Vito BrusascoShow email address
Centro Polifunzionale di Scienze Motorie, Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy. | Dipartimento di Medicina Sperimentale, Università di ...
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Vito Brusasco:Expert Impact
Concepts for whichVito Brusascohas direct influence:Deep inhalation,Airway responsiveness,Nedocromil sodium,Lung volume,Lung function,Allergen challenge,Late asthmatic reaction,Pulmonary resistance.
Vito Brusasco:KOL impact
Concepts related to the work of other authors for whichfor which Vito Brusasco has influence:Lung function,Cystic fibrosis,Pulmonary disease,Copd patients,Chronic obstructive,Physical activity,Asthma control.
KOL Resume for Vito Brusasco
Centro Polifunzionale di Scienze Motorie, Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy.
Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy
Centro Polifunzionale di Scienze Motorie, Dipartimento di Medicina Sperimentale, Università di Genova, IRCCS Ospedale Policlinico San Martino, Genova, Italy
Department of Experimental Medicine, University of Genoa, Via Leon Battista Alberti 2, 16132, Genoa, Italy
Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, Genoa, Italy
5 University of Genoa Genova, Italy.
School of Medical and Pharmaceutical Sciences, University of Genoa, Genoa, Italy
4 University of Genoa Genoa, Italy.
University of Genoa, San Martino Hospital Department of Internal Medicine and Medical Specialties Genoa Italy
1 Scuola di Scienze Mediche e Farmaceutiche Università di Genova Genova, Italy and.
Department of Internal Medicine and Medical Specialties, University of Genoa, Genoa, Italy
Dept of Internal Medicine, Genoa University, Genoa, Italy
University of Genoa, Genoa, Italy
Respiratory Diseases, ‘UniversitàdegliStudi’ of Genua, Genua
Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova, Genova, Italy
University of Genoa, Respiratory Physiopathology Unit, Department of Internal Medicine, Genoa, Italy
Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, 16132 Genova, Italy
Unità Operativa Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova, Italy
Dipartimento di Medicina Interna, Universitαave; di Genova, Genova
Dept of Internal Medicine, University of Genoa, Genoa
1European Respiratory Journal, 2Proceedings of the American Thoracic Society, 3American Journal of Respiratory Cell and Molecular Biology, 4Journal of Applied Physiology, 5Primary Care Respiratory Journal, 6Respiratory Research, 7Respirology, 8International Journal of COPD, and 9Respiratory Medicine.
1Unità Operativa (U.O.) Medicina Preventiva e del Lavoro, Laboratorio di Fisiopatologia Respiratoria, 2U.O. Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova, Azienda Ospedaliera Universitaria “San Martino”, Genova, and 3Centro di Fisiopatologia Respiratoria e dello Studio della Dispnea, Azienda Ospedaliera S.Croce e Carle, Cuneo, Italy.
1Pneumologia-Fisiopatologia Respiratoria and 3Dietetica e Nutrizione Clinica, Azienda Ospedaliera S. Luigi, Orbassano (Torino); 2TBM Laboratory, Dipartimento di Bioingegneria, Politecnico di Milano, Milano, Italy; 4Department of Physiology and Biophysics, and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; 5Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova, Genova, Italy; and 6Centro di Fisiopatologia Respiratoria e di Studio della Dispnea, Azienda Ospedaliera S. Croce e Carle, Cuneo, Italy
Dipartimento di Medicina Interna, Università di Genova, Viale Benedetto XV, 6, 16132 Genova, Italy,
1Dept of Preventive and Occupational Medicine - Laboratory of Respiratory Pathophysiology, 2Dept of Haematology, San Marino University, and 3Unit of Respiratory Pathophysiology, Dept of Internal Medicine, University of Genoa, Genova, Italy.
For affiliations, please see the Acknowledgements section.
