Jamie L. Scholl

Jamie L. Scholl

Division Of Basic Biomedical Sciences, Sanford School Of Medicine, University Of South Dakota, Vermillion, South Dakota, Usa

Direct Impact

Concepts for which Jamie L Scholl has direct influence:

amphetamine withdrawal
ventral hippocampus
corticotropin-releasing factor
cerebral arterioles
nucleus accumbens
anxiety-like behavior
prenatal alcohol

External impact

Concepts related to the work of other authors for which Jamie L Scholl has influence:

cerebral arterioles
female rats
dorsomedial hypothalamus
rat brain
corticotropin-releasing factor
acute sibutramine
substance disorders

Prominent publications by Jamie L. Scholl

KOL-Index: 25 Early-life adversity is associated with increased risk for substance abuse in later life, with women more likely to report past and current stress as a mediating factor in their substance use and relapse as compared to men. Preclinical models of neonatal and peri-adolescent (early through late adolescence) stress all support a direct relationship between experiences of early-life adversity ...
Known for
Crf-Serotonin Interactions | Direct Relationship | Neurobiology | Neonatal Peri-Adolescent
KOL-Index: 22 Mild traumatic brain injury (mTBI) produces symptoms similar to those typifying posttraumatic stress disorder (PTSD) in humans. We sought to determine whether a rodent model of stress concurrent with mTBI produces characteristics of PTSD such as impaired contextual fear extinction, while also examining concurrent alterations to limbic monoamine activity in brain regions relevant to fear and ...
Known for
Open Arms | Greater Freezing | Serotonergic Effects | Extinction Limbic
KOL-Index: 22 The use of animal models for behavioral and pharmaceutical testing is employed in many different fields of research but often relies solely on male animals. When females are included, the existing literature frequently offers inconsistent results regarding the effects of sex and/or estrous cycle on anxiety-like behaviors. Our current study sought to establish baseline or normative behaviors ...
Known for
Male Naturally-Cycling Female Sprague-Dawley | Differences Anxiety | Estrous Cycle Effects | Commonly Employed Tests
KOL-Index: 21 A significant proportion of college students are adult children of an alcoholic parent (ACoA), which can confer greater risk of depression, poor self-esteem, alcohol and drug problems, and greater levels of college attrition. However, some ACoA are resilient to these negative outcomes. The goal of this study was to better understand the psychobiological factors that distinguish resilient and ...
Known for
Resilient | Neural Psychological Characteristics | Hazardous | Students Engaged
KOL-Index: 19 Adult psychiatric disorders characterized by cognitive deficits reliant on prefrontal cortex (PFC) dopamine are promoted by teenage bullying. Similarly, male Sprague-Dawley rats exposed to social defeat in mid-adolescence (P35-39) show impaired working memory in adulthood (P56-70), along with decreased medial PFC (mPFC) dopamine activity that results in part from increased dopamine ...
Known for
Increased Dopamine Transporter-Mediated Clearance | Adolescent-Like Phenotype | P35 | Decreased Medial Pfc Mpfc
KOL-Index: 18 Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic dorsal raphe nucleus (dRN) of adult rats. Interactions between serotonin and CRF systems are thought to mediate anxiety behavior. Therefore, we ...
Known for
Early Social | Reared Rats | Drug Cannula | Nucleus Reduces
KOL-Index: 18 Abstract Objective Evidence supports an association between freezing of gait (FOG) severity and cognitive functioning in patients with Parkinson’s disease (PD); however, results are varied. Here we sought to explore the differences in cognitive measurements via multivariable statistical models in patients with PD. Methods PD patients with (PDFOG+, n=41) and without FOG (PDFOG–, n=39) and ...
Known for
Moca Scores | Cognitive Measurements | N39 | Dimensional Card Sort Dccs
KOL-Index: 16 While it is known that dilation of cerebral arterioles to NOS-dependent agonists is impaired in rats exposed to prenatal alcohol, no studies have examined the influence of prenatal alcohol on constrictor response of cerebral arterioles. Our goal was to determine whether constrictor responses of cerebral resistance arterioles are altered by prenatal exposure to alcohol and if any changes ...
Known for
Exposed Prenatal | Sprague-Dawley Rat | Cerebral Ischemic Damage | Increased Metabolic Demand
KOL-Index: 15 Amphetamine withdrawal increases anxiety and stress sensitivity related to blunted ventral hippocampus (vHipp) and enhances the central nucleus of the amygdala (CeA) serotonin responses. Extracellular serotonin levels are regulated by the serotonin transporter (SERT) and organic cation transporter 3 (OCT3), and vHipp OCT3 expression is enhanced during 24 hours of amphetamine withdrawal, ...
Known for
Transporter Sert | Equivalent Pattern | Serotonergic Imbalance | Acute Withdrawal
KOL-Index: 14 RationaleAdverse social experience in adolescence causes reduced medial prefrontal cortex (mPFC) dopamine (DA) and associated behavioral deficits in early adulthood.ObjectiveThis study aims to determine whether mPFC DA hypofunction following social stress is specific to adolescent experience and if this results from stress-induced DA D2 receptor activation.Materials and methodsMale rats ...
Known for
P56 | Defeat Experience | P40 | Methodsmale Rats

Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, USA

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