• KOL
    • Acute Encephalopathy
    • Masashi Mizuguchi
    • Masashi Mizuguchi: Influence Statistics

      Masashi Mizuguchi

      Masashi Mizuguchi

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      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, School of Medicine Bldg. 3, Rm. N205, 7-3-1 Hongo Bunkyo-ku, 113-0033, ...

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      Masashi Mizuguchi:Expert Impact

      Concepts for whichMasashi Mizuguchihas direct influence:Acute encephalopathy,Acute gastroenteritis,Tuberous sclerosis,Delirious behavior,Frontal lobes,Sequence analysis,Dhaka city,Zellweger syndrome.

      Masashi Mizuguchi:KOL impact

      Concepts related to the work of other authors for whichfor which Masashi Mizuguchi has influence:Acute encephalopathy,Tuberous sclerosis,Shiga toxin,Influenza virus,Biphasic seizures,Central nervous,Periventricular leukomalacia.

      KOL Resume for Masashi Mizuguchi

      Year
      2022

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, School of Medicine Bldg. 3, Rm. N205, 7-3-1 Hongo Bunkyo-ku, 113-0033, Tokyo, Japan

      2021

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

      2020

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan

      2018

      Department of Developmental Medical Sciences Graduate School of Medicine, University of Tokyo Bunkyo‐ku Tokyo Japan

      2017

      the University of Tokyo Department of Developmental Medical Sciences, Graduate School of Medicine Tokyo Japan

      Department of Pediatrics, Graduate School of Medicine, The University of Tokyo.

      2016

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo.

      2015

      Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

      2014

      Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Japan

      2013

      From the Department of Developmental Medical Sciences (M. Shinohara, M. Saitoh, M.M.), Graduate School of Medicine, the University of Tokyo; Addictive Substance Project (D.N., K.I.), Tokyo Metropolitan Institute of Medical Sciences; Department of Pediatrics (S.H.), Fukuoka University; Department of Pediatrics (J.-i.T.), Kameda Medical Center; Department of Cell Therapy and Transplantation Medicine (J.T.), the University of Tokyo; Department of Pediatrics (K.K.), Saitama Medical Children's Hospital; Department of Neurology (M. Kubota), National Center for Child Health and Development; Department of Pediatrics (G.Y.), Tokyo Medical University; Department of Pediatrics (T.S.), Gunma Children's Medical Center; Department of Pediatrics (A.K.), Kitano Hospital; Department of Pediatrics (M. Kikuchi), Hitachi General Hospital; Department of Pediatrics (M.T.), Kagoshima University; Department of Pediatrics (T.G.), Tokyo Metropolitan Children's Medical Center; and Department of Pediatrics (H.Y.), Saitama Medical University, Japan.

      Graduate School of Medicine The University of Tokyo Department of Developmental Medical Sciences Tokyo Japan

      2012

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan

      2011

      Institute of International Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

      Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

      2010

      Tokyo University, Tokyo, Japan

      2009

      The University of Tokyo, Tokyo, Japan (W. Chanit, A. Thongprachum, M. Mizuguchi, H. Ushijima)

      Aino College, Tokyo (S. Okitsu)

      Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine,

      2008

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-8655, Japan

      2007

      Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

      2006

      Department of Pediatrics, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo, Japan

      2005

      Department of Pediatrics, Graduate School of Medicine, the University of Tokyo

      2004

      Department of Pediatrics, Jichi Medical School, Kawachi-gun, Tochigi, Japan

      2003

      Department of Pediatrics, Jichi Medical School, Tochigi, 3, 311-1 Yakushiji, Minamikawachi, Kawachi-gun, 329-0498, Tochigi, Japan

      2002

      Department of Pediatrics, Jichi Medical School, Minamikawachi, and

      2001

      Department of Pediatrics, Jichi Medical School, 3,311-1 Yakushiji, Minamikawachi, Kawachi-gun, Tochigi 329-0498 Japan

