Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpétrière, 91 Blvd de l'Hôpital, 75634 Paris Cedex 13, France | Service de Biochimie Médicale, Faculté de Médecine ...
KOL Resume for M Zenatti
Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpétrière, 91 Blvd de l'Hôpital, 75634 Paris Cedex 13, France
Service de Biochimie Médicale, Faculté de Médecine Pitié-Salpétrière, 91 Bd de l'Hopital, 75634 Paris Cedex 13, France
Service de Biochimie Médicale, Faculté de Médecine, Pitié-Salpétrière, 91 bd de l'hopital, 75634 Paris Cedex 13 France
M Zenatti: Influence Statistics
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Prominent publications by M Zenatti
The authors used incubated adrenal mitochondria to study the in vitro effect of suramin, an antiparasitic drug, on the transformation of corticosterone and 18-hydroxycorticosterone into aldosterone. The results show that, under conditions preserving membrane integrity, the "impermeance" of suramin meant that concentrations similar to the plasma-levels reached in treated patients induced only slight inhibition of the final intramitochondrial steps in aldosterone synthesis. However, ...
Cortisol and testosterone: Inhibitory agents of the mineralocorticoid pathway. Is there a physiopathological meaning in adrenal tumors?
[ PUBLICATION ]
The authors incubated adrenal mitochondria to study the in vitro action of cortisol and testosterone on the transformation of corticosterone and 18-hydroxycorticosterone into aldosterone. The results show that cortisol at concentrations of 5 x 10(-6) and 10(-4) M inhibit the conversion of corticosterone into aldosterone by 23.6 to 90%; testosterone 5 x 10(-5) and 10(-4) M inhibit the reaction by 78.4 and 87.2%, respectively. The inhibition of the conversion of 18-hydroxycorticosterone ...
|Known for Adrenal Mitochondria | 18 Hydroxycorticosterone | Aldosterone Animals | 11 Beta|
The action of verapamil, a calcium channel blocker, on the last step of aldosterone biosynthesis (transformation of 18-hydroxycorticosterone into aldosterone) was studied using duck adrenal mitochondria in the absence of regulatory factors. Results show that 10(-5) M verapamil inhibits the transformation of 18-hydroxycorticosterone into aldosterone by 52.8%. Moreover, our findings show that verapamil induces only a slight inhibition of respiratory capacity without action on respiratory ...
|Known for Aldosterone Synthesis | Calcium Channel Blocker | Verapamil Adrenal | Cytochrome P450|
Key People For Adrenal Carcinoma
M Zenatti:Expert Impact
Concepts for whichM Zenattihas direct influence:Adrenal carcinoma, Aldosterone synthesis, Adrenal mitochondria, Adrenal tumors, Steroid synthesis, 18 hydroxycorticosterone, Adrenal cortical carcinoma, Calcium channel blocker.
M Zenatti:KOL impact
Concepts related to the work of other authors for whichfor which M Zenatti has influence:Potassium homeostasis, Adrenal incidentaloma, Mineralocorticoid insufficiency, Developing hypokalemia, Calcium channel, Severe hypertension, Antihypertensive therapy.
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