 | Caroline Anne SabinShow email addressUniversity College London, London, UK | Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London, London, UK | Centre ... |
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Caroline Anne Sabin:Expert Impact
Concepts for whichCaroline Anne Sabinhas direct influence:Antiretroviral therapy,Hiv infection,United kingdom,Viral load,Cd4 count,Cardiovascular disease,Myocardial infarction,Cd4 cell count.
Caroline Anne Sabin:KOL impact
Concepts related to the work of other authors for whichfor which Caroline Anne Sabin has influence:Antiretroviral therapy,Hiv infection,Human immunodeficiency virus,Viral load,Liver transplantation,Infected patients,Cardiovascular disease.
KOL Resume for Caroline Anne Sabin
| Year | |
|---|---|
| 2022 | University College London, London, UK |
| 2021 | Institute for Global Health UCL London UK University College London, London, United Kingdom |
| 2020 | Institute for Global Health University College London London UK University College London (UCL), London, United Kingdom. NIHR HPRU in Blood Borne and Sexually Transmitted Infections at UCL |
| 2019 | Institute for Global Health, UCL, London, United Kingdom Medical Research Council (MRC) Clinical Trials Unit at University College London (UCL), 90 High Holborn, WC1V 6LJ, London, UK |
| 2018 | Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, Royal Free Campus, University College London, London, UK. National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at University College London, London, UK Department of Infection & Population Health, University College London, London, United Kingdom |
| 2017 | Department of Infection and Population Health, University College London, United Kingdom National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London University of North Dakota |
| 2016 | Research Department of Infection and Population Health , University College London , UK. Royal Free Hospital NHS Foundation Trust and University College London, London, UK Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA. University College London, London, United Kingdom; |
| Concept | World rank |
|---|---|
| viral rebounds | #1 |
| individuals shallower decline | #1 |
| patients interposition graft | #1 |
| uk shortterm mortality | #1 |
| hiv1 subtype ethnicity | #1 |
| hiv drug therapy | #1 |
| advancement hiv | #1 |
| natural cytomegalovirus retinitis | #1 |
| wlwh population | #1 |
| hiv disease death | #1 |
| cd4 count haart | #1 |
| aged 45–60 | #1 |
| lpv atazanavir ritonavir | #1 |
| people shorter appointment | #1 |
| pound17 | #1 |
| cumulative incidence cod | #1 |
| p00001 immunological responses | #1 |
| ltnp hiv infection | #1 |
| interposition graft difference | #1 |
| nshpc women | #1 |
| art continental ancestry | #1 |
| virologic failure codons | #1 |
| diagnosis shortterm mortality | #1 |
| viral rebounds loss | #1 |
| initiation cd4 cell | #1 |
| 2 proportion stage | #1 |
| primary prophylaxis individuals | #1 |
| cohort uk | #1 |
| msm late diagnosis | #1 |
| hcv infection death | #1 |
| plwh aged | #1 |
| depressive symptoms syphilis | #1 |
| haart hdl | #1 |
| comorbidities wlwh | #1 |
| atazanavir regimen | #1 |
| differences plwh | #1 |
| lee severe lee | #1 |
| reaction viraemia | #1 |
| shortterm mortality diagnosis | #1 |
| nuisance interference | #1 |
| year hiv diagnosis | #1 |
| hiv rna hivick | #1 |
| uk vascular resection | #1 |
| pbac scores ddavp | #1 |
| median egfr patients | #1 |
| associations widespread pain | #1 |
| development k65r | #1 |
| wlhiv methods | #1 |
| viral subtype patients | #1 |
| outcomes physical symptoms | #1 |
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Prominent publications by Caroline Anne Sabin
BACKGROUND: Recommendations have differed nationally and internationally with respect to the best time to start antiretroviral therapy (ART). We compared effectiveness of three strategies for initiation of ART in high-income countries for HIV-positive individuals who do not have AIDS: immediate initiation, initiation at a CD4 count less than 500 cells per μL, and initiation at a CD4 count less than 350 cells per μL.
