• Disease
  • Balloon
  • Balloon Dilation
  • James E Lock

    Prominent publications by James E Lock

    KOL Index score: 17618

    OBJECTIVE: Successful mitral valve replacement in young children is limited by the lack of small prosthetic valves. Supra-annular prosthesis implantation can facilitate mitral valve replacement with a larger prosthesis in children with a small annulus, but little is known about its effect on the outcomes of mitral valve replacement in young children.

    METHODS: One hundred eighteen children underwent mitral valve replacement at 5 years of age or younger from 1976-2006. Mitral valve ...

    Also Ranks for: Mitral Valve Replacement |  5 years |  prosthesis implantation |  supra annular |  heart valve
    KOL Index score: 14962

    OBJECTIVES: The purpose of this study was to evaluate the prevalence of and risk factors for aortopulmonary collateral vessels in patients who have undergone a bidirectional Glenn or Fontan procedure, or both.

    BACKGROUND: Aortopulmonary collateral vessels are frequently observed angiographically in patients after a bidirectional Glenn or Fontan procedure. These vessels may provide a source of pulmonary blood flow competitive with anterograde cavopulmonary flow.

    METHODS: We performed a ...

    Also Ranks for: Collateral Vessels |  bidirectional glenn |  patients fontan procedure |  vena cava |  oxygen saturation
    KOL Index score: 14205

    After modified Fontan procedures with atriopulmonary anastomoses or right atrium-right ventricle conduits, some patients have progressive exercise intolerance, effusions, arrhythmias, or protein-losing enteropathy. Theoretic advantages of a lateral atrial tunnel cavopulmonary anastomosis and published clinical results suggest that conversion of other Fontan procedures to the lateral atrial tunnel may afford clinical improvement for some patients. Eight patients (8 to 25 years old) with ...

    Also Ranks for: Fontan Procedure |  conversion patients |  lateral atrial tunnel |  clinical improvement |  proteinlosing enteropathy
    KOL Index score: 13874

    OBJECTIVE: Pulmonary atresia with intact ventricular septum is a complex congenital cardiovascular anomaly that frequently requires single ventricle palliation. Fetal diagnosis of pulmonary atresia with intact ventricular septum is common, but the natural history of pulmonary atresia with intact ventricular septum diagnosed in midgestation, predictors of neonatal anatomy, and predictors of biventricular repair have not been determined. The objective of this study was to determine whether ...

    Also Ranks for: Intact Ventricular Septum |  tricuspid valve |  pulmonary atresia |  biventricular repair |  fetal heart
    KOL Index score: 13833

    BACKGROUND: Aortic stenosis in the midgestation fetus with a normal-sized or dilated left ventricle predictably progresses to hypoplastic left heart syndrome when associated with certain physiological findings. Prenatal balloon aortic valvuloplasty may improve left heart growth and function, possibly preventing evolution to hypoplastic left heart syndrome.

    METHODS AND RESULTS: Between March 2000 and October 2008, 70 fetuses underwent attempted aortic valvuloplasty for critical aortic ...

    Also Ranks for: Aortic Stenosis |  biventricular outcome |  heart syndrome |  technical success |  evolving hypoplastic
    KOL Index score: 13617

    OBJECTIVE: The options for mitral valve replacement in children with irreparable mitral valve disease have been limited to fixed-diameter prostheses that do not accommodate for somatic growth. We have modified an externally stented bovine jugular vein graft (Melody valve) for implantation in this cohort. Because it is not a fixed-diameter prosthesis, we hypothesized that the valve can be expanded in the catheterization laboratory as the child grows.

    METHODS: The medical records of ...

    Also Ranks for: Melody Valve |  jugular vein |  implantation mitral |  stented bovine |  prosthesis heart
    KOL Index score: 12950

    BACKGROUND: Pulmonary arteriovenous malformations (PAVMs) are a known complication after some types of cavopulmonary anastomoses (CVPAs). Their cause is unknown, but they may be related to the absence of pulsatile flow or the presence or absence of circulating factors. These PAVMs are diffuse and are presumed to be progressive and irreversible.

