• Disease
  • Allergic
  • Allergic Rhinitis
  • F Estelle R Simons

    Prominent publications by F Estelle R Simons

    KOL Index score: 15272

    BACKGROUND: Platelet-activating factor (PAF) is an important mediator of anaphylaxis in animals, and interventions that block PAF prevent fatal anaphylaxis. The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported.

    METHODS: We measured serum PAF levels and PAF acetylhydrolase activity in 41 patients with anaphylaxis and in 23 control patients. Serum PAF acetylhydrolase activity was also measured in 9 patients with peanut ...

    Also Ranks for: Paf Acetylhydrolase |  patients anaphylaxis |  activating factor |  peanut hypersensitivity |  grade 1
    KOL Index score: 13869

    BACKGROUND: An inhaled glucocorticoid is currently the medication of choice for long-term control of persistent asthma in children. The role of long-acting beta2-adrenergic-receptor agonists, such as salmeterol, needs to be defined.

    METHODS: We conducted a randomized, double-blind, placebo-controlled, parallel-group, one-year study of 241 children (mean [+/-SD] age, 9.3+/-2.4 years) with clinically stable asthma and less than one month of prior glucocorticoid use. We compared inhaled ...

    Also Ranks for: Salmeterol Placebo |  children asthma |  airway hyperresponsiveness |  inhaled glucocorticoid |  12 months
    KOL Index score: 12850

    We compared the protective effect and duration of action of inhaled formoterol, a new, long-acting, selective beta 2-agonist, to inhaled salbutamol and placebo in a double-blind, randomized, crossover study in 16 children with asthma with a mean age of 10.3 +/- 0.4 years. Mean baseline FEV1 was 96 +/- 3% predicted and mean provocative concentration of methacholine (milligrams per milliliter) required to decrease FEV1 by 20% (PC20) was 0.81 +/- 0.25 mg/ml of methacholine. On the 4 study ...

    Also Ranks for: 12 Hours |  fev1 pc20 |  inhaled formoterol |  new long |  topic doseresponse relationship
    KOL Index score: 12712

    BACKGROUND: Peanut allergy is one of the most common forms of food allergy encountered in clinical practice.  In most cases, it does not spontaneously resolve; furthermore, it is frequently implicated in acute life-threatening reactions. The current management of peanut allergy centres on meticulous avoidance of peanuts and peanut-containing foods. Allergen-specific oral immunotherapy (OIT) for peanut allergy aims to induce desensitisation and then tolerance to peanut, and has the ...

    Also Ranks for: Peanut Allergy |  oit treatment |  preschool desensitization |  specific oral |  arachis child child
    KOL Index score: 12632

    The balance of interleukin-4 (IL-4) to interferon-gamma (IFN-gamma) production that is induced following exposure to common environmental antigens is believed to be instrumental in determining whether hypersensitivity or clinical unresponsiveness results to that antigen. To date, evaluation of cytokine (protein) production has been based predominantly on allergen-reactive CD4 T-cell clones or activation of fresh unselected peripheral blood mononuclear cell (PBMC) populations with ...

    Also Ranks for: Allergic Rhinitis |  gamma production |  normal controls |  il4 ifn |  primary culture
    KOL Index score: 12579

    BACKGROUND: The evidence base for the use of H1-antihistamines in the treatment of perennial allergic rhinitis is considerably smaller than it is in the treatment of seasonal allergic rhinitis.

    OBJECTIVE: We hypothesized that desloratadine, a new, nonsedating selective H1-antihistamine, would be efficacious and safe in the treatment of perennial allergic rhinitis.

    METHODS: In a multicenter, randomized, placebo-controlled, double-blind, parallel-group study, 676 patients with symptomatic ...

    Also Ranks for: Perennial Allergic |  desloratadine treatment |  4 weeks |  rhinitis symptoms |  morning evening
    KOL Index score: 12476

    The Joint Task Force for the American Academy of Allergy, Asthma and Immunology and the American College of Allergy, Asthma and Immunology was charged with formulating a position paper regarding the potential release of intranasal corticosteroids for over-the-counter use. We took the position that safety issues regarding this proposal would be our sole concern. We reviewed the literature to evaluate the frequency and severity of potential adverse events related to the administration of ...

