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    • Amphetamine Withdrawal
    • Kenneth J Renner
    • Kenneth J Renner: Influence Statistics

      Kenneth J Renner

      Kenneth J Renner

      Department of Biology, University of South Dakota, Vermillion, SD 57069 USA | Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University ...

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      Kenneth J Renner:Expert Impact

      Concepts for whichKenneth J Rennerhas direct influence:Amphetamine withdrawal,Serotonergic activity,Ventral hippocampus,Central nucleus,Serotonin release,Opponent recognition,Monoamine levels,Chronic amphetamine.

      Kenneth J Renner:KOL impact

      Concepts related to the work of other authors for whichfor which Kenneth J Renner has influence:Social defeat,Male rats,Nucleus accumbens,Sexual behavior,Physical activity,Rainbow trout,5 ht.

      KOL Resume for Kenneth J Renner

      Year
      2022

      Department of Biology, University of South Dakota, Vermillion, SD 57069 USA

      2021

      Department of Biology, University of South Dakota, Vermillion, SD 57069, USA.

      2020

      Department of Biology, University of South Dakota, Vermillion, SD 57069, USA

      2019

      Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, SD 57069, USA. Electronic address:

      2018

      Center for Brain and Behavior Research, Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota

      2017

      Department of Biology, University of South Dakota, Vermillion, SD, USA;, View further author information

      2016

      Center for Brain and Behavior Research, Department of Biology, University of South Dakota, Vermillion, SD, USA

      Department of Biology, University of South Dakota, Vermillion, South Dakota, United States of America

      2015

      Center for Brain and Behavior Research, University of South Dakota, Vermillion, SD, United States

      2014

      University of South Dakota Department of Biology & Center for Brain and Behavior Research Vermillion SD USA

      2013

      Department of Biology, University of South Dakota, Vermillion, SD, USA

      2012

      University of South Dakota Neuroscience Group Basic Biomedical Sciences Sanford School of Medicine Vermillion SD USA

      2011

      Department of Biology, University of South Dakota, 57069, Vermillion, SD, USA

      2010

      Biology Dept, University of South Dakota, SD, USA

      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota; and

      2009

      Department of Biology, University of South Dakota

      2008

      Department of Biology & Neuroscience Group, University of South Dakota, 414 E. Clark St. Vermillion, SD, 57069, USA

      2007

      Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 East Clark Street, Vermillion, SD, USA

      Department of Biology, The University of South Dakota, Vermillion, South Dakota 57069

      2006

      Division of Basic Biomedical Sciences, Neuroscience Group, Sanford School of Medicine at the University of South Dakota, 414 East Clark Street, Vermillion, SD 57069, USA

      Department of Biology and Neuroscience, University of South Dakota

      2005

      Department of Biology and Neuroscience Group, Division of Basic Biomedical Sciences, School of Medicine, The University of South Dakota, Vermillion, SD 57069, USA

      2004

      Biology Department and Neuroscience Group, University of South Dakota, Vermillion, SD 57069, USA

      2003

      Biology and Neuroscience, University of South Dakota, Vermillion, SD, USA

      2002

      Department of Biology and Neuroscience Group, University of South Dakota, 414 East Clark Street, Vermillion, SD 57069-3290, USA

      2001

      Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, South Dakota, 57069-2390

      2000

      Department of Biology and Neuroscience Group, University of South Dakota, Vermillion, South Dakota, 57069

      1999

      Department of Psychology, Hunter College of CUNY, New York, N.Y. and, Department of Biology, University of South Dakota, Vermillion, S. Dak., USA

      1997

      Department of Biology, The University of South Dakota, Vermillion, SDUSA

      1996

      Department of Zoology, Oregon State University, Corvallis, Oreg., Biomedical Sciences Department, Southwest Missouri State University Springfield, Mo., USA

      1993

      Department of Biomedical Sciences, Southwest Missouri State University, Springfield, MO 65804 USA

      1992

      Department of Biomedical Sciences, Southwest Missouri State University, Springfield, MO 65804, USA

      1989

      Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, U.S.A.

      1988

      Department of Chemistry, University of Kansas, Lawrence, KA 66045 U.S.A.

      1987

      Department of Chemistry, University of Kansas, Lawrence, KA 66045, U.S.A.

      Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021 USA

      1986

      Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 1002 USA

      The Rockefeller University, New York, NY 10021, U.S.A.

      1985

      Rockefeller University, New York, NY 10021 U.S.A.

