 | Kenneth J RennerShow email addressDepartment of Biology, University of South Dakota, Vermillion, SD 57069 USA | Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University ... |
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Kenneth J Renner:Expert Impact
Concepts for whichKenneth J Rennerhas direct influence:Amphetamine withdrawal,Serotonergic activity,Ventral hippocampus,Central nucleus,Serotonin release,Opponent recognition,Monoamine levels,Chronic amphetamine.
Kenneth J Renner:KOL impact
Concepts related to the work of other authors for whichfor which Kenneth J Renner has influence:Social defeat,Male rats,Nucleus accumbens,Sexual behavior,Physical activity,Rainbow trout,5 ht.
KOL Resume for Kenneth J Renner
| Year | |
|---|---|
| 2022 | Department of Biology, University of South Dakota, Vermillion, SD 57069 USA |
| 2021 | Department of Biology, University of South Dakota, Vermillion, SD 57069, USA. |
| 2020 | Department of Biology, University of South Dakota, Vermillion, SD 57069, USA |
| 2019 | Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, SD 57069, USA. Electronic address: |
| 2018 | Center for Brain and Behavior Research, Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota |
| 2017 | Department of Biology, University of South Dakota, Vermillion, SD, USA;, View further author information |
| 2016 | Center for Brain and Behavior Research, Department of Biology, University of South Dakota, Vermillion, SD, USA Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America |
| 2015 | Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, United States |
| 2014 | University of South Dakota Department of Biology & Center for Brain and Behavior Research Vermillion SD USA |
| 2013 | Department of Biology, University of South Dakota, Vermillion, SD, USA |
| 2012 | University of South Dakota Neuroscience Group Basic Biomedical Sciences Sanford School of Medicine Vermillion SD USA |
| 2011 | Department of Biology, University of South Dakota, 57069, Vermillion, SD, USA |
| 2010 | Biology Dept, University of South Dakota, SD, USA Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; and |
| 2009 | Department of Biology, University of South Dakota |
| 2008 | Department of Biology & Neuroscience Group, University of South Dakota, 414 E. Clark St. Vermillion, SD, 57069, USA |
| 2007 | Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD, USA Department of Biology, The University of South Dakota, Vermillion, South Dakota 57069 |
| 2006 | Division of Basic Biomedical Sciences, Neuroscience Group, Sanford School of Medicine at the University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA Department of Biology and Neuroscience, University of South Dakota |
| 2005 | Department of Biology and Neuroscience Group, Division of Basic Biomedical Sciences, School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA |
| 2004 | Biology Department and Neuroscience Group, University of South Dakota, Vermillion, SD 57069, USA |
| 2003 | Biology and Neuroscience, University of South Dakota, Vermillion, SD, USA |
| 2002 | Department of Biology and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069-3290, USA |
| 2001 | Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, South Dakota, 57069-2390 |
| 2000 | Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, South Dakota, 57069 |
| 1999 | Department of Psychology, Hunter College of CUNY, New York, N.Y. and, Department of Biology, University of South Dakota, Vermillion, S. Dak., USA |
| 1997 | Department of Biology, The University of South Dakota, Vermillion, SDUSA |
| 1996 | Department of Zoology, Oregon State University, Corvallis, Oreg., Biomedical Sciences Department, Southwest Missouri State University Springfield, Mo., USA |
| 1993 | Department of Biomedical Sciences, Southwest Missouri State University, Springfield, MO 65804 USA |
| 1992 | Department of Biomedical Sciences, Southwest Missouri State University, Springfield, MO 65804, USA |
| 1989 | Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, U.S.A. |
| 1988 | Department of Chemistry, University of Kansas, Lawrence, KA 66045 U.S.A. |
| 1987 | Department of Chemistry, University of Kansas, Lawrence, KA 66045, U.S.A. Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021 USA |
| 1986 | Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 1002 USA The Rockefeller University, New York, NY 10021, U.S.A. |
| 1985 | Rockefeller University, New York, NY 10021 U.S.A. |
| 1984 | Department of Physiology and Cell Biology, University of Kansas, Lawrence, KSUSA Rockefeller University, New York, N.Y. 10021, USA |
| 1981 | Department of Physiology and Cell Biology, University of Kansas, Lawrence, KS 66045, USA |
| Concept | World rank |
|---|---|
| restrained dominants | #1 |
| content ventromedial | #1 |
| 432 protein spots | #1 |
| higher raphé | #1 |
| rplcnanoesims treatment | #1 |
| restraint extracellular | #1 |
| 5ht heightened aggression | #1 |
| size escalation | #1 |
| vmnpl ovariectomized rats | #1 |
| cpu induced | #1 |
| aggression animal receptors | #1 |
