Prominent publications by Albert A Manian

KOL Index score: 9443

Cardiovascular effects of several imipramine analogs were investigated in the anesthetized mongrel dogs. Significant reduction in the cardiac output produced by lower doses (2.5 mg/kg, i.v.) of imipramine and 2-OH-DMI was not due to a depression of myocardial contractility. In contrast, 2-OH-imipramine (1.25 mg/kg) and DMI (2.5 mg/kg) significantly reduced contractility within 10 min after i.v. administration; however, significant decrease in the cardiac output did not occur until after ...

Known for Myocardial Contractility |  Cardiac Output |  Tricyclic Antidepressants |  Anesthetized Dogs |  Imipramine Dmi
KOL Index score: 7626

A series of chlorpromazine metabolites and derivatives have been assayed for their ability to compete with 3H-haloperidol binding to dopamine receptors in membranes of rat corpus striatum. 3-Hydroxylation of chlorpromazine doubles affinity for receptor sites, while 7-hydroxychlorpromazine has a potency similar to that of chlorpromazine itself. Other patterns of hydroxylation reduce affinity. Side chain demethylation lowers affinity for binding sites. Several metabolites which lack ...

Known for Dopamine Receptors |  Chlorpromazine Metabolites |  Haloperidol Binding |  Rat Corpus Striatum |  Blood Levels
KOL Index score: 7585

Tissue slices were prepared from paired areas of the rat hypothalamus and brain stem. Exposure of the brain slices for 6 min to 5×10−5 M norepinephrine (NE) consistently resulted in a 3- to 5-fold increase in the level of adenosine 3′,5′monophosphate (cyclic AMP). Prochlorperazine and 7-hydroxychlorpromazine at 10−5 M antagonized the increase of the cyclic nucleotide elicited by NE in the hypothalamus and the brain stem (p<0.01), while 8-hydroxychlorpromazine and imipramine were ...

Known for Rat Brain |  Psychotropic Drugs |  Cyclic Response |  Tissue Slices |  Chlorpromazine Cpz
KOL Index score: 6840

Incubated tissue slices from rat cerebral cortex and medial and lateral hypothalamus readily accumulated cyclic adenosine 3',5'-monophosphate (cyclic AMP) in response to added norepinephrine (NE). The monohydroxylated derivatives of chlorpromazine (CPZ), prochlorperazine, perphenazine, promazine and fluphenazine and respective parent compounds including promethazine and thiothixene were the most potent inhibitors of the stimulation of cyclic AMP by NE. For the most part, the NE-induced ...

Known for Adenylate Cyclase |  Rat Brain |  Cpz Prochlorperazine |  Cerebral Cortex |  Incubated Tissue
KOL Index score: 5584

Inhibition by phenothiazine derivatives was evaluated with respect to the catalytic component of adenylate cyclase prepared from either a high speed particulate fraction of rat cerebral cortex and hypothalamus or neuronal and glial-enriched fractions from rat and rabbit cerebral cortex. The dihydroxylated analogues of chlorpromazine, prochlorperazine, perphenazine and promazine along with the dioxo form of chlorpromazine were the most potent inhibitors of either basal activity or ...

Known for Adenylate Cyclase |  Basal Activity |  Cerebral Cortex |  Parent Compounds |  Vitro Techniques
KOL Index score: 5516

Dopamine (DA) at 10−4M readily activated adenylate cyclase in homogenates of neuronal and glial-enriched fractions prepared from rat cerebral cortex, thalamus, striatum and the total homogenate from the striatum. Several derivatives of phenothiazines were tested for their ability to modify either the control component or the DA-sensitive receptor moiety of the enzyme. Dihydroxy analogues of chlorpromazine (CPZ), prochlorperazine, perphenazine. promazine and 7.8-dioxo-CPZ exhibited the ...

