Barbara D. Foleno

Barbara D. Foleno

Johnson & Johnson Pharmaceutical Research & Development, L.l.c., Raritan, New Jersey 08869

Direct Impact

Concepts for which Barbara D Foleno has direct influence:

antibacterial activity
murf inhibitors
streptococcus pneumoniae
mura enzyme
coagulase-negative staphylococci
two-component regulatory systems
pseudomonas aeruginosa

External impact

Concepts related to the work of other authors for which Barbara D Foleno has influence:

streptococcus pneumoniae
preexisting parc mutation
staphylococcus aureus
west south central regions
pseudomonas aeruginosa
muropeptide ligase
induced-fit mechanism

Prominent publications by Barbara D. Foleno

KOL-Index: 33 JNJ-Q2, a novel fluorinated 4-quinolone, was evaluated for its antibacterial potency by broth and agar microdilution MIC methods in studies focused on skin and respiratory tract pathogens, including strains exhibiting contemporary fluoroquinolone resistance phenotypes. Against a set of 118 recent clinical isolates of Streptococcus pneumoniae, including fluoroquinolone-resistant variants ...
KOL-Index: 13 The susceptibility of 513 clinical isolates to doripenem was determined by broth microdilution, agar dilution, and Etest. Overall agreements for Etest and agar dilution MIC values compared to reference broth microdilution at +/-1 log(2) dilution were 88% and 94%, respectively. Etest MIC values demonstrated 98% agreement within +/-2 log(2) dilutions compared to the reference broth microdilution method.
Known for
Log2 | 513 Isolates | Microdilution | Dilution Etest
KOL-Index: 12 MurF is a key enzyme in the biosynthesis of the bacterial cell wall in both gram-positive and gram-negative bacteria. This enzyme has not been extensively exploited as a drug target, possibly due to the difficulty in obtaining one of the substrates, UDP-MurNAc-L-Ala-gamma-D-Glu-meso-diaminopimelate, which is usually purified from bacteria. We have identified putative inhibitors of ...
Known for
Udp-Murnac-L-Ala-Gamma-D-Glu-Meso-Diaminopimelate | Gamma Glu | Murf Enzyme Inhibitors | Muropeptide Ligase Enzyme
KOL-Index: 12 A series of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives has been synthesized. Several functional groups were identified as the optimal C3-substituents, and the best compounds in this series possess potent in vitro antibacterial activity against erythromycin-susceptible and erythromycin-resistant bacteria.
KOL-Index: 11 Escherichia coli and Klebsiella pneumoniae isolates with extended-spectrum beta-lactamases (ESBLs) or AmpC cephalosporinases generally respond as predicted to NCCLS tests for ESBL production. However, inoculum size may affect MICs. The effect of inoculum level in clinical isolates expressing beta-lactamases were studied at inocula within 0.5 log unit of the standard inoculum, using broth ...
Known for
M-10 | Nccls Tests | Higher Inoculum | Tem-43
KOL-Index: 11 MurF catalyzes the last cytoplasmic step of bacterial cell wall synthesis and is essential for bacterial survival. Our previous studies used a pharmacophore model of a MurF inhibitor to identify additional inhibitors with improved properties. We now present the characterization of two such inhibitors, the diarylquinolines DQ1 and DQ2. DQ1 inhibited Escherichia coli MurF (50% inhibitory ...
Known for
Bacterial Wall Synthesis | 24 Microm | Product Compared | Muropeptide
KOL-Index: 11 A novel series of ketolides containing heteroaryl groups that are linked to the erythronolide ring via a C6-carbazate functionality has been successfully synthesized. Careful modulation of the heteroaryl groups, the length and degree of saturation of the C6-carbazate linker, and the substituents present on each of the carbazate nitrogens led to compounds with potent activity against key ...
Known for
Potent Activity | C6-Carbazate Linker | Key Bacterial Respiratory Pathogens | Ketolides Series
KOL-Index: 10 A class of antibacterials has been discovered that inhibits the growth of Gram-positive pathogenic bacteria. RWJ-49815, a representative of a family of hydrophobic tyramines, in addition to being a potent bactericidal Gram-positive antibacterial, inhibits the autophosphorylation of kinase A of the KinA::Spo0F two-component signal transduction system in vitro. Analogs of RWJ-49815 vary ...
Known for
Antibacterials Represent | Bacteria Ability | Inhibit Growth
KOL-Index: 10 The in vitro activity of l-ofloxacin was determined against coagulase-negative staphylococci that were induced to norfloxacin resistance. l-Ofloxacin was the most active agent tested with an MIC90 of 4 micrograms/ml compared with greater than 128, 32, and 128 micrograms/ml for norfloxacin, ciprofloxacin, and enoxacin, respectively. Rifampin-resistant, coagulase-negative staphylococci were ...
Known for
128 Micrograms | Enoxacin | Norfloxacin Resistance | Rifampin-Resistant Organisms
KOL-Index: 10 Novel C6-carbamate ketolides with C2-fluorination and C9-oximation have been synthesized. The best compounds in this series displayed MIC values of 0.03-0.12 microg/mL against streptococci containing erm and mef resistance determinants and 2-4 microg/mL against Haemophilus influenzae. Several compounds also showed measurable activity against erm(B)-containing enterococci with MIC values of ...
Known for
C9-Oximation | Erm Mef Resistance Determinants | 2-4 Microg | C2-Fluorination

Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Raritan, New Jersey 08869

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