• Disease
  • Amphetamine
  • Amphetamine Withdrawal
  • Jamie L Scholl

    Prominent publications by Jamie L Scholl

    KOL Index score: 12374

    Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala is associated with anxiety states and fear. Conversely, stress-induced increases in ventral hippocampal serotonin (5-HT) levels have been linked to coping mechanisms. The goal of this study was to investigate the neurobiological changes induced by ...

    Also Ranks for: Amphetamine Withdrawal |  ventral hippocampus |  central amygdala |  5ht levels |  glucocorticoid receptors
    KOL Index score: 12115

    Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse. Rats undergoing amphetamine withdrawal fail to exhibit stress-induced increases in serotonin (5-HT) release in the ventral hippocampus and show heightened anxiety-like behaviors. Therefore, we tested the hypothesis that reducing 5-HT levels in the ventral hippocampus is a causal mechanism in increasing anxiety-like behaviors during amphetamine ...

    Also Ranks for: Ventral Hippocampus |  amphetamine withdrawal |  anxiety behavior |  5 ht |  male rats
    KOL Index score: 11164

    Social isolation of rodents during development is thought to be a relevant model of early-life chronic stress. We investigated the effects of early-life social isolation on later adult fear and anxiety behavior, and on corticosterone stress responses, in male rats. On postnatal day 21, male rats were either housed in isolation or in groups of 3 for a 3 week period, after which, all rats were group-reared for an additional 2 weeks. After the 5-week treatment, adult rats were examined for ...

    Also Ranks for: Adult Rats |  social isolation |  conditioned fear |  stress responses |  increased anxiety
    KOL Index score: 10242

    Post-weaning social isolation of rats is utilized as a model of early life stress. We have previously demonstrated that rats exposed to post-weaning social isolation exhibit greater anxiety-like behaviors as adults. Furthermore, these rats exhibit greater density of corticotropin-releasing factor (CRF) type 2 receptors in the dorsal raphe nucleus. Therefore, we examined whether antagonism of CRF(2) receptors in the dorsal raphe nucleus reverses the effects of post-weaning social ...

    Also Ranks for: Dorsal Raphe |  social isolation |  anxiety states |  spraguedawley receptors |  male rats
    KOL Index score: 10121

    Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic dorsal raphe nucleus (dRN) of adult rats. Interactions between serotonin and CRF systems are thought to mediate anxiety behavior. Therefore, we investigated the effects of CRF receptor antagonism within the dRN on social anxiety-like behavior ...

    Also Ranks for: Social Isolation |  receptor antagonism |  anxiety behavior |  dorsal raphe |  releasing factor
    KOL Index score: 9462

    Stress induced by early life social isolation leads to long-lasting alterations in stress responses and serotonergic activity. Corticotropin-releasing factor (CRF) is a neurotransmitter that mediates stress responses and alters serotonergic activity. We tested the hypothesis that the stress of early life isolation enhances responses to CRF in adulthood by determining the effect of CRF infusions into the dorsal raphe nucleus (dRN) on 5-HT release in the nucleus accumbens (NAc) of adult ...

    Also Ranks for: Adult Rats |  social isolation |  nucleus accumbens |  early life |  spraguedawley receptors
    KOL Index score: 8315

    Amphetamine use is associated with dysphoric states, including heightened anxiety, that emerge within 24h of withdrawal from the drug. Corticotropin-releasing factor increases serotonin release in the central nucleus of the amygdala, and this neurochemical circuitry may play a role in mediating fear and anxiety states. We have previously shown that chronic amphetamine treatment increases corticotropin-releasing factor receptor type-2 levels in the serotonergic dorsal raphe nucleus of the ...

