Prominent publications by Robert M Naclerio

KOL Index score: 17180

IMPORTANCE: Dupilumab has demonstrated efficacy in patients with asthma and atopic dermatitis, which are both type 2 helper T-cell-mediated diseases.

OBJECTIVE: To assess inhibition of interleukins 4 and 13 with dupilumab in patients with chronic sinusitis and nasal polyposis.

DESIGN, SETTING, AND PARTICIPANTS: A randomized, double-blind, placebo-controlled parallel-group study conducted at 13 sites in the United States and Europe between August 2013 and August 2014 in 60 adults with ...

Known for Chronic Sinusitis |  Subcutaneous Dupilumab |  Nasal Polyposis |  Monoclonal Antibodies |  16 Weeks
KOL Index score: 14945

BACKGROUND: Fluticasone furoate (USAN-approved name) is a novel, enhanced-affinity glucocorticoid administered in a unique side-actuated device for the management of seasonal allergic rhinitis (SAR).

OBJECTIVE: We sought to evaluate the efficacy and safety of once-daily fluticasone furoate nasal spray, 110 microg, in patients aged 12 years or older with fall SAR.

METHODS: Patients (n = 299) received fluticasone furoate or placebo for 2 weeks in this double-blind, parallel-group ...

Known for Fluticasone Furoate |  Seasonal Allergic Rhinitis |  Nasal Spray |  110 Microg |  Sar Treatment
KOL Index score: 14065

Patients with allergic rhinitis often have immediate symptoms after antigen challenge (the early-phase response), followed several hours later by a recurrence of symptoms (the late-phase response). Systemic glucocorticosteroids are known to inhibit the late-phase but not the early-phase response. We studied the effect of one week of pretreatment with topical (rather than systemic) glucocorticosteroids on the response to nasal challenge with antigen in a double-blind, randomized, ...

Known for Topical Glucocorticosteroids |  Allergic Rhinitis |  Mediator Release |  Nasal Challenge |  Levels Histamine
KOL Index score: 13318

IMPORTANCE: Total intravenous anesthesia (TIVA) with propofol has been associated with reduced operative time, decreased perioperative risks, and decreased intraoperative blood loss compared with inhalational anesthesia (IA). During endoscopic sinus surgery (ESS), reduced bleeding from the mucosal surfaces could improve visualization of the anatomy and decrease the risk of serious complications.

OBJECTIVE: To compare blood loss during ESS between patients receiving TIVA with propofol and ...

Known for Blood Loss |  Endoscopic Sinus Surgery |  Randomized Clinical Trial |  Inhalation Anesthesia |  Intravenous Anesthetics
KOL Index score: 12857

Previous studies have demonstrated symptoms and mediator release occurring as long as 11 h after nasal challenge with antigen in selected allergic subjects. Pretreatment with systemic steroids reduced symptoms and mediators including histamine, TAME-esterase activity, and kinins. The aims of the present study were to characterize the cell influx during the late-phase response to antigen challenge and to determine the effect of pretreatment with systemic steroids on this response. We ...

Known for Antigen Challenge |  Late Response |  Nasal Washings |  Inflammatory Cells |  Cell Influx
KOL Index score: 12689

BACKGROUND: Eye symptoms frequently occur in patients with allergic rhinitis and are among the most bothersome symptoms. Intranasal steroids have been shown to reduce ocular symptoms associated with allergic nasal symptoms, even though they do not reach the eye.

OBJECTIVE: To elucidate a mechanism to explain these observations.

METHODS: We performed a double-blind, placebo-controlled, crossover experiment in 20 subjects with seasonal allergic rhinitis. Nasal antigen challenge was ...

Known for Eye Symptoms |  Ocular Reflex |  Topical Steroids |  Intranasal Adult |  Fluticasone Furoate
KOL Index score: 12315

Allergic rhinitis (AR; also nasal allergies or "hay fever") is a chronic upper airway inflammatory disease that affects ∼60 million adults and children in the United States. The duration and severity of AR symptoms contribute to a substantial burden on patients' quality of life (QoL), sleep, work productivity, and activity. This study was designed to examine symptoms, QoL, productivity, comorbidities, disease management, and pharmacologic treatment of AR in United States and ex-U.S. ...

Known for Allergic Rhinitis |  Latin America |  United States |  Life Qol |  Work Productivity
KOL Index score: 11794

Intranasal steroids have been shown to affect ocular symptoms of allergic rhinitis (AR). The results of the published literature, however, are not uniform across all products. This study was designed to evaluate whether the effects of fluticasone furoate nasal spray (FFNS) are consistent across different allergy seasons and different geographic regions for individual nasal and ocular symptoms of seasonal allergic rhinitis (SAR). An integrated analysis was performed on data from four ...

Known for Ocular Symptoms |  Allergic Rhinitis |  Fluticasone Furoate |  Nasal Spray |  110 Micrograms
KOL Index score: 11691

We have recently demonstrated that kinins are generated in vivo after nasal challenge with antigen of allergic, but not nonallergic, individuals. The present study was undertaken as a first step in determining the mechanism(s) of kinin formation during the allergic reaction and was directed towards establishing the availability and origin of kininogens in nasal secretions. Allergic individuals (n = 6) and nonallergic controls (n = 5) were challenged with antigen; and by using specific ...

Known for Antigen Challenge |  Nasal Secretions |  Allergic Individuals |  Kinin Formation |  Molecular Weight
KOL Index score: 11586

The purpose of our study was to assess the effect of cold, dry air (CDA) on the nasal mucosa of selected individuals in relation to the release of inflammatory mediators associated with mast cells. 12 subjects with a history of nasal symptoms of rhinorrhea and congestion upon cold or dry environmental exposure were challenged by nasal breathing of CDA and warm, moist air (WMA). Each subject was tested on two occasions with the order of the challenges reversed. Symptom scores were ...

Known for Nasal Challenge |  Symptom Scores |  Dry Air |  Inflammatory Mediators |  Mast Cells
KOL Index score: 11241

BACKGROUND: Allergic patients often complain of eye symptoms during the allergy season. A possible mechanism for these eye symptoms is a nasal ocular reflex.

OBJECTIVE: To demonstrate eye symptoms after nasal allergen challenge.

METHODS: In a double-blind, placebo-controlled, crossover, clinical trial, 20 patients with seasonal allergic rhinitis were challenged in 1 nostril with antigen, and the response was monitored in both nostrils and in both eyes. Symptoms were recorded. Filter ...

Known for Eye Symptoms |  Allergic Rhinitis |  Ocular Reflex |  Nasal Challenge |  Histamine Levels
KOL Index score: 10935

OBJECTIVE: Clinical data and recent guidelines support the positive effects of intranasal corticosteroids on allergic rhinitis-associated ocular symptoms. This article reviews the epidemiology and pathophysiology of ocular allergy symptoms and efficacy, tolerability, and potential mechanisms of action of intranasal corticosteroids in the treatment of this condition.


REVIEW METHODS: A search of pertinent literature identified in vitro, preclinical, and ...

Known for Intranasal Corticosteroids |  Ocular Symptoms |  Allergic Rhinitis |  Clinical Data |  Review Methods
KOL Index score: 10807

Chronic rhinosinusitis (CRS) is a complex disease consisting of several disease variants with different underlying pathophysiologies. Limited knowledge of the mechanisms of these disease subgroups is possibly the greatest obstacle in understanding the causes of CRS and improving treatment. It is generally agreed that there are clinically relevant CRS phenotypes defined by an observable characteristic or trait, such as the presence or absence of nasal polyps. Defining the phenotype of the ...

Known for Clinical Immunology |  Chronic Rhinosinusitis |  European Academy |  Practall Document |  Crs Endotypes


Robert M Naclerio: Influence Statistics

Sample of concepts for which Robert M Naclerio is among the top experts in the world.
Concept World rank
moxifloxacin limited #1
allergic rhinitis objective #1
eosinophils life #1
future directions sinusitis #1
needle epithelium allergic #1
nasal ocular reflexes #1
nasalocular reflexes role #1
rw immersion #1
increase sinus inflammation #1
allergic response pretreatment #1
sleep domain loratadinemontelukast #1
perennial mucosa nasal #1
tests placebos #1
unanswered questions sinusitis #1
nonsmoking subjects budesonide #1
response nasal #1
normal sphenoid #1
sinuses desloratadine treatment #1
titration pilot study #1
nac olo #1
intranasal corticosteroids treatment #1
separate nasal challenges #1
allergic seasonal spectrometry #1
twg supine position #1
antigen eosinophil influx #1
condition inspired air #1
immersion feet #1
clemastine 05 #1
th2 passive sensitization #1
seasonal desensitization allergic #1
fexofenadine histamine release #1
warm water feet #1
ige levels severity #1
intranasal ciprofloxacin #1
mucosal surface temperature #1
specific ige grades #1
hha latephase response #1
reduced ability air #1
subjects nasal polyps #1
gata3 crs subjects #1
antigen study #1
c57bl 6 lymphocytes #1
biologics uncertainties #1
02 eosinophils #1
168 micrograms #1
disease control biologics #1
histamine antigen challenge #1
study triamcinolone acetonide #1
antiallergic effects drugs #1
npif budesonide #1

Key People For Allergic Rhinitis

Top KOLs in the world
JeanClaude Bousquet
allergic rhinitis asthma control chronic respiratory diseases
Giorgio Walter Canonica
allergic rhinitis severe asthma sublingual immunotherapy
Eli O Meltzer
allergic rhinitis fluticasone propionate united states
Paul B Van Cauwenberge
allergic rhinitis nasal polyps chronic rhinosinusitis
Claus Bachert
nasal polyps chronic rhinosinusitis allergic rhinitis
Alkis G Togias
allergic rhinitis peanut allergy infectious diseases

Robert M Naclerio:Expert Impact

Concepts for whichRobert M Nacleriohas direct influence:Allergic rhinitis,  Nasal challenge,  Chronic rhinosinusitis,  Nasal mucosa,  Nasal secretions,  Antigen challenge,  Dry air,  Seasonal allergic rhinitis.

Robert M Naclerio:KOL impact

Concepts related to the work of other authors for whichfor which Robert M Naclerio has influence:Allergic rhinitis,  Chronic rhinosinusitis,  Nasal polyps,  Mast cells,  Histamine release,  Endoscopic sinus surgery,  Allergen challenge.



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Department of Surgery, Section of Otolaryngology–Head and Neck Surgery, The University of Chicago, Chicago, Illinois, USA | Department of Otolaryngology–Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA | Pr

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