Hidemitsu Harada

Hidemitsu Harada

Division Of Developmental Biology And Regenerative Medicine, Department Of Anatomy, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate 028-3694, Japan.

Direct Impact

Concepts for which Hidemitsu Harada has direct influence:

ameloblast differentiation
stem cells
dental epithelial
mouse incisors
root formation
amelogenin protein
gene expression

External impact

Concepts related to the work of other authors for which Hidemitsu Harada has influence:

tooth agenesis
collagen fibrils
gene expression
ameloblast differentiation
root formation
mouse incisor
alpha protein

Prominent publications by Hidemitsu Harada

KOL-Index: 32 Dental noble alloys often contain copper (Cu). Eluted metal ions sometimes irritate oral tissues. The most eluted ions are Cu ions. The purpose of this study was to investigate the effects of low cytotoxic (IC90, 100 µmol/L) Cu ions on macrophages by proteome analyses consisting of two-dimensional (2D) electrophoresis and matrix-assisted laser desorption/ionization -time of flight ...
Known for
Ions Macrophages | Eluted | Macrophage Protein
KOL-Index: 31 While the prevalence of supernumerary teeth (ST) is high in permanent dentition, the etiology of ST in humans remains unclear. However, multiple murine models of ST have elaborated on dated mechanisms traditionally ascribed to ST etiology: one involves the rescue of rudimental teeth, and the second considers the contribution of odontogenic epithelial stem cells. It remains unclear whether ...
Known for
Computed Tomography Scan | Surrounding Epithelial Cells | ≥3 | Murine Models
KOL-Index: 30 We have recently developed a novel in vitro model using HAT-7 rat ameloblast cells to functionally study epithelial ion transport during amelogenesis. Our present aims were to identify key transporters of bicarbonate in HAT-7 cells and also to examine the effects of fluoride exposure on vectorial bicarbonate transport, cell viability, and the development of transepithelial resistance. To ...
Known for
Tight Junction Formation | Fluorescent Indicator Bcecf | Forskolin | Hat-7 Rat Ameloblast Cells
KOL-Index: 29 Stem cells are maintained in specific niches that strictly regulate their proliferation and differentiation for proper tissue regeneration and renewal. Molecular oxygen (O2) is an important component of the niche microenvironment, but little is known about how O2 governs epithelial stem cell (ESC) behavior. Here, we demonstrate that O2 plays a crucial role in regulating the proliferation of ...
Known for
Niche Maintained | Renewal Molecular | Yap Taz | Proliferation Rhoa
KOL-Index: 27 During tooth development, ameloblasts differentiate from inner enamel epithelial cells to enamel-forming cells by modulating the signal pathways mediating epithelial-mesenchymal interaction and a cell-autonomous gene network. The differentiation process of epithelial cells is characterized by marked changes in their morphology and polarity, accompanied by dynamic cytoskeletal reorganization ...
Known for
Matrix Ameloblasts
KOL-Index: 26 OBJECTIVES: Lysophosphatidic acid (LPA) is a potent bioactive phospholipid that exerts various functions upon binding to six known G protein-coupled receptors (LPA1-6); however; its role in a tooth remains unclear. This study aimed to explore the impact of the LPA/LPA receptor 6 (LPA6)/RhoA signaling axis on maturation stage ameloblasts (M-ABs), which are responsible for enamel ...
Known for
Abnormal Enamel Epithelium | Morphology Polarity | Molars | Lpa6 Knockout Mice
KOL-Index: 24 We previously demonstrated that the uptake of M180 amelogenin protein in dental epithelial cells (HAT-7) results in increased levels of amelogenin mRNA through enhanced mRNA stabilization. To determine the processes involved in the uptake of extracellular M180 amelogenin by cells and in amelogenin intracellular trafficking in the amelogenin protein-mediated amelogenin mRNA expression ...
Known for
Lamp3 M180 | Protein Lamp1 | Amelogenin Degradation | Dental Epithelial Cells
KOL-Index: 23 Various growth factors have been implicated in the regulation of cell proliferation and differentiation during tooth development. It has been unclear if insulin-like growth factors (IGFs) participate in the epithelium-mesenchyme interactions of tooth development. We previously produced three-dimensional sandwich co-culture systems (SW) containing a collagen membrane that induce the ...
Known for
Igf2r Induction | Expression Igf2 | Igfrs | Three-Dimensional Sandwich Co-Culture Systems
KOL-Index: 21 OBJECTIVES: The boundary where inner and outer enamel epithelia meet is referred to as the cervical loop (CL) in molar tooth germs. In contrast, rodent incisors are continuously growing: the labial side of the teeth is covered with enamel (crown-analog), and the lingual side is covered with cementum (root-analog). These results in the appearance of CL in the frontal sections apart from the ...
Known for
Sonic Hedgehog | Three-Dimensional Expression | Supra-Inner Enamel Epithelium | Enamel Knot-Like Structures

Division of Developmental Biology and Regenerative Medicine, Department of Anatomy, Iwate Medical University, 1-1-1, Idaidori, Yahaba, Iwate 028-3694, Japan.

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