Brian J Golbourn: Influence Statistics

Brian J Golbourn

Brian J Golbourn

John G. Rangos Sr. Research Center, Children’s Hospital of Pittsburgh, and Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA ...

Brian J Golbourn: Expert Impact

Concepts for which Brian J Golbourn has direct influence: Aurora kinase , 3 medulloblastoma , Effective therapy , Tumor cell , Inbred nod mice , Pediatric ependymoma , Supratentorial ependymoma .

Brian J Golbourn: KOL impact

Concepts related to the work of other authors for which for which Brian J Golbourn has influence: Focused ultrasound , Brain tumors , Rhabdoid tumor , Dna repair , Aurora kinase , Parp inhibitors , Glioblastoma cells .

KOL Resume for Brian J Golbourn

Year
2022

John G. Rangos Sr. Research Center, Children’s Hospital of Pittsburgh, and Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Department of Cell Biology, SickKids Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

2021

Department of Neurological Surgery, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

2020

John G. Rangos Sr. Research Center, Children's Hospital of Pittsburgh, Pittsburgh, PA, USA; Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Department of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

2019

Department of Neurological Surgery, Children's Hospital Pittsburgh, Pittsburgh, Pennsylvania

2018

The Division of Laboratory Medicine and Pathobiology, The Hospital for Sick Children, Canada

2016

The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, Toronto, ON, M5G 0A4, Canada

2015

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada. Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

