• KOLs Community
    • Amino
    • Amino Acid
    • Peter Bork
    • Peter Bork

      Peter Bork

      Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. | Max Delbrück Centre for Molecular Medicine, Berlin, Germany | Department of ...



      KOL Resume for Peter Bork


      Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.

      Max Delbrück Centre for Molecular Medicine, Berlin, Germany

      Yonsei Frontier Lab (YFL), Yonsei University, Seoul 03722, South Korea.


      European Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany.

      Molecular Medicine Partnership Unit, Heidelberg, Germany

      Yonsei Frontier Lab (YFL), Yonsei University, Seoul, 03722 South Korea


      Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany;,

      Molecular Medicine Partnership Unit, European Molecular Biology Laboratory, University of Heidelberg, 69117, Heidelberg, Germany


      Department of Bioinformatic Biocentrum, Würzburg University, 97074 Würzburg, Germany

      The list of author affiliations is available in the supplementary materials.

      MGP MetaGénoPolis, INRA, Université Paris-Saclay, 78350 Jouy en Josas, France



      Peter Bork: Influence Statistics

      Sample of concepts for which Peter Bork is among the top experts in the world.
      Concept World rank
      vkind domain #1
      eukaryotic thermostability proteomes #1
      nasonia gene transfer #1
      drosophila kelch motif #1
      single copy orthologs #1
      bcps hdaci #1
      modules washington #1
      dcp1 hpat #1
      macrolide early life #1
      ptrn #1
      caenorhabditis elegans p15 #1
      groups orthologous #1
      regions dep domain #1
      combination 4 fsps #1
      gunc #1
      ests new genes #1
      database lsat #1
      context genomes #1
      humans nuclear animals #1
      cells rna severity #1
      imidazole propionate diabetes #1
      resource protein kinases #1
      phylogeny software species #1
      newly synthesized egfrs #1
      smart version #1
      environments genome evolution #1
      undetected chimeras #1
      g2d #1
      blast rate #1
      mobile modules motifs #1
      dietrelated obesity #1
      drugs hydrophobic interactions #1
      domain distributions eukaryotes #1
      theoretical mycoplasma #1
      viral geography oceans #1
      maternal transmission birth #1
      bacterial evolution comparison #1
      gene richness causality #1
      prokaryotic genome quality #1
      gst 1 peptide #1
      metabolic anchor reactions #1
      genes pairwise interactions #1
      amop muc4 #1
      protein domains metazoans #1
      domain families identification #1
      gut bacteria environment #1
      metagenomics processing ngless #1
      genetic capacity #1
      dietrelated obesity diet #1
      caenorhabditis algorithms alkyl #1


      Prominent publications by Peter Bork

      KOL-Index: 17509

      BACKGROUND: The HRDC (helicase and RNaseD C-terminal) domain is found at the C terminus of many RecQ helicases, including the human Werner and Bloom syndrome proteins. RecQ helicases have been shown to unwind DNA in an ATP-dependent manner. However, the specific functional roles of these proteins in DNA recombination and replication are not known. An HRDC domain exists in both of the human RecQ homologues that are implicated in human disease and may have an important role in their ...

      Known for Hrdc Domain | Bloom Syndrome | Recq Helicases | Proteins Sequence | Dimensional Structure
      KOL-Index: 15179

      Vertebrate TAP and its yeast ortholog Mex67p are involved in the export of messenger RNAs from the nucleus. TAP has also been implicated in the export of simian type D viral RNAs bearing the constitutive transport element (CTE). Although TAP directly interacts with CTE-bearing RNAs, the mode of interaction of TAP/Mex67p with cellular mRNAs is different from that with the CTE RNA and is likely to be mediated by protein-protein interactions. Here we show that Mex67p directly interacts with ...

      Known for Nuclear Export | Tap Mex67p | Cellular Mrnas | Proteins Sequence | Rna Binding
      KOL-Index: 14389

      Metazoan NXF1-p15 heterodimers promote the nuclear export of bulk mRNA across nuclear pore complexes (NPCs). In vitro, NXF1-p15 forms a stable complex with the nucleoporin RanBP2/Nup358, a component of the cytoplasmic filaments of the NPC, suggesting a role for this nucleoporin in mRNA export. We show that depletion of RanBP2 from Drosophila cells inhibits proliferation and mRNA export. Concomitantly, the localization of NXF1 at the NPC is strongly reduced and a significant fraction of ...