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      Sample of concepts for which Masashi Mizuguchi is among the top experts in the world.
      Concept World rank
      adane ranbp2 #1
      patients early steroid #1
      encephalopathy interaction #1
      protooncogene prevention #1
      japan febrile status #1
      ane virological proof #1
      encephalopathy ane1 #1
      recommendations comments #1
      sequelae distinction #1
      encephalopathy adane #1
      severe neurologic complication #1
      amino acid q125h #1
      human leukoencephalitis #1
      familial recurrent ane #1
      asd placebo arm #1
      m1977l #1
      cerebellar cortex drpla #1
      lungs hundreds #1
      45kd heparinbinding protein #1
      il1rn frequency #1
      childhood ane #1
      intravenous administration toxin #1
      acute encephalopathy report #1
      ane east asia #1
      tuberous sclerosis tuberin #1
      73 patients cohort #1
      child newborn leukoencephalitis #1
      gammaglobulin treatment patients #1
      distinction clinically conditions #1
      controls il1rn #1
      hamartin gcr #1
      heterotopic nodules specimen #1
      ane clinical variables #1
      diseases status marmoratus #1
      tertiary status epilepticus #1
      large cohort fibroids #1
      mers mumps vaccination #1
      prominent clasmatodendrosis #1
      conditions neurofibromatosis type #1
      aet aesd #1
      homogeneity disease #1
      thickest distribution #1
      prominent clasmatodendrosis atm #1
      pathological significance findings #1
      hallmark bilateral thalamus #1
      japanese children pathological #1
      basal prosencephalon #1
      holoprosencephaly laminar heterotopia #1
      acute hemorrhagic pandemics #1
      Sign-in to see all concepts, it's free!

      Prominent publications by Masashi Mizuguchi

      KOL-Index: 13159

      Group A rotaviruses are the most common cause of acute viral diarrhea in humans and animals throughout the world. Previous surveillance studies of group A rotaviruses in Thailand indicated that the dominant types of rotaviruses were changing from time to time. During 2000 and 2001, the G9 rotavirus emerged as the most prevalent genotype, with an exceptionally high frequency (91.6%) in Chiang Mai, Thailand. In the year 2002-2004, group A rotavirus was detected in 98 out of 263 (37.3%) ...

      Known for Chiang Thailand | Incidence G9p8 | Genotype Distribution | G1 G2 | Chain Reaction
      KOL-Index: 12757

      Acute respiratory infections are the major cause of morbidity and mortality globally. Human bocavirus (HBoV), a novel virus, is recognized to increasingly associate with previously unknown etiology respiratory infections in young children. In this study, the epidemiological, clinical, and molecular characteristics of HBoV infections were described in hospitalized Vietnamese pediatric patients. From April 2010 to May 2011, 1,082 nasopharyngeal swab samples were obtained from patients with ...

      Known for Acute Respiratory Infections | Human Bocavirus | Hbov Children | Preschool Dna | Minh City
      KOL-Index: 12530

      Infection with Shiga toxin (Stx)-producing Escherichia coli O157:H7, which causes diarrhea and hemorrhagic colitis in humans, often results in fatal systemic complications, such as neurological damage and hemolytic-uremic syndrome. Because Stx circulating in the blood is a major causative factor of these complications, the development of a Stx neutralizer that functions in the circulation holds promise as a viable therapy. Here we developed a series of carbosilane dendrimers, in which ...

      Known for Coli O157 | Super Twig | Shiga Toxin | Oriented Carbohydrates | Infections Escherichia
      KOL-Index: 12298

      Antiviral medications with activity against influenza viruses are important in controlling influenza. We compared intravenous peramivir, a potent neuraminidase inhibitor, with oseltamivir in patients with seasonal influenza virus infection. In a multinational, multicenter, double-blind, double-dummy randomized controlled study, patients aged ≥ 20 years with influenza A or B virus infection were randomly assigned to receive either a single intravenous infusion of peramivir (300 or 600 mg) ...

