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    • Benjamin Aaron Alman
    • Benjamin Aaron Alman

      Benjamin Aaron Alman

      Department of Orthopaedic Surgery, Duke University, Durham, NC, USA | Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States | ...



      KOL Resume for Benjamin Aaron Alman


      Department of Orthopaedic Surgery, Duke University, Durham, NC, USA


      Department of Orthopaedics, Duke University Medical Center, Durham, NC, USA; Department of Orthopaedics, Hospital for Sick Kids, Toronto, ON, Canada.

      Regeneration Next Initiative,

      Duke University School of Medicine


      Duke University, Durham, North Carolina.


      Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA


      Department of Orthopaedic Surgery, Duke University, 200 Trent Drive, Orange Zone 5th floor, 27710, Durham, NC, USA

      Developmental & Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada


      From the Department of Orthopaedic Surgery and RegenerationNext Initiative and

      Duke University, Durham, North Carolina,


      Department of Surgery, Duke University Medical Center, Durham, NC, USA.

      Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

      Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada


      Present addresses: Orthopedic Research Laboratories, Department of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA (A.M.C.) and Division of Orthopedic Surgery, Duke University Medical Center, Durham, North Carolina, USA (B.A.A.).

      Department of Orthopedic Surgery, Duke University, Durham, NC 27710;

      University of Toronto Laboratory Medicine and Pathobiology Toronto Ontario Canada


      Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. E-mail address:

      Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON Canada

      Duke Univ., DURHAM, NC, USA


      University of Toronto Department of Surgery Toronto Ontario Canada



      Benjamin Aaron Alman: Influence Statistics

      Sample of concepts for which Benjamin Aaron Alman is among the top experts in the world.
      Concept World rank
      βcateninregulatory function #1
      betacatenin bone development #1
      condition irreversible degeneration #1
      molecular signaling level #1
      enchondroma malignant chondrosarcoma #1
      modulating beta #1
      5b5 antibody #1
      cohorts prolonged ambulation #1
      desmoid progression #1
      phosphogsk3beta total gsk3beta #1
      intracellular biosynthesis cholesterol #1
      fold type iii #1
      pathway enchondromas #1
      intracellular biosynthesis lipids #1
      homeostasis hedgehog #1
      duchenne canada #1
      radiograph neuromuscular #1
      current wound therapies #1
      fibrous dysplasia estrogen #1
      pirl laser wounds #1
      association 4g allele #1
      longterm deflazacort treatment #1
      betacatenin fold #1
      contracted clubfoot #1
      pdgf plantar #1
      spindle fibroblast cells #1
      murine fracture sites #1
      neuromuscular congenital forms #1
      expressing progeny #1
      fibromatosis contracture #1
      benjamin alman colleagues #1
      betacatenin healing #1
      muscle tissue bones #1
      lithium chloride phosphorylation #1
      mutational status betacatenin #1
      outcome distraction osteogenesis #1
      pdgf aggressive #1
      catenin fibronectin #1
      joints current treatment #1
      fetal erythromyeloid progenitors #1
      20 clubfeet #1
      colleagues morphogenic pathway #1
      osteoclasts bone development #1
      disease fascia protein #1
      cases aggressive fibromatosis #1
      molecular etiology characteristics #1
      expression palmar #1
      human enchondromatosis #1
      distal limb length #1
      signal transduction indian #1


      Prominent publications by Benjamin Aaron Alman

      KOL-Index: 16833

      BACKGROUND: Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially improve patient outcome. The signaling pathways regulating bone healing are beginning to be unraveled, and they provide clues into pharmacologic management. The beta-catenin signaling pathway, which activates T cell factor (TCF)-dependent transcription, has emerged as a key regulator in embryonic ...

      Known for Bone Healing | Catenin Signaling | Fracture Repair | Osteoblasts Mice | Osteoblast Lineage
      KOL-Index: 15807

      BACKGROUND: Pain is one of the most common and distressing symptoms reported by adolescents with cancer. Despite advancements in pain assessment and management research, pain due to cancer and/or its treatments continues to be poorly managed. Our research group has developed a native iPhone application (app) called Pain Squad to tackle the problem of poorly managed pain in the adolescent with cancer group. The app functions as an electronic pain diary and is unique in its ability to ...