Cattedra di Fisiopatologia Respiratoria, DISM, Università di Genova, Genoa, Italy
Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova; and Centro di Fisiopatologia Respiratoria e dello Studio della Dispnea, Azienda Ospedaliera S Croce e Carle, Cuneo, Italy
Médecine interne, Université de Gênes, Italie
Dipartimento di Medicina Interna, Università di Genova, 16132 Genova
Respiratory Pathophysiology Unit, Dept. of Internal Medicine, University of Genoa, Italy
1Internal Medicine, University of Genoa, Genova, Italy. 2Pulmonary Division, LDS Hospital, Salt Lake City, UT, USA. 3Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
For affiliations, please see Acknowledgements section
Dipartimento di Medicina Clinica, University of Rome “La Sapienza”, Rome, Italy, Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy, and Centro di Fisiopatologia Respiratoria e di Studio della DispneaAzienda Ospedaliera S. Croce e Carle, Cuneo, Italy
From aDipartimento di Medicina Interna, Università di Genova, Genoa; bClinica Pediatrica, Università di Verona; and cIstituto Pio XII, Misurina Italy
Facoltà di Medicina e Chirurgia, Università di Genova, Genova, Italy.
Servizio di Fisiopatologia Respiratoria, Dipartimento di Medicina Interna e Specialità Mediche, Università di Genova, 16132 Genova, Italy
Dipartimenti di Scienze Motorie e Riabilitative, di Medicina Interna, e di Medicina Sperimentale, Università di Genova, 16132 Genoa, Italy
Dipartimento di Medicina Interna, Universitàdi Genova, 16132 Genova; and
Department of Motor Sciences, University of Genova, 16132 Genoa;
Dipartimenti di Scienze Motorie e Riabilitative di Medicina Interna e di Oncologia Biologica e Genetica, Università di Genova, 16132 Genova; and Divisione di Pneumologia, Istituto G. Gaslini, 16130 Genova, Italy
Clinica di Malattie dell' Apparato Respiratorio and Istituto di Radiologia Medica, Istituo di Recovero e Cura a Carattere Scientifico, 27100 Pavia, Italy; Servizio di Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo, Italy; Laboratorium voor Pneumologie, Universitaire Ziekenhuis Gasthuisberg, B-3000 Leuven, Belgium; and Cattedra di Fisiopatologia Respiratoria, Dipartimento di Scienze Motorie e Riabilitative, Universitàdi Genova, 16132 Genoa, Italy
Dipartimento di Scienze Motorie e Riabilitative, Università degli Studi di Genova, 16132 Genova; and
Dipartimento di Science Medico & Riabilitazione, Universita of Genova, 16132 Genova Italy
Cattedra di Fisiopatologia Respiratoria, Dipartimento di Scienze Motorie e Riabilitative, Università di Genova, Italy.
Department of Motor Sciences, University of Genova, Genova, Italy
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Prominent publications by Vito Brusasco
Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD.
[ PUBLICATION ]
BACKGROUND: A study was undertaken to record exacerbations and health resource use in patients with COPD during 6 months of treatment with tiotropium, salmeterol, or matching placebos.
METHODS: Patients with COPD were enrolled in two 6-month randomised, placebo controlled, double blind, double dummy studies of tiotropium 18 micro g once daily via HandiHaler or salmeterol 50 micro g twice daily via a metered dose inhaler. The two trials were combined for analysis of heath outcomes ...
|Known for Tiotropium Salmeterol | Health Outcomes | Life Copd | Patient Year | Compared Placebo|
Exercise‐induced asthma, respiratory and allergic disorders in elite athletes: epidemiology, mechanisms and diagnosis: Part I of the report from the Joint Task Force of the European Respiratory Societ
[ PUBLICATION ]
AIMS: To analyze the changes in the prevalence of asthma, bronchial hyperresponsiveness (BHR) and allergies in elite athletes over the past years, to review the specific pathogenetic features of these conditions and to make recommendations for their diagnosis.
