Prominent publications by Jacek Sygut

KOL Index score: 10049

CONTEXT: An activating mutation in the gene BRAF has been correlated with poorer prognosis and more aggressive clinical course in papillary thyroid carcinoma (PTC). We therefore hypothesized that the good prognosis, high 5-year disease-free rate and high survival rate of patients with less aggressive papillary thyroid microcarcinoma (pT1aNo-x) would be associated with a lower incidence of the BRAF(V600E) mutation.

OBJECTIVES: To evaluate the frequency of the activating mutation ...

Known for Brafv600e Mutation |  Papillary Thyroid |  Ptc Study |  Lymph Node |  Poorer Prognosis
KOL Index score: 8148

BACKGROUND: Phaeochromocytoma (PCC) and paraganglioma (PGL) can occur sporadically or as a part of familial cancer syndromes. Red flags of hereditary syndromes are young age and multifocal tumours. We hypothesized that such patients are candidates for further molecular diagnosis in case of normal results in 'classical' genes.

MATERIAL AND METHODS: We selected patients with PCC/PGL under the age of 40 and/or with multiple tumours. First, we tested the genes RET, VHL, NF1, SDHB, SDHC and ...

Known for Hereditary Syndromes |  Mutations Max |  Neoplasms Adult |  Pcc Pgl |  Susceptibility Genes
KOL Index score: 4868

The aims of this study were to analyze the cadherin/catenin adhesion complex in cells from abdominal and extra-abdominal aggressive fibromatosis tumors, and to estimate the correlation between the expression of the tested proteins and the clinical data of the desmoid patients. Immunohistochemistry was used to examine the expression of the cadherin/catenin adhesion complex: APC protein, alpha-, beta-catenin, and N-cadherin in archival material derived from 15 cases of extra-abdominal ...

Known for Aggressive Fibromatosis |  Desmoid Tumor |  Beta Catenin |  Positive Cells |  Humans Immunohistochemistry
KOL Index score: 2463

Tuberous sclerosis complex (tsc), a phacomatosis, is a rare genetic disease (autosomal dominant; incidence: 1 in 6,800-17,300) associated with mutations in the TSC1 and TSC2 genes, 70% of which are sporadic. The disease causes benign tumours in the brain, kidneys, heart, lungs, skin, and eyes; thyroid lesions are extremely rare. A 13-year-old euthyroid boy with a hereditary form of tsc (del 4730G in TSC2, also seen in 2 sisters and the father) was admitted to hospital with a thyroid ...

Known for Papillary Thyroid Carcinoma |  Tuberous Sclerosis |  Tsc1 Tsc2 Genes |  Tsc Rare |  Endocrine Neoplasia


Jacek Sygut: Influence Statistics

Sample of concepts for which Jacek Sygut is among the top experts in the world.
Concept World rank
fasciae aponeuroses #4
± nucleus #5
examined desmoid cases #5
desmoid cases #5
content desmoid #5
nucleus desmoid tumours #5
expression desmoid #5
aggressive humans ki67 #5
desmoid tumours agnors #5
agnor proteins expression #5
nucleus agnor content #5
nuclear proliferative proteins #5
ki67 agnors expression #5
± dot area #5
nuclear expression mcm7 #8
agnors agnor parameters #11
nucleus agnor area #11
nuclear expression ki67 #12
agnor area nucleus #13
ki67 agnors #13
agnor dot #15
agnors area #16
cases paraffin sections #18
activity desmoid #19
agnors expression #27
mcm5 proteins #32
nucleus agnor #34
agnors agnor #36
sporadic desmoid tumours #36
agnor content #38
phaeochromocytoma pcc #39
mcm5 mcm7 #45
desmoid cells #46
immunohistochemistry nm23 #47
ret y791f #49
cases desmoid #52
occurrence medullary #55
extraabdominal desmoid tumor #66
agnor parameters #73
immunohistochemical algorithms #77
desmoid patients #87
mutations max #88
tate pet #92
mcm7 ki67 #97
patients pdtc #97
± area #98

Key People For Aggressive Fibromatosis

Top KOLs in the world
Benjamin Aaron Alman
aggressive fibromatosis desmoid tumors fracture repair
Murray, F Brennan
gastric cancer soft tissue pancreatic adenocarcinoma
Alessandro Gronchi
retroperitoneal sarcoma soft tissue neoadjuvant chemotherapy
Hubert J Wolfe
situ hybridization aggressive fibromatosis primary biliary cirrhosis
Gunar K Zagars
radiation therapy prostate cancer androgen ablation
desmoid tumor ulcerative colitis intramuscular myxoma

Jacek Sygut:Expert Impact

Concepts for whichJacek Syguthas direct influence:Aggressive fibromatosis,  Desmoid tumor,  Thyroid cancer,  Thyroid carcinoma,  Follicular thyroid,  Papillary thyroid carcinoma,  Papillary carcinoma,  Follicular carcinoma.

Jacek Sygut:KOL impact

Concepts related to the work of other authors for whichfor which Jacek Sygut has influence:Thyroid cancer,  Brafv600e mutation,  Desmoid tumors,  Malignant melanoma,  Aggressive fibromatosis,  Rhabdomyoblastic differentiation,  Becker nevus.



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Department of Tumor Pathology, Greater Poland Cancer Centre in Poznan, Poznan. | Holycross Cancer Centre Department of Surgical Pathology Kielce Poland | Holycross Cancer Centre in Kielce, Poland | Holycross Cancer Center Department of Pathology and

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