    Also Ranks for: Intranasal Corticosteroids |  joint task force |  allergy asthma |  perennial rhinitis |  inhalation administration
    KOL Index score: 12364

    In a double-blind, randomized, parallel-group 5-week study, cetirizine, 5 mg or 10 mg daily, was ingested by 10 and nine children, respectively. Cetirizine was rapidly absorbed with mean peak cetirizine concentrations of 427.6 +/- SD, 144.2 ng/ml, 1.4 +/- 1.1 hours after the 5 mg dose, and 978.4 +/- 340.6 ng/ml, 0.8 +/- 0.4 hours after the 10 mg dose. The dose-independent serum-elimination half-life of cetirizine was 7.1 +/- 1.6 hours after cetirizine, 5 mg, and 6.9 +/- 1.6 hours after ...

    Also Ranks for: Allergic Rhinitis |  dose cetirizine |  5 10 |  24 hours |  wheal flare
    KOL Index score: 12346

    Food allergy is an important public health problem that affects children and adults and may be increasing in prevalence. Despite the risk of severe allergic reactions and even death, there is no current treatment for food allergy: the disease can only be managed by allergen avoidance or treatment of symptoms. The diagnosis and management of food allergy also may vary from one clinical practice setting to another. Finally, because patients frequently confuse nonallergic food reactions, ...

    Also Ranks for: Food Allergy |  diagnosis management |  clinical guidelines |  infectious diseases |  national institute
    KOL Index score: 12060

    BACKGROUND: Auvi-Q is a novel epinephrine autoinjector (EAI) that provides audio and visual cues for patients at risk for life-threatening allergic reactions.

    OBJECTIVE: We tested the preference for Auvi-Q or EpiPen with regard to method of instruction, preference to carry, device size, and device shape.

    METHODS: This large, multicenter, simulated-use study evaluated whether adults (aged 18-65 years), caregivers (parents/guardians aged 18-65 years of children aged 5-17 years), and ...

    Also Ranks for: Epipen Auviq |  preference auvi |  epinephrine autoinjector |  aged anaphylaxis |  1865 years
    KOL Index score: 11943

    OBJECTIVES: The long-acting beta2-adrenergic agonist salmeterol prevents exercise-induced asthma, but tolerance may develop to its bronchoprotective effect. We wanted to ascertain if the development of tolerance could be prevented by using a low-dose treatment regimen of 50 microg once daily, instead of the usual dose of 50 microg twice daily, in adolescents receiving regular glucocorticoid inhalations. Methods. In a randomized, double-blind, 2x28-day crossover study, we administered ...

    Also Ranks for: Induced Asthma |  bronchoprotective salmeterol |  50 microg |  inhaled glucocorticoid |  drug tolerance
    KOL Index score: 11890

    BACKGROUND: This is the first prospective, randomized, double-blind, placebo-controlled study showing statistical improvement of an H(1)-antihistamine in children with seasonal allergic rhinitis in all symptoms throughout the entire treatment period.

    OBJECTIVE: This randomized, placebo-controlled, parallel-group, double-blind study was performed to assess the efficacy and safety of fexofenadine in children with seasonal allergic rhinitis.

    METHODS: This study was conducted at 148 centers ...

    Also Ranks for: Seasonal Allergic Rhinitis |  fexofenadine children |  nasal congestion |  aged 6 |  efficacy safety
    KOL Index score: 11685

    BACKGROUND: Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may cause death. Adrenaline is recommended as the initial treatment of choice for anaphylaxis.

    OBJECTIVES: To assess the benefits and harms of adrenaline (epinephrine) in the treatment of anaphylaxis.

    SEARCH STRATEGY: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2007, Issue 1), MEDLINE (1966 to March 2007), EMBASE (1966 to March 2007), CINAHL (1982 ...

    Also Ranks for: Adrenaline Anaphylaxis |  epinephrine treatment |  adrenergic agonists inclusion |  ongoing trials |  unpublished material
    KOL Index score: 11591

    BACKGROUND: Identification of patients at risk for asthma exacerbations can assist physicians in addressing disease management and improve asthma-related health outcomes.