METHODS: The Task Force reviewed present literature by searching Medline up to November 2006 for relevant papers by the search words: asthma, bronchial responsiveness, EIB, athletes and sports. Sign criteria were used to assess ...
|Known for Elite Athletes | Diagnosis Asthma | Task Force | Bronchial Hyperresponsiveness | Endurance Sports|
Treatment of exercise‐induced asthma, respiratory and allergic disorders in sports and the relationship to doping: Part II of the report from the Joint Task Force of European Respiratory Society (ERS)
[ PUBLICATION ]
AIM: The aims of part II is to review the current recommended treatment of exercise-induced asthma (EIA), respiratory and allergic disorders in sports, to review the evidence on possible improvement of performance in sports by asthma drugs and to make recommendations for their treatment.
METHODS: The literature cited with respect to the treatment of exercise induced asthma in athletes (and in asthma patients) is mainly based upon the systematic review given by Larsson et al. (Larsson K, ...
|Known for Induced Asthma | Task Force | Treatment Eia | Sports Performance | Inhalation Adrenergic|
[ PUBLICATION ]
BACKGROUND: Evidence has been provided that high-dose indacaterol (300 μg) can reduce lung hyperinflation in moderate-to-severe chronic obstructive pulmonary disease (COPD).
AIM: To study whether low-dose indacaterol (150 μg) also reduces lung hyperinflation in comparison with the recommended dose of tiotropium (18 μg) in moderate COPD.
METHODS: This was a multicenter, randomized, blinded, 3-period cross-over, placebo-controlled study. Spirometry and lung volumes were measured before and ...
|Known for Lung Hyperinflation | Indacaterol Tiotropium | Inspiratory Capacity | Humans Indans | 150 Μg|
To determine the sensitivity of pulmonary resistance (RL) to changes in breathing frequency and tidal volume, we measured RL in intact anesthetized dogs over a range of breathing frequencies and tidal volumes centering around those encountered during quiet breathing. To investigate mechanisms responsible for changes in RL, the relative contribution of airway resistance (Raw) and tissue resistance (Rti) to RL at similar breathing frequencies and tidal volumes was studied in six excised, ...
|Known for Tidal Volume | Pulmonary Resistance | Raw Rti | Breathing Frequency | Alveolar Capsules|
OBJECTIVES: To evaluate the effect of beclomethasone/formoterol versus budesonide/formoterol (non-inferiority) and versus formoterol (superiority) in patients with severe stable chronic obstructive pulmonary disease (COPD).
METHODS: A double-blind, double-dummy, randomised, active-controlled, parallel-group study. After 4 weeks run-in with ipratropium/salbutamol (40/200 μg, three times daily) patients were randomised to receive beclomethasone/formoterol (200/12 μg pressurised metered ...
|Known for Beclomethasone Formoterol | 48 Weeks | Copd Exacerbations | Randomised Controlled | Chronic Obstructive Quality|
[ PUBLICATION ]
In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory treatments. We studied 71 patients with chronic asthma and allergic sensitization to perennial allergens. Airway responsiveness was determined by inhalation of methacholine, and ...
|Known for Allergic Asthma | Airway Inflammation | Bronchoalveolar Lavage | Bronchial Biopsy | Inflammatory Cells|
Late-phase Asthmatic Reaction to Inhaled Allergen Is Associated with Early Recruitment of Eosinophils in the Airways
[ PUBLICATION ]
To determine whether a link exists between the recruitment of inflammatory cells in the airways and the development of the late-phase asthmatic reaction, we studied with bronchoalveolar lavage 54 asthmatic patients either at baseline (10 patients) or 4 h (11 patients), 24 h (13 patients), and 72 h (20 patients) after allergen inhalation challenge. Among the patients studied 4 h after allergen challenge, five were known to have a late-phase asthmatic response and showed a significant ...
