Benjamin Aaron Alman: Influence Statistics

Benjamin Aaron Alman

Benjamin Aaron Alman

Department of Orthopaedic Surgery, Duke University, Durham, NC, USA | Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States | ...

Benjamin Aaron Alman: Expert Impact

Concepts for which Benjamin Aaron Alman has direct influence: Aggressive fibromatosis , Desmoid tumors , Desmoid tumor , Fracture repair , Growth plate , Eosinophilic granuloma , Duchenne muscular dystrophy .

Benjamin Aaron Alman: KOL impact

Concepts related to the work of other authors for which for which Benjamin Aaron Alman has influence: Wound healing , Stem cells , Duchenne muscular dystrophy , Desmoid tumors , Bone regeneration , Aggressive fibromatosis , Cell proliferation .

KOL Resume for Benjamin Aaron Alman


Department of Orthopaedic Surgery, Duke University, Durham, NC, USA


Department of Orthopaedics, Duke University Medical Center, Durham, NC, USA; Department of Orthopaedics, Hospital for Sick Kids, Toronto, ON, Canada.

Regeneration Next Initiative,

Duke University School of Medicine


Duke University, Durham, North Carolina.


Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC, USA


Department of Orthopaedic Surgery, Duke University, 200 Trent Drive, Orange Zone 5th floor, 27710, Durham, NC, USA

Developmental & Stem Cell Biology Program, Hospital for Sick Children, Toronto, ON, Canada


From the Department of Orthopaedic Surgery and RegenerationNext Initiative and

Duke University, Durham, North Carolina,


Department of Surgery, Duke University Medical Center, Durham, NC, USA.

Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.

Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada


Present addresses: Orthopedic Research Laboratories, Department of Orthopedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA (A.M.C.) and Division of Orthopedic Surgery, Duke University Medical Center, Durham, North Carolina, USA (B.A.A.).

Department of Orthopedic Surgery, Duke University, Durham, NC 27710;

University of Toronto Laboratory Medicine and Pathobiology Toronto Ontario Canada


Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada. E-mail address:

Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, ON Canada

Duke Univ., DURHAM, NC, USA


University of Toronto Department of Surgery Toronto Ontario Canada

Prominent publications by Benjamin Aaron Alman

KOL-Index: 16833 . BACKGROUND: Delayed fracture healing causes substantial disability and usually requires additional surgical treatments. Pharmacologic management to improve fracture repair would substantially improve patient outcome. The signaling pathways regulating bone healing are beginning to be unraveled, and they provide clues into pharmacologic management. The beta-catenin signaling pathway, which ...
Known for Bone Healing | Catenin Signaling | Fracture Repair | Osteoblasts Mice
KOL-Index: 15807 . BACKGROUND: Pain is one of the most common and distressing symptoms reported by adolescents with cancer. Despite advancements in pain assessment and management research, pain due to cancer and/or its treatments continues to be poorly managed. Our research group has developed a native iPhone application (app) called Pain Squad to tackle the problem of poorly managed pain in the adolescent ...
Known for Adolescents Cancer | Pain App | Usability Feasibility | Compliance Satisfaction
KOL-Index: 15221 . Beta-catenin is a critical regulator of cell behavior during embryogenesis and neoplastic processes. It also plays a crucial role in repair by modulating dermal fibroblast activity during the proliferative phase of cutaneous wound healing. We hypothesize that growth factors liberated during the initial phase of wound healing convey signals to induce activation of beta-catenin-mediated ...
Known for Growth Factors | Wound Healing | Proliferative Phase | Beta Catenin
KOL-Index: 13299 . Sporadic aggressive fibromatosis (also called desmoid tumor) is a monoclonal proliferation of spindle (fibrocyte-like) cells that is locally invasive but does not metastasize. A similarity to abdominal fibromatoses (desmoids) in familial adenomatous polyposis and a cytogenetic study showing partial deletion of 5q in a subset of aggressive fibromatoses suggests that the adenomatous ...
Known for Desmoid Tumor | Catenin Protein | Aggressive Fibromatoses | Normal Tissues
KOL-Index: 13228 . BACKGROUND: Although simulation-based training is becoming widespread in surgical education and research supports its use, one major limitation is cost. Until now, little has been published on the costs of simulation in residency training. At the University of Toronto, a novel competency-based curriculum in orthopaedic surgery has been implemented for training selected residents, which ...
Known for Orthopaedic Residents | Competency Based | Simulation Training | Medical Residency
KOL-Index: 13169 . Growth plate chondrocytes undergo a tightly regulated process of differentiation, allowing for the longitudinal growth of bones. Although it is known that parathyroid hormone related protein (PTHrP) and Indian hedgehog regulate the differentiation of growth plate chondrocytes, how these pathways interact to regulate chondrocyte development is not fully elucidated. We examined how the ...
Known for Growth Plate | Chondrocyte Differentiation | Gli2 Gli3 | Cell Proliferation
KOL-Index: 12018 . BACKGROUND: The U.S. Department of Justice's investigations into financial relationships between surgical device manufacturers and orthopaedic surgeons have raised the question as to whether surgeons can continue to collaborate with industry and maintain public trust. We explored postoperative patients' views on financial relationships between surgeons and surgical device manufacturers, ...
Known for Financial Relationships | Patients Surgeon | Hip Arthroplasty Replacement | Surgical Device Manufacturers
KOL-Index: 11648 . BACKGROUND: Scoliosis due to progressive muscle weakness occurs in almost all males with Duchenne muscular dystrophy, and it progresses relentlessly. Previous studies have shown that corticosteroid treatment slows the decline in muscle strength and stabilizes muscle strength in patients with this disease. We hypothesized that steroids may also attenuate the development of scoliosis. The ...
Known for Steroid Treatment | Muscular Dystrophy | Scoliosis Patients | Muscle Strength
KOL-Index: 11621 . Growth plate chondrocytes undergo a coordinated differentiation process resulting in terminal differentiation and new bone formation. Enchondromas are pre-malignant, benign cartilaginous lesions that arise from growth plate chondrocytes that fail to undergo terminal differentiation. NOV (nephroblastoma overexpressed) is a member of the CCN family of proteins, which share a common ...
Known for Ccn Members | Nov Expression | Terminal Differentiation | Signaling Proteins
KOL-Index: 11553 . Aggressive fibromatosis (desmoid tumor) is a locally invasive soft tissue neoplasm associated with mutations resulting in β-catenin-mediated transcriptional activation. This tumor is composed of cells with histological and molecular characteristics common to proliferating mesenchymal cells of dermal wounds. Using immunohistochemistry and RT–PCR, we show that Rhamm, a protein with an ...
Known for Aggressive Fibromatosis | Desmoid Tumor | Genetic Deletion | Knockout Mice
KOL-Index: 11349 . PURPOSE: Pediatric surgeons are increasingly called on by obstetrical colleagues to counsel parents about the implications of a prenatal ultrasound finding. Our understanding of the natural history of many prenatally diagnosed surgical conditions has grown significantly in recent years. Whether prenatal surgical consultation can influence perinatal course had not been ...
Known for Perinatal Management | Prenatal Diagnosis | Pediatric Surgeon | Surgical Consultation
KOL-Index: 11138 . Desmoid tumors arise sporadically or as part of the extraintestinal manifestations of familial adenomatous polyposis (FAP). In FAP, two distinct clinical presentations of the desmoid phenotype are seen: 1) one or a few desmoid tumors present predominantly in the abdominal wall or the abdomen; 2) a florid proliferation of tumors early in life, mostly near the axial skeleton or extremities. ...
Known for Apc Gene | Desmoid Tumor | Germline Mutation | Adenomatous Polyposis
KOL-Index: 10914 . Background: Traditional recommendations hold that open fractures in both children and adults require urgent surgical débridement for a number of reasons, including the preservation of soft-tissue viability and vascular status as well as the prevention of infection. Following the widespread use of early administration of antibiotics, a number of single-institution studies challenged the ...
Known for Acute Infection | Fractures Children | Hours Injury | Surgical Débridement
KOL-Index: 10898 . STUDY DESIGN: A cross-sectional evaluation of patients after surgery for adolescent idiopathic scoliosis (AIS). OBJECTIVES: To determine the agreement between patients' and parents' perceptions of the patient's postoperative appearance and to compare those perceptions with physical and radiographic measures of deformity. SUMMARY OF BACKGROUND DATA: Improving cosmesis is an important aim of ...
Known for Patients Parents | Idiopathic Scoliosis | Quality Life | Radiographic Measures
KOL-Index: 10804 . Proper regulation of Indian hedgehog (Ihh) signaling is vital for chondrocyte proliferation and differentiation in the growth plate. Its dysregulation causes skeletal dysplasia, osteoarthritis or cartilaginous neoplasia. Here, we show that Suppressor of fused (Sufu) and Kif7 are essential regulators of Ihh signaling. While Sufu acts as a negative regulator of Gli transcription factors, ...
Known for Growth Plate | Sufu Kif7 | Hedgehog Signaling | Transcription Factors

Key People For Aggressive Fibromatosis

Top KOLs in the world
Benjamin Aaron Alman
aggressive fibromatosis desmoid tumors fracture repair
Murray, F Brennan
gastric cancer soft tissue pancreatic adenocarcinoma
Alessandro Gronchi
retroperitoneal sarcoma soft tissue neoadjuvant chemotherapy
Hubert J Wolfe
situ hybridization aggressive fibromatosis primary biliary cirrhosis
Gunar K Zagars
radiation therapy prostate cancer androgen ablation
desmoid tumor ulcerative colitis intramuscular myxoma

Department of Orthopaedic Surgery, Duke University, Durham, NC, USA | Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC 27710, United States | Department of Orthopaedic Surgery, Duke University School of Medicine, 2771