      Known for Oral Oseltamivir | Influenza Virus | Intravenous Peramivir | Antiviral Agents | Carbocyclic Administration
      KOL-Index: 12039

      A novel reverse transcription-multiplex polymerase chain reaction assay was developed to detect Aichi virus, human parechovirus, enteroviruses, and human bocavirus. A mixture of four pairs of published specific primers, 6261 and 6779, ev22(+) and ev22(-), F1 and R1, 188F and 542R, was used to amplify the viral genomes and specifically generate four different amplicon sizes of 519, 270, 440, and 354 bp for Aichi virus, human parechovirus, enteroviruses, and human bocavirus, respectively. ...

      Known for Human Bocavirus | Aichi Virus | Multiplex Pcr | Acute Gastroenteritis | Infants Children
      KOL-Index: 11683

      Porcine kobuvirus is a new candidate species of the genus Kobuvirus in the family Picornaviridae, and information is still limited. The identification of porcine kobuvirus has been performed by the sequence analyses of the 3D region of the viruses. Therefore, the purpose of this study was to characterize the molecular properties of VP1 nucleotide sequences of the porcine kobuviruses isolated from porcine stool samples in Japan during 2009 and Thailand between 2006 and 2008. In addition, ...

      Known for Porcine Kobuvirus | Sequence Analysis | Vp1 Region | Thailand Japan | Strains Study
      KOL-Index: 11611

      Human caliciviruses, including norovirus (NoV) and sapovirus (SaV), are recognized as common pathogens that cause acute viral gastroenteritis in children and adults throughout the world. To gain an overview of molecular epidemiology of human caliciviruses in children hospitalized with acute gastroenteritis in Chiang Mai, Thailand, from 2002 to 2004, NoV and SaV were detected and characterized molecularly for identification of their genotypes. From a total of 248 fecal specimens ...

      Known for Acute Gastroenteritis | Genetic Diversity | Nov Sav | Chiang Thailand | Children Hospitalized
      KOL-Index: 11491

      OBJECTIVE: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a childhood encephalopathy following severe febrile seizures. The pathogenesis of AESD is considered to be fever-induced seizure susceptibility and excitotoxicity, which may be caused by sodium channel dysfunction in some cases. Here we studied whether mutations in genes encoding sodium channels, SCN1A and SCN2A, predispose children to AESD.

      METHODS: We recruited 92 AESD patients in a nationwide ...

      Known for Sodium Channel | Febrile Seizures | Acute Encephalopathy | Dravet Syndrome | Scn2a Mutation
      KOL-Index: 11039

      An unusual strain of human rotavirus G3P[10] (CMH079/05) was detected in a stool sample of a 2-year-old child admitted to the hospital with severe diarrhea in Chiang Mai, Thailand. Analysis of the VP7 gene sequence revealed highest identities with unusual human rotavirus G3 strain CMH222 at 98.7% on the nucleotide and 99.6% on the amino acid levels. Phylogenetic analysis of the VP7 sequence confirmed that the CMH079/05 strain formed a cluster with G3 rotavirus reference strains and ...

      Known for Human Rotavirus | Phylogenetic Analysis | Vp6 Nsp4 | Molecular Characterization | Chiang Thailand
      KOL-Index: 10909

      Group A rotavirus (RVA) is the most common cause of severe acute viral gastroenteritis in humans and animals worldwide. This study characterized the whole genome sequences of porcine RVAs, 2 G3P[23] strains (CMP40/08 and CMP48/08), 1 G9P[23] strain (CMP45/08), and 1 G3P[13] strain (CMP29/08). These strains were collected from diarrheic piglets less than 7weeks of age in 4 pig farms in Chiang Mai, Thailand, in 2008. The VP7-VP4-VP6-VP1-VP2-VP3-NSP1-NSP2-NSP3-NSP4-NSP5 genes of CMP40/08 ...

