Prominent publications by Lars Nannestad Jørgensen

KOL Index score: 22401

BACKGROUND: Major abdominal and pelvic surgery carries a high risk of venous thromboembolism (VTE). The efficacy of thromboprophylaxis with low-molecular weight heparin (LMWH) administered during the in-hospital period is well documented, but the optimal duration of thromboprophylaxis after surgery remains controversial. Some studies suggest that patients undergoing major abdominal surgery benefit from prolongation of the thromboprophylaxis to 1 month after surgery. No systematic review ...

Also Ranks for: Prolonged Thromboprophylaxis |  pelvic surgery |  molecular weight |  control lmwh |  venous thromboembolism vte
KOL Index score: 20837

BACKGROUND: Available evidence on the effects of a high fraction of inspired oxygen (FIO2) of 60% to 90% compared with a routine fraction of inspired oxygen of 30% to 40%, during anaesthesia and surgery, on mortality and surgical site infection has been inconclusive. Previous trials and meta-analyses have led to different conclusions on whether a high fraction of supplemental inspired oxygen during anaesthesia may decrease or increase mortality and surgical site infections in surgical ...

Also Ranks for: Inspired Oxygen |  risk bias |  surgical patients |  mortality trials |  site infection
KOL Index score: 17141

CONTEXT: Use of 80% oxygen during surgery has been suggested to reduce the risk of surgical wound infections, but this effect has not been consistently identified. The effect of 80% oxygen on pulmonary complications has not been well defined.

OBJECTIVE: To assess whether use of 80% oxygen reduces the frequency of surgical site infection without increasing the frequency of pulmonary complications in patients undergoing abdominal surgery.


Also Ranks for: Pulmonary Complications |  abdominal surgery |  surgical site infection |  80 oxygen |  atelectasis pneumonia
KOL Index score: 12635

BACKGROUND: Comorbidity has a negative influence on the long-term prognosis in patients with colorectal cancer, whereas its impact on the postoperative course is less clear.

OBJECTIVES: The aim of this study was to investigate the influence of comorbidity on anastomotic leak and short-term outcomes after resection for colonic cancer.

DESIGN: This is a retrospective nationwide cohort study

SETTING: : Data were obtained from the Danish Colorectal Cancer Group and the National Patient ...

Also Ranks for: Anastomotic Leak |  charlson comorbidity |  elective surgery |  colonic cancer |  day mortality
KOL Index score: 11558

BACKGROUND: Incisional hernia repair is a frequent surgical procedure, but perioperative risk factors and outcomes have not been prospectively assessed in large-scale studies. The aim of this nationwide study was to analyze surgical risk factors for early and late outcomes after incisional hernia repair.

STUDY DESIGN: We conducted a prospective nationwide study on all elective incisional hernia repairs registered in the Danish Ventral Hernia Database between January 1, 2007 and December ...

Also Ranks for: Reoperation Recurrence |  incisional hernia |  repair risk factors |  nationwide prospective study |  surgical risk
KOL Index score: 11252

BACKGROUND: A high perioperative inspiratory oxygen fraction may reduce the risk of surgical site infections, as bacterial eradication by neutrophils depends on wound oxygen tension. Two trials have shown that a high perioperative inspiratory oxygen fraction (FiO(2) = 0.80) significantly reduced risk of surgical site infections after elective colorectal surgery, but a third trial was stopped early because the frequency of surgical site infections was more than doubled in the group ...

Also Ranks for: Abdominal Surgery |  pulmonary complications |  surgical site infection |  oxygen fraction |  randomized clinical trial
KOL Index score: 10808

BackgroundLaparoscopic ventral hernia repair (LVHR) is a well established procedure in the treatment of ventral hernias. It is our clinical experience that patients suffer intense postoperative pain, but this issue and other recovery parameters have not been studied in detail.MethodsThirty-five patients with hernias >3 cm prospectively underwent LVHR using “double-crown” titanium tack mesh fixation. Pre- and postoperative pain was measured on a 0–100-mm visual analogue scale (VAS) and ...

Also Ranks for: 6 Months |  quality life |  ventral hernia |  patients pain |  follow studies
KOL Index score: 10612

BackgroundLaparoscopic surgery for colonic cancer decreases the incidence of postoperative complications and length of hospital stay as compared with open surgery, while the oncologic outcome remains equivalent. It is unknown whether the surgical approach impacts on the long-term rate of incisional hernia. Furthermore, risk factors for incisional hernia formation are not fully elucidated. The aim of this study was to evaluate the long-term effect of elective open versus laparoscopic ...