METHODS: We used data from the HIV-CAUSAL Collaboration of cohort ...
| Known for Antiretroviral Therapy | Cd4 Count | Art Initiation | 500 Cells | Hiv Diagnosis |
OBJECTIVE: To assess the obstetric outcome in women with von Willebrand's disease or factor XI deficiency.
SETTING: Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital.
POPULATION: Women with von Willebrand's disease (n = 31) and with factor XI deficiency (n = 11) registered at the Royal Free Hospital Haemophilia Centre who had had a pregnancy within the previous 17 years (1980-1996), including 84 in women with von Willebrand's disease and 28 in women with factor XI ...
| Known for Factor Deficiency | Willebrands Disease | Pregnancy Women | Haemophilia Centre | Prophylactic Treatment |
Insulin Resistance Plays a Significant Role in Liver Fibrosis in Chronic Hepatitis C and in the Response to Antiviral Therapy
[ PUBLICATION ]
OBJECTIVES: To assess whether insulin resistance is associated with liver fibrosis in a group of patients with chronic hepatitis C virus (HCV) infection and whether there were any differences in insulin resistance between Asians and the indigenous Caucasian population. Secondly, to assess whether insulin resistance is associated with sustained virological response to antiviral therapy.
METHODS: We determined insulin resistance in 59 (30 Caucasians; 29 Asians) consecutive patients with ...
| Known for Insulin Resistance | Antiviral Therapy | Liver Fibrosis | Patients Hcv | Sustained Virological Response |
OBJECTIVES: To describe the viral response to HAART by weeks 4 and 8 in previously antiretroviral-naive patients. To assess whether the weeks 4 or 8 viral loads are useful predictors of viral suppression by week 24.
DESIGN: A large clinical database including 453 antiretroviral-naive patients whose plasma viral load was monitored every 4 weeks.
METHODS: Observed probabilities of achieving a viral load < or = 500 copies/ml by week 24 (days 84-168) from starting highly active ...
| Known for Viral Load | 24 Weeks | Virological Response | Highly Active | Copies Week |
Cardiovascular disease and use of contemporary protease inhibitors: the D:A:D international prospective multicohort study.
[ PUBLICATION ]
BACKGROUND: Although earlier protease inhibitors have been associated with increased risk of cardiovascular disease, whether this increased risk also applies to more contemporary protease inhibitors is unknown. We aimed to assess whether cumulative use of ritonavir-boosted atazanavir and ritonavir-boosted darunavir were associated with increased incidence of cardiovascular disease in people living with HIV.
METHODS: The prospective Data Collection on Adverse Events of Anti-HIV Drugs ...
| Known for Cardiovascular Disease | Protease Inhibitors | 1000 Personyears | Darunavir Ritonavir | People Hiv |
Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration
[ PUBLICATION ]
BACKGROUND: With the advent of effective antiretroviral treatment, the life expectancy for people with HIV is now approaching that seen in the general population. Consequently, the relative importance of other traditionally non-AIDS-related morbidities has increased. We investigated trends over time in all-cause mortality and for specific causes of death in people with HIV from 1999 to 2011.
METHODS: Individuals from the Data collection on Adverse events of anti-HIV Drugs (D:A:D) study ...
| Known for Death People | 1000 Personyears | Liver Disease | Multicohort Collaboration | Cd4 Cell Count |
Durability of viral suppression with first-line antiretroviral therapy in patients with HIV in the UK: an observational cohort study
[ PUBLICATION ]
BACKGROUND: The length of time that people with HIV on antiretroviral therapy (ART) with viral load suppression will be able to continue before developing viral rebound is unknown. We aimed to investigate the rate of first viral rebound in people that have achieved initial suppression with ART, to determine factors associated with viral rebound, and to use these estimates to predict long-term durability of viral suppression.