| serotonergic activity aggression | #1 |
| withdrawal transporter expression | #1 |
| social hydrocortisone injections | #1 |
| lower signal accumulation | #1 |
| responses nociceptive stimuli | #1 |
| ovariectomized rat levels | #1 |
| primed rats effects | #1 |
| sleep albinism | #1 |
| 100 crf crf2 | #1 |
| dopa aggressive | #1 |
| 2de maps vmn | #1 |
| anolis reflection | #1 |
| subordinates 300 | #1 |
| dentate gyrus weeks | #1 |
| lizards rapid | #1 |
| opponent unfamiliar | #1 |
| perfusate 5ht | #1 |
| teenage bullying | #1 |
| patterns subordinate males | #1 |
| pleiotropic function oca2 | #1 |
| aggression sympathetic social | #1 |
| monoamine detection | #1 |
| differentiates rapid | #1 |
| kclinduced swd | #1 |
| extinction limbic | #1 |
| publication animals puromycin | #1 |
| puromycin intracranial injection | #1 |
| potential interactive role | #1 |
| treatment ldopa treatment | #1 |
| grey mcg | #1 |
| hippocampus amphetamine | #1 |
| complex behavior neuropeptides | #1 |
| electroshock electroshock stimuli | #1 |
| brain monoamine concentrations | #1 |
| nonrestrained dominants | #1 |
| darkened eyespots males | #1 |
| drn receptor levels | #1 |
| social defeat mtbi | #1 |
| poa mcg | #1 |
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Prominent publications by Kenneth J Renner
Decreases in serotonergic activity in the central nucleus of the amygdala reduce responses to stressors, suggesting an important role for serotonin in this region of the amygdala in stress reactivity. However, it is not known whether exposure to stressors actually increases serotonin release in the central nucleus of the amygdala. The current experiment tested the hypothesis that restraint stress increases extracellular serotonin within the central nucleus of the amygdala and adjacent ...
| Known for Central Nucleus | Restraint Stress | Serotonin Release | Releasing Factor | Receptors Corticotropin |
Interactions between central corticotropin-releasing factor (CRF) and serotonergic systems are believed to be important for mediating fear and anxiety behaviors. Recently we demonstrated that infusions of CRF into the rat dorsal raphe nucleus result in a delayed increase in serotonin release within the medial prefrontal cortex that coincided with a reduction in fear behavior. The current studies were designed to study the CRF receptor mechanisms and pathways involved in this serotonergic ...
| Known for Dorsal Raphe | Type 2 | Spraguedawley Receptors | Central Nucleus | Releasing Factor |
Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. Chronic amphetamine increases anxiety states in rats when measured at 24 h and at 2 weeks of withdrawal. However, the effects of chronic amphetamine exposure and withdrawal on long term anxiety-like behavior and adult neurogenesis in the dentate gyrus are unknown. Adult male rats were administered amphetamine ...
| Known for Dentate Gyrus | Chronic Amphetamine | Anxiety States | Adult Neurogenesis | Weeks Withdrawal |
Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala is associated with anxiety states and fear. Conversely, stress-induced increases in ventral hippocampal serotonin (5-HT) levels have been linked to coping mechanisms. The goal of this study was to investigate the neurobiological changes induced by ...
| Known for Amphetamine Withdrawal | Ventral Hippocampus | Central Amygdala | 5ht Levels | Glucocorticoid Receptors |
Corticotropin-releasing factor 1 and 2 receptors in the dorsal raphé differentially affect serotonin release in the nucleus accumbens
[ PUBLICATION ]
Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal raphé nucleus. We directly tested this hypothesis by using in vivo microdialysis to determine the effects of CRF and CRF receptor antagonists in the dorsal raphé nucleus on ...
| Known for Nucleus Accumbens | Serotonin Release | 2 Receptors | Releasing Factor | Serotonergic Activity |
Serotonin in the ventral hippocampus modulates anxiety-like behavior during amphetamine withdrawal
[ PUBLICATION ]
Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse. Rats undergoing amphetamine withdrawal fail to exhibit stress-induced increases in serotonin (5-HT) release in the ventral hippocampus and show heightened anxiety-like behaviors. Therefore, we tested the hypothesis that reducing 5-HT levels in the ventral hippocampus is a causal mechanism in increasing anxiety-like behaviors during amphetamine ...
| Known for Ventral Hippocampus | Amphetamine Withdrawal | Anxiety Behavior | 5 Ht | Male Rats |
Central serotonergic neurons have been implicated in numerous animal behaviors and psychiatric disorders, but the molecular mechanisms underlying their development are not well understood. Here we generated Lmx1b (LIM homeobox transcription factor 1 beta) conditional knock-out mice (Lmx1b(f/f/p)) in which Lmx1b was only deleted in Pet1 (pheochromocytoma 12 ETS factor-1)-expressing 5-HT neurons. In Lmx1b(f/f/p) mice, the initial generation of central 5-HT neurons appeared normal. However, ...
