• Disease
  • Systemic
  • Systemic Lupus
  • Systemic Lupus Erythematosus
  • Graham Robert Vivian Hughes

    Prominent publications by Graham Robert Vivian Hughes

    KOL Index score: 14975

    OBJECTIVE: To investigate antibodies to complement 1q (anti-C1q) and investigate the correlation between anti-C1q titres and renal disease in systemic lupus erythematosus (SLE).

    METHODS: 151 SLE patients were studied. In patients with biopsy proven lupus nephritis (n = 77), activity of renal disease was categorised according to the BILAG renal score. Sera were tested for anti-C1q by enzyme immunoassay. Serum samples were randomly selected from 83 SLE patients who had no history of renal ...

    Also Ranks for: Renal Disease |  anti c1q |  systemic lupus |  positive predictive |  patients nephritis
    KOL Index score: 14566

    PURPOSE: To determine whether the features of the antiphospholipid syndrome (APS) are in any way influenced by the presence or absence of systemic lupus erythematosus (SLE). We followed up patients with 'primary' APS (PAPS) and APS secondary to SLE (APS plus SLE) with the objective of comparing laboratory and clinical events and of determining whether patients with PAPS would have evolution to SLE.

    PATIENTS AND METHODS: A total of 114 patients from 3 European referral centers were ...

    Also Ranks for: Patients Aps |  antiphospholipid syndrome |  antinuclear antibodies |  low c4 levels |  hemolytic anemia
    KOL Index score: 13019

    The objective was to determine whether the frequency of flare in systemic lupus erythematosus (SLE), patients is increased during pregnancy and the puerperium. Seventy-eight pregnancies in 68 SLE patients attending the lupus pregnancy clinic, at St. Thomas' Hospital, during the last 5 yr were included. The pregnancy period and 8 weeks post-delivery were considered. This group was compared with a control group of 50 consecutive, non-pregnant, age-matched SLE patients attending our weekly ...

    Also Ranks for: Lupus Flare |  pregnancy puerperium |  sle patients |  erythematosus systemic |  seventyeight pregnancies
    KOL Index score: 12856

    OBJECTIVE: To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression.

    METHODS: The clinical and serologic features of APS (Sapporo preliminary criteria) in 1,000 patients from 13 European countries were analyzed using a computerized database.

    RESULTS: The cohort consisted of 820 female patients (82.0%) and 180 male patients (18.0%) with a mean +/- SD age of 42 +/- 14 years at study ...

    Also Ranks for: Antiphospholipid Syndrome |  disease expression |  livedo reticularis |  patients aps |  higher frequency
    KOL Index score: 12697

    OBJECTIVE: To investigate the ability of human anti-beta 2-glycoprotein I (anti-beta 2 GPI) antibodies to recognize the cofactor adherent on endothelial cells (EC) and to modulate endothelial functions.

    METHODS: Six human affinity-purified polyclonal anti-beta 2 GPI IgG and 2 IgM monoclonal antibodies (MAb) were obtained from patients with the antiphospholipid syndrome. The antibodies were tested for their ability to 1) bind to endothelial monolayers through the adherent beta 2 GPI and ...

    Also Ranks for: Antiphospholipid Antibodies |  endothelial cells |  beta 2 |  umbilical veins |  cell adhesion
    KOL Index score: 12294

    We retrospectively studied a large cohort of patients with primary antiphospholipid syndrome (APS) from 4 different referral centers to analyze the clinical and serologic features and, specifically, to determine the number of patients going on to develop systemic lupus erythematosus (SLE) or other autoimmune disease after long-term follow-up. The study included 128 unselected patients with primary APS who fulfilled the Sapporo International Criteria from 4 different tertiary hospitals in ...

    Also Ranks for: Sle Patients |  primary aps |  anticardiolipin antibodies |  antiphospholipid syndrome |  follow studies
    KOL Index score: 12037

    The families of 29 patients with systemic lupus erythematosus and 42 normal subjects were studied to determine the inheritance of the HLA-A, B, C, and DR antigens and also the complement polymorphisms for C2, C4A, C4B, and Bf, which are encoded in the same region of the sixth chromosome. Null (silent) alleles for C4A, C4B, or C2 were found in 24 of the 29 (83%) patients compared with 18 of the 42 (43%) normal controls. HLA-DR3 was present in 20 (69%) of the patients and seven out of 39 ...