METHODS: The UK Collaborative HIV Cohort (UK CHIC) Study is an ...
| Known for Viral Suppression | People Hiv | Art Baseline | Observational Cohort Study | 200 Copies |
OBJECTIVE: To compare regimens consisting of either efavirenz or nevirapine and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV-infected, antiretroviral-naive, and AIDS-free individuals with respect to clinical, immunologic, and virologic outcomes.
DESIGN: Prospective studies of HIV-infected individuals in Europe and the US included in the HIV-CAUSAL Collaboration.
METHODS: Antiretroviral therapy-naive and AIDS-free individuals were followed from the time they ...
| Known for Efavirenz Versus | 12 Months | Virologic Failure | Cd4 Cell Count | Reverse Transcriptase |
Impact of HIV-1 Subtype on CD4 Count at HIV Seroconversion, Rate of Decline, and Viral Load Set Point in European Seroconverter Cohorts
[ PUBLICATION ]
BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes.
METHODS: We used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline ...
| Known for Viral Load | Hiv Seroconversion | Cd4 Count | Subtype Subtypes | 6 Months |
The late diagnosis and consequent short-term mortality of HIV-infected heterosexuals (England and Wales, 2000–2004)
[ PUBLICATION ]
OBJECTIVES: To describe the proportion of HIV-infected heterosexual individuals diagnosed late and estimate how much mortality could have been prevented by earlier diagnosis.
DESIGN: A population-based study using surveillance reports from England and Wales.
METHODS: Calculation of proportions diagnosed late (CD4 cell count < 200 cells/mul) and short-term mortality (death within a year of diagnosis).
RESULTS: A total of 16 375 heterosexual individuals were diagnosed with HIV (2000-2004): ...
| Known for Late Diagnosis | Term Mortality | England Wales | Diagnosed Hiv | 200 Cells |
Effect of HCV Infection on Cause-Specific Mortality After HIV Seroconversion, Before and After 1997
[ PUBLICATION ]
BACKGROUND & AIMS: Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acquired immune deficiency syndrome (AIDS), and hepatitis or liver disease, adjusting for the duration of HIV infection.
METHODS: We analyzed data from the 16 cohorts of the ...
| Known for Hcv Infection | Hiv Seroconversion | Infected Individuals | Liver Disease | Risk Death |
BACKGROUND: Human herpesvirus 6 (HHV-6) and HHV-7 are two lymphotropic herpesviruses, which, like cytomegalovirus (CMV), have the potential to be pathogenic in immunocompromised individuals. We have conducted a prospective investigation to compare the natural history of HHV-6 and HHV-7 infection with that of CMV after renal transplantation.
METHODS: Polymerase chain reaction was used to identify infections and quantify the viral load of CMV, HHV-6, and HHV-7 in peripheral blood samples ...
| Known for Renal Transplantation | Cmv Hhv7 | Human Herpesvirus Hhv6 | Viral Load | Patients Rejection |
BACKGROUND/AIMS: Although there have been a few reports regarding the effect of basal core promoter (BCP) double mutations (A1762T and G1764A) on hepatitis B viral loads, the association remains uncertain. We aim to determine the association after controlling for HBeAg - a strong confounding factor.
METHODS: We selected randomly 190 individuals from a Chinese cohort of 2258 subjects for cross-sectional analysis and 56 of the 190 for longitudinal analysis of viral loads.
RESULTS: In ...
| Known for Double Mutations | Longitudinal Analysis | Viral Load | Hbeag Positive | Core Promoter |
Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
[ PUBLICATION ]
OBJECTIVES: To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy.
DESIGN: Cohort study.
SETTING: Outpatient HIV clinics throughout the United Kingdom. Population Adult patients from the UK Collaborative HIV Cohort (UK CHIC) Study with CD4 count ≤ 350 cells/mm(3) at start of ...
| Known for Life Expectancy | Uk Chic | Late Diagnosis | Hiv Cohort | Antiretroviral Therapy |
BACKGROUND: Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality.
METHODS AND FINDINGS: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm(3) or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June ...
| Known for Eastern Europe | Late Presentation | Lp Hiv | Aids Death | Positive Persons |
