• Disease
  • Bipolar
  • Bipolar Disorder
  • Mauricio Mauricio Tohen

    Prominent publications by Mauricio Mauricio Tohen

    KOL Index score: 17748

    OBJECTIVE: Since stability of DSM-IV diagnoses of disorders with psychotic features requires validation, we evaluated psychotic patients followed systematically in the McLean-Harvard International First Episode Project.

    METHOD: We diagnosed 517 patients hospitalized in a first psychotic illness by SCID-based criteria at baseline and at 24 months to assess stability of specific DSM-IV diagnoses.

    RESULTS: Among 500 patients (96.7%) completing the study, diagnoses remained stable in 77.6%, ...

    Also Ranks for: Psychotic Disorder |  major diagnosis |  episode project |  harvard international |  diagnoses schizophrenia
    KOL Index score: 17174

    OBJECTIVE: A cavum between the septi pellucidi may reflect neurodevelopmental anomalies in midline structures of the brain. The authors examined cavum septi pellucidi in subjects with schizophrenia, affective disorder, and schizotypal personality disorder and in normal subjects.

    METHOD: Thirty schizophrenic patients (15 chronic, 15 first-episode), 16 patients with affective disorder (first-episode), 21 patients with schizotypal personality disorder, and 46 normal subjects were evaluated ...

    Also Ranks for: Affective Disorder |  septi pellucidi |  schizotypal personality |  mri study |  normal subjects
    KOL Index score: 16351

    There are no rapid-acting intramuscular formulations of atypical antipsychotics available for quickly calming an agitated patient with bipolar disorder. In this study, 201 agitated patients with bipolar mania were randomly assigned to receive one to three injections of the atypical antipsychotic olanzapine (10 mg, first two injections; 5 mg, third injection), the benzodiazepine lorazepam (2 mg, first two injections; 1 mg, third injection), or placebo (placebo, first two injections; ...

    Also Ranks for: Bipolar Mania |  intramuscular injections |  olanzapine lorazepam |  agitation patients |  2 hours
    KOL Index score: 15848

    BACKGROUND: To evaluate the 12-week outcomes (effectiveness, tolerability, and patterns of medication use) of olanzapine (either in antimanic monotherapy or in combination with other antipsychotics, anticonvulsants, and/or lithium) in patients with bipolar mania or mixed mania.

    METHOD: EMBLEM (European Mania in Bipolar Longitudinal Evaluation of Medication) is a 24-month prospective observational study of in- and outpatients with acute mania/mixed mania conducted in 14 European ...

    Also Ranks for: Olanzapine Monotherapy |  european mania |  combination therapy |  bipolar longitudinal |  antimanic agents
    KOL Index score: 14511

    OBJECTIVE: Few long-term studies have compared the efficacy and safety of typical and atypical antipsychotic medications directly in patients with a first episode of psychosis who met the criteria for schizophrenia or a related psychotic disorder. This study compared the acute and long-term effectiveness of haloperidol with that of olanzapine in patients with first-episode psychosis in a large, controlled clinical trial.

    METHOD: Patients with first-episode psychosis (N=263) were randomly ...

    Also Ranks for: Episode Psychosis |  olanzapine patients |  versus haloperidol |  comparative efficacy |  symptom severity
    KOL Index score: 13910

    OBJECTIVE: The authors compared the efficacy of olanzapine and lithium in the prevention of mood episode relapse/recurrence.

    METHOD: Patients with a diagnosis of bipolar disorder (manic/mixed), a history of two or more manic or mixed episodes within 6 years, and a Young Mania Rating Scale total score > or =20 entered the study and received open-label co-treatment with olanzapine and lithium for 6-12 weeks. Those meeting symptomatic remission criteria (Young Mania Rating Scale score < or ...

    Also Ranks for: Olanzapine Lithium |  bipolar disorder |  maintenance treatment |  relapse recurrence |  weight gain
    KOL Index score: 13784

    OBJECTIVE: The effect of antipsychotic medication on neurocognitive function remains controversial, especially since most previous work has compared the effects of novel antipsychotic medications with those of high doses of conventional medications. This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis.

    METHOD: Patients with a first episode of schizophrenia, schizoaffective disorder, or schizophreniform disorder ...

    Also Ranks for: Episode Psychosis |  haloperidol patients |  effects treatment |  low doses |  neurocognitive function
    KOL Index score: 13273

    OBJECTIVE: The effects of olanzapine and divalproex for the treatment of mania were compared in a large randomized clinical trial.

    METHOD: A 3-week, randomized, double-blind trial compared flexibly dosed olanzapine (5-20 mg/day) to divalproex (500-2500 mg/day in divided doses) for the treatment of patients hospitalized for acute bipolar manic or mixed episodes. The Young Mania Rating Scale and the Hamilton Depression Rating Scale were used to quantify manic and depressive symptoms, ...

    Also Ranks for: Treatment Olanzapine |  acute mania |  dry mouth |  rating scale |  divalproextreated patients
    KOL Index score: 13269

    BACKGROUND: In chronic schizophrenia, the P300 is broadly reduced and shows a localized left temporal deficit specifically associated with reduced gray matter volume of the left posterior superior temporal gyrus (STG). In first-episode patients, a similar left temporal P300 deficit is present in schizophrenia, but not in affective psychosis. The present study investigated whether the left temporal P300-left posterior STG volume association is selectively present in first-episode ...