    Also Ranks for: Null Alleles |  c4a c4b |  disease susceptibility |  lupus erythematosus |  female genes
    KOL Index score: 11719

    OBJECTIVE: To elucidate the specificity of anticardiolipin antibodies (aCL) from patients with the antiphospholipid syndrome (APS) to various phospholipids (PLs), DNA, and beta 2-glycoprotein I (beta 2-GPI).

    METHODS: Five monoclonal aCL were established from peripheral blood lymphocytes of 3 patients with the APS. The reactivity of monoclonal aCL with various PLs, with DNA, and with beta 2-GPI was examined by enzyme-linked immunosorbent assay (ELISA).

    RESULTS: All of the monoclonal aCL ...

    Also Ranks for: Anticardiolipin Antibodies |  antiphospholipid syndrome |  beta 2gpi |  monoclonal acl |  cryptic epitope
    KOL Index score: 11590

    Paired serum and saliva samples from seven patients with systemic sicca syndrome (SSS), 15 patients with rheumatoid arthritis and a positive Schirmer's test (RA+), 15 patients with rheumatoid arthritis and negative Schirmer's test (RA-) and 14 normal individuals were analysed for albumin and immunoglobulin concentration as well as IgA and IgM rheumatoid factor (RF) activity. Protein levels in saliva were higher in SSS and RA+ but, when corrected for serum concentration and salivary flow ...

    Also Ranks for: Rheumatoid Arthritis |  serum saliva |  secretory component |  systemic sicca syndrome |  15 patients
    KOL Index score: 11456

    A new fluorimetric assay was used to measure the relative amounts of antibodies to individual nuclear histones in sera from 102 patients with systemic lupus erythematosus (SLE), mixed connective tissue disease, primary sicca syndrome, and rheumatoid arthritis with vasculitis. In SLE sera, the predominant responses were to histones H-1, H-2B, and H-3, with marked elevations of binding to H-1 and H-2B in one-third of the patients, and to H-3 in one-fourth; antibodies of both the IgG and ...

    Also Ranks for: Lupus Erythematosus |  rheumatoid arthritis |  h1 h2b |  systemic rheumatic disease |  antibody specificity
    KOL Index score: 11384

    OBJECTIVES: Beta2-Glycoprotein I (beta2GPI) exon 7 polymorphism leads to a valine leucine amino acid exchange at position 247 in domain 5 of beta2GPI, between the phospholipid binding site and the cryptic site of the epitopes for anti-beta2GPI antibodies. Therefore, position 247 polymorphism may affect the conformational change of beta2GPI and the exposure of the epitopes for anticardiolipin antibodies (aCL) (= anti-beta2GPI antibodies). In this study we analysed the genetic polymorphism ...

    Also Ranks for: Primary Antiphospholipid |  antibeta2gpi antibodies |  genetic polymorphism |  aps patients |  glycoprotein beta2gpi
    KOL Index score: 11374

    OBJECTIVE: Thromboembolic manifestations or thrombocytopenia in association with anticardiolipin antibodies (aCL) or lupus anticoagulant are known as the antiphospholipid syndrome (APS). Efforts have been made to elucidate precise clinical features and adequate therapeutic options for treating patients with APS. However, the lack of a proper international standard for measurement of aCL makes it difficult to compare data derived from different laboratories. We attempted to design a ...

    Also Ranks for: Anticardiolipin Antibodies |  igg acl |  antiphospholipid syndrome aps |  antibeta2gpi antibody |  humans immunoglobulin
    KOL Index score: 11278

    The clinical significance of anti-beta 2 glycoprotein I (beta 2-GPI) antibodies was evaluated in patients with antiphospholipid syndrome (APS), primary and secondary to systemic lupus erythematosus (SLE). Anti-beta 2-GPI were tested in 120 patients (39 primary APS, 32 APS with SLE and 49 SLE without APS) by ELISA utilizing irradiated plates in the absence of cardiolipin. Anticardiolipin antibodies (aCL) and antiphosphatidylserine antibodies were also measured in the same patients using ...