Known for Adenylate Cyclase |  Rat Brain |  Striatum Dopamine |  Cerebral Cortex |  Induced Activation
KOL Index score: 5071

The relative muscarinic anticholinergic actions of phenothiazines and related drugs are thought to regulate the propensity of these agents to elicit extrapyramidal side effects, especially those resembling the symptoms of Parkinson's disease. Pimozide, which closely resembles the butyrophenones in its chemical structure and its potent and selective dopamine receptor blockade, differs from the butyrophenones in its relatively low incidence of extrapyramidal side effects. In assays of the ...

Known for Muscarinic Cholinergic |  Receptor Binding |  Extrapyramidal Effects |  Low Incidence |  Pimozide Chlorpromazine
KOL Index score: 4750

The antiprotozoal activity of chlorpromazine against the pathogenic protozoan Leishmania donovani, in both its amastigote and promastigote stages, was characterized. Chlorpromazine at concentrations greater than or equal to 3.12 micrograms/ml (9.8 X 10(-6) M) produced a significant reduction in viable promastigotes. The minimal protozoacidal concentration for promastigotes, defined as that concentration which produced greater than or equal to 90% reduction in viable parasites after 18 h, ...

Known for Antileishmanial Activity |  Pathogenic Protozoan |  Leishmania Leishmaniasis |  Animals Chlorpromazine |  Flagellar Motility
KOL Index score: 4399

Effects of chlorpromazine (CPZ) and three metabolites (3,7-dihydroxy-CPZ; 7,8-dihydroxy-CPZ; 7-hydroxy-CPZ) on behavioral performance of rats were tested by three methods: (a) continuous nondiscriminative lever-pressing shock-avoidance response without a warning signal; (b) discriminative pole-climbing shock avoidance and escape; (c) discriminative control of behavior by drug states. Both types of avoidance were much more impaired by CPZ than by the metabolites. The metabolite producing ...

Known for Chlorpromazine Cpz |  Drug States |  Male Rats |  Control Behavior |  Avoidance Learning
KOL Index score: 3842

Certain pharmacological responses in mice and rats were contrasted following acute and chronic administrations of chlordiazepoxide. In both species, studies were conducted after oral or intraperitoneal administration of drug. The tests used were (a) hexobarbital sleeping time, (b) hotplate analgesia, (c) maximal electroshock seizure, (d) spontaneous motor activity, (e) forced locomotor activity (rotarod) and (f) pit avoidance learning. Differences in drug response between acute and ...

Known for Pharmacologic Responses |  Drug Administration |  Locomotor Activity |  Avoidance Learning |  Acute Chronic
KOL Index score: 3596

Cyclic guanosine 3' ,5'-monophosphate(cyclic GMP) levels were increased in incubated tissue slices from rat cerebral cortex in response to added cholinomimetic agents (carbachol and choline chloride) and neuroleptic compounds (chlorpromazine, 8-hydroxychlorpromazine, 7-hydroxychlorpromazine methiodide, haloperidol, thioridazine, chlorpromazine sulfoxide and promethazine). Calcium ion was required for this effect. Moreover, selected agents namely, 7,8-dihydroxychlorpromazine, ...

Known for Rat Cerebral Cortex |  Cyclic Gmp |  Choline Chloride |  Carbachol Cerebral |  Incubated Tissue Slices
KOL Index score: 3523

Data are presented for thin-layer chromatographic behavior of chlorpromazine and thirty-five of its metabolites, as well as for the thin-layer chromatographic behavior of forty-two still unidentified metabolites found free or as glucuronides in plasma, erythrocytes, urine or feces. Tables are given on the frequency of occurrence of each compound in each source. The presence and identification of several new phenothiazine metabolites and their methoxylated analogs are reported.

Known for Chlorpromazine Metabolites |  Gas Chromatography |  Phenothiazines Promazine |  Layer Chromatographic |  Data Presented
KOL Index score: 2730

An exploratory study consisting of physiochemical and animal experiments was undertaken with the objective of developing one or more metal-L-DOPA chelate systems for an improved transport of L-DOPA into the brain. This approach is based on a theoretical speculation that the pyridoxal-dependent decarboxylation of L-DOPA in the precerebral areas might be obviated by an appropriate metal chelation of the aminocarboxylate end of the L-DOPA molecule. Equilibium studies on the interactions of ...