      Known for Mrna Export | Pore Complex | Nxf1 Npc | Binding Site | Cytoplasmic Filaments
      KOL-Index: 13706

      MicroRNAs (miRNAs) silence the expression of target genes post-transcriptionally. Their function is mediated by the Argonaute proteins (AGOs), which colocalize to P-bodies with mRNA degradation enzymes. Mammalian P-bodies are also marked by the GW182 protein, which interacts with the AGOs and is required for miRNA function. We show that depletion of GW182 leads to changes in mRNA expression profiles strikingly similar to those observed in cells depleted of the essential Drosophila miRNA ...

      Known for Mrna Degradation | Gw182 Mirnas | Amino Acid | Protein Expression | Mirna Pathway
      KOL-Index: 13567

      Computer analysis of a conserved domain, BRCT, first described at the carboxyl terminus of the breast cancer protein BRCA1, a p53 binding protein (53BP1), and the yeast cell cycle checkpoint protein RAD9 revealed a large superfamily of domains that occur predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain consists of approximately 95 amino acid residues and occurs as a tandem repeat at the carboxyl terminus of numerous proteins, ...

      Known for Conserved Domains | Cell Cycle | Dna Damage | Checkpoint Protein | Brct Domain
      KOL-Index: 13360

      In the course of evolution, genomes are shaped by processes like gene loss, gene duplication, horizontal gene transfer, and gene genesis (the de novo origin of genes). Here we reconstruct the gene content of ancestral Archaea and Proteobacteria and quantify the processes connecting them to their present day representatives based on the distribution of genes in completely sequenced genomes. We estimate that the ancestor of the Proteobacteria contained around 2500 genes, and the ancestor ...

      Known for Gene Content | Archaeal Genome | Bacterial Models | Transfer Horizontal | Novo Origin
      KOL-Index: 12516

      Shc is an Src homology 2 (SH2) domain protein thought to be an important component of the signaling pathway leading from cell surface receptors to Ras. A new phosphotyrosine interaction (PI) domain (also known as the phosphotyrosine binding (PTB) domain) has been described in the amino terminus of Shc. The Shc PI domain binding specificity is dependent on residues lying amino-terminal to the phosphotyrosine rather than carboxyl-terminal as is seen with SH2 domains. We randomly ...

      Known for Shc Phosphotyrosine | Interaction Domain | Binding Proteins | Egf Receptor | Src Homology
      KOL-Index: 12009

      DNA mismatch repair deficiency is observed in about 15% of human colorectal, gastric, and endometrial tumors and in lower frequencies in a minority of other tumors thereby causing insertion/deletion mutations at short repetitive sequences, recognized as microsatellite instability (MSI). Evolution of tumors, including those with MSI, is a continuous process of mutation and selection favoring neoplastic growth. Mutations in microsatellite-bearing genes that promote tumor cell growth in ...

      Known for Common Target | Dna Repair | Microsatellite Mutations | Endometrial Tumors | Genes Msi
      KOL-Index: 11849

      BACKGROUND: The 1.83 Megabase (Mb) sequence of the Haemophilus influenzae chromosome, the first completed genome sequence of a cellular life form, has been recently reported. Approximately 75 % of the 4.7 Mb genome sequence of Escherichia coli is also available. The life styles of the two bacteria are very different - H. influenzae is an obligate parasite that lives in human upper respiratory mucosa and can be cultivated only on rich media, whereas E. coli is a saprophyte that can grow ...

      Known for Escherichia Coli | Haemophilus Influenzae | Genome Bacterial | Sequence Similarity | Computer Analysis
      KOL-Index: 11695

      INTRODUCTION: The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and functional differentiation of the mammary gland. The pathway also has important roles in mammary tumourigenesis. Prolactin regulated target genes are not yet well defined in tumour cells, and we undertook, to the best of our knowledge, the first large genetic screen of breast cancer cells treated with or without exogenous prolactin. We ...

