Prominent publications by Malcolm Watson Greaves

KOL Index score: 12695

Phenolic compounds used in pharmaceutical and industrial products can cause irritant contact dermatitis. We studied the effects of resorcinol, phenol, 3,5-xylenol, chloroxylenol, and 4-hexyl-resorcinol on normal human epidermal keratinocytes and dermal fibroblasts for cytotoxicity and cytokine release, determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide methodology and enzyme-linked immunosorbent assay, respectively. An inverse correlation between phenol ...

Also Ranks for: Sodium Dodecyl Sulfate |  cytokine release |  human keratinocytes |  survival cells |  dermal fibroblasts
KOL Index score: 11967

BACKGROUND: Circulating functional autoantibodies to the high-affinity IgE receptor (Fc(epsilon)RI) or to IgE have been found in approximately one third of patients with chronic idiopathic urticaria (CIU).

OBJECTIVE: We sought to compare basophil histamine release and basophil numbers in patients with CIU with and without autoantibodies.

METHODS: Basophil histamine release to the anti-Fc(epsilon)RI mAb 22E7, anti-IgE, and formyl-methionyl-leucyl-phenylalanine (fMLP); basophil numbers; ...

Also Ranks for: Basophil Histamine |  patients ciu |  anti ige |  idiopathic urticaria
KOL Index score: 11501

BACKGROUND: Circulating autoantibodies against FcepsilonRI, IgE, or both occur in approximately one third of patients with chronic idiopathic urticaria (CIU), but not all autoantibodies initiate histamine release.

OBJECTIVE: We sought to classify patients with CIU into subsets on the basis of serum bioactivity and immunoreactivity and to examine the relationship between newly defined subtype and disease severity.

METHODS: Sera from patients with CIU (n = 78), dermog-raphism (n = 15), and ...

Also Ranks for: Patients Ciu |  ige autoantibodies |  histamine release |  chronic idiopathic |  anti fcepsilonri
KOL Index score: 10612

Previous studies identified autoantibodies against the IgE high affinity receptor alpha-chain, Fc epsilon RI alpha, in sera of selected patients with severe chronic idiopathic urticaria. We have now determined the incidence of anti-Fc epsilon RI alpha autoantibodies in a group of 163 patients. Intradermal injection of autologous serum caused skin reactions indicative of mast cell degranulation in 98 (60%) patients. Based on histamine release from IgE-sensitized and nonsensitized basophil ...

Also Ranks for: Histamine Release |  chronic urticaria |  mast cell |  patients sera |  affinity ige
KOL Index score: 10078

BACKGROUND: Most urticarias are induced by vasoactive mediators such as histamine released from mast cells. Although mast cells are activated by allergens through cross-linking of cell-surface--bound IgE, this mechanism does not appear to explain most cases of chronic urticaria, which, when allergic, infectious, drug-induced, or physical causes cannot be identified, are classified as idiopathic.

METHODS: We recruited 26 patients with chronic idiopathic urticaria, in whom intradermal ...

Also Ranks for: Chronic Urticaria |  serum patients |  ige receptor |  alpha subunit |  mast cells
KOL Index score: 9956

BACKGROUND: Previous studies defining the histopathologic features of patients with chronic idiopathic urticaria (CIU) were performed on wheals of uncertain duration and before the identification of functional autoantibodies against FcepsilonRI and/or IgE, now known to be present in approximately 30% of patients with CIU.

OBJECTIVE: We sought to determine the timing of the inflammatory infiltrate in the wheals of patients with CIU and to detect differences between patients with and ...

Also Ranks for: Chronic Idiopathic Urticaria |  patients ciu |  ige autoantibodies |  uninvolved skin |  biopsy specimens
KOL Index score: 9847

Circulating histamine releasing factor(s) have been demonstrated previously in chronic urticaria by an immediate weal-and-flare response to intradermal autologous serum injection. We have studied 25 chronic urticaria patients by in vivo skin testing with autologous sera and an in vitro histamine release assay using mixed leukocytes of healthy donors, to define the nature and functional properties of the serum factor(s). Twenty showed a weal response to autologous serum (mean +/- s.e.m., ...

Also Ranks for: Chronic Urticaria |  histamine releasing |  healthy donors |  autologous serum |  autoantibodies basophils
KOL Index score: 9797

BACKGROUND: Histamine-releasing activity (HRA) is detectable in up to 50% of patients with chronic ordinary urticaria.

OBJECTIVES: To determine the effect of cyclosporin on clinical features and HRA in patients with chronic urticaria.

METHODS: Thirty patients with severe unremitting disease, responding poorly to antihistamines and showing a positive autologous serum skin test (ASST) as a marker of HRA, were randomized to 4 mg kg-1 daily of cyclosporin (Sandimmun, n = 20) or placebo (n = ...

Also Ranks for: 4 Weeks |  chronic idiopathic urticaria |  reduction uas |  cyclosporin treatment |  primary measure
KOL Index score: 9332

The buttock skin of clinically normal human subjects was subjected to approximately 2.5 minimal erythema doses of ultraviolet A irradiation. Deep red erythema developed during irradiation, faded slightly within the next few hours, increased to maximum intensity between 9-15 h, and decreased gradually thereafter although still persisting strongly at 48 h. Suction blister exudates were obtained at 0, 5, 9, 15, 24, and 48 h after irradiation as well as suction blister exudates from a ...

Also Ranks for: Arachidonic Acid |  increased concentrations |  human skin |  uva irradiation |  control levels
KOL Index score: 9115

1 Clinically normal human abdominal skin was irradiated with either three times its minimal erythema dose (MED) of ultraviolet B (u.v.B) or six MEDs of ultraviolet C (u.v.C) radiation. In both instances erythema was maximal at 24 h. 2 Exudate was recovered by a suction bulla technique from normal and irradiated skin at 24 h after irradiation. 3 Arachidonic acid, prostaglandins E2 and FSalpha, as measured by GC--MS, were significantly elevated at 24 h. Radioimmunoassay also showed ...

Also Ranks for: Arachidonic Acid |  human skin |  gas chromatography |  ultraviolet uv |  aged prostaglandins
KOL Index score: 9004

The major histocompatibility complex (MHC) acts as a marker for self during T-cell ontogeny and is associated with the pathogenesis of many autoimmune diseases. Recent investigations have shown about 30% of patients with chronic idiopathic urticaria (CIU) have IgG autoantibodies against the high-affinity IgE receptor, FcepsilonRI, or IgE. A link between MHC class II alleles and CIU has not been reported previously. DNA was extracted from blood of 100 Caucasian patients with CIU, and the ...

Also Ranks for: Chronic Idiopathic Urticaria |  ciu patients |  human leucocyte |  hla class |  autoimmune diseases
KOL Index score: 8907

Use of differential effects of agonists and antagonists has provided an experimental basis for subdivision of histamine receptors into H1 and H2. This has enabled classification of the responses to histamine in a wide range of organs and tissues. In human skin the vascular and sensory effects of histamine have been studied, and the influence of histamine on epidermal cell growth has been evaluated in vitro. The direct vasodilator and vascular permeability actions of histamine appear to ...

Also Ranks for: Histamine Receptors |  human skin |  h1 antagonists |  capillary permeability |  axon reflex
KOL Index score: 8829

A two-centre trial has been carried out on 224 patients with chronic plaque psoriasis randomly allocated to treatment with a standard dithranol regimen of 8-methoxypsoralen and long-wave ultraviolet light (P.U.V.A.). Lesions in 91% of the 113 in the P.U.V.A. group cleared satisfactorily compared with 82% of 111 in the dithranol group, but clearing took longer (34.4 +/- 1.8 S.E. days) with P.U.V.A. than with dithranol (20.4 +/- 0.9 S.E. days). P.U.V.A. treatment took less patient-time and ...

Also Ranks for: Puva Patients |  plaque psoriasis |  dithranol treatment |  60 years |  publication administration
KOL Index score: 8781

BACKGROUND: Previous studies defining the clinical features of patients with chronic idiopathic urticaria (CIU) were performed before the identification of functional autoantibodies against FcepsilonRI and/or IgE, now known to be present in approximately 30% of patients with CIU.

OBJECTIVE: Our purpose was to determine whether there are differences between patients with and those without autoantibodies in the clinical features or severity of CIU.

METHODS: The clinical features of 107 ...

Also Ranks for: Patients Autoantibodies |  chronic idiopathic urticaria |  severe ciu |  systemic symptoms |  autoimmune diseases

Key People For Chronic Urticaria

Top KOLs in the world
Malcolm ****** *******
chronic urticaria human skin arachidonic acid
Allen * ******
factor xii chronic urticaria histamine release
Torsten *********
allergic rhinitis chronic urticaria mast cells
C * * *******
chronic urticaria basophil numbers autologous serum
Michihiro *********
atopic dermatitis mast cells histamine release
Alexander ****
atopic dermatitis human eosinophils chronic urticaria

Malcolm Watson Greaves:Expert Impact

Concepts for whichMalcolm Watson Greaveshas direct influence:Chronic urticaria,  Human skin,  Arachidonic acid,  Leukotriene b4,  Histamine release,  Cold urticaria,  Chronic idiopathic urticaria,  Cholinergic urticaria.

Malcolm Watson Greaves:KOL impact

Concepts related to the work of other authors for whichfor which Malcolm Watson Greaves has influence:Chronic urticaria,  Mast cells,  Atopic dermatitis,  Leukotriene b4,  Human skin,  Arachidonic acid,  Histamine release.



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Department of Cutaneous Allergy, St. John's Institute of Dermatology, St Thomas` Hospital, London, UK | Cutaneous Allergy Clinic, St Johns Institute of Dermatology, St Thomas’ Hospital, London, UK | St John's Institute of Dermatology St Thomas' Hospi