Known for Metal Chelates |  Chelating Agents |  Parkinson Disease |  Dopa Animals |  Phenomena Chemistry
KOL Index score: 2722

Conditions have been established for the quantitative formation of radiolabeled derivatives of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma extracts.Tritiated N-acetyl derivatives are formed from the demethylated compounds and C14-quaternary amines from the tertiary amines by acetylation and methylation, respectively. These reactions are quantitative over a wide range of concentrations.The reactions may be performed sequentially when chloropromazine ...

Known for Chlorpromazine Sulfoxide |  Internal Standards |  Protein Binding |  Dogs Humans |  Phenomena Chemistry


Albert A Manian: Influence Statistics

Sample of concepts for which Albert A Manian is among the top experts in the world.
Concept World rank
metabolite orthoquinone forms #1
dioh cpz #1
inhibitory actions atp #1
chlorpromazine † #1
effects chlorpromazine metabolites #1
† nor2 #1
chlorpromazine 78 #1
hydroxychlorpromazine major #1
orthoquinone forms #1
marked efflux calcium #1
respiration 78dihydroxychlorpromazine #1
calcium mitochondrial preparations #1
sulfoxide demethylated #1
37 dihydroxychlorpromazine #1
78dihydroxychlorpromazine marked efflux #1
chlorpromazine metabolites 7hydroxychlorpromazine #1
respiration 78 #1
inhibition 78dihydroxycpz #2
spiperone central #2
cortex chlorpromazine cyclic #2
solvents chlorpromazine #2
nor1 analog #2
78dimethoxycpz activity #2
378trihydroxycpz 78dihydroxycpz #2
dihydroxyprochlorperazine #2
drug tolerance electroshock #2
pharmacologic responses chlordiazepoxide #2
chlorpromazine derivatives†‡ #2
78 dioh #2
phosphate phosphate acceptor #2
study reduced effectiveness #2
tritiated nacetyl derivatives #2
chlorpromazine sulfoxide derivatives #2
8hydroxycpz #2
labelled pirenzepine #2
free unchanged forms #2
8hydroxycpz cpz #2
inhibition 37dihydroxycpz #2
levels hydroxy derivatives #2
trihydroxy cpz #2
central nervous 7hydroxychlorpromazine #2
promazine phenothiazine #2
78dihydroxycpz 78dimethoxycpz #2
7hydroxycpz 3hydroxycpz #2
displacement labelled pirenzepine #2
c14quaternary amines #2
calmodulin sites action #2
radioassay chlorpromazine #2
multistep syntheses structures #2
37dihydroxycpz 7hydroxycpz #2

Key People For Chlorpromazine Metabolites

Top KOLs in the world
IRENE S Forrest
chlorpromazine metabolism psychiatric patients phenothiazine drugs
Albert A Manian
adenylate cyclase chlorpromazine metabolites tricyclic antidepressants
psychiatric patients chlorpromazine metabolism phenothiazine drugs
urinary chlorpromazine tissue levels brain mitochondria
Daniel H Efron
chlorpromazine sulfoxide demethylated analogs plasma imipramine
D E Green
cytochrome oxidase energy coupling guinea pigs

Albert A Manian:Expert Impact

Concepts for whichAlbert A Manianhas direct influence:Chlorpromazine metabolites,  Adenylate cyclase,  Tricyclic antidepressants,  Rat brain,  Dopamine receptors,  Phenothiazine derivatives,  Hydroxylated metabolites,  Rat cerebral cortex.

Albert A Manian:KOL impact

Concepts related to the work of other authors for whichfor which Albert A Manian has influence:Adenylate cyclase,  Tricyclic antidepressants,  Rat brain,  Cyclic nucleotides,  Plasma levels,  Active metabolites,  Cerebral cortex.



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Neurosciences Research Branch, National Institute of Mental Health, Rockville, Maryland 20857 | Neuroscience Research Branch, National Institute of Mental Health, Rockville, Maryland, 20857, U.S.A. | Department of Pharmacology, College of Medicine, U

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