      Known for Breast Cancer | Heat Shock | Janus Kinase | Cells Prolactin | Apoptosis Regulation
      KOL-Index: 11439

      Microsatellite instability (MSI) caused by deficient DNA mismatch-repair functions is a hallmark of cancers associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome but is also found in about 15% of all sporadic tumors. Most affected microsatellites reside in untranslated intergenic or intronic sequences. However, recently few genes with coding microsatellites were also shown to be mutational targets in MSI-positive cancers and might represent important mutation ...

      Known for Coding Microsatellites | Mismatch Repair | Systematic Identification | Cancer Cells | Mutation Frequency
      KOL-Index: 11402

      Anopheles gambiae is the principal vector of malaria, a disease that afflicts more than 500 million people and causes more than 1 million deaths each year. Tenfold shotgun sequence coverage was obtained from the PEST strain of A. gambiae and assembled into scaffolds that span 278 million base pairs. A total of 91% of the genome was organized in 303 scaffolds; the largest scaffold was 23.1 million base pairs. There was substantial genetic variation within this strain, and the apparent ...

      Known for Genome Sequence | Anopheles Gambiae | Malaria Mosquito | Insect Proteins | Pest Strain
      KOL-Index: 11391

      Vertebrate TAP (also called NXF1) and its yeast orthologue, Mex67p, have been implicated in the export of mRNAs from the nucleus. The TAP protein includes a noncanonical RNP-type RNA binding domain, four leucine-rich repeats, an NTF2-like domain that allows heterodimerization with p15 (also called NXT1), and a ubiquitin-associated domain that mediates the interaction with nucleoporins. Here we show that TAP belongs to an evolutionarily conserved family of proteins that has more than one ...

      Known for Rna Export | Caenorhabditis Elegans | Proteins Sequence | Tap Nxf1 | Higher Eukaryotes
      KOL-Index: 11260

      The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implicated also in a variety of other processes, such as cell cycle progression, a direct function of Ran has so far only been demonstrated for importin-mediated nuclear import. We have now identified an entire class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. ...

      Known for Binding Proteins | Nuclear Sequence | Acid Xenopus | Importin Beta | Saccharomyces Cerevisiae
      KOL-Index: 11040

      Microsatellite instability (MSI) caused by defective DNA mismatch repair (MMR) is a hallmark of hereditary nonpolyposis colorectal cancers (HNPCC) but also occurs in about 15% of sporadic tumors. If instability affects microsatellites in coding regions, translational frameshifts lead to truncated proteins often marked by unique frameshift peptide sequences at their C-terminus. Since MSI tumors show enhanced lymphocytic infiltration and our previous analysis identified numerous coding ...

      Known for Frameshift Peptide | Msi Tumors | Cytotoxic Tumor Cells | Transforming Growth Factor | Colorectal Neoplasms

      Key People For Amino Acid

      Top KOLs in the world
      bacteriophage t4 structural proteins disc genes genetics
      David J Lipman
      national center genbank sequence databases database resources
      Alan R Coulson
      caenorhabditis elegans nucleotide sequence physical map
      Frederick Sanger
      nucleotide sequence dna polymerase serum albumin
      Desmond G Higgins
      gene expression sequence alignment clustal omega
      Toby James Gibson
      linear motifs amino acid elm resource

      Peter Bork:Expert Impact

      Concepts for whichPeter Borkhas direct influence:Amino acid,  Sequence analysis,  Gene expression,  Tara oceans,  Gut microbiome,  Alternative splicing,  Gut microbiota.

      Peter Bork:KOL impact

      Concepts related to the work of other authors for whichfor which Peter Bork has influence:Gut microbiota,  Gene expression,  Amino acid,  Breast cancer,  Human genome,  Protein interaction,  Sequence analysis.



      Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

      Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany. | Max Delbrück Centre for Molecular Medicine, Berlin, Germany | Department of Bioinformatics, Biocenter, University of Würzburg, Würzburg, Germany | Structural and Co

    Download on the App StoreGet it on Google Play

    Copyright © 2023 - KOL means Key Opinion Leaders .

    KOL does not provide medical advice, diagnosis or treatment.