      Known for Adolescents Cancer | Pain App | Usability Feasibility | Compliance Satisfaction | Testing Adolescent
      KOL-Index: 15221

      Beta-catenin is a critical regulator of cell behavior during embryogenesis and neoplastic processes. It also plays a crucial role in repair by modulating dermal fibroblast activity during the proliferative phase of cutaneous wound healing. We hypothesize that growth factors liberated during the initial phase of wound healing convey signals to induce activation of beta-catenin-mediated TCF-dependent signaling during the proliferative phase. Dermal fibroblasts were isolated and cultured ...

      Known for Growth Factors | Wound Healing | Proliferative Phase | Beta Catenin | Synthase Kinase
      KOL-Index: 13299

      Sporadic aggressive fibromatosis (also called desmoid tumor) is a monoclonal proliferation of spindle (fibrocyte-like) cells that is locally invasive but does not metastasize. A similarity to abdominal fibromatoses (desmoids) in familial adenomatous polyposis and a cytogenetic study showing partial deletion of 5q in a subset of aggressive fibromatoses suggests that the adenomatous polyposis coli (APC) gene plays a role in its pathogenesis. APC helps regulate the cellular level of ...

      Known for Desmoid Tumor | Catenin Protein | Aggressive Fibromatoses | Normal Tissues | Neoplastic Genes
      KOL-Index: 13228

      BACKGROUND: Although simulation-based training is becoming widespread in surgical education and research supports its use, one major limitation is cost. Until now, little has been published on the costs of simulation in residency training. At the University of Toronto, a novel competency-based curriculum in orthopaedic surgery has been implemented for training selected residents, which makes extensive use of simulation. Despite the benefits of this intensive approach to simulation, there ...

      Known for Orthopaedic Residents | Competency Based | Simulation Training | Medical Residency | Academic Year
      KOL-Index: 13169

      Growth plate chondrocytes undergo a tightly regulated process of differentiation, allowing for the longitudinal growth of bones. Although it is known that parathyroid hormone related protein (PTHrP) and Indian hedgehog regulate the differentiation of growth plate chondrocytes, how these pathways interact to regulate chondrocyte development is not fully elucidated. We examined how the interaction between PTHrP and the hedgehog activated transcription factors, Gli2 and Gli3, regulates ...

      Known for Growth Plate | Chondrocyte Differentiation | Gli2 Gli3 | Cell Proliferation | Protein Pthrp
      KOL-Index: 12018

      BACKGROUND: The U.S. Department of Justice's investigations into financial relationships between surgical device manufacturers and orthopaedic surgeons have raised the question as to whether surgeons can continue to collaborate with industry and maintain public trust. We explored postoperative patients' views on financial relationships between surgeons and surgical device manufacturers, their views on disclosure as a method to manage these relationships, and their opinions on ...

      Known for Financial Relationships | Patients Surgeon | Hip Arthroplasty Replacement | Surgical Device Manufacturers | Knee Arthroplasty
      KOL-Index: 11648

      BACKGROUND: Scoliosis due to progressive muscle weakness occurs in almost all males with Duchenne muscular dystrophy, and it progresses relentlessly. Previous studies have shown that corticosteroid treatment slows the decline in muscle strength and stabilizes muscle strength in patients with this disease. We hypothesized that steroids may also attenuate the development of scoliosis. The purpose of this study was to compare the prevalence of scoliosis in male patients with Duchenne ...

      Known for Steroid Treatment | Muscular Dystrophy | Scoliosis Patients | Muscle Strength | Duchenne Predictive
      KOL-Index: 11621

      Growth plate chondrocytes undergo a coordinated differentiation process resulting in terminal differentiation and new bone formation. Enchondromas are pre-malignant, benign cartilaginous lesions that arise from growth plate chondrocytes that fail to undergo terminal differentiation. NOV (nephroblastoma overexpressed) is a member of the CCN family of proteins, which share a common multi-modular organization. While the role of NOV in chondrocyte development and cartilage neoplasia is not ...

      Known for Ccn Members | Nov Expression | Terminal Differentiation | Signaling Proteins | Chondrocyte Development
      KOL-Index: 11553

      Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue neoplasm associated with mutations resulting in β-catenin-mediated transcriptional activation. This tumor is composed of cells with histological and molecular characteristics common to proliferating mesenchymal cells of dermal wounds. Using immunohistochemistry and RT–PCR, we show that Rhamm, a protein with an important role in wound healing and neoplastic progression, is also expressed at high levels in aggressive ...