2014

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON Canada

2012

Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, ON, Canada

Prominent publications by Brian J Golbourn

KOL-Index: 9337 . Magnetic Resonance Image-guided Focused Ultrasound (MRgFUS) has been used to achieve transient blood brain barrier (BBB) opening without tissue injury. Delivery of a targeted ultrasonic wave causes an interaction between administered microbubbles and the capillary bed resulting in enhanced vessel permeability. The use of MRgFUS in the brainstem has not previously been shown but could ...
Known for Brain Barrier | Focused Ultrasound | Bbb Opening | Drug Delivery
KOL-Index: 8495 . Malignant astrocytomas are highly invasive brain tumors. The Rho family of cytoskeletal GTPases are key regulators of astrocytoma migration and invasion; expression of the guanine nucleotide exchange factor ECT2 is elevated in primary astrocytomas and predicts both survival and malignancy. Mice bearing orthotopically implanted astrocytoma cells with diminished ECT2 levels following ECT2 ...
Known for Astrocytoma Cells | Ect2 Expression | Amoeboid Phenotype | Binding Protein
KOL-Index: 7972 . Malignant gliomas are highly proliferative and invasive neoplasms where total surgical resection is often impossible and effective local radiation therapy difficult. Consequently, there is a need to develop a greater understanding of the molecular events driving invasion and to identify novel treatment targets. Using microarray analysis comparing normal brain samples and mesenchymal ...
Known for Gbm Invasion | Lim Kinase | Cell Migration | Actin Filaments
KOL-Index: 7727 . Proliferating cancer cells are characterized by high rates of glycolysis, lactate production, and altered mitochondrial metabolism. This metabolic reprogramming provides important metabolites for proliferation of tumor cells, including glioblastoma. These biological processes, however, generate oxidative stress that must be balanced through detoxification of reactive oxygen species (ROS). ...
Known for Oxidative Stress | Tumor Cells | Glioblastoma Growth | Pink1 Loss
KOL-Index: 7247 . Inhibition of Aurora kinase B has been evaluated as a therapy to block solid tumor growth in breast cancer, hepatocellular carcinoma, lung adenocarcinoma, and colorectal cancer models. Aurora kinase inhibitors are in early clinical trials for the treatment of leukemia. We hypothesized that Aurora B inhibition would reduce malignant glioma cell viability and result in impaired tumor growth ...
Known for Aurora Kinase | Glioma Cell | Tumor Growth | Azd1152 Hqpa
KOL-Index: 7243 . Medulloblastoma comprises four molecular subgroups of which Group 3 medulloblastoma is characterized by MYC amplification and MYC overexpression. Lymphoma cells expressing high levels of MYC are susceptible to apoptosis following treatment with inhibitors of mitosis. One of the key regulatory kinases involved in multiple stages of mitosis is Aurora kinase B. We hypothesized that ...
Known for Aurora Kinase | Neoplastic Humans | Myc Overexpressing | Cell Tumor
KOL-Index: 7051 . Pediatric high-grade astrocytomas (pHGA) and diffuse intrinsic pontine gliomas (DIPG) are devastating malignancies for which no effective therapies exist. We investigated the therapeutic potential of PARP1 inhibition in preclinical models of pHGA and DIPG. PARP1 levels were characterized in pHGA and DIPG patient samples and tumor-derived cell lines. The effects of PARP inhibitors ...
Known for Ribose Polymerase | Intrinsic Pontine | Parp1 Activity | Pediatric Diffuse
KOL-Index: 6964 . Medulloblastoma is the most common malignant pediatric brain tumor, with metastases present at diagnosis conferring a poor prognosis. Mechanisms of dissemination are poorly understood and metastatic lesions are genetically divergent from the matched primary tumor. Effective and less toxic therapies that target both compartments have yet to be identified. Here, we report that the analysis ...
Known for Sonic Hedgehog | Signal Transduction | Shh Medulloblastoma | Tumor Cell
KOL-Index: 6772 . First-line cancer therapies such as alkylating agents and radiation have limited survival benefits for Glioblastoma (GBM) patients. Current research strongly supports the notion that inhibition of aberrant tumor metabolism holds promise as a therapeutic strategy when used in combination with radiation and chemotherapy. Hexokinase 2 (HK2) has been shown to be a key driver of altered ...
Known for Hexokinase 2 | Tumor Metabolism | Glioblastoma Gbm | Cell Lines
KOL-Index: 6724 . Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy. We sought to identify ways of sensitizing tumor cells to alkylating agents while leaving normal cells unharmed, increasing therapeutic response while minimizing toxicity. Using an ...
Known for Alkylating Agents | Animal Drug Resistance | Ataxia Telangiectasia | Dna Glycosylase
KOL-Index: 6246 . Glioblastoma (GBM) is the most common primary brain tumor in adults. Despite current advances in therapy consisting of surgery followed by chemotherapy and radiation, the overall survival rate still remains poor. Therapeutic failures are partly attributable to the highly infiltrative nature of tumor adjacent to normal brain parenchyma. Recently, evidence is mounting to suggest that actin ...
Known for Role Drebrin | Cell Motility | Brain Tumor | Actinbinding Protein
KOL-Index: 6066 . The cofilin pathway plays a central role in the regulation of actin polymerization and the formation of cell membrane protrusions that are essential for cell migration. Overexpression of cofilin has been linked to the aggressiveness of a variety of different cancers. In these cancers, the phosphorylation of cofilin at Ser3 is a key regulatory mechanism modulating cofilin activity. The ...
Known for Cofilin Activity | Cell Migration | Activation Status | Local Invasiveness
KOL-Index: 5609 . Cdc42 is a Rho-GTPase which plays a major role in regulating cell polarity and migration by specifying the localization of filopodia. However, the role of Cdc42 in GBM invasion has not been thoroughly investigated. We generated stable doxycycline-inducible clones expressing wild type (WT)-, constitutively active (CA)-, and dominant negative (DN)-Cdc42 in three different human glioma cell ...
Known for Role Cdc42 | Cell Adhesion | Glioblastoma Multiforme | Malignant Gliomas
KOL-Index: 5214 . Pediatric ependymomas are highly recurrent tumors resistant to conventional chemotherapy. Telomerase, a ribonucleoprotein critical in permitting limitless replication, has been found to be critically important for the maintenance of tumor-initiating cells (TICs). These TICs are chemoresistant, repopulate the tumor from which they are identified, and are drivers of recurrence in numerous ...
Known for Pediatric Ependymoma | Telomerase Activity | Alternative Lengthening | Maintenance Mechanisms
KOL-Index: 4371 . We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific ...
Known for Rhabdoid Tumor | Differential Methylation | Epigenomic Analyses | Specific Therapeutic

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John G. Rangos Sr. Research Center, Children’s Hospital of Pittsburgh, and Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA | Department of Neurological Surgery, University of Pittsburgh School of M