    Also Ranks for: Releasing Factor |  chronic amphetamine |  serotonin release |  central nucleus |  spraguedawley receptors
    KOL Index score: 8258

    Previous studies have shown that the Wistar-Kyoto (WKY) rat strain may be a genetic model of depression when their behaviors are compared to Sprague-Dawley (SD) or Wistar (WIS) rats. Significant differences in dopamine (DA), serotonin (5-HT), and norepinephrine (NE) transporter site densities have been reported when comparing WKY to both SD and WIS rats. Susceptibility of WKY rats to anxiety and depressive behavior may be related to underlying differences in monoamine levels in various ...

    Also Ranks for: Monoamine Levels |  wky rats |  depressive behavior |  rat strain |  brain regions
    KOL Index score: 8117

    BACKGROUND AND PURPOSE: Ceftriaxone is a β-lactam antibiotic and glutamate transporter activator that reduces the reinforcing effects of psychostimulants. Ceftriaxone also reduces locomotor activation following acute psychostimulant exposure, suggesting that alterations in dopamine transmission in the nucleus accumbens contribute to its mechanism of action. In the present studies we tested the hypothesis that pretreatment with ceftriaxone disrupts acute cocaine-evoked dopaminergic ...

    Also Ranks for: Nucleus Accumbens |  ceftriaxone cocaine |  dopamine transmission |  synthase kinase |  locomotor activation
    KOL Index score: 7988

    Withdrawal from psychostimulants increases anxiety states, and amphetamine-treated rats show increased CRF(2) receptors in the serotonergic cell body region, the dorsal raphe nucleus (dRN). In the current study, amphetamine (2.5 mg/kg, i.p., 14 days) pre-treated rats spent less time in open arms of the elevated plus maze compared saline pre-treated rats at both 24h or 2 weeks of withdrawal, and CRF(2) receptor antagonism (ASV-30; 2 microg/0.5 microl) within the dRN reversed the effects ...

    Also Ranks for: Amphetamine Withdrawal |  receptor antagonism |  anxiety states |  dorsal raphe |  2 weeks
    KOL Index score: 7870

    RationaleAdverse social experience in adolescence causes reduced medial prefrontal cortex (mPFC) dopamine (DA) and associated behavioral deficits in early adulthood.ObjectiveThis study aims to determine whether mPFC DA hypofunction following social stress is specific to adolescent experience and if this results from stress-induced DA D2 receptor activation.Materials and methodsMale rats exposed to repeated social defeat during adolescence or adulthood had mPFC DA activity sampled 17 days ...

    Also Ranks for: Adolescent Social |  prefrontal cortex |  male rats |  dopamine activity |  experience stress
    KOL Index score: 7842

    Amphetamine withdrawal in both humans and rats is associated with increased anxiety states, which are thought to contribute to drug relapse. Serotonin in the ventral hippocampus mediates affective behaviors, and reduced serotonin levels in this region are observed in rat models of high anxiety, including during withdrawal from chronic amphetamine. This goal of this study was to understand the mechanisms by which reduced ventral hippocampus serotonergic neurotransmission occurs during ...

    Also Ranks for: Ventral Hippocampus |  chronic amphetamine |  acute withdrawal |  organic cation |  drug relapse
    KOL Index score: 6895

    Repeated amphetamine treatment results in behavioral sensitization in a high percentage of rats. Alterations to plasma corticosterone, neural monoamines and stress behavior can accompany amphetamine sensitization. Whether these changes occur following repeated amphetamine treatment in the absence of behavioral sensitization is not known. Male Sprague-Dawley rats were treated with amphetamine (2.5 mg/kg, i.p.) or saline once daily for 6 days. Amphetamine-induced locomotion and stereotypy, ...

    Also Ranks for: Amphetamine Sensitization |  individual differences |  limbic monoamines |  nucleus accumbens |  rats behavioral
    KOL Index score: 6567

    The use of animal models for behavioral and pharmaceutical testing is employed in many different fields of research but often relies solely on male animals. When females are included, the existing literature frequently offers inconsistent results regarding the effects of sex and/or estrous cycle on anxiety-like behaviors. Our current study sought to establish baseline or normative behaviors in three commonly employed tests of anxiety-like behavior, and determine any sex or cycle ...