| Known for Central Serotonergic Neurons | Knockout Mice | Expression Lmx1b | Locomotor Activity | Stages Development |
The effects of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), on serotonin1 (5-HT1) and 5-HT2 receptors were investigated using the high degree of resolution provided by quantitative autoradiography in an effort to determine the synaptic location of these receptors. 5,7-DHT treatment resulted in a decrease in 5-HT1 binding in the dentate gyrus and CA3c/4 of the anterior hippocampus and in the dorsal raphe nucleus, whereas no changes were observed in the posterior hippocampus ...
| Known for Quantitative Autoradiography | Central Nervous | 5ht2 Receptors | 5 Ht1 | Dorsal Raphe |
Adolescent Male Rats Exposed to Social Defeat Exhibit Altered Anxiety Behavior and Limbic Monoamines as Adults
[ PUBLICATION ]
Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and ...
| Known for Limbic Monoamines | Male Rats | Social Defeat | Anxiety Behavior | Stress Psychological |
Microdissection techniques were utilized to measure the activity of choline acetyltransferase (ChAT) (enzyme responsible for synthesis of acetylcholine) in individual basal forebrain nuclei of aged (24 month) and young (4 month) male and female rats. Small but consistent decreases in the activity of ChAT in aged rats were found, and the location of the changes was dependent on the sex of the rat. Aged female rats showed approximately 30% lower ChAT and 40% lower acetylcholinesterase ...
| Known for Basal Forebrain | Activity Chat | Choline Acetyltransferase | Aged Rats | Age Dependent |
To assess whether the brain's monoaminergic and/or corticotropin-releasing factor (CRF) systems may be involved in mediating the appetite-suppressing effects of high environmental ammonia levels, we exposed rainbow trout to one of four NH4Cl treatments (0, 500, 750, 1000 micromol l(-1)) for 24 or 96 h and monitored changes in food intake, brain serotonin (5-HT) and dopamine (DA) activity, CRF and urotensin I (UI) mRNA levels, and plasma cortisol levels. Food intake decreased in a ...
| Known for Ammonia Exposure | Rainbow Trout | Food Intake | Suppressing Effects | Mrna Levels |
Early life social isolation alters corticotropin-releasing factor responses in adult rats
[ PUBLICATION ]
Stress induced by early life social isolation leads to long-lasting alterations in stress responses and serotonergic activity. Corticotropin-releasing factor (CRF) is a neurotransmitter that mediates stress responses and alters serotonergic activity. We tested the hypothesis that the stress of early life isolation enhances responses to CRF in adulthood by determining the effect of CRF infusions into the dorsal raphe nucleus (dRN) on 5-HT release in the nucleus accumbens (NAc) of adult ...
| Known for Adult Rats | Social Isolation | Nucleus Accumbens | Early Life | Spraguedawley Receptors |
Rapid activation of central serotonergic systems occurs in response to the social stress of aggression in dominant lizards. The most rapid expression of serotonergic activity occurs in nucleus accumbens, hippocampus and brainstem. To compare previously measured responses induced by social stressors with those provoked by physical stress, serotonergic activity was examined following restraint stress (handling) and forced physical exertion. After handling, some male Anolis carolinensis ...
| Known for Serotonergic Activity | Nucleus Accumbens | Physical Stress | Locus Ceruleus | Medial Amygdala |
Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus
[ PUBLICATION ]
In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not clear. We hypothesize that the mechanism involves corticosteroid-induced alterations in the uptake of 5-HT from extracellular fluid through the action of corticosterone-sensitive organic cation transporters (OCTs). To determine if OCTs affect the clearance of 5-HT from the extracellular ...
| Known for Medial Hypothalamus | Organic Cation | 5 Ht | Extracellular Fluid | Behavioral Responses |
GABAergic Regulation of Lordosis: Influence of Gonadal Hormones on Turnover of GABA and Interaction of GABA with 5-HT
[ PUBLICATION ]
The role of GABAergic neurons in activating female sexual behavior and possible mechanisms for GABAergic effects on behavior were examined in female rats. First, effects of the ovarian hormones estrogen and progesterone (P), at doses which promote lordosis, on levels and turnover/activity of GABA, were examined in brain areas which regulate lordosis. Utilizing AOAA, an inhibitor of GABA degradation, the accumulation rate of GABA (turnover/activity) was assessed in ovariectomized (Ovx), ...
| Known for Female Rats | Gabaergic Neurons | Estrogen Progesterone | Gaba Vmn | Sexual Behavior |
