• Disease
  • Lung
  • Lung Cancer
  • Keith M Sigel

    Prominent publications by Keith M Sigel

    KOL Index score: 13259

    OBJECTIVE: To determine rates of anal dysplasia in a cohort of HIV-infected men who have sex with men (MSM), women, and heterosexual men with abnormal anal cytology.

    DESIGN/METHODS: We evaluated histologic findings in 728 HIV-infected MSM, women, and heterosexual men referred for high-resolution anoscopy (HRA) after abnormal anal cytology in a single-center cohort study. Using multivariable logistic regression, we evaluated predictors of high-grade squamous intraepithelial lesion (HSIL) ...

    Also Ranks for: Anal Dysplasia |  msm women |  hsil cancer |  hiv infected |  viral load
    KOL Index score: 12330

    BACKGROUND: Data on patients with coronavirus disease 2019 (COVID-19) who return to hospital after discharge are scarce. Characterization of these patients may inform post-hospitalization care.

    OBJECTIVE: To describe clinical characteristics of patients with COVID-19 who returned to the emergency department (ED) or required readmission within 14 days of discharge.

    DESIGN: Retrospective cohort study of SARS-COV-2-positive patients with index hospitalization between February 27 and April ...

    Also Ranks for: Hospital Discharge |  admission covid19 |  respiratory distress |  new york city |  studies sars
    KOL Index score: 12212

    Importance: In the last 4 decades, survival among patients with human papillomavirus (HPV)-associated cancers has improved, while the incidence of these cancers has increased among younger cohorts. Among survivors of HPV-associated cancers, persistent HPV infection may remain a risk factor for preventable HPV-associated second primary cancers (HPV-SPCs).

    Objectives: To investigate the risk of HPV-SPCs among survivors of HPV-associated index cancers and to test the hypothesis that the ...

    Also Ranks for: Primary Cancers |  risk hpv |  human papillomavirus |  aged neoplasms |  retrospective studies
    KOL Index score: 12090

    RATIONALE: Prior studies have shown an anticancer effect of metformin in patients with breast and colorectal cancer. It is unclear, however, whether metformin has a mortality benefit in lung cancer.

    OBJECTIVES: To compare overall survival of patients with diabetes with stage IV non-small cell lung cancer (NSCLC) taking metformin versus those not on metformin.

    METHODS: Using data from the Surveillance, Epidemiology, and End Results registry linked to Medicare claims, we identified 750 ...

    Also Ranks for: Patients Metformin |  lung cancer |  diabetes treated |  potential confounders |  small cell
    KOL Index score: 11873

    BACKGROUND: There are limited data regarding the clinical impact of coronavirus disease 2019 (COVID-19) on people living with human immunodeficiency virus (PLWH). In this study, we compared outcomes for PLWH with COVID-19 to a matched comparison group.

    METHODS: We identified 88 PLWH hospitalized with laboratory-confirmed COVID-19 in our hospital system in New York City between 12 March and 23 April 2020. We collected data on baseline clinical characteristics, laboratory values, HIV ...

    Also Ranks for: New York City |  hospitalized patients |  human immunodeficiency virus |  hiv status |  outcomes plwh
    KOL Index score: 11393

    BACKGROUND: Squamous cell carcinoma of the anus (SCCA) incidence is rising in the United States. Study of incidence trends by stage at diagnosis, age-specific and birth cohort patterns, and trends in mortality could provide evidence for a true increase and etiological clues for the increase in incidence.

    METHODS: Using the US Cancer Statistics dataset, we examined trends in SCCA incidence (2001-2015) and mortality (2001-2016) rates. Join-point regression was used to compute annual and ...

    Also Ranks for: United States |  squamous cell carcinoma |  anus incidence |  aapc 95 |  stage scca
    KOL Index score: 9834

    BACKGROUND: Some interstitial lung diseases are associated with lung cancer. However, it is unclear whether asymptomatic interstitial lung abnormalities convey an independent risk.

    OBJECTIVES: The goal of this study was to assess whether interstitial lung abnormalities are associated with an increased risk of lung cancer.

    METHODS: Data from all participants in the National Lung Cancer Trial were analyzed, except for subjects with preexisting interstitial lung disease or prevalent lung ...

    Also Ranks for: Interstitial Lung Abnormalities |  lung cancer |  chest radiography |  screening trial |  early detection
    KOL Index score: 9830

    ObjectivesThe primary objective was to compare the performance of 3 different abbreviated MRI (AMRI) sets extracted from a complete gadoxetate-enhanced MRI obtained for hepatocellular carcinoma (HCC) screening. Secondary objective was to perform a preliminary cost-effectiveness analysis, comparing each AMRI set to published ultrasound performance for HCC screening in the USA.MethodsThis retrospective study included 237 consecutive patients (M/F, 146/91; mean age, 58 years) with chronic ...

    Also Ranks for: Carcinoma Screening |  abbreviated mri |  hepatobiliary phase |  sensitivity hcc |  resonance imaging
    KOL Index score: 9826

    BACKGROUND: Concurrent chemoradiotherapy is an established component of the nonoperative management of locally advanced head and neck squamous cell carcinoma (HNSCC), but the standard dose of 100 mg/m2 cisplatin every 3 weeks is associated with clinically significant toxicity. Interest in a more tolerable regimen has led to the widespread use of weekly lower dose cisplatin, but few randomized trials have compared these approaches.

    METHODS: We examined outcomes of patients with stage ...

    Also Ranks for: Squamous Cell Carcinoma |  3 weeks |  hdc ldc |  head neck |  dose cisplatin
    KOL Index score: 9773

    BACKGROUND: HIV infection is independently associated with risk of lung cancer, but few data exist for the relation between longitudinal measurements of immune function and lung-cancer risk in people living with HIV.

