Albert A Manian: Influence Statistics

Albert A Manian

Albert A Manian

Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857 | Neuroscience Research Branch, National Institute of Mental Health, Rockville, ...

Albert A Manian: Expert Impact

Concepts for which Albert A Manian has direct influence: Chlorpromazine metabolites , Adenylate cyclase , Tricyclic antidepressants , Rat brain , Dopamine receptors , Phenothiazine derivatives , Hydroxylated metabolites .

Albert A Manian: KOL impact

Concepts related to the work of other authors for which for which Albert A Manian has influence: Adenylate cyclase , Tricyclic antidepressants , Rat brain , Cyclic nucleotides , Plasma levels , Active metabolites , Cerebral cortex .

KOL Resume for Albert A Manian

Year
1982

Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857

1981

Neuroscience Research Branch, National Institute of Mental Health, Rockville, Maryland, 20857, U.S.A.

1978

Department of Pharmacology, Michigan State University, East Lansing, MI 48824, USA

Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, MD 20857, U.S.A.

1977

Regis Chemical Company, 8210 N. Austin Avenue, Morton Grove, Illinois 60053

Division of Cardiovascular Research, Department of Pharmacology, College of Pharmacy, University of Houston, Houston, Texas, 77004, U.S.A.

Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852

1976

National Institute of Mental Health, Rockville, Md. 20852 (U.S.A.)

Illinois State Psychiatric Institute, Chicago, Ill. 60612 (USA)

Department of Pharmacology, University of New Mexico School of Medicine, Albuquerque, N.Mex. 87131, U.S.A.

1975

Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852

National Institute of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014

Regis Chemical Company, 8210 N. Austin Avenue, Morton Grove, Ill. 60053

1974

National Institute of Mental Health, Rockville, Maryland, U.S.A.

Abteilung für Neuroanatomie, Institut für Pharmakologie, Universität Hamburg, GFR

Department of Pharmacology, University of Pittsburgh School of Pharmacy, 15261, Pittsburgh, PA

1973

Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Md. 20852 U.S.A.

1972

Regis Chemical Company, 1101 N. Franklin Street, Chicago, Illinois 60610

Department of Pharmacology, College of Medicine Ohio State University, Columbus, Ohio 43210 USA

Psychopharmacology Research Branch, National Institute of Mental Health, 20203, Chevy Chase, Maryland

1971

Psychopharmacology Research Branch, National Institute of Mental Health Chevy Chase, Maryland, USA

Germantown Laboratories, Affiliated with the Franklin Institute 4150 Henry Avenue, Philadelphia, Pa. 19144

Pharmacology Section, Psycho-pharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland 20852

1970

Pharmacology Section, Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Maryland 20015

The Research Institute of Temple University, Philadelphia, Pa. 19144

1969

National Institute of Mental Health, Health Sciences and Mental Health Administration, Chevy Chase, Md. 20203, U.S.A.

1968

Psychopharmacology Research Branch, National Institute of Mental Health, Chevy Chase, Md

Department of Pharmacology, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213

1967

Battelle Memorial Institute and National Institute of Mental Health, Columbus, Ohio 43201

Psychopharmacology Research Branch, National Institute of Mental Health National Institutes of Health, Bethesda, Maryland, USA

Research Institute of Temple University, Philadelphia, Pa. 19144

National Institute of Mental Health, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Md., U.S.A.

1965

Psychopharmacology Service Center, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, USA