      1984

      Department of Physiology and Cell Biology, University of Kansas, Lawrence, KSUSA

      Rockefeller University, New York, N.Y. 10021, USA

      1981

      Department of Physiology and Cell Biology, University of Kansas, Lawrence, KS 66045, USA

      Sample of concepts for which Kenneth J Renner is among the top experts in the world.
      Concept World rank
      amphetamine withdrawal withdrawal #1
      monoamine levels subregions #1
      locus ceruleus vta #1
      exertion handling #1
      mcg vmh #1
      accumbens 500 #1
      crf dorsal #1
      opponent perception #1
      oct3 vhipp #1
      agonistic displays vertebrates #1
      swd cck8s #1
      nucleus accumbens crf #1
      elevated serotonergic activity #1
      perception larger #1
      rapid responses restraint #1
      oct3 sert expression #1
      critical role aggression #1
      activity dominants #1
      losers interaction #1
      nac isolationreared animals #1
      males reflection #1
      raphé crf #1
      stimuli 5ht #1
      electroshocks responses #1
      withdrawal sert #1
      onset social challenge #1
      aggression stalkeyed fly #1
      cpu induced #1
      alters serotonergic activity #1
      serotonergic activity imcg #1
      increased aggression raphe #1
      nonnociceptive stimuli responses #1
      social stress mtbi #1
      estrogen regulation proteins #1
      enhanced ventral hippocampal #1
      cck8s generation #1
      hatching frog #1
      heightened serotonin #1
      derived cave morphs #1
      5ht overflow vmh #1
      limbic glucocorticoids #1
      beetle parental behavior #1
      materials methodsmale rats #1
      prior social status #1
      serotonergic responses #1
      aggression sympathetic social #1
      beetle parental #1
      dentate gyrus 20 #1
      smaller treated opponents #1

      Prominent publications by Kenneth J Renner

      KOL-Index: 14223

      Decreases in serotonergic activity in the central nucleus of the amygdala reduce responses to stressors, suggesting an important role for serotonin in this region of the amygdala in stress reactivity. However, it is not known whether exposure to stressors actually increases serotonin release in the central nucleus of the amygdala. The current experiment tested the hypothesis that restraint stress increases extracellular serotonin within the central nucleus of the amygdala and adjacent ...

      Known for Central Nucleus | Restraint Stress | Serotonin Release | Releasing Factor | Receptors Corticotropin
      KOL-Index: 13075

      Interactions between central corticotropin-releasing factor (CRF) and serotonergic systems are believed to be important for mediating fear and anxiety behaviors. Recently we demonstrated that infusions of CRF into the rat dorsal raphe nucleus result in a delayed increase in serotonin release within the medial prefrontal cortex that coincided with a reduction in fear behavior. The current studies were designed to study the CRF receptor mechanisms and pathways involved in this serotonergic ...

      Known for Dorsal Raphe | Type 2 | Spraguedawley Receptors | Central Nucleus | Releasing Factor
      KOL-Index: 12566

      Acute amphetamine administration activates monoaminergic pathways and increases systemic corticosterone, both of which influence anxiety states and adult dentate gyrus neurogenesis. Chronic amphetamine increases anxiety states in rats when measured at 24 h and at 2 weeks of withdrawal. However, the effects of chronic amphetamine exposure and withdrawal on long term anxiety-like behavior and adult neurogenesis in the dentate gyrus are unknown. Adult male rats were administered amphetamine ...

      Known for Dentate Gyrus | Chronic Amphetamine | Anxiety States | Adult Neurogenesis | Weeks Withdrawal
      KOL-Index: 12374

      Withdrawal from amphetamine increases anxiety and reduces the ability to cope with stress, which are factors that are believed to contribute to drug relapse. Stress-induced serotonergic transmission in the central nucleus of the amygdala is associated with anxiety states and fear. Conversely, stress-induced increases in ventral hippocampal serotonin (5-HT) levels have been linked to coping mechanisms. The goal of this study was to investigate the neurobiological changes induced by ...

      Known for Amphetamine Withdrawal | Ventral Hippocampus | Central Amygdala | 5ht Levels | Glucocorticoid Receptors
      KOL-Index: 12187

      Corticotropin-releasing factor (CRF) is a neurohormone that mediates stress, anxiety, and affects serotonergic activity. Studies have shown that CRF has dose-dependent opposing effects on serotonergic activity. This effect has been hypothesized to be differentially mediated by CRF(1) and CRF(2) receptors in the dorsal raphé nucleus. We directly tested this hypothesis by using in vivo microdialysis to determine the effects of CRF and CRF receptor antagonists in the dorsal raphé nucleus on ...

      Known for Nucleus Accumbens | Serotonin Release | 2 Receptors | Releasing Factor | Serotonergic Activity
      KOL-Index: 12115

      Withdrawal from amphetamine is associated with increased anxiety and sensitivity to stressors which are thought to contribute to relapse. Rats undergoing amphetamine withdrawal fail to exhibit stress-induced increases in serotonin (5-HT) release in the ventral hippocampus and show heightened anxiety-like behaviors. Therefore, we tested the hypothesis that reducing 5-HT levels in the ventral hippocampus is a causal mechanism in increasing anxiety-like behaviors during amphetamine ...

      Known for Ventral Hippocampus | Amphetamine Withdrawal | Anxiety Behavior | 5 Ht | Male Rats
      KOL-Index: 11684

      Central serotonergic neurons have been implicated in numerous animal behaviors and psychiatric disorders, but the molecular mechanisms underlying their development are not well understood. Here we generated Lmx1b (LIM homeobox transcription factor 1 beta) conditional knock-out mice (Lmx1b(f/f/p)) in which Lmx1b was only deleted in Pet1 (pheochromocytoma 12 ETS factor-1)-expressing 5-HT neurons. In Lmx1b(f/f/p) mice, the initial generation of central 5-HT neurons appeared normal. However, ...