      Known for Rotavirus Strains | Porcine Rvas | Vp7 Gene | Genome Viral | Genomic Analysis
      KOL-Index: 10858

      Information about viral acute respiratory infections (ARIs) is essential for prevention, diagnosis and treatment, but it is limited in tropical developing countries. This study described the clinical and epidemiological characteristics of ARIs in children hospitalized in Vietnam. Nasopharyngeal samples were collected from children with ARIs at Ho Chi Minh City Children's Hospital 2 between April 2010 and May 2011 in order to detect respiratory viruses by polymerase chain reaction. ...

      Known for Respiratory Virus | Hbov Hrv | Infections Aris | Influenza Human | Detected Children
      KOL-Index: 10819

      A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire. A total of 983 cases reportedly had acute encephalopathy during the past 3 years, 2007-2010. Among the pathogens of the preceding infection, influenza virus was the most common, followed by human herpesvirus-6 (HHV-6) and rotavirus. Among syndromes of acute encephalopathy, acute encephalopathy with biphasic seizures and late ...

      Known for Acute Encephalopathy | Aesd Mers | Influenza Virus | Japan Ane | Nationwide Survey
      KOL-Index: 10664

      Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder. Genetic disorders frequently accompany autism spectrum disorder, such as tuberous sclerosis complex caused by haploinsufficiency of the TSC1 and TSC2 genes. Accumulating evidence implicates a relationship between autism spectrum disorder and signal transduction that involves tuberous sclerosis complex 1, tuberous sclerosis complex 2 and mammalian target of rapamycin. Here we show behavioural ...

      Known for Mouse Models | Sclerosis Complex | Mammalian Target | Autism Spectrum Disorder | Impaired Social Interaction
      KOL-Index: 10573

      Mutations in the Cyclin-dependent kinase-like 5 (CDKL5) gene cause severe neurodevelopmental disorders accompanied by intractable epilepsies, i.e. West syndrome or atypical Rett syndrome. Here we report generation of the Cdkl5 knockout mouse and show that CDKL5 controls postsynaptic localization of GluN2B-containing N-methyl-d-aspartate (NMDA) receptors in the hippocampus and regulates seizure susceptibility. Cdkl5 -/Y mice showed normal sensitivity to kainic acid; however, they ...

      Known for Cdkl5 Mice | Nmda Receptor | Seizure Susceptibility | Hippocampal Ca1 Region | Increased Ratio
      KOL-Index: 10280

      Tuberous sclerosis complex (TSC) is a genetically heterogeneous disease caused by mutations of TSC1 or TSC2 genes. It involves multiple organ systems resulting in mild to lethal hamartoma formation due to gene mutation in the germ line and loss of heterozygosity (LOH) in somatic cells. Hamartin (TSC1) and tuberin (TSC2) are expressed broadly. However, little is known about tissue susceptibility to hamartomas when equal or similar amounts of TSC gene expression are present. In this study, ...

      Known for Tuberous Sclerosis | Hamartin Tuberin | Complex Tsc | Cardiac Rhabdomyoma | Protein Tumor

      Key People For Acute Encephalopathy

      Top KOLs in the world
      #1
      Masashi Mizuguchi
      acute encephalopathy tuberous sclerosis sequence analysis
      #2
      Hideo Yamanouchi
      acute encephalopathy tuberous sclerosis cortical dysplasia
      #3
      Jun‐ichi Takanashi
      acute encephalopathy reversible splenial lesion biphasic seizures
      #4
      Takashi Ichiyama
      acute encephalopathy kawasaki disease cerebrospinal fluid
      #5
      Yoshihiro Maegaki
      acute encephalopathy status epilepticus febrile seizures
      #6
      Akihisa Okumura
      acute encephalopathy preterm infants periventricular leukomalacia

      Department of Developmental Medical Sciences, Graduate School of Medicine, The University of Tokyo, School of Medicine Bldg. 3, Rm. N205, 7-3-1 Hongo Bunkyo-ku, 113-0033, Tokyo, Japan | Department of Developmental Medical Sciences, Graduate School of

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