Prominent publications by Albert A Manian

KOL-Index: 9443 . Cardiovascular effects of several imipramine analogs were investigated in the anesthetized mongrel dogs. Significant reduction in the cardiac output produced by lower doses (2.5 mg/kg, i.v.) of imipramine and 2-OH-DMI was not due to a depression of myocardial contractility. In contrast, 2-OH-imipramine (1.25 mg/kg) and DMI (2.5 mg/kg) significantly reduced contractility within 10 min after ...
Known for Myocardial Contractility | Cardiac Output | Tricyclic Antidepressants | Anesthetized Dogs
KOL-Index: 7626 . A series of chlorpromazine metabolites and derivatives have been assayed for their ability to compete with 3H-haloperidol binding to dopamine receptors in membranes of rat corpus striatum. 3-Hydroxylation of chlorpromazine doubles affinity for receptor sites, while 7-hydroxychlorpromazine has a potency similar to that of chlorpromazine itself. Other patterns of hydroxylation reduce ...
Known for Dopamine Receptors | Chlorpromazine Metabolites | Haloperidol Binding | Rat Corpus Striatum
KOL-Index: 7585 . Tissue slices were prepared from paired areas of the rat hypothalamus and brain stem. Exposure of the brain slices for 6 min to 5×10−5 M norepinephrine (NE) consistently resulted in a 3- to 5-fold increase in the level of adenosine 3′,5′monophosphate (cyclic AMP). Prochlorperazine and 7-hydroxychlorpromazine at 10−5 M antagonized the increase of the cyclic nucleotide elicited by NE in the ...
Known for Rat Brain | Psychotropic Drugs | Cyclic Response | Tissue Slices
KOL-Index: 6840 . Incubated tissue slices from rat cerebral cortex and medial and lateral hypothalamus readily accumulated cyclic adenosine 3',5'-monophosphate (cyclic AMP) in response to added norepinephrine (NE). The monohydroxylated derivatives of chlorpromazine (CPZ), prochlorperazine, perphenazine, promazine and fluphenazine and respective parent compounds including promethazine and thiothixene were ...
Known for Adenylate Cyclase | Rat Brain | Cpz Prochlorperazine | Cerebral Cortex
KOL-Index: 5584 . Inhibition by phenothiazine derivatives was evaluated with respect to the catalytic component of adenylate cyclase prepared from either a high speed particulate fraction of rat cerebral cortex and hypothalamus or neuronal and glial-enriched fractions from rat and rabbit cerebral cortex. The dihydroxylated analogues of chlorpromazine, prochlorperazine, perphenazine and promazine along with ...
Known for Adenylate Cyclase | Basal Activity | Cerebral Cortex | Parent Compounds
KOL-Index: 5516 . Dopamine (DA) at 10−4M readily activated adenylate cyclase in homogenates of neuronal and glial-enriched fractions prepared from rat cerebral cortex, thalamus, striatum and the total homogenate from the striatum. Several derivatives of phenothiazines were tested for their ability to modify either the control component or the DA-sensitive receptor moiety of the enzyme. Dihydroxy analogues ...
Known for Adenylate Cyclase | Rat Brain | Striatum Dopamine | Cerebral Cortex
KOL-Index: 5071 . The relative muscarinic anticholinergic actions of phenothiazines and related drugs are thought to regulate the propensity of these agents to elicit extrapyramidal side effects, especially those resembling the symptoms of Parkinson's disease. Pimozide, which closely resembles the butyrophenones in its chemical structure and its potent and selective dopamine receptor blockade, differs from ...
Known for Muscarinic Cholinergic | Receptor Binding | Extrapyramidal Effects | Low Incidence
KOL-Index: 4750 . The antiprotozoal activity of chlorpromazine against the pathogenic protozoan Leishmania donovani, in both its amastigote and promastigote stages, was characterized. Chlorpromazine at concentrations greater than or equal to 3.12 micrograms/ml (9.8 X 10(-6) M) produced a significant reduction in viable promastigotes. The minimal protozoacidal concentration for promastigotes, defined as that ...
Known for Antileishmanial Activity | Pathogenic Protozoan | Leishmania Leishmaniasis | Animals Chlorpromazine
KOL-Index: 4399 . Effects of chlorpromazine (CPZ) and three metabolites (3,7-dihydroxy-CPZ; 7,8-dihydroxy-CPZ; 7-hydroxy-CPZ) on behavioral performance of rats were tested by three methods: (a) continuous nondiscriminative lever-pressing shock-avoidance response without a warning signal; (b) discriminative pole-climbing shock avoidance and escape; (c) discriminative control of behavior by drug states. Both ...
Known for Chlorpromazine Cpz | Drug States | Male Rats | Control Behavior
KOL-Index: 3842 . Certain pharmacological responses in mice and rats were contrasted following acute and chronic administrations of chlordiazepoxide. In both species, studies were conducted after oral or intraperitoneal administration of drug. The tests used were (a) hexobarbital sleeping time, (b) hotplate analgesia, (c) maximal electroshock seizure, (d) spontaneous motor activity, (e) forced locomotor ...
Known for Pharmacologic Responses | Drug Administration | Locomotor Activity | Avoidance Learning
KOL-Index: 3596 . Cyclic guanosine 3' ,5'-monophosphate(cyclic GMP) levels were increased in incubated tissue slices from rat cerebral cortex in response to added cholinomimetic agents (carbachol and choline chloride) and neuroleptic compounds (chlorpromazine, 8-hydroxychlorpromazine, 7-hydroxychlorpromazine methiodide, haloperidol, thioridazine, chlorpromazine sulfoxide and promethazine). Calcium ion was ...
Known for Rat Cerebral Cortex | Cyclic Gmp | Choline Chloride | Carbachol Cerebral
KOL-Index: 3523 . Data are presented for thin-layer chromatographic behavior of chlorpromazine and thirty-five of its metabolites, as well as for the thin-layer chromatographic behavior of forty-two still unidentified metabolites found free or as glucuronides in plasma, erythrocytes, urine or feces. Tables are given on the frequency of occurrence of each compound in each source. The presence and ...
Known for Chlorpromazine Metabolites | Gas Chromatography | Phenothiazines Promazine | Layer Chromatographic
KOL-Index: 2730 . An exploratory study consisting of physiochemical and animal experiments was undertaken with the objective of developing one or more metal-L-DOPA chelate systems for an improved transport of L-DOPA into the brain. This approach is based on a theoretical speculation that the pyridoxal-dependent decarboxylation of L-DOPA in the precerebral areas might be obviated by an appropriate metal ...
Known for Metal Chelates | Chelating Agents | Parkinson Disease | Dopa Animals
KOL-Index: 2722 . Conditions have been established for the quantitative formation of radiolabeled derivatives of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma extracts.Tritiated N-acetyl derivatives are formed from the demethylated compounds and C14-quaternary amines from the tertiary amines by acetylation and methylation, respectively. These reactions are quantitative ...
Known for Chlorpromazine Sulfoxide | Internal Standards | Protein Binding | Dogs Humans

Key People For Chlorpromazine Metabolites

Top KOLs in the world
#1
IRENE S Forrest
chlorpromazine metabolism psychiatric patients phenothiazine drugs
#2
Albert A Manian
adenylate cyclase chlorpromazine metabolites tricyclic antidepressants
#3
FRED M FORREST
psychiatric patients chlorpromazine metabolism phenothiazine drugs
#4
MAGDALENA BERGER WECHSLER
urinary chlorpromazine tissue levels brain mitochondria
#5
Daniel H Efron
chlorpromazine sulfoxide demethylated analogs plasma imipramine
#6
D E Green
cytochrome oxidase energy coupling guinea pigs

Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857 | Neuroscience Research Branch, National Institute of Mental Health, Rockville, Maryland, 20857, U.S.A. | Department of Pharmacology, College of Medicine, U