      Known for Central Serotonergic Neurons | Knockout Mice | Expression Lmx1b | Locomotor Activity | Stages Development
      KOL-Index: 11322

      The effects of the serotonin neurotoxin 5,7-dihydroxytryptamine (5,7-DHT), on serotonin1 (5-HT1) and 5-HT2 receptors were investigated using the high degree of resolution provided by quantitative autoradiography in an effort to determine the synaptic location of these receptors. 5,7-DHT treatment resulted in a decrease in 5-HT1 binding in the dentate gyrus and CA3c/4 of the anterior hippocampus and in the dorsal raphe nucleus, whereas no changes were observed in the posterior hippocampus ...

      Known for Quantitative Autoradiography | Central Nervous | 5ht2 Receptors | 5 Ht1 | Dorsal Raphe
      KOL-Index: 10528

      Social stress in adolescence is correlated with emergence of psychopathologies during early adulthood. In this study, the authors investigated the impact of social defeat stress during mid-adolescence on adult male brain and behavior. Adolescent male Sprague-Dawley rats were exposed to repeated social defeat for 5 days while controls were placed in a novel empty cage. When exposed to defeat-associated cues as adults, previously defeated rats showed increased risk assessment and ...

      Known for Limbic Monoamines | Male Rats | Social Defeat | Anxiety Behavior | Stress Psychological
      KOL-Index: 9930

      Microdissection techniques were utilized to measure the activity of choline acetyltransferase (ChAT) (enzyme responsible for synthesis of acetylcholine) in individual basal forebrain nuclei of aged (24 month) and young (4 month) male and female rats. Small but consistent decreases in the activity of ChAT in aged rats were found, and the location of the changes was dependent on the sex of the rat. Aged female rats showed approximately 30% lower ChAT and 40% lower acetylcholinesterase ...

      Known for Basal Forebrain | Activity Chat | Choline Acetyltransferase | Aged Rats | Age Dependent
      KOL-Index: 9843

      To assess whether the brain's monoaminergic and/or corticotropin-releasing factor (CRF) systems may be involved in mediating the appetite-suppressing effects of high environmental ammonia levels, we exposed rainbow trout to one of four NH4Cl treatments (0, 500, 750, 1000 micromol l(-1)) for 24 or 96 h and monitored changes in food intake, brain serotonin (5-HT) and dopamine (DA) activity, CRF and urotensin I (UI) mRNA levels, and plasma cortisol levels. Food intake decreased in a ...

      Known for Ammonia Exposure | Rainbow Trout | Food Intake | Suppressing Effects | Mrna Levels
      KOL-Index: 9462

      Stress induced by early life social isolation leads to long-lasting alterations in stress responses and serotonergic activity. Corticotropin-releasing factor (CRF) is a neurotransmitter that mediates stress responses and alters serotonergic activity. We tested the hypothesis that the stress of early life isolation enhances responses to CRF in adulthood by determining the effect of CRF infusions into the dorsal raphe nucleus (dRN) on 5-HT release in the nucleus accumbens (NAc) of adult ...

      Known for Adult Rats | Social Isolation | Nucleus Accumbens | Early Life | Spraguedawley Receptors
      KOL-Index: 9460

      Rapid activation of central serotonergic systems occurs in response to the social stress of aggression in dominant lizards. The most rapid expression of serotonergic activity occurs in nucleus accumbens, hippocampus and brainstem. To compare previously measured responses induced by social stressors with those provoked by physical stress, serotonergic activity was examined following restraint stress (handling) and forced physical exertion. After handling, some male Anolis carolinensis ...

      Known for Serotonergic Activity | Nucleus Accumbens | Physical Stress | Locus Ceruleus | Medial Amygdala
      KOL-Index: 9460

      In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not clear. We hypothesize that the mechanism involves corticosteroid-induced alterations in the uptake of 5-HT from extracellular fluid through the action of corticosterone-sensitive organic cation transporters (OCTs). To determine if OCTs affect the clearance of 5-HT from the extracellular ...

      Known for Medial Hypothalamus | Organic Cation | 5 Ht | Extracellular Fluid | Behavioral Responses
      KOL-Index: 9307

      The role of GABAergic neurons in activating female sexual behavior and possible mechanisms for GABAergic effects on behavior were examined in female rats. First, effects of the ovarian hormones estrogen and progesterone (P), at doses which promote lordosis, on levels and turnover/activity of GABA, were examined in brain areas which regulate lordosis. Utilizing AOAA, an inhibitor of GABA degradation, the accumulation rate of GABA (turnover/activity) was assessed in ovariectomized (Ovx), ...

      Known for Female Rats | Gabaergic Neurons | Estrogen Progesterone | Gaba Vmn | Sexual Behavior

      Key People For Amphetamine Withdrawal

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      Department of Biology, University of South Dakota, Vermillion, SD 57069 USA | Neuroscience Group, Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, Vermillion, SD 57069 USA | Department of Biology, Univers

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