    METHODS AND RESULTS: All patients with congenital heart disease (CHD) seen at Children's Hospital, Boston, Mass, between 1970 and 1993 were ...

    Also Ranks for: Congenital Heart Disease |  hepatic venous |  patients chd |  biliary atresia |  pulmonary veins
    KOL Index score: 12913

    To assess the safety and efficacy of percutaneous balloon valvuloplasty in calcific aortic stenosis, balloon dilatation of critically stenosed, calcified aortic valves was performed in five postmortem hearts, in five patients intraoperatively before aortic valve replacement, and in two elderly patients percutaneously at the time of diagnostic catheterization. The etiology of aortic stenosis in the 12 cases was rheumatic in two, congenital bicuspid calcific stenosis in one, and senile ...

    Also Ranks for: Balloon Dilatation |  elderly patients |  percutaneous valvuloplasty |  aortic stenosis |  valve leaflets
    KOL Index score: 12720

    OBJECTIVES: This study was designed to evaluate the safety, procedural success, and short-term effectiveness of the Melody transcatheter pulmonary valve (Medtronic, Inc., Minneapolis, Minnesota) in patients with dysfunctional right ventricular outflow tract conduits.

    BACKGROUND: Conduit dysfunction has recently been treated with transcatheter pulmonary valve placement. There have been no prospective, multicenter trials evaluating this technology.

    METHODS: Standardized entry criteria, ...

    Also Ranks for: Ventricular Outflow |  pulmonary valve |  clinical trial |  melody transcatheter |  tract conduit
    KOL Index score: 12530

    BACKGROUND: The Melody transcatheter pulmonary valve (TPV) was approved for implantation in obstructed right ventricular outflow tract conduits in 2010 after a multicenter trial demonstrating improvements in conduit obstruction, regurgitation, and right ventricular pressure. A recognized risk and contraindication to TPV implantation is the demonstration of coronary artery (CA) compression during balloon angioplasty or stent placement in the overlying conduit. This study is the first to ...

    Also Ranks for: Valve Implantation |  coronary artery |  tetralogy fallot |  risk compression |  great arteries
    KOL Index score: 12490

    BACKGROUND: Transcatheter pulmonary valve placement is an emerging therapy for pulmonary regurgitation and right ventricular outflow tract obstruction in selected patients. The Melody valve was recently approved in the United States for placement in dysfunctional right ventricular outflow tract conduits.

    METHODS AND RESULTS: From January 2007 to August 2009, 136 patients (median age, 19 years) underwent catheterization for intended Melody valve implantation at 5 centers. Implantation was ...

    Also Ranks for: Pulmonary Valve |  united states |  stent fracture |  ventricular outflow |  prosthesis implantation
    KOL Index score: 12313

    OBJECTIVES: We report the largest and the longest follow-up to date of patients who underwent transcatheter patent foramen ovale (PFO) closure for paradoxical embolism.

    BACKGROUND: Closure of a PFO has been proposed as an alternative to anticoagulation in patients with presumed paradoxical emboli.

    METHODS: Data were collected for patients following PFO closure with the Clamshell, CardioSEAL or Buttoned Devices at two institutions.

    RESULTS: There were 63 patients (46 +/- 18 years) with a ...

    Also Ranks for: Device Placement |  paradoxical emboli |  recurrent neurological events |  closure pfo |  patent foramen
    KOL Index score: 12230

    BACKGROUND: Infants born with hypoplastic left heart syndrome and an intact or highly restrictive atrial septum face a neonatal mortality of at least 48% despite early postnatal left atrial decompression and palliative surgery. Prenatal left atrial decompression has been suggested as a means of improving these outcomes. This study reports the feasibility of fetal catheterization to create an interatrial communication and describes technical considerations.