      Known for Aggressive Fibromatosis | Desmoid Tumor | Genetic Deletion | Knockout Mice | Rhamm Cell Proliferation
      KOL-Index: 11349

      PURPOSE: Pediatric surgeons are increasingly called on by obstetrical colleagues to counsel parents about the implications of a prenatal ultrasound finding. Our understanding of the natural history of many prenatally diagnosed surgical conditions has grown significantly in recent years. Whether prenatal surgical consultation can influence perinatal course had not been investigated.

      METHODS: During an 21-month period, 12,865 prenatal ultrasound studies were performed on a total of 4,551 ...

      Known for Perinatal Management | Prenatal Diagnosis | Pediatric Surgeon | Surgical Consultation | Utero Intervention
      KOL-Index: 11138

      Desmoid tumors arise sporadically or as part of the extraintestinal manifestations of familial adenomatous polyposis (FAP). In FAP, two distinct clinical presentations of the desmoid phenotype are seen: 1) one or a few desmoid tumors present predominantly in the abdominal wall or the abdomen; 2) a florid proliferation of tumors early in life, mostly near the axial skeleton or extremities. These different phenotypes have been associated with different sites of germline mutations in the ...

      Known for Apc Gene | Desmoid Tumor | Germline Mutation | Adenomatous Polyposis | Beta Catenin
      KOL-Index: 10914

      Background: Traditional recommendations hold that open fractures in both children and adults require urgent surgical débridement for a number of reasons, including the preservation of soft-tissue viability and vascular status as well as the prevention of infection. Following the widespread use of early administration of antibiotics, a number of single-institution studies challenged the belief that urgent surgical débridement decreases the risk of acute infection. Methods: We performed a ...

      Known for Acute Infection | Fractures Children | Hours Injury | Surgical Débridement | Gustilo Anderson
      KOL-Index: 10898

      STUDY DESIGN: A cross-sectional evaluation of patients after surgery for adolescent idiopathic scoliosis (AIS).

      OBJECTIVES: To determine the agreement between patients' and parents' perceptions of the patient's postoperative appearance and to compare those perceptions with physical and radiographic measures of deformity.

      SUMMARY OF BACKGROUND DATA: Improving cosmesis is an important aim of surgery. Patients' appearances may influence their evaluation of its outcome.

      METHODS: Physical and ...

      Known for Patients Parents | Idiopathic Scoliosis | Quality Life | Radiographic Measures | Appearance Adolescent
      KOL-Index: 10804

      Proper regulation of Indian hedgehog (Ihh) signaling is vital for chondrocyte proliferation and differentiation in the growth plate. Its dysregulation causes skeletal dysplasia, osteoarthritis or cartilaginous neoplasia. Here, we show that Suppressor of fused (Sufu) and Kif7 are essential regulators of Ihh signaling. While Sufu acts as a negative regulator of Gli transcription factors, Kif7 functions both positively and negatively in chondrocytes. Kif7 plays a role in the turnover of ...

      Known for Growth Plate | Sufu Kif7 | Hedgehog Signaling | Transcription Factors | Primary Cilium

      Key People For Aggressive Fibromatosis

      Top KOLs in the world
      Benjamin Aaron Alman
      aggressive fibromatosis desmoid tumors fracture repair
      Murray, F Brennan
      gastric cancer soft tissue pancreatic adenocarcinoma
      Alessandro Gronchi
      retroperitoneal sarcoma soft tissue neoadjuvant chemotherapy
      Hubert J Wolfe
      situ hybridization aggressive fibromatosis primary biliary cirrhosis
      Gunar K Zagars
      radiation therapy prostate cancer androgen ablation
      Jyrki J REITAMO
      desmoid tumor ulcerative colitis intramuscular myxoma

      Benjamin Aaron Alman:Expert Impact

      Concepts for whichBenjamin Aaron Almanhas direct influence:Aggressive fibromatosis,  Desmoid tumors,  Desmoid tumor,  Fracture repair,  Growth plate,  Eosinophilic granuloma,  Duchenne muscular dystrophy,  Growth factor.

      Benjamin Aaron Alman:KOL impact

      Concepts related to the work of other authors for whichfor which Benjamin Aaron Alman has influence:Wound healing,  Stem cells,  Duchenne muscular dystrophy,  Desmoid tumors,  Bone regeneration,  Aggressive fibromatosis,  Cell proliferation.



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      Department of Orthopaedic Surgery, Duke University, Durham, NC, USA | Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States | Department of Orthopaedic Surgery, Duke University School of Medicine, 2771

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