    OBJECTIVE: We sought to evaluate whether level of impairment, as defined by the 2007 asthma guidelines, predicts risk for future asthma exacerbations.

    METHODS: The study included children aged 6 to 11 years (n = 82) and adolescent/adult patients aged 12 years and older (n = 725) from The Epidemiology and Natural History ...

    Also Ranks for: Treatment Regimens |  asthma exacerbations |  impairment domain |  patients risk |  baseline month
    KOL Index score: 11228

    BACKGROUND: The optimal time for transferring responsibilities for anaphylaxis recognition and epinephrine auto-injector use from adults to children and teenagers has not yet been defined.

    OBJECTIVE: To determine whether pediatric allergists have age-specific goals for beginning to transfer responsibilities for anaphylaxis recognition and epinephrine auto-injector use from parents and caregivers to children and teenagers at risk of anaphylaxis in the community.

    METHODS: Members of the ...

    Also Ranks for: Anaphylaxis Recognition |  children teenagers |  epinephrine auto |  transfer responsibilities |  patients age


    F Estelle R Simons: Influence Statistics

    Sample of concepts for which F Estelle R Simons is among the top experts in the world.
    Concept World rank
    308±005 #1
    asthma exacerbation combination #1
    th2 th9associated cytokines #1
    pg tmax #1
    epinephrine auto #1
    injection epipen #1
    il9ralpha pharmacological inhibition #1
    humans ragweed allergy #1
    transient pallor #1
    vaporizers placebos formoterol #1
    03 intramuscular #1
    stings syndrome #1
    hfe eai #1
    anaphylaxis wallet #1
    epinephrine bioavailability #1
    stated expiration #1
    23 07 hours #1
    auvi epipen #1
    epinephrine auc #1
    epinephrine epipen #1
    storage epinephrine #1
    p300 female histamine #1
    epinephrine young #1
    sublingual formulations epinephrine #1
    mosquito aegypti saliva #1
    skeeter syndrome #1
    followup test participants #1
    comparison loratadine #1
    patients chlorpheniramine #1
    quandary physicians #1
    injector children #1
    th2like bias #1
    children 15 30 #1
    epinephrine intramuscular injection #1
    tmax 5 minutes #1
    aedes immunoglobulin #1
    older antihistamines #1
    cns teratogenic #1
    dose intervals rationale #1
    oral clearance levocetirizine #1
    possibility mastocytosis #1
    mcc vitro characteristics #1
    evening terfenadine dose #1
    sublingual chemistry #1
    initiation allergen challenge #1
    cetirizine 250 #1
    chlorpheniramine cetirizine #1
    cetirizine 5 #1
    epinephrine administration rate #1

    Key People For Allergic Rhinitis

    Top KOLs in the world
    JeanClaude Bousquet
    allergic rhinitis asthma control chronic respiratory diseases
    Giorgio Walter Canonica
    allergic rhinitis severe asthma sublingual immunotherapy
    Eli O Meltzer
    allergic rhinitis fluticasone propionate united states
    Paul B Van Cauwenberge
    allergic rhinitis nasal polyps chronic rhinosinusitis
    Claus Bachert
    nasal polyps chronic rhinosinusitis allergic rhinitis
    Alkis G Togias
    allergic rhinitis peanut allergy infectious diseases

    F Estelle R Simons:Expert Impact

    Concepts for whichF Estelle R Simonshas direct influence:Allergic rhinitis,  Mosquito allergy,  Allergy organization,  Atopic dermatitis,  Evidence base,  Food allergy.

    F Estelle R Simons:KOL impact

    Concepts related to the work of other authors for whichfor which F Estelle R Simons has influence:Allergic rhinitis,  Food allergy,  Atopic dermatitis,  Chronic urticaria,  Severe asthma,  Mast cells,  Sublingual immunotherapy.



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    University of Manitoba | Department of Pediatrics Child Health, Department of Immunology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada | Department of Pediatrics and Child Health, Department of Immunology, Faculty of Medici