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    • Robert Jan Van Oostenbrugge
    • Robert Jan van Oostenbrugge

      Robert Jan van Oostenbrugge

      Neurology, Maastricht University Medical Center, Maastricht, The Netherlands | Department of Neurology, CARIM – School for Cardiovascular Diseases Maastricht University ...



      KOL Resume for Robert Jan van Oostenbrugge


      Neurology, Maastricht University Medical Center, Maastricht, The Netherlands


      Department of Neurology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, The Netherlands


      9, Department of Neurology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands


      Department of Neurology and CArdiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.

      MH&NS, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands



      Robert Jan van Oostenbrugge: Influence Statistics

      Sample of concepts for which Robert Jan van Oostenbrugge is among the top experts in the world.
      Concept World rank
      mmseor15 #1
      leakage volume nawm #1
      higher ambulatory #1
      ambulatory levels evrs #1
      rbc velocity increase #1
      parenchymal diffusivity ∆d #1
      7t leakage #1
      pad collateral grades #1
      increase feed vessel #1
      auc oacich #1
      angiography collateral status #1
      ipsilateral mild #1
      psa orgee #1
      angiogenic tcells #1
      tfpi ila #1
      periventricular wmh #1
      oac 30 #1
      24hour baseline #1
      clean registry pad #1
      orgee 95 #1
      circulation occlusion #1
      wml ila #1
      score oac #1
      cgm sex characteristics #1
      baseline parenchymal diffusivity #1
      psd orgee #1
      oac 30day mortality #1
      analysis epilepsy female #1
      association perivascular spaces #1
      pbr glycocalyx #1
      stroke fhstroke #1
      perilesional zone wmh #1
      perivascular spaces progression #1
      cognitive dysfunction svd #1
      intracerebral hemorrhage analyses #1
      illness vrs #1
      mets subtypes #1
      recovery intravoxel #1
      aspiration endovascular procedures #1
      heparinreleasable tfpi patients #1
      parenchymal diffusivity × #1
      wml 95 #1
      cta improves #1
      wmh 2 years #1
      hypoperfusion wmh #1
      plasma tpaactivity #1
      marker csvd #1
      wmh perilesional zones #1
      csvd microvasculature #1
      csvd #1


      Prominent publications by Robert Jan van Oostenbrugge

      KOL-Index: 18776

      BACKGROUND: Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral ...

      Known for Ischaemic Stroke | Cerebral Microbleeds | Intracranial Haemorrhage | Pooled Analysis | Individual Patient Data
      KOL-Index: 18648

      BACKGROUND: CT perfusion (CTP) and diffusion or perfusion MRI might assist patient selection for endovascular thrombectomy. We aimed to establish whether imaging assessments of irreversibly injured ischaemic core and potentially salvageable penumbra volumes were associated with functional outcome and whether they interacted with the treatment effect of endovascular thrombectomy on functional outcome.

      METHODS: In this systematic review and meta-analysis, the HERMES collaboration pooled ...

      Known for Endovascular Thrombectomy | Functional Outcome | Patients Ctp | Ischaemic Stroke | Penumbral Imaging
      KOL-Index: 17668

      BACKGROUND: In 2015, five randomised trials showed efficacy of endovascular thrombectomy over standard medical care in patients with acute ischaemic stroke caused by occlusion of arteries of the proximal anterior circulation. In this meta-analysis we, the trial investigators, aimed to pool individual patient data from these trials to address remaining questions about whether the therapy is efficacious across the diverse populations included.

      METHODS: We formed the HERMES collaboration to ...

      Known for Endovascular Thrombectomy | Individual Patient Data | Randomised Trials | Reduced Disability | Ischaemic Stroke
      KOL-Index: 17620

      IMPORTANCE: Endovascular thrombectomy with second-generation devices is beneficial for patients with ischemic stroke due to intracranial large-vessel occlusions. Delineation of the association of treatment time with outcomes would help to guide implementation.

      OBJECTIVE: To characterize the period in which endovascular thrombectomy is associated with benefit, and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial ...

      Known for Endovascular Thrombectomy | Medical Therapy | 3 Months | Ard 95 | Symptom Onset
      KOL-Index: 16567

      BACKGROUND: General anaesthesia (GA) during endovascular thrombectomy has been associated with worse patient outcomes in observational studies compared with patients treated without GA. We assessed functional outcome in ischaemic stroke patients with large vessel anterior circulation occlusion undergoing endovascular thrombectomy under GA, versus thrombectomy not under GA (with or without sedation) versus standard care (ie, no thrombectomy), stratified by the use of GA versus standard ...

      Known for Endovascular Thrombectomy | Functional Outcome | General Anaesthesia | Ischaemic Stroke | Individual Patient Data
      KOL-Index: 15421

      BACKGROUND: Evidence regarding whether imaging can be used effectively to select patients for endovascular thrombectomy (EVT) is scarce. We aimed to investigate the association between baseline imaging features and safety and efficacy of EVT in acute ischaemic stroke caused by anterior large-vessel occlusion.

      METHODS: In this meta-analysis of individual patient-level data, the HERMES collaboration identified in PubMed seven randomised trials in endovascular stroke that compared EVT with ...

      Known for Evt Patients | Endovascular Stroke | Mortality 90 | Baseline Imaging | Symptomatic Intracranial
      KOL-Index: 13862

      Background and Purpose- The volume of estimated ischemic core using computed tomography perfusion (CTP) imaging can identify ischemic stroke patients who are likely to benefit from reperfusion, particularly beyond standard time windows. We assessed the accuracy of pretreatment CTP estimated ischemic core in patients with successful endovascular reperfusion. Methods- Patients from the HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials) and EXTEND-IA TNK ...

