Prominent publications by Douglas D Richman†

KOL Index score: 21803

BACKGROUND: Combination antiretroviral therapy with indinavir, zidovudine, and lamivudine can suppress the level of human immunodeficiency virus (HIV) RNA in plasma below the threshold of detection for two years or more. We investigated whether a less intensive maintenance regimen could sustain viral suppression after an initial response to combination therapy.

METHODS: HIV-infected subjects who had CD4 cell counts greater than 200 per cubic millimeter, who had been treated with ...

Also Ranks for: Hiv Rna |  zidovudine lamivudine |  viral suppression |  drug therapy |  subjects indinavir
KOL Index score: 20070

Asymptomatic replication of human herpesviruses (HHV) is frequent in HIV-infected men and is associated with increased T-cell activation and HIV disease progression. We hypothesized that the presence of replication of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) (the most frequently detected HHV) might influence HIV DNA decay during antiretroviral therapy (ART). We investigated 607 peripheral blood mononuclear cell (PBMC) samples from 107 CMV-seropositive, HIV-infected men who have ...

Also Ranks for: Hiv Dna |  antiretroviral therapy |  human herpesvirus |  cmv ebv |  art initiation
KOL Index score: 16050

CONTEXT: In HIV-infected patients having virologic suppression (plasma HIV RNA <50 copies/mL) with antiretroviral therapy, intermittent episodes of low-level viremia have been correlated with slower decay rates of latently infected cells and increased levels of viral evolution, but the clinical significance of these episodes is unknown.

OBJECTIVE: To determine if HIV-infected patients with intermittent viremia have a higher risk of virologic failure (confirmed HIV RNA >200 ...

Also Ranks for: Intermittent Viremia |  virologic failure |  50 copies |  hiv rna |  drug therapy
KOL Index score: 15838

Potent antiretroviral therapy can reduce human immunodeficiency virus (HIV) in plasma to levels below the limit of detection for up to 2 years, but the extent to which viral replication is suppressed is unknown. To search for ongoing viral replication in 10 patients on combination antiretroviral therapy for up to 1 year, the emergence of genotypic drug resistance across different compartments was studied and correlated with plasma viral RNA levels. In addition, lymph node (LN) ...

Also Ranks for: Potent Antiretroviral Therapy |  genotypic resistance |  virus replication |  lymph nodes |  rna viral
KOL Index score: 15508

CONTEXT: The availability of new antiretroviral drugs and formulations, including drugs in new classes, and recent data on treatment choices for antiretroviral-naive and -experienced patients warrant an update of the International AIDS Society-USA guidelines for the use of antiretroviral therapy in adult human immunodeficiency virus (HIV) infection.

OBJECTIVES: To summarize new data in the field and to provide current recommendations for the antiretroviral management and laboratory ...

Also Ranks for: Antiretroviral Treatment |  hiv infection |  usa panel |  2008 recommendations |  international aids society
KOL Index score: 15379

BACKGROUND: The relationship between the timing of the initiation of antiretroviral therapy (ART) after infection with human immunodeficiency virus type 1 (HIV-1) and the recovery of CD4+ T-cell counts is unknown.

METHODS: In a prospective, observational cohort of persons with acute or early HIV-1 infection, we determined the trajectory of CD4+ counts over a 48-month period in partially overlapping study sets: study set 1 included 384 participants during the time window in which they ...

Also Ranks for: Art Cd4 |  cell recovery |  cubic millimeter |  hiv1 infection |  antiretroviral therapy
KOL Index score: 15295

OBJECTIVE: Human immunodeficiency virus type 1 blood plasma viral load is correlated with the sexual transmission of HIV, although transmission from men involves virus from semen instead of blood. We quantified HIV-1 RNA in the blood and semen of men who did or did not transmit HIV to their sex partners. We compared the relationships of HIV-1 transmission risk with blood plasma viral load, seminal plasma viral load, herpes simplex virus 2 serostatus and other factors.


Also Ranks for: Hiv Transmission |  viral load |  simplex virus |  semen blood |  human homosexuality
KOL Index score: 14830

We prospectively studied 132 patients with acquired immunodeficiency syndrome (AIDS) to determine the cross-sectional prevalence of cytomegalovirus retinitis. All patients had serum CD4+ lymphocyte counts to determine the degree of immune dysfunction. Correlations between CD4+ counts, the presence of cytomegalovirus retinitis or human immunodeficiency virus (HIV)-related noninfectious retinal vasculopathy, and ocular symptoms were made. The study disclosed that 26 of 132 patients with ...

