Prominent publications by John Marshall

KOL Index score: 22472

BACKGROUND: Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In a previous phase 2 induction study, etrolizumab significantly improved clinical remission versus placebo in patients with moderately to severely active ulcerative colitis. We aimed to evaluate the efficacy and safety of etrolizumab for maintenance of remission in patients with moderately to severely active ulcerative colitis.

METHODS: We conducted a randomised, placebo-controlled, double-blind, phase 3 ...

Also Ranks for: Ulcerative Colitis |  patients etrolizumab |  3 study |  remission week |  rectal bleeding
KOL Index score: 16724

CONTEXT: Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America.

OBJECTIVE: To describe characteristics, treatment, and outcomes of critically ill patients in Canada with 2009 influenza A(H1N1) infection.

DESIGN, SETTING, AND PATIENTS: A prospective observational study of 168 critically ill patients with 2009 influenza A(H1N1) infection in 38 adult and pediatric intensive care units (ICUs) in Canada between April ...

Also Ranks for: 2009 Influenza |  critical illness |  icu stay |  infection canada |  28 patients
KOL Index score: 16384

Fusarium graminearum and F. pseudograminearum are important plant pathogens in New Zealand and around the world. Headblight and crown rot diseases of cereals caused by these species are responsible for large economic losses due to reduction in seed quality and contamination of grain with tricothecene mycotoxins. In the current study we have used two different molecular phylogenetic approaches, AFLPs and gene genealogies, to gain insight into the evolutionary relationships between F. ...

Also Ranks for: New Zealand |  fusarium graminearum |  molecular phylogenetic analysis |  gene genealogies |  evolutionary relationships
KOL Index score: 14030

Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited.

Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19.

Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or ...

Also Ranks for: Organ Support |  patients severe covid19 |  coronavirus infections |  viral respiration |  hormones adult
KOL Index score: 13235

BACKGROUND: Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In a previous phase 2 induction study, etrolizumab significantly improved clinical remission versus placebo in patients with moderately to severely active ulcerative colitis. We aimed to compare the safety and efficacy of etrolizumab with infliximab in patients with moderately to severely active ulcerative colitis.

METHODS: We conducted a randomised, double-blind, double-dummy, parallel-group, phase 3 study ...

Also Ranks for: Ulcerative Colitis |  patients etrolizumab |  phase 3 |  clinical remission |  severely active
KOL Index score: 12726

Importance: The evidence for benefit of convalescent plasma for critically ill patients with COVID-19 is inconclusive.

Objective: To determine whether convalescent plasma would improve outcomes for critically ill adults with COVID-19.

Design, Setting, and Participants: The ongoing Randomized, Embedded, Multifactorial, Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) enrolled and randomized 4763 adults with suspected or confirmed COVID-19 between March 9, 2020, and ...

Also Ranks for: Convalescent Plasma |  organ support |  posterior probability |  critically patients |  2 units
KOL Index score: 11200

OBJECTIVE: While the use of a protocol to guide sedation and analgesia therapy in the intensive care unit has been shown to improve patient outcomes, compliance is often poor. We hypothesized that a formal, consistent intervention by pharmacists to promote adherence to our institution's sedation guidelines would improve clinical outcomes. The purpose of this study was to document the impact of daily pharmacist interventions on clinical outcomes of intensive care unit patients prescribed ...

Also Ranks for: Mechanical Ventilation |  sedation protocol |  clinical pharmacist |  intensive unit |  topic respiration
KOL Index score: 11004

Objective. —To further define the safety and efficacy of recombinant human interleukin 1 receptor antagonist (rhIL-1ra) in the treatment of sepsis syndrome.Study Design. —Randomized, double-blind, placebo-controlled, multicenter, multinational clinical trial.Population. —A total of 893 patients with sepsis syndrome received an intravenous loading dose of rhIL-1ra, 100 mg, or placebo followed by a continuous 72-hour intravenous infusion of rhIL-1ra (1.0 or 2.0 mg/kg per hour) or ...

Also Ranks for: Sepsis Syndrome |  placebo patients |  rhil1ra treatment |  predicted risk |  receptor antagonist
KOL Index score: 10592

Wild birds harbor a huge diversity of avian avulaviruses (formerly avian paramyxoviruses). Antarctic penguin species have been screened for avian avulaviruses since the 1980s and, as such, are known hosts of these viruses. In this study, we screened three penguin species from the South Shetland Islands and the Antarctic Peninsula for avian avulaviruses. We show that Adelie penguins (Pygoscelis adeliae) are hosts for four different avian avulavirus species, the recently described avian ...

Also Ranks for: Avian Avulavirus |  antarctic penguins |  penguin species |  wild birds |  pygoscelis adeliae
KOL Index score: 9942

OBