• Disease
  • Iga
  • Iga Nephropathy
  • Bruce A Julian

    Prominent publications by Bruce A Julian

    KOL Index score: 15797

    OBJECTIVE: Lupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE) that exhibits familial aggregation and may progress to end-stage renal disease (ESRD). LN is more prevalent among African Americans than among European Americans. This study was undertaken to investigate the hypothesis that the apolipoprotein L1 gene (APOL1) nephropathy risk alleles G1/G2, common in African Americans and rare in European Americans, contribute to the ethnic disparity in ...

    Also Ranks for: African Americans |  lupus nephritis |  renal disease |  chronic lipoproteins |  g1 g2
    KOL Index score: 14150

    IgA1 in the circulation and glomerular deposits of patients with IgA nephropathy (IgAN) is aberrantly glycosylated; the hinge-region O-linked glycans are galactose-deficient. The circulating IgA1 of patients with Henoch-Schoenlein purpura nephritis (HSPN) has a similar defect. This aberrancy exposes N-acetylgalactosamine-containing neoepitopes recognized by naturally occurring IgG or IgA1 antibodies resulting in formation of immune complexes. IgA1 contains up to six O-glycosylation sites ...

    Also Ranks for: Immune Complexes |  mesangial cells |  purpura nephritis |  iga nephropathy |  aberrant glycosylation
    KOL Index score: 13133

    BACKGROUND: Two apolipoprotein L1 gene (APOL1) renal-risk variants in donors and African American (AA) recipient race are associated with worse allograft survival in deceased-donor kidney transplantation (DDKT) from AA donors. To detect other factors impacting allograft survival from deceased AA kidney donors, APOL1 renal-risk variants were genotyped in additional AA kidney donors.

    METHODS: The APOL1 genotypes were linked to outcomes in 478 newly analyzed DDKTs in the Scientific Registry ...

    Also Ranks for: Apol1 Genotype |  kidney transplantation |  renal risk |  allograft survival |  deceased african
    KOL Index score: 12879

    Since the renin angiotensin system (RAS) is established as an important factor in renal disease progression, we determined whether RAS alleles that have been linked to variability in outcome in several cardiovascular diseases also affect progression of IgA nephropathy. These genetic variants include: (1) angiotensin I converting enzyme deletion polymorphism in intron 16 (ACE I/D), reported to be associated with increased risk of myocardial infarction as well as left ventricular ...

    Also Ranks for: Gene Polymorphism |  iga nephropathy |  patients progression |  renal function |  converting enzyme
    KOL Index score: 12790

    In patients with IgA nephropathy (IgAN), circulatory IgA1 and IgA1 in mesangial deposits contain elevated amounts of galactose-deficient IgA1 (Gd-IgA1). We hypothesized that a fraction of Gd-IgA1 from the glomerular deposits and/or circulation may be excreted into the urine and thus represent a disease-specific biomarker. Levels of urinary IgA and Gd-IgA1 were determined in 207 patients with IgAN, 205 patients with other renal diseases, and 57 healthy controls, recruited in USA, Japan, ...

    Also Ranks for: Gd Iga1 |  patients igan |  iga nephropathy |  diseasespecific biomarker |  serum urine
    KOL Index score: 12693

    Circulating immune complexes (CICs) isolated from sera of patients with IgA nephropathy (IgAN) consist of undergalactosylated, mostly polymeric, and J chain-containing IgA1 and IgG antibodies specific for N-acetylgalactosamine (GalNAc) residues in O-linked glycans of the hinge region of IgA1 heavy chains. Antibodies with such specificity occur in sera of IgAN patients, and in smaller quantities in patients with non-IgA proliferative glomerulonephritis and in healthy controls; they are ...

    Also Ranks for: Hinge Region |  circulating immune complexes |  iga1 igg |  olinked glycans |  sera patients
    KOL Index score: 12542

    A chromosome 22q13 locus strongly associates with increased risk for idiopathic focal segmental glomerulosclerosis (FSGS), HIV-1-associated nephropathy (HIVAN), and hypertensive ESRD among individuals of African descent. Although initial studies implicated MYH9, more recent analyses localized the strongest association within the neighboring APOL1 gene. In this replication study, we examined the six top-most associated variants in APOL1 and MYH9 in an independent cohort of African ...

    Also Ranks for: Iga Nephropathy |  african americans |  apol1 variants |  fsgs hivan |  focal segmental
    KOL Index score: 12535

    Levels of IgA1, IgA2, IgM, and IgG antibodies specific for 10 ubiquitous food and bacterial antigens were examined by radioimmunoassay in the sera of 29 patients with IgA-associated renal diseases and 22 normal individuals. No significant differences were observed between patient and normal groups in the levels of IgA1 antibodies, and IgA2 antibodies were detected in only a few individuals in either group. Minor differences in IgM or IgG antibodies were seen against some antigens. ...

    Also Ranks for: Environmental Antigens |  iga1 igg |  renal diseases |  iga humans |  glomerular mesangium
    KOL Index score: 12504

    BACKGROUND: IgA nephropathy (IgAN) is the leading primary GN worldwide. The disease is thought to result from glomerular deposition of circulating immune complexes of IgG bound to galactose-deficient IgA1 (Gd-IgA1). However, routine immunofluorescence microscopy fails to detect IgG in many kidney biopsies from patients with IgAN and the specificity of IgG in immunodeposits has not been tested.

    METHODS: We used remnant frozen kidney-biopsy specimens from 34 patients with IgAN; 14 were ...

    Also Ranks for: Iga Nephropathy |  igg autoantibodies |  glomerular immunodeposits |  kidney biopsies |  circulating immune complexes
    KOL Index score: 12477

    IgA nephropathy is an autoimmune disease characterized by IgA1-containing glomerular immune deposits. We previously proposed a multi-hit pathogenesis model in which patients with IgA nephropathy have elevated levels of circulatory IgA1 with some O-glycans deficient in galactose (Gd-IgA1, autoantigen). Gd-IgA1 is recognized by anti-glycan IgG and/or IgA autoantibodies, resulting in formation of pathogenic immune complexes. Some of these immune complexes deposit in the kidney, activate ...

    Also Ranks for: Iga Nephropathy |  igg autoantibodies |  serum galactose |  immune complexes |  renal diseases
    KOL Index score: 12437

    African Americans carrying two apolipoprotein L1 gene (APOL1) renal risk variants have a high risk for nephropathy. However, only a minority develops end-stage renal disease (ESRD). Hence, modifying factors likely contribute to initiation of kidney disease such as endogenous (HIV infection) or exogenous (interferon treatment) environmental modifiers. In this report, genome-wide association studies and a meta-analysis were performed to identify novel loci for nondiabetic ESRD in African ...

    Also Ranks for: African Americans |  kidney disease |  esrd apol1 |  environment interaction |  risk variants
    KOL Index score: 11779

    BACKGROUND: Sera of patients with IgA nephropathy (IgAN) contain circulating immune complexes (CIC) composed of galactose-deficient IgA1 complexed with antiglycan antibodies. The role of these CIC in the pathogenesis of IgAN is not known.

    METHODS: We studied how proliferation of cultured mesangial cells (MC) is affected by CIC prepared from sera of IgAN patients and healthy control subjects using size-exclusion chromatography. CIC-containing fractions were added to serum-starved MC in ...

    Also Ranks for: Mesangial Cells |  immune complexes |  iga nephropathy |  sera patients |  mesangium glomerulonephritis
    KOL Index score: 11730

    BACKGROUND: Osteopenia is a major complication of renal transplantation. Immunosuppressive regimens including cyclosporine, which permit the use of lower doses of glucocorticoids, may reduce glucocorticoid-induced osteopenia.

    METHODS: We prospectively studied the magnitude, distribution, and mechanism of bone loss in 20 adults who received renal allografts from living related donors, who had good renal function, and who were treated with azathioprine, cyclosporine, and low doses of ...

    Also Ranks for: Renal Transplantation |  mineral density |  rapid loss |  parathyroid hormone |  alkaline phosphatase
    KOL Index score: 11618

    BACKGROUND AND OBJECTIVES: We assessed the activation of the oxidative stress pathway in patients with IgA nephropathy (IgAN), while evaluating the classic marker of the disease (galactose-deficient serum IgA1).

    DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Sera from 292 patients and 69 healthy controls from Italy and the United States were assayed for advanced oxidation protein products (AOPPs), free sulfhydryl groups on albumin (SH-Alb), and IgA1 with galactose-deficient hinge-region ...

    Also Ranks for: Oxidative Stress |  deficient iga1 |  serum levels |  patients igan |  progression iga nephropathy
    KOL Index score: 11379

    BACKGROUND AND OBJECTIVES: There is increasing evidence that galactose-deficient IgA1 (Gd-IgA1) and Gd-IgA1-containing immune complexes are important for the pathogenesis of IgA nephropathy (IgAN). In the present study, we assessed a novel noninvasive multi-biomarker approach in the diagnostic test for IgAN.

    MATERIALS AND METHODS: We compared serum levels of IgA, IgG, Gd-IgA1, Gd-IgA1-specific IgG and Gd-IgA1-specific IgA in 135 IgAN patients, 79 patients with non-IgAN chronic kidney ...

    Also Ranks for: Igan Patients |  serum levels |  gd iga1 |  iga nephropathy |  specific igg


    Bruce A Julian: Influence Statistics

    Sample of concepts for which Bruce A Julian is among the top experts in the world.
    Concept World rank
    nephropathy report #1
    igan immunodeposits pla2r #1
    withdrawal enalapril #1
    conclusion allograft #1
    abnormal glycosylation iga1 #1
    diseasespecific therapy #1
    immune profile diagnosis #1
    tissandié colleagues #1
    nord recipients #1
    26 patients trial #1
    iga renal #1
    individual complement protein #1
    iga1 circulating #1
    galactose deficient glycans #1
    iga1 sialylated #1
    iga humans iga #1
    iga1 percent #1
    hematocrit reticulocyte count #1
    glycans gd #1
    hereditary iga nephropathy #1
    interval purpura onset #1
    large critical lack #1
    igg autoantibodies specific #1
    evaluation familial glomerulonephritis #1
    underlying disorders mechanisms #1
    diseasespecific treatment #1
    cell subsets release #1
    pte enzyme inhibitors #1
    igg igan biopsies #1
    11 african americans #1
    105 iga #1
    antibodies antiidiotypic autoantibodies #1
    clinicopathologic recurrence #1
    serial galactose #1
    birthplaces ancestors #1
    acridinium assay sensitivity #1
    iga1 lectin #1
    nephropathy iga nephropathy #1
    excess erythropoietin production #1
    iga female glomerulonephritis #1
    hla igan #1
    iga1 fragment #1
    biotinlabeled lectin #1
    tapering discontinuing cyclosporine #1
    discontinuing cyclosporine csa #1
    igan clinical subset #1
    enalapril erythrocytosis #1
    birthplaces patients #1
    reticulocyte count withdrawal #1
    losartan rna #1

    Key People For Iga Nephropathy

    Top KOLs in the world
    Bruce A Julian
    iga nephropathy african americans renal transplantation
    Yasuhiko Tomino
    iga nephropathy diabetic rats chronic kidney disease
    John Feehally
    iga nephropathy renal function acute kidney injury
    Rosanna Coppo
    iga nephropathy glomerular disease oxford classification
    F Paolo Principal discussant: Schena
    iga nephropathy renal damage growth factor
    Robert J Wyatt
    iga nephropathy complement activation serum levels

    Bruce A Julian:Expert Impact

    Concepts for whichBruce A Julianhas direct influence:Iga nephropathy,  African americans,  Renal transplantation,  Galactosedeficient iga1,  Immune complexes,  Iga humans,  Patients iga,  Gd iga1.

    Bruce A Julian:KOL impact

    Concepts related to the work of other authors for whichfor which Bruce A Julian has influence:Iga nephropathy,  Kidney transplantation,  Lupus nephritis,  Renal function,  Oxford classification,  Bone marrow,  Mass spectrometry.



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    University of Alabama at Birmingham School of Medicine, Birmingham, AL USA | Comprehensive Transplant Institute, University of Alabama School of Medicine, Birmingham, AL. | University of Alabama School of Medicine, Birmingham, AL. | Department of Med