Also Ranks for: Cytomegalovirus Retinitis |  patients cd4 |  50 cells |  retinal vasculopathy |  human immunodeficiency virus
KOL Index score: 14708

BACKGROUND: It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started prophylactic ART an estimated 10 days (Participant A; 54-year-old male) and 12 days (Participant B; 31-year-old male) after infection with peak plasma HIV RNA of 220 copies/mL and 3,343 copies/mL, respectively. Extensive testing of blood and ...

Also Ranks for: Hiv1 Rna Art |  acute hiv |  cd4 cells |  early initiation |  antiretroviral therapy
KOL Index score: 14367

Asymptomatic cytomegalovirus (CMV) replication occurs frequently in the genital tract in untreated HIV-infected men and is associated with increased immune activation and HIV disease progression. To determine the connections between CMV-associated immune activation and the size of the viral reservoir, we evaluated the interactions between (i) asymptomatic seminal CMV replication, (ii) levels of T cell activation and proliferation in blood, and (iii) the size and transcriptional activity ...

Also Ranks for: Hiv Dna |  cell activation |  cmv replication |  blood plasma |  cytomegalovirus infections
KOL Index score: 14300

To determine the effects of immunomodulatory agents upon HIV replication in macrophages, cultured monocyte-derived macrophages were treated with various substances and then infected with a macrophage-tropic strain of HIV-1. Pretreatment with rIFN-alpha, IFN-beta, and IFN-gamma, or bacterial LPS prevented viral replication in macrophages. In treated cultures, little or no infectious HIV or p24 core antigen was released into the supernatant, no virions were seen by electron microscopy, no ...

Also Ranks for: Productive Infection |  hiv macrophages |  bacterial lipopolysaccharide |  human immunodeficiency virus |  viral replication
KOL Index score: 14017

OBJECTIVE: Assays for drug resistance testing in human immunodeficiency virus type 1 (HIV-1) infection are now available and clinical studies suggest that viral drug resistance is correlated with poor virologic response to new therapy. The International AIDS Society-USA sought to update prior recommendations to provide guidance for clinicians regarding indications for HIV-1 resistance testing.

PARTICIPANTS: An International AIDS Society-USA 13-member physician panel with expertise in ...

Also Ranks for: Viral Drug Resistance |  usa panel |  infectious rna |  microbial drug therapy |  aids society
KOL Index score: 13634

Type 1 human immunodeficiency viruses encoding mutated nef reading frames are 10- to 30-fold less infectious than are isogenic viruses in which the nef gene is intact. This defect in infectivity causes nef-negative viruses to grow at an attenuated rate in vitro. To investigate the mechanism of Nef-mediated enhancement of viral growth rate and infectivity, a complementation analysis of nef mutant viruses was performed. To provide Nef in trans upon viral infection, a CEM derivative cell ...

Also Ranks for: Virus Type |  nef protein |  human immunodeficiency |  gene products |  viral infectivity
KOL Index score: 13184

CONTEXT: New trial data and drug regimens that have become available in the last 2 years warrant an update to guidelines for antiretroviral therapy (ART) in human immunodeficiency virus (HIV)-infected adults in resource-rich settings.

OBJECTIVE: To provide current recommendations for the treatment of adult HIV infection with ART and use of laboratory-monitoring tools. Guidelines include when to start therapy and with what drugs, monitoring for response and toxic effects, special ...

Also Ranks for: Antiretroviral Treatment |  usa panel |  adult hiv infection |  cd4 cell count |  art patients

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Douglas D Richman†:Expert Impact

Concepts for whichDouglas D Richman†has direct influence:Antiretroviral therapy,  Hiv infection,  Human immunodeficiency virus,  Immunodeficiency virus,  Human immunodeficiency,  Hiv rna,  Hiv dna,  Reverse transcriptase.

Douglas D Richman†:KOL impact

Concepts related to the work of other authors for whichfor which Douglas D Richman† has influence:Antiretroviral therapy,  Hiv infection,  Human immunodeficiency virus,  Viral load,  Reverse transcriptase,  Protease inhibitors,  Cd4 cells.



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University of California San Diego, San Diego, California | University of California San Diego, Distinguished Professor of Pathology and Medicine (Active Emeritus); Director, The HIV Institute; Co- Director, San Diego Center for AIDS Research; Floren