
Madeleine A Duvic
mycosis fungoides cell lymphoma alopecia areata
John R Gibson
tazarotene gel glabellar lines plaque psoriasis

Gerald David Weinstein:Expert Impact

Concepts for whichGerald David Weinsteinhas direct influence:Tazarotene gel,  Dna synthesis,  Photodynamic therapy,  Normal epidermis,  Proliferating cells,  Puva therapy,  Actinic keratoses,  Photodamaged skin.

Gerald David Weinstein:KOL impact

Concepts related to the work of other authors for whichfor which Gerald David Weinstein has influence:Photodynamic therapy,  Psoriatic arthritis,  Patients psoriasis,  Atopic dermatitis,  Actinic keratoses,  Monoclonal antibodies,  Biologic agents.



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Department of Dermatology, University of California at Irvine, Irvine, California | Department of Dermatology, University of California at Irvine, California | Department of Dermatology, University of California, Irvine, Irvine, CA, USA; and *Valeant

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