    Also Ranks for: Female Rats |  anxietylike behaviors |  sex difference |  estrous cycle |  social behavior
    KOL Index score: 5921

    Being bullied during adolescence is associated with later mental illnesses characterized by deficits in cognitive tasks mediated by prefrontal cortex (PFC) dopamine (DA). Social defeat of adolescent male rats, as a model of teenage bullying victimization, results in medial PFC (mPFC) dopamine (DA) hypofunction in adulthood that is associated with increased drug seeking and working memory deficits. Increased expression of the DA transporter (DAT) is also seen in the adult infralimbic mPFC ...

    Also Ranks for: Prefrontal Cortex |  social stress |  adolescent defeat |  mpfc dopamine |  vivo chronoamperometry


    Jamie L Scholl: Influence Statistics

    Sample of concepts for which Jamie L Scholl is among the top experts in the world.
    Concept World rank
    μg crf2 #3
    crf2 2 μg #3
    infusion crf2 #3
    amphetaminetreated rats receptors #3
    amphetamine dysphoric #3
    amphetamine central nucleus #3
    psychostimulants anxiety states #3
    antisauvagine30 2 #3
    response pretreated rats #3
    adolescence pnd42 #3
    amphetamine dysphoric states #3
    reversed crf2 #3
    isolation crf2 #3
    vtd qod #4
    oxideasv30 nanoparticles #4
    tbi glucocorticoid receptors #4
    iron oxideasv30 complexes #4
    ubxn2a suppresses mortalin #4
    vtd induces #4
    cerebral arterioles u46619 #4
    action cepo #4
    cepo action cepo #4
    normalizing cognitive function #4
    alcohol dilation #4
    asv30 brain #4
    vtd mortalin #4
    mortalin vtd #4
    therapeutic neurotrophic agent #4
    prenatal alcohol age #4
    asvinduced behavioral #4
    2 crf2 receptors #4
    alcohol constrictor #4
    tbis stressful #4
    ventricular asv #4
    anxietylike behaviors withdrawal #4
    ubxn2a colon #4
    potential neuro cardiotoxicity #4
    concerns potential neuro #4
    infusion asv30 #4
    asv30 oxide nanoparticles #4
    bbb asv30 #4
    carbamoylated epo cepo #4
    cepo action #4
    01 vtd #4
    iron oxideasv30 #4
    vtd 01 #4
    877 μg fe2o3 #4
    erythropoietin epo cepo #4
    oxideasv30 complexes #4
    function carbamoylated #4

    Key People For Amphetamine Withdrawal

    Top KOLs in the world
    George F Koob
    nucleus accumbens animal models drug addiction
    Athina Markou
    nicotine withdrawal brain reward function wistar receptors
    Larry Kokkinidis
    acoustic startle locomotor activity electrical stimulation
    Manit Srisurapanont
    alcohol dependence major depressive disorder amphetamine withdrawal
    Alasdair M Barr
    antipsychotic drugs insulin resistance psychotic symptoms
    Robert J Barrett
    drug discrimination training dose electroconvulsive shock

    Jamie L Scholl:Expert Impact

    Concepts for whichJamie L Schollhas direct influence:Amphetamine withdrawal,  Ventral hippocampus,  Nucleus accumbens,  Spraguedawley receptors,  Adult rats,  Social defeat,  Prenatal alcohol,  Anxiety states.

    Jamie L Scholl:KOL impact

    Concepts related to the work of other authors for whichfor which Jamie L Scholl has influence:Social isolation,  Prefrontal cortex,  Male rats,  Ventral hippocampus,  Amphetamine withdrawal,  Chronic stress,  Nucleus accumbens.



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    University of South Dakota, Sanford School of Medicine, Division of Basic Biomedical Sciences, Vermillion, South Dakota, USA | Basic Biomedical Sciences and Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakot