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    • Antiretroviral Therapy
    • Caroline Anne Sabin
    • Caroline Anne Sabin: Influence Statistics

      Caroline Anne Sabin

      Caroline Anne Sabin

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      University College London, London, UK | Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London, London, UK | Centre ...

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      Caroline Anne Sabin:Expert Impact

      Concepts for whichCaroline Anne Sabinhas direct influence:Antiretroviral therapy,Hiv infection,United kingdom,Viral load,Cd4 count,Cardiovascular disease,Myocardial infarction,Cd4 cell count.

      Caroline Anne Sabin:KOL impact

      Concepts related to the work of other authors for whichfor which Caroline Anne Sabin has influence:Antiretroviral therapy,Hiv infection,Human immunodeficiency virus,Viral load,Liver transplantation,Infected patients,Cardiovascular disease.

      KOL Resume for Caroline Anne Sabin

      Year
      2022

      University College London, London, UK

      2021

      Institute for Global Health UCL London UK

      University College London, London, United Kingdom

      2020

      Institute for Global Health University College London London UK

      University College London (UCL), London, United Kingdom.

      NIHR HPRU in Blood Borne and Sexually Transmitted Infections at UCL

      2019

      Institute for Global Health, UCL, London, United Kingdom

      Medical Research Council (MRC) Clinical Trials Unit at University College London (UCL), 90 High Holborn, WC1V 6LJ, London, UK

      2018

      Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for Global Health, Royal Free Campus, University College London, London, UK.

      National Institute for Health Research (NIHR) Health Protection Research Unit (HPRU) in Blood Borne and Sexually Transmitted Infections at University College London, London, UK

      Department of Infection & Population Health, University College London, London, United Kingdom

      2017

      Department of Infection and Population Health, University College London, United Kingdom

      National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections at University College London

      University of North Dakota

      2016

      Research Department of Infection and Population Health , University College London , UK.

      Royal Free Hospital NHS Foundation Trust and University College London, London, UK

      Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.

      University College London, London, United Kingdom;

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      Sample of concepts for which Caroline Anne Sabin is among the top experts in the world.
      Concept World rank
      viral rebounds #1
      individuals shallower decline #1
      patients interposition graft #1
      uk shortterm mortality #1
      hiv1 subtype ethnicity #1
      hiv drug therapy #1
      advancement hiv #1
      natural cytomegalovirus retinitis #1
      wlwh population #1
      hiv disease death #1
      cd4 count haart #1
      aged 45–60 #1
      lpv atazanavir ritonavir #1
      people shorter appointment #1
      pound17 #1
      cumulative incidence cod #1
      p00001 immunological responses #1
      ltnp hiv infection #1
      interposition graft difference #1
      nshpc women #1
      art continental ancestry #1
      virologic failure codons #1
      diagnosis shortterm mortality #1
      viral rebounds loss #1
      initiation cd4 cell #1
      2 proportion stage #1
      primary prophylaxis individuals #1
      cohort uk #1
      msm late diagnosis #1
      hcv infection death #1
      plwh aged #1
      depressive symptoms syphilis #1
      haart hdl #1
      comorbidities wlwh #1
      atazanavir regimen #1
      differences plwh #1
      lee severe lee #1
      reaction viraemia #1
      shortterm mortality diagnosis #1
      nuisance interference #1
      year hiv diagnosis #1
      hiv rna hivick #1
      uk vascular resection #1
      pbac scores ddavp #1
      median egfr patients #1
      associations widespread pain #1
      development k65r #1
      wlhiv methods #1
      viral subtype patients #1
      outcomes physical symptoms #1
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      Prominent publications by Caroline Anne Sabin

      KOL-Index: 20387

      BACKGROUND: Recommendations have differed nationally and internationally with respect to the best time to start antiretroviral therapy (ART). We compared effectiveness of three strategies for initiation of ART in high-income countries for HIV-positive individuals who do not have AIDS: immediate initiation, initiation at a CD4 count less than 500 cells per μL, and initiation at a CD4 count less than 350 cells per μL.

      METHODS: We used data from the HIV-CAUSAL Collaboration of cohort ...

      Known for Antiretroviral Therapy | Cd4 Count | Art Initiation | 500 Cells | Hiv Diagnosis
      KOL-Index: 17769

      OBJECTIVE: To assess the obstetric outcome in women with von Willebrand's disease or factor XI deficiency.

      SETTING: Haemophilia Centre and Haemostasis Unit, The Royal Free Hospital.

      POPULATION: Women with von Willebrand's disease (n = 31) and with factor XI deficiency (n = 11) registered at the Royal Free Hospital Haemophilia Centre who had had a pregnancy within the previous 17 years (1980-1996), including 84 in women with von Willebrand's disease and 28 in women with factor XI ...

      Known for Factor Deficiency | Willebrands Disease | Pregnancy Women | Haemophilia Centre | Prophylactic Treatment
      KOL-Index: 17375

      OBJECTIVES: To assess whether insulin resistance is associated with liver fibrosis in a group of patients with chronic hepatitis C virus (HCV) infection and whether there were any differences in insulin resistance between Asians and the indigenous Caucasian population. Secondly, to assess whether insulin resistance is associated with sustained virological response to antiviral therapy.

      METHODS: We determined insulin resistance in 59 (30 Caucasians; 29 Asians) consecutive patients with ...

      Known for Insulin Resistance | Antiviral Therapy | Liver Fibrosis | Patients Hcv | Sustained Virological Response
      KOL-Index: 15588

      OBJECTIVES: To describe the viral response to HAART by weeks 4 and 8 in previously antiretroviral-naive patients. To assess whether the weeks 4 or 8 viral loads are useful predictors of viral suppression by week 24.

      DESIGN: A large clinical database including 453 antiretroviral-naive patients whose plasma viral load was monitored every 4 weeks.

      METHODS: Observed probabilities of achieving a viral load < or = 500 copies/ml by week 24 (days 84-168) from starting highly active ...

      Known for Viral Load | 24 Weeks | Virological Response | Highly Active | Copies Week
      KOL-Index: 14687

      BACKGROUND: Although earlier protease inhibitors have been associated with increased risk of cardiovascular disease, whether this increased risk also applies to more contemporary protease inhibitors is unknown. We aimed to assess whether cumulative use of ritonavir-boosted atazanavir and ritonavir-boosted darunavir were associated with increased incidence of cardiovascular disease in people living with HIV.

      METHODS: The prospective Data Collection on Adverse Events of Anti-HIV Drugs ...

      Known for Cardiovascular Disease | Protease Inhibitors | 1000 Personyears | Darunavir Ritonavir | People Hiv
      KOL-Index: 14216

      BACKGROUND: With the advent of effective antiretroviral treatment, the life expectancy for people with HIV is now approaching that seen in the general population. Consequently, the relative importance of other traditionally non-AIDS-related morbidities has increased. We investigated trends over time in all-cause mortality and for specific causes of death in people with HIV from 1999 to 2011.

      METHODS: Individuals from the Data collection on Adverse events of anti-HIV Drugs (D:A:D) study ...

      Known for Death People | 1000 Personyears | Liver Disease | Multicohort Collaboration | Cd4 Cell Count
      KOL-Index: 13911

      BACKGROUND: The length of time that people with HIV on antiretroviral therapy (ART) with viral load suppression will be able to continue before developing viral rebound is unknown. We aimed to investigate the rate of first viral rebound in people that have achieved initial suppression with ART, to determine factors associated with viral rebound, and to use these estimates to predict long-term durability of viral suppression.

      METHODS: The UK Collaborative HIV Cohort (UK CHIC) Study is an ...

      Known for Viral Suppression | People Hiv | Art Baseline | Observational Cohort Study | 200 Copies
      KOL-Index: 13750

      OBJECTIVE: To compare regimens consisting of either efavirenz or nevirapine and two or more nucleoside reverse transcriptase inhibitors (NRTIs) among HIV-infected, antiretroviral-naive, and AIDS-free individuals with respect to clinical, immunologic, and virologic outcomes.

      DESIGN: Prospective studies of HIV-infected individuals in Europe and the US included in the HIV-CAUSAL Collaboration.

      METHODS: Antiretroviral therapy-naive and AIDS-free individuals were followed from the time they ...

      Known for Efavirenz Versus | 12 Months | Virologic Failure | Cd4 Cell Count | Reverse Transcriptase
      KOL-Index: 13671

      BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) subtype may influence disease progression. We compared CD4 lymphocyte cell count levels at seroconversion, decline rates and viral load set point in individuals infected with different HIV-1 subtypes.

      METHODS: We used data from the Concerted Action on SeroConversion to AIDS and Death in Europe (CASCADE) collaboration, restricted to those infected since 1996, aged ≥15 years, and applied mixed effects models for CD4 cell count decline ...

      Known for Viral Load | Hiv Seroconversion | Cd4 Count | Subtype Subtypes | 6 Months
      KOL-Index: 13658

      OBJECTIVES: To describe the proportion of HIV-infected heterosexual individuals diagnosed late and estimate how much mortality could have been prevented by earlier diagnosis.

      DESIGN: A population-based study using surveillance reports from England and Wales.

      METHODS: Calculation of proportions diagnosed late (CD4 cell count < 200 cells/mul) and short-term mortality (death within a year of diagnosis).

      RESULTS: A total of 16 375 heterosexual individuals were diagnosed with HIV (2000-2004): ...

      Known for Late Diagnosis | Term Mortality | England Wales | Diagnosed Hiv | 200 Cells
      KOL-Index: 13638

      BACKGROUND & AIMS: Individuals with human immunodeficiency virus (HIV) infection frequently also are infected with hepatitis C virus (HCV) (co-infection), but little is known about its effects on the progression of HIV-associated disease. We aimed to determine the effects of co-infection on mortality from HIV and/or acquired immune deficiency syndrome (AIDS), and hepatitis or liver disease, adjusting for the duration of HIV infection.

      METHODS: We analyzed data from the 16 cohorts of the ...

      Known for Hcv Infection | Hiv Seroconversion | Infected Individuals | Liver Disease | Risk Death
      KOL-Index: 13248

      BACKGROUND: Human herpesvirus 6 (HHV-6) and HHV-7 are two lymphotropic herpesviruses, which, like cytomegalovirus (CMV), have the potential to be pathogenic in immunocompromised individuals. We have conducted a prospective investigation to compare the natural history of HHV-6 and HHV-7 infection with that of CMV after renal transplantation.

      METHODS: Polymerase chain reaction was used to identify infections and quantify the viral load of CMV, HHV-6, and HHV-7 in peripheral blood samples ...

      Known for Renal Transplantation | Cmv Hhv7 | Human Herpesvirus Hhv6 | Viral Load | Patients Rejection
      KOL-Index: 13230

      BACKGROUND/AIMS: Although there have been a few reports regarding the effect of basal core promoter (BCP) double mutations (A1762T and G1764A) on hepatitis B viral loads, the association remains uncertain. We aim to determine the association after controlling for HBeAg - a strong confounding factor.

      METHODS: We selected randomly 190 individuals from a Chinese cohort of 2258 subjects for cross-sectional analysis and 56 of the 190 for longitudinal analysis of viral loads.

      RESULTS: In ...

      Known for Double Mutations | Longitudinal Analysis | Viral Load | Hbeag Positive | Core Promoter
      KOL-Index: 13221

      OBJECTIVES: To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy.

      DESIGN: Cohort study.

      SETTING: Outpatient HIV clinics throughout the United Kingdom. Population Adult patients from the UK Collaborative HIV Cohort (UK CHIC) Study with CD4 count ≤ 350 cells/mm(3) at start of ...

      Known for Life Expectancy | Uk Chic | Late Diagnosis | Hiv Cohort | Antiretroviral Therapy
      KOL-Index: 13202

      BACKGROUND: Few studies have monitored late presentation (LP) of HIV infection over the European continent, including Eastern Europe. Study objectives were to explore the impact of LP on AIDS and mortality.

      METHODS AND FINDINGS: LP was defined in Collaboration of Observational HIV Epidemiological Research Europe (COHERE) as HIV diagnosis with a CD4 count <350/mm(3) or an AIDS diagnosis within 6 months of HIV diagnosis among persons presenting for care between 1 January 2000 and 30 June ...

      Known for Eastern Europe | Late Presentation | Lp Hiv | Aids Death | Positive Persons

      Key People For Antiretroviral Therapy

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      University College London, London, UK | Health Protection Research Unit in Blood Borne and Sexually Transmitted Infections at University College London, London, UK | Centre for Clinical Research, Epidemiology, Modelling and Evaluation, Institute for

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