Also Ranks for: Incisional Hernia |  colonic cancer |  laparoscopic surgery |  nationwide cohort |  postoperative complications
KOL Index score: 10592

OBJECTIVE: The combination of plasma tissue inhibitor of metalloproteinases-1 (TIMP-1) and carcinoembryonic antigen (CEA) may be valuable biomarkers for early detection of colorectal cancer (CRC). A prospective, population based study was performed to validate this hypothesis.

MATERIAL AND METHODS: Individuals (n = 4509) referred for large bowel endoscopy due to symptoms of CRC were prospectively included. Baseline data and concurrent diseases were recorded. The primary endpoint was ...

Also Ranks for: Colorectal Cancer |  early detection crc |  plasma timp1 |  carcinoembryonic antigen |  large bowel
KOL Index score: 10419

BACKGROUND: Enhanced recovery after surgery has been shown to lead to improved postoperative outcomes after several surgical procedures. However, only a few studies have examined the application of enhanced recovery after surgery after abdominal wall reconstruction. The aim of the current observational cohort study was to evaluate the outcomes of enhanced recovery after surgery after abdominal wall reconstruction in a large cohort.

METHOD: This was a retrospective cohort study comparing ...

Also Ranks for: Enhanced Recovery |  abdominal wall reconstruction |  readmission rate |  postoperative complications |  surgical procedures
KOL Index score: 10151

BACKGROUND: Surgical outcome results after repair for parastomal hernia are sparsely reported and based on small-scale studies.

OBJECTIVE: This study aims to analyze surgical risk factors for 30-day reoperation and mortality, and, secondarily, to report the risk of reoperation for recurrence.

DESIGN: This is a retrospective analysis of nationwide perioperative surgical variables. The primary outcome was reoperation for surgical complications and/or mortality within 30 days after ...

Also Ranks for: Parastomal Hernia Repair |  ventral humans |  retrospective analysis |  follow studies |  postoperative complications
KOL Index score: 10136

BACKGROUND: Disturbed metabolism in the extracellular matrix (ECM) contributes to formation of abdominal wall hernias. The aim of this study was to gain deeper insight into the ECM turnover in hernia patients by analyzing serum biomarkers specifically reflecting collagen synthesis and breakdown in the interstitial matrix (types I, III, and V collagens) and in the basement membrane (type IV collagen).

MATERIAL AND METHODS: Patients with 3 different types of hernias were included: Primary ...

Also Ranks for: Collagen Turnover |  incisional hernia |  interstitial matrix |  basement membrane |  patients inguinal
KOL Index score: 10102

OBJECTIVE: To investigate the impact of anastomotic leak (AL) on disease recurrence and long-term mortality in patients alive 120 days after curative resection for colonic cancer.

BACKGROUND: There is no solid data as to whether AL after colonic cancer surgery increases the risk of disease recurrence.

METHODS: This was a nationwide cohort study of 9333 patients, prospectively registered in the database of the Danish Colorectal Cancer Group and merged with data from the Danish Pathology ...

Also Ranks for: Colonic Cancer |  distant recurrence |  curative resection |  anastomotic leak |  term mortality
KOL Index score: 9938

Serological biomarkers may be an option for early detection of colorectal cancer (CRC). The present study assessed eight cancer-associated protein biomarkers in plasma from subjects undergoing first time ever colonoscopy due to symptoms attributable to colorectal neoplasia. Plasma AFP, CA19-9, CEA, hs-CRP, CyFra21-1, Ferritin, Galectin-3 and TIMP-1 were determined in EDTA-plasma using the Abbott ARCHITECT® automated immunoassay platform. Primary endpoints were detection of (i) CRC and ...

Also Ranks for: Colorectal Neoplasia |  protein biomarkers |  early detection crc |  detection cancer |  risk adenoma

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Lars Nannestad Jørgensen:Expert Impact

Concepts for whichLars Nannestad Jørgensenhas direct influence:Colorectal cancer,  Incisional hernia,  Inguinal hernia,  Hernia repair,  Colonic cancer,  Ventral hernia,  Acute pancreatitis,  Abdominal wall.

Lars Nannestad Jørgensen:KOL impact

Concepts related to the work of other authors for whichfor which Lars Nannestad Jørgensen has influence:Incisional hernia,  Colorectal cancer,  Wound healing,  Anastomotic leakage,  Venous thromboembolism,  Postoperative complications,  Acute pancreatitis.



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Digestive Disease Center, Bispebjerg Hospital, Copenhagen, Denmark | Institute for Clinical Medicine, University of Copenhagen, Copenhagen, Denmark | Digestive Disease Center (L.N.J.), Bispebjerg and Frederiksberg Hospital, University of Copenhagen,