    METHODS: We followed up participants with HIV from the Veterans Aging Cohort Study for a minimum of 3 years between Jan 1, 1998, and Dec 31, 2012, and used cancer registry data to identify incident cases of lung cancer. The index date for each patient was the later of the ...

    Also Ranks for: Lung Cancer |  hiv infection |  cd4 cd8 |  ratio cohort |  immune function
    KOL Index score: 9541

    OBJECTIVE: Utilizing the Veterans Aging Cohort Study, the largest HIV cohort in North America, we conducted one of the few comprehensive comparisons of cancer incidence time trends in HIV-infected (HIV+) versus uninfected persons during the antiretroviral therapy (ART) era.

    DESIGN: Prospective cohort study.

    METHODS: We followed 44 787 HIV+ and 96 852 demographically matched uninfected persons during 1997-2012. We calculated age-, sex-, and race/ethnicity-standardized incidence rates and ...

    Also Ranks for: Cancer Incidence |  antiretroviral therapy |  uninfected persons |  hiv aids |  north america
    KOL Index score: 9389

    Almost half of patients with COPD do not adhere to their medications. Illness and medication beliefs are important determinants of adherence in other chronic diseases. Using the framework of the Common Sense Model of Self-Regulation (CSM), we determined associations between potentially modifiable beliefs and adherence to COPD medications in a cohort of English- and Spanish-speaking adults with COPD from New York and Chicago. Medication adherence was assessed using the Medication ...

    Also Ranks for: Medication Adherence |  pulmonary disease |  chronic obstructive |  ethnic groups |  new york
    KOL Index score: 9328

    p16INK4a immunohistochemistry (IHC) is widely used to facilitate the diagnosis of human papillomavirus (HPV)-associated cervical precancerous lesions. Although most p16 results are distinctly positive or negative, certain ones are ambiguous: they meet some but not all requirements for the "block-positive" pattern. It is unclear whether ambiguous p16 immunoreactivity indicates oncogenic HPV infection or risk of progression. Herein, we compared HPV genotypes and subsequent high-grade ...

    Also Ranks for: P16 Immunohistochemistry |  intraepithelial neoplasia |  human papillomavirus |  differential diagnosis |  hpv genotypes
    KOL Index score: 8987

    OBJECTIVES: Prior studies have shown an anticancer effect of statins in patients with certain malignancies. However, it is unclear whether statins have a mortality benefit in lung cancer. We compared survival of patients with stage IV non-small cell lung cancer (NSCLC) receiving vs. not receiving statins prior to diagnosis.

    METHODS: Using data from the Surveillance, Epidemiology and End Results registry linked to Medicare claims, we identified 5118 patients  >65 years of age diagnosed ...

    Also Ranks for: Lung Cancer |  patients statins |  hazard ratio |  mortality benefit |  reductase inhibitors
    KOL Index score: 8894

    OBJECTIVE: Lung cancer is the leading cause of non-AIDS-defining cancer deaths among HIV-infected individuals. Although lung cancer screening with low-dose computed tomography (LDCT) is endorsed by multiple national organizations, whether HIV-infected individuals would have similar benefit as uninfected individuals from lung cancer screening is unknown. Our objective was to determine the benefits and harms of lung cancer screening among HIV-infected individuals.

    DESIGN: We modified an ...

    Also Ranks for: Lung Cancer |  early detection |  hiv infected |  ldct screening |  target population


    Keith M Sigel: Influence Statistics

    Sample of concepts for which Keith M Sigel is among the top experts in the world.
    Concept World rank
    progression anal intraepithelial #1
    human papillomavirus 11 #1
    cancer incidence veterans #1
    initial lsil #1
    anus study #1
    hrhpvassociated anal cancer #1
    heterosexual rates #1
    classified block #1
    nurse specialty pharmacy #1
    escamosas anales #1
    p16positive lsils #1
    alto grado #1
    navigators specialty #1
    vph subtipos #1
    197 patients medicaid #1
    46 36 lsils #1
    common aidsdefining cancers #1
    positive p16 hiv #1
    hepatitis medications #1
    viral vih #1
    subtipos 16 #1
    novo intraanal hsil #1
    pa approvals #1
    cancer outcomes veterans #1
    lung cancer complication #1
    lsil 16 #1
    negativos vph #1
    lesional outcomes #1
    progression p16 #1
    155 hivuninfected msm #1
    anal low #1
    hsils range #1
    subtipo 18 #1

    Key People For Lung Cancer

    Top KOLs in the world
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Freddie Ian Bray
    cancer incidence nordic countries mortality rates
    Jacques Ferlay
    cancer incidence global burden latin america
    Adi F Gazdar
    lung cancer cell lines aberrant methylation
    Frances Alice Shepherd
    lung cancer small cell adjuvant chemotherapy

    Keith M Sigel:Expert Impact

    Concepts for whichKeith M Sigelhas direct influence:Lung cancer,  Adjuvant chemotherapy,  New york city,  Hiv status,  Squamous cell carcinoma,  United states,  Human papillomavirus,  Cancer risk.

    Keith M Sigel:KOL impact

    Concepts related to the work of other authors for whichfor which Keith M Sigel has influence:Lung cancer,  Hiv infection,  Cytokine storm,  United states,  Human immunodeficiency virus,  Antiretroviral therapy,  Medication adherence.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Division of General Internal Medicine, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: Keith.Sigel@mssm.edu. | Icahn School of Medicine at Mount Sinai, New York, NY, USA. | Icahn School of Medicine at Mount Sinai, New York,