    Also Ranks for: Atrial Septum |  heart syndrome |  highly restrictive |  septal defect |  balloon dilation
    KOL Index score: 12173

    Preliminary reports have documented the utility of balloon aortic valvuloplasty as a palliative treatment for high-risk patients with critical aortic stenosis, but the effect of this procedure on cardiac performance has not been studied in detail. Accordingly, 32 patients (mean age 79 years) with long-standing, calcific aortic stenosis were treated at the time of cardiac catheterization with balloon dilatation of the aortic valve, and serial changes in left ventricular and valvular ...

    Also Ranks for: Aortic Valve |  balloon dilatation |  decrease time |  cardiac catheterization |  doppler echocardiography
    KOL Index score: 11804

    BACKGROUND: Among patients undergoing transcatheter pulmonary valve (TPV) replacement with the Melody valve, risk factors for Melody stent fracture (MSF) and right ventricular outflow tract (RVOT) reintervention have not been well defined.

    METHODS AND RESULTS: From January 2007 to January 2010, 150 patients (median age, 19 years) underwent TPV implantation in the Melody valve Investigational Device Exemption trial. Existing conduit stents from a prior catheterization were present in 37 ...

    Also Ranks for: Stent Fracture |  valve implantation |  ventricular outflow |  rvot reintervention |  patients tpv


    James E Lock: Influence Statistics

    Sample of concepts for which James E Lock is among the top experts in the world.
    Concept World rank
    pathologic follow #1
    covered stent case #1
    pa injury incidence #1
    normalsized ventricles followup #1
    44 17 mm #1
    29 catheterizations #1
    intrinsic narrowing #1
    catheterization pa angiography #1
    mm hg bms #1
    device placement patient #1
    fetal hemodynamic instability #1
    cutting balloons #1
    repeat 26 #1
    long term fraction #1
    spc burden #1
    myocardial infarction caf #1
    neonates aortic stenosis #1
    transcatheter rehabilitation #1
    patient fistulas #1
    fetuses intervention #1
    12 mm device #1
    pressure ratio p0001 #1
    dilation pressure balloons #1
    subsequent balloon dilatation #1
    stenosis balloon #1
    survival bmvp #1
    type longer duration #1
    hlhs risk factors #1
    septal plane #1
    coil loops #1
    ability uhp balloons #1
    congenital operative defects #1
    mechanism bpv failure #1
    rigid defect #1
    251 124 #1
    repeat balloon dilation #1
    conduit tear #1
    mvr experience #1
    diaphragm obstruction #1
    intervention bmvp #1
    balloon annulus ratio #1
    birth prenatal intervention #1
    bms small conduits #1
    84 angioplasty procedures #1
    bav optimal acute #1
    bmvp patients #1
    hemodynamic relief #1
    defects transesophageal #1
    multiple muscular vsds #1
    younger subgroup scamp #1

    Key People For Balloon Dilation

    Top KOLs in the world
    James E Lock
    balloon dilation aortic stenosis cardiac catheterization
    Todd Huntley Baron
    endoscopic ultrasound pancreatic necrosis gastrointestinal endoscopy
    Wilfrido R Castañeda–Zuñiga
    vena cava subclavian artery biliary complications
    Ho Young Song
    stent placement balloon dilation tissue hyperplasia
    Peter B Cotton
    chronic pancreatitis oddi dysfunction pancreas divisum
    Glen A Lehman
    chronic pancreatitis oddi dysfunction pancreas divisum

    James E Lock:Expert Impact

    Concepts for whichJames E Lockhas direct influence:Balloon dilation,  Aortic stenosis,  Cardiac catheterization,  Pulmonary artery,  Congenital heart disease,  Transcatheter closure,  Baffle fenestration,  Aortic valve.

    James E Lock:KOL impact

    Concepts related to the work of other authors for whichfor which James E Lock has influence:Congenital heart disease,  Fontan operation,  Pulmonary valve,  Cardiac catheterization,  Transcatheter closure,  Balloon angioplasty,  Heart syndrome.



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    Department of Cardiology, Boston Children's Hospital and Harvard Medical School, Boston, MA. | Department of Cardiology, Boston Children's Hospital, Boston, Massachusetts. | Department of Pediatrics, Harvard Medical School, Boston, MA, USA | Departme