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    • Hugo Van Den Bossche
    • Hugo Van Den Bossche

      Hugo Van Den Bossche

      Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium | Research Laboratories, Janssen Pharmaceutica, B-2340 Beerse, ...



      KOL Resume for Hugo Van Den Bossche


      Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium


      Dept. of Comparative Biochemistry, Janssen Pharmaceutica, B-2340 Beerse, Belgium


      Laboratory of Comparative Biochemistry, Janssen Pharmaceutica, B-2340 Beerse, Belgium


      Janssen Pharmaceutica Research Laboratories, B-2340, Beerse, Belgium


      Janssen Pharmaceutica, Research Laboratories, B 2340 Beerse, Belgium


      Department of Comparative Biochemistry, Janssen Pharmaceutica, Research Laboratories, B-2340 Beerse, Belgium


      Janssen Pharmaceutica, Research Laboratoria, Beerse, Belgium


      Janssen Pharmaceutica, Research Laboratories, Beerse, Belgium


      Janssen Pharmaceutica n.v., Beerse, Belgium


      Janssen Pharmaceutica n.v., Research Laboratiria Beerse, Belgium



      Hugo Van Den Bossche: Influence Statistics

      Sample of concepts for which Hugo Van Den Bossche is among the top experts in the world.
      Concept World rank
      pasteur electron transport #1
      leishmaniasis schistosomicides chagas #1
      antimycin kcn sensitive #1
      carboxylyases manganese muscles #1
      endogenous glycogen utilization #1
      electron transport nadh2 #1
      muris low #1
      semirational approach basis #1
      stage haemonchus #1
      nadh2 kcn #1
      sparticles smp #1
      sonic oscillatioins #1
      mebendazole glucose #1
      3omethylglueose #1
      mebendazole anthelmintics #1
      glucose suum #1
      mitochondria44 passage #1
      exogenous substrate conditions33 #1
      miconazole uptake #1
      mg44 idp #1
      ascaris idp #1
      soluble fraction22 reaction #1
      dehydrogenase muris #1
      proline palmitic #1
      minor rat pinworm44 #1
      atpase activity sparticles #1
      ascaris growth #1
      observations larvae #1
      nadh2 succinates thiazoles #1
      diseases chloroquineresistant malaria #1
      aerobic metabolism observations #1
      peculiar anthelmintic chemotherapy #1
      haemonchus pasteur #1
      authors ascaris infection #1
      smp mitochondria44 #1
      glucose ascaris suum #1
      smp urea #1
      reverse direction reduction #1
      mebendazole glucose uptake #1
      adaptation muris #1
      gel detergents ascaris #1
      spindler ascaris #1


      Prominent publications by Hugo Van Den Bossche

      KOL-Index: 9578

      Staphylococcus aureus can be protected by unsaturated unesterified fatty acids against the growth inhibitory effects of miconazole and ketoconazole observed at concentrations greater than 10(-6) M and greater than 10(-5) M, respectively. Miconazole's fungicidal activity is partly antagonized by oleic acid. However, the effect of ketoconazole on the viability of Candida albicans was not affected by this fatty acid. Cytochrome oxidase and ATPase activities are more sensitive to miconazole ...

      Known for Miconazole Ketoconazole | Candida Albicans | Staphylococcus Aureus | Oleic Acid | Fungicidal Activity
      KOL-Index: 8300

      The conformation of three imidazole derivatives, miconazole, ketoconazole and deacylated ketoconazole (R 39 519) inserted in a lipid layer was calculated using a procedure of conformational analysis. For each imidazole derivative all probable conformers were inserted into a dipalmitoyl phosphatidylcholine (DPPC) monolayer. Miconazole maintains its two dichlorophenyl groups in the hydrophobic phase whereas the imidazole moiety is orientated in the hydrophilic phase. Ketoconazole ...

      Known for Conformational Analysis | Lipid Layer | Miconazole Ketoconazole | Drug Molecule | Hydrophobic Region
      KOL-Index: 8264

      The growth of Candida albicans was studied in control cultures and in the presence of miconazole or clotrimazole. Each drug prolonged the lag phase and reduced the total final population. Although miconazole, at the low concentrations used, was a less potent inhibitor than clotrimazole in the main logarithmic phase, it was more fungicidal. The antifungal activity of miconazole on C. albicans was inversely proportional to the number of cells inoculated in the media. The effects of ...

      Known for Candida Albicans | Miconazole Clotrimazole | Antifungal Activity | Lag Phase | Potent Inhibitor
      KOL-Index: 7467

      A system is described which allows the semi-quantitative investigation of the interaction between Candida albicans and leukocytes in culture with and without the addition of chemotherapeutic agents. Both polymorphonuclear leukocytes and macrophages avidly engulfed added yeast cells. However, they did not succeed in eradicating the fungus even when only 450 yeast cells were added to 3 X 10(6) leukocytes. This is probably due to several factors, including the decline in the functiontional ...