      Known for Ischemic Core | Computed Tomography Perfusion | 24 Hours | Ctp Imaging | Stroke Patients
      KOL-Index: 13669

      BACKGROUND: Randomized, clinical trials in selected acute ischemic stroke patients reported that for every hour delay of endovascular treatment (EVT), chances of functional independence diminish by up to 3.4%. These findings may not be fully generalizable to clinical practice because of strict in- and exclusion criteria in these trials. Therefore, we aim to assess the association of time to EVT with functional outcome in current, everyday clinical practice.

      METHODS: The MR CLEAN Registry ...

      Known for Endovascular Treatment | Acute Ischemic Stroke | Time Evt | Functional Outcome | Successful Reperfusion
      KOL-Index: 13526

      BACKGROUND AND PURPOSE: Recent randomized trials have proven the benefit of intra-arterial treatment (IAT) with retrievable stents in acute ischemic stroke. Patients with poor or absent collaterals (preexistent anastomoses to maintain blood flow in case of a primary vessel occlusion) may gain less clinical benefit from IAT. In this post hoc analysis, we aimed to assess whether the effect of IAT was modified by collateral status on baseline computed tomographic angiography in the ...

      Known for Collateral Status | Tomographic Angiography | Arterial Treatment | Iat Patients | Baseline Computed
      KOL-Index: 13404

      Importance: The positive treatment effect of endovascular therapy (EVT) is assumed to be caused by the preservation of brain tissue. It remains unclear to what extent the treatment-related reduction in follow-up infarct volume (FIV) explains the improved functional outcome after EVT in patients with acute ischemic stroke.

      Objective: To study whether FIV mediates the relationship between EVT and functional outcome in patients with acute ischemic stroke.

      Design, Setting, and Participants: ...

      Known for Acute Ischemic Stroke | Infarct Volume | Endovascular Therapy | Functional Outcome | Evt Patients
      KOL-Index: 13374

      BACKGROUND: Endovascular or intra-arterial treatment (IAT) increases the likelihood of recanalization in patients with acute ischemic stroke caused by a proximal intracranial arterial occlusion. However, a beneficial effect of IAT on functional recovery in patients with acute ischemic stroke remains unproven. The aim of this study is to assess the effect of IAT on functional outcome in patients with acute ischemic stroke. Additionally, we aim to assess the safety of IAT, and the effect ...

      Known for Clinical Trial | Acute Ischemic Stroke | Endovascular Treatment | Study Protocol | 24 Hours
      KOL-Index: 13362

      Background and Purpose- Thrombus imaging characteristics have been reported to be useful to predict functional outcome and reperfusion in acute ischemic stroke. However, conflicting data about this subject exist in patients undergoing endovascular treatment. Therefore, we aimed to evaluate whether thrombus imaging characteristics assessed on computed tomography are associated with outcomes in patients with acute ischemic stroke treated by endovascular treatment. Methods- The MR CLEAN ...

      Known for Endovascular Treatment | Acute Ischemic Stroke | Functional Outcome | Thrombus Imaging | Computed Tomography
      KOL-Index: 12860

      BACKGROUND: Whether infarct size modifies intra-arterial treatment effect is not certain, particularly in patients with large infarcts. We examined the effect of the baseline Alberta Stroke Program Early CT Score (ASPECTS) on the safety and efficacy of intra-arterial treatment in a subgroup analysis of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN).

      METHODS: MR CLEAN was a randomised, controlled, open-label, ...

      Known for Alberta Stroke Program | Patients Aspects | Arterial Treatment | Computed Tomography | 0 4
      KOL-Index: 12487

      Aortic stiffness predicts an excess risk of stroke, supposedly via cerebral small-vessel disease. White matter hyperintensities, silent lacunar infarcts, and brain microbleeds, manifestations of cerebral small-vessel disease on neuroimaging, may precede overt cerebrovascular disease. Therefore, we assessed whether aortic stiffness is also related to such lesions. In 167 hypertensive patients (85 men) without a history of cardiovascular or cerebrovascular disease, a mean age of ...

      Known for Hypertensive Patients | Aortic Pulse | Cerebral Small | Wave Velocity | Vessel Disease
      KOL-Index: 12481

      IMPORTANCE: Intra-arterial treatment (IAT) for acute ischemic stroke caused by intracranial arterial occlusion leads to improved functional outcome in patients treated within 6 hours after onset. The influence of treatment delay on treatment effect is not yet known.

      OBJECTIVE: To evaluate the influence of time from stroke onset to the start of treatment and from stroke onset to reperfusion on the effect of IAT.

      DESIGN, SETTING, AND PARTICIPANTS: The Multicenter Randomized Clinical Trial ...

      Known for Acute Ischemic Stroke | Treatment Time | Clinical Trial | 6 Hours | Onset Reperfusion

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      Robert Jan van Oostenbrugge:Expert Impact

      Concepts for whichRobert Jan van Oostenbruggehas direct influence:Acute ischemic stroke,  Endovascular treatment,  Ischemic stroke,  Functional outcome,  Endovascular thrombectomy,  Lacunar stroke,  Clean registry,  Ischaemic stroke.

      Robert Jan van Oostenbrugge:KOL impact

      Concepts related to the work of other authors for whichfor which Robert Jan van Oostenbrugge has influence:Ischemic stroke,  Mechanical thrombectomy,  Endovascular treatment,  Cognitive impairment,  Functional outcome,  Blood pressure,  Large vessel occlusion.



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      Neurology, Maastricht University Medical Center, Maastricht, The Netherlands | Department of Neurology, CARIM – School for Cardiovascular Diseases Maastricht University Medical Center+, Maastricht, The Netherlands | Department of Neurology, CARIM Sch

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