• Acute Ischemic Stroke
    • Brachial Arterial Flow...
    • Brachial arterial flow mediated dilation in acute ischemic stroke: Influence Statistics

      Expert Impact

      Concepts for whichthey havehas direct influence:Acute ischemic stroke,Ischemic stroke,Fmd patients,Acute ischemic,Poor outcome,Relationship fmd,Mediated dilation,Flow mediated.

      Key People For Acute Ischemic Stroke

      Top KOLs in the world
      Jeffrey L Saver
      acute ischemic stroke endovascular thrombectomy united states
      Werner MD Hacke
      atrial fibrillation ischemic stroke thrombolytic therapy
      Geoffrey Alan Donnan
      ischemic stroke atrial fibrillation intracerebral haemorrhage
      Michael Douglas Hill
      ischemic stroke endovascular treatment intracerebral hemorrhage
      Joseph P Broderick
      intracerebral hemorrhage ischemic stroke endovascular therapy
      Harold P Jr Adams
      ischemic stroke cerebral infarction subarachnoid hemorrhage

      Brachial arterial flow mediated dilation in acute ischemic stroke


      BACKGROUND AND PURPOSE: Brachial arterial flow-mediated dilation (FMD) reflects endothelium-dependent vasodilation function. FMD is diminished in patients with endothelial dysfunction (ED). Our aim was to investigate the relationship between FMD and outcome for patients with acute ischemic stroke.

      METHODS: We measured FMD in 120 consecutive patients (58.3% male, median age 73 years) with acute ischemic stroke within the first 48 h of onset of the stroke, using high-resolution ultrasonography. FMD was calculated as the relationship between basal diameter of the brachial artery before (d(1)) and after (d(2)) transient vascular occlusion (300 mmHg for 4 min) was measured using a sphygmomanometer (FMD = d(2) - d(1)/d(1) x 100). Poor outcome was defined as modified Rankin Scale at 3 months >2. FMD was categorized according to ROC analysis and we defined ED as FMD < or = 4.5%.

      RESULTS: Thirty-three patients (27.5%) had ED. Median % FMD was 9.12 (7.48). FMD negatively correlated to stroke severity (P = 0.045). Median FMD was significantly lower [4.5 (2.3, 10.3) vs. 9.4 (5.6, 15.1), P = 0.003] for patients with poor outcome (n = 38). The adjusted odds ratio of poor outcome for FMD < or = 4.5% was 3.03 (95% CI, 1.09-27.3).

      CONCLUSIONS: Impaired FMD in patients with acute ischemic stroke is associated with poor outcome.

      Sign-in to see all concepts, it's free!


    Download on the App StoreGet it on Google Play

    Copyright © 2023 KOL - Key Opinion Leaders, LLC.

    KOL does not provide medical advice, diagnosis or treatment.