|Known for Bronchoalveolar Lavage | Phase Asthmatic | Inhaled Allergen | Percentage Eosinophils | Inflammatory Cells|
The effects of full lung inflation on respiratory conductance (Grs) and reactance (Xrs) were measured in 15 subjects with moderate to severe chronic obstructive pulmonary disease (COPD) and 11 matched healthy control subjects. Airway distensibility was estimated from the ratio of the difference of Grs between functional residual capacity and total lung capacity to the relevant changes in lung volume (ΔGrs/ΔVl) or transpulmonary pressure (ΔGrs/ΔPtp). Similar analysis was applied to Xrs to ...
|Known for Airway Distensibility | Lung Inflation | Pulmonary Disease | Copd Subjects | Chronic Obstructive|
[ PUBLICATION ]
We studied nine asthmatic patients with a history of exercise-induced asthma (EIA) in order to investigate whether inflammatory changes in the airways occur after exercise and are eventually associated with the development of a late-phase asthmatic response. On two separate study days, bronchoalveolar lavage (BAL), bronchial lavage (BL), and bronchial biopsy (BB) were performed 3 h after an exercise or a methacholine (MCh) challenge. On two other separate occasions, FEV1 was monitored ...
|Known for Airway Inflammation | Induced Asthma | Exercise Patients | Expiratory Volume | Bronchoalveolar Lavage|
Dissociation between exhaled nitric oxide and hyperresponsiveness in children with mild intermittent asthma
[ PUBLICATION ]
BACKGROUND: Bronchial hyperresponsiveness and airway inflammation are distinctive features of asthma. Evaluation of nitric oxide (NO) levels in expired air have been proposed as a reliable method for assessing the airway inflammatory events in asthmatic subjects. A study was undertaken to evaluate whether airway hyperresponsiveness is related to levels of exhaled NO.
METHODS: Thirty two steroid-naive atopic children with mild intermittent asthma of mean (SD) age 11.8 (2.3) years and 28 ...
|Known for Mild Intermittent Asthma | Nitric Oxide | Airway Hyperresponsiveness | Vital Capacity | Levels Exhaled|
[ PUBLICATION ]
We determined the dose-response curves to inhaled methacholine (MCh) in 16 asthmatic and 8 healthy subjects with prohibition of deep inhalations (DIs) and with 5 DIs taken after each MCh dose. Flow was measured on partial expiratory flow-volume curves at an absolute lung volume (plethysmographically determined) equal to 25% of control forced vital capacity (FVC). Airway inflammation was assessed in asthmatic subjects by analysis of induced sputum. Even when DIs were prohibited, the dose ...
|Known for Deep Inhalations | Airway Responsiveness | Asthmatic Subjects | Methacholine Mch | Induced Sputum|
[ PUBLICATION ]
Lung mechanics and airway responsiveness to methacholine (MCh) were studied in seven volunteers before and after a 20-min intravenous infusion of saline. Data were compared with those of a time point-matched control study. The following parameters were measured: 1-s forced expiratory volume, forced vital capacity, flows at 40% of control forced vital capacity on maximal (Vm(40)) and partial (Vp(40)) forced expiratory maneuvers, lung volumes, lung elastic recoil, lung resistance (Rl), ...
|Known for Airway Responsiveness | Saline Infusion | Lung Mechanics | Deep Inhalation | Vital Capacity|
[ PUBLICATION ]
To investigate the impact of expiratory flow limitation (FL) on breathing pattern and end-expiratory lung volume (EELV), we imposed a small expiratory threshold load for a few breaths during exercise in nine volunteers (29-62 yr): six were healthy and three had mild-to-moderate airflow obstruction (67-71% predicted forced expiratory volume in 1 s). Six subjects showed evidence of FL, i.e., tidal expiratory flow impinging on maximal forced expiratory flow, at one or more exercise levels. ...
|Known for Expiratory Flow | Lung Volume | Eelv Exercise | Breathing Pattern | Respiratory Mechanics|