    Also Ranks for: Antiphospholipid Syndrome |  acl aps |  beta 2 |  sle patients |  gpi antibodies
    KOL Index score: 11271

    OBJECTIVES: To investigate the causes, course, and outcome of critical illness requiring emergency admission to the intensive care unit (ICU) in patients with systemic lupus erythematosus (SLE) or the antiphospholipid syndrome (APS), or both.

    METHODS: Critically ill patients with SLE or APS, or both, admitted to a London teaching hospital ICU over a 15 year period were studied. Demographic, diagnostic, physiological, laboratory, and survival data were analysed. Kaplan-Meier survival ...

    Also Ranks for: Systemic Lupus Erythematosus |  icu patients |  critical illness |  antiphospholipid syndrome aps |  admission death


    Graham Robert Vivian Hughes: Influence Statistics

    Sample of concepts for which Graham Robert Vivian Hughes is among the top experts in the world.
    Concept World rank
    female siblings treatment #1
    c20 hde #1
    nervous publication antibodies #1
    amam5 activity #1
    infarction antiphospholipid #1
    systemic lupus detection #1
    vasculitis patients median #1
    eeg aps #1
    igm regression slopes #1
    ferrante paper #1
    sle publication abortion #1
    valid assays #1
    ungleiche #1
    hughes antiphospholipid syndrome #1
    antibeta2gpi aps #1
    rare complication sle #1
    activity chronicity scores #1
    hughes aps #1
    hughes publication antibodies #1
    igg4 subclasses anticardiolipin #1
    systemic male phospholipids #1
    valid igg #1
    common major illness #1
    hughes antiphospholipid #1
    antidna antibodies igg1 #1
    lupus patients outcome #1
    association anticardiolipin #1
    liver uptake hdrbc #1
    pbs assays #1
    analysis hde #1
    resistant subacute #1
    sle eic levels #1
    anticardiolipin antidna antibodies #1
    anticardiolipin antibodies patients #1
    sle icu admission #1
    pft sle #1
    vdrl antigen #1
    hematological immune cytopenias #1
    humans phospholipids #1
    ivig alternative treatment #1
    49 healthy subjects #1
    scle common manifestation #1
    systemic radioimmunoassay #1
    aged thrombosis #1
    sle fetal loss #1
    antiphospholipid tests #1
    antibodies lupus #1
    sicam1 31 #1
    sera igg2 #1
    preirradiation density #1

    Key People For Systemic Lupus Erythematosus

    Top KOLs in the world
    David Alan Isenberg
    systemic lupus erythematosus patients sle rheumatoid arthritis
    Michelle A Petri
    systemic lupus erythematosus lupus nephritis patients sle
    D Gladman Gladman
    psoriatic arthritis systemic lupus erythematosus patients psa
    Murray B Urowitz
    systemic lupus erythematosus patients sle lupus nephritis
    James F Fries
    rheumatoid arthritis physical function systemic lupus erythematosus
    Norman Talal
    sex hormones lupus erythematosus sjögrens syndrome

    Graham Robert Vivian Hughes:Expert Impact

    Concepts for whichGraham Robert Vivian Hugheshas direct influence:Systemic lupus erythematosus,  Antiphospholipid syndrome,  Lupus erythematosus,  Systemic lupus,  Antiphospholipid antibodies,  Anticardiolipin antibodies,  Hughes syndrome,  Patients sle.

    Graham Robert Vivian Hughes:KOL impact

    Concepts related to the work of other authors for whichfor which Graham Robert Vivian Hughes has influence:Systemic lupus erythematosus,  Antiphospholipid syndrome,  Lupus nephritis,  Sle patients,  Anticardiolipin antibodies,  Autoimmune diseases,  Rheumatoid arthritis.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    The London Lupus Centre, London Bridge Hospital, London, UK | The London Lupus Centre, London Bridge Hospital, London, England, UK | The London Lupus Centre, London Bridge Hospital, London UK | Head of the London Lupus Center, London Bridge Hospital,