      Known for Mixed Cultures | Candida Albicans | Ketoconazole Leukocytes | Intracellular Killing | Antifungal Agents
      KOL-Index: 7370

      The antifungal and antibacterial drug miconazole has been shown to inhibit, at concentrations lower than those affecting growth, the transport of adenine, guanine and hypoxanthine by Candida albicans in suspension culture. The decrease in the incorporation of purines into nucleic acids seems to be the consequence of an inhibitory effect on their uptake into the cells. When the purines were replaced by adenosine, deoxyadenosine and guanosine, miconazole increased the uptake and ...

      Known for Candida Albicans | Biochemical Effects | Amino Acids | Acid Transport | Antifungal Agents
      KOL-Index: 6914

      The effects of miconazole and its new derivative ketoconazole on Candida albicans have been evaluated by light and electron microscopy. The growth characteristics and morphology of C. albicans in culture for various periods of time in a solution consisting of Eagle's minimum essential medium supplemented with amino acids and fetal calf serum are emphasized. This medium, normally used for culturing mammalian cells, promotes a rather fast growth of C. albicans and favours the development ...

      Known for Candida Albicans | Electron Microscopy | Morphological Study | Fetal Calf Serum | Miconazole Ketoconazole
      KOL-Index: 6237

      Van Den Bossche H. and De Nollin S. 1973. Effects of mebendazole on the absorption of low molecular weight nutrients by Ascaris suum. International Journal for Parasitology3: 401–407. The effect of the anthelmintic drug, mebendazole, on the uptake and/or transport of glucose, fructose, 3-O-methylglucose, glycine, proline, methionine and palmitic acid was studied on in vitro incubated Ascaris suum. The experiments presented indicate that mebendazole inhibits the uptake and/or transport of ...

      Known for Ascaris Suum | Glucose Uptake | International Journal | Effects Mebendazole | Animals Anthelmintics
      KOL-Index: 5573

      Mebendazole, its fluorine analogue flubendazole, and other benzimidazole derivatives are active against many gastrointestinal and tissue-stage helminths. This article reviews the published literature and proceedings of a workshop on the use of benzimidazoles against larval echinococcosis (hydatid disease). Orally administered high doses (30–50 mg/kg body weight) of mebendazole given daily for 20–90 days to rodents or sheep infected with larvalEchinococcus granulosus cause damage or ...

      Known for Larval Echinococcosis | Cysts Patients | Hydatid Disease | Cyst Fluid | Benzimidazole Derivatives
      KOL-Index: 4986

      Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 10(-8) to 10(-5) M when the yeast was grown on media favoring the cell form. The inhibitory potency of terconazole on ...

      Known for Effects Terconazole | Electron Microscopy | Antifungal Agents | Candida Albicans | Broad Spectrum
      KOL-Index: 4831

      Ketoconazole, an orally active antimycotic drug, is a potent inhibitor of ergosterol biosynthesis in Candida albicans when added to culture media which support yeast or mycelial growth or to cultures containing outgrown mycelium. This inhibition coincides with accumulation of sterols with a methyl group at C-14 and can thus be attributed to an interference with one of the reactions involved in the removal of the 14 alpha-methyl group of lanosterol. When administered to rats infected with ...

      Known for Drug Ketoconazole | Vivo Effects | Cholesterol Synthesis | Culture Media | Rat Liver
      KOL-Index: 4605

      Van den Bossche H. and Borgers M. 1973. Subcellular distribution of digestive enzymes in Ascaris intestine. International Journal for Parasitology3: 59–65. The microvilli of the intestinal cells of Ascaris suum resemble the microvilli of the mammalian intestine in respect to their morphologic structure; their behaviour to homogenization in the presence of a chelating agent; the presence of the disaccharide hydrolases, maltase, sucrase and trehalase and the presence of an enzyme which ...

      Known for Ascaris Suum | Intestinal Cells | Acid Phosphatase | International Journal | Sucrase Trehalase
      KOL-Index: 4457

      Ketoconazole is one of the new members of the imidazole series with a broad-spectrum antifungal profile. Although sharing its basic active principles with the other imidazoles, ketoconazole obtains its superior in vivo activity mainly from its good oral absorption and its lower degree of inactivation once absorbed. Its selective toxicity for yeasts and fungi is found to be primarily linked to the inhibition of ergosterol biosynthesis and to interference with other membrane lipids. In ...

      Known for Imidazoles Ketoconazole | Candida Albicans | Ergosterol Biosynthesis | Systemic Fungal Infections | Antifungal Agents

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      Hugo Van Den Bossche:Expert Impact

      Concepts for whichHugo Van Den Bosschehas direct influence:Ascaris suum,  Candida albicans,  Carbohydrate metabolism,  Miconazole ketoconazole,  Conformational analysis,  Lipid layer,  Mixed cultures,  Larval echinococcosis.

      Hugo Van Den Bossche:KOL impact

      Concepts related to the work of other authors for whichfor which Hugo Van Den Bossche has influence:Candida albicans,  Antifungal agents,  Cytochrome p450,  Fasciola hepatica,  Sterol biosynthesis,  Echinococcus granulosus,  Hydatid disease.



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      Department of Comparative Biochemistry, Janssen Pharmaceutica Research Laboratories, B-2340 Beerse, Belgium | Research Laboratories, Janssen Pharmaceutica, B-2340 Beerse, Belgium | Department of Comparative Biochemistry, Research Laboratories, Jansse

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