    Also Ranks for: Episode Schizophrenia |  magnetic resonance imaging |  affective psychosis |  temporal gyrus |  gray matter
    KOL Index score: 12819

    BACKGROUND: A 6-week double-blind, randomized, placebo-controlled trial was conducted to determine the efficacy of combined therapy with olanzapine and either valproate or lithium compared with valproate or lithium alone in treating acute manic or mixed bipolar episodes.

    METHODS: The primary objective was to evaluate the efficacy of olanzapine (5-20 mg/d) vs placebo when added to ongoing mood-stabilizer therapy as measured by reductions in Young Mania Rating Scale (YMRS) scores. Patients ...

    Also Ranks for: Lithium Treatment |  efficacy olanzapine |  patients bipolar disorder |  partially nonresponsive |  mixed episodes
    KOL Index score: 12587

    OBJECTIVES: Unipolar and bipolar depression differ neurobiologically and in clinical presentation. Existing depression rating instruments, used in bipolar depression, fail to capture the necessary phenomenological nuances, as they are based on and skewed towards the characteristics of unipolar depression. Both clinically and in research there is a growing need for a new observer-rated scale that is specifically designed to assess bipolar depression.

    METHODS: An instrument reflecting the ...

    Also Ranks for: Bipolar Depression |  rating scale |  statistical female humans |  madrs ymrs |  illness bdrs
    KOL Index score: 12555

    OBJECTIVE: It has been hypothesized that the morbidity and mortality associated with schizophrenia can be prevented by providing effective treatment during the first episode of psychosis. Hence, the authors examined patients with first-episode psychosis to determine the efficacy and safety of olanzapine and haloperidol treatment.

    METHOD: A subpopulation of first-episode patients (N=83) from a large prospective, multicenter, international, double-blind, 6-week acute treatment study was ...

    Also Ranks for: Episode Psychosis |  haloperidol treatment |  olanzapine treated |  onset illness |  psychotic symptoms
    KOL Index score: 12538

    BACKGROUND: Improving patients' health-related quality of life (HRQOL) could be a treatment goal for bipolar depression.

    OBJECTIVES: The objectives of these secondary analyses of a previous report were to determine the benefits of olanzapine alone and olanzapine-fluoxetine combination (OFC) for improving HRQOL in patients with bipolar depression using both a generic and a depression-specific HRQOL instrument, and to examine the association between the 2 HRQOL instruments and the ...

    Also Ranks for: Bipolar Depression |  mental health |  life hrqol |  fluoxetine combination |  patients ofc


    Mauricio Mauricio Tohen: Influence Statistics

    Sample of concepts for which Mauricio Mauricio Tohen is among the top experts in the world.
    Concept World rank
    exacerbation bipolar mania #1
    sas percentage #1
    combination ect #1
    severity threshold mcsd #1
    predictors relapse recurrence #1
    mania rating #1
    psychosis mddp #1
    moderate confusion #1
    olanzapine acute mania #1
    p0001 olanzapine #1
    lithium patients illness #1
    construct validity qlds #1
    olanzapine madrs #1
    haloperidol week #1
    divalproextreated patients #1
    healthy controls glx #1
    mania white #1
    haloperidol olanzapine treatment #1
    disorder pharmacotherapies #1
    current manic #1
    placebo controlled data #1
    remission olanzapine #1
    olanzapine randomized #1
    depressive aspects #1
    acute dysphoric #1
    risk severe kds #1
    symptomatic depression epss #1
    mania olanzapine #1
    efficacy disposition measures #1
    greater olanzapine #1
    olanzapine dysphoric #1
    expert guidelines patients #1
    ect anticonvulsants #1
    12 olanzapine #1
    olanzapine adolescent #1
    glx nacetyl aspartate #1
    olanzapine carbamazepine #1
    syndromal recovery #1
    predominant depressive #1
    compared divalproex #1
    bipolar maintenance treatment #1
    female humans polypharmacy #1
    baseline bipolar patients #1
    carbamazepine manic episodes #1
    published practice guidelines #1
    thought processes improvement #1
    comparators olanzapine #1
    topic olanzapine #1
    sga combination treatment #1
    patients functional scales #1

    Key People For Bipolar Disorder

    Top KOLs in the world
    Eduardo Eduard
    bipolar disorder cognitive impairment acute mania
    Robert M Post
    bipolar disorder affective illness depressed patients
    Susan L McElroy
    bipolar disorder binge eating bulimia nervosa
    Paul E Keck
    bipolar disorder acute mania united states
    Joseph R Calabrese
    bipolar disorder suicidal ideation rapid cycling
    Gary S Sachs
    bipolar disorder rapid cycling acute mania

    Mauricio Mauricio Tohen:Expert Impact

    Concepts for whichMauricio Mauricio Tohenhas direct influence:Bipolar disorder,  Bipolar depression,  Acute mania,  Bipolar mania,  Patients bipolar disorder,  Bipolar disorders,  Bipolar choice,  Mixed features.

    Mauricio Mauricio Tohen:KOL impact

    Concepts related to the work of other authors for whichfor which Mauricio Mauricio Tohen has influence:Bipolar disorder,  Atypical antipsychotics,  Patients schizophrenia,  Weight gain,  Mental health,  Acute mania,  Depressive symptoms.



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    Department of Psychiatry & Behavioral Sciences, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. | Department of Psychiatry and Behavioral Sciences, School of Medicine, University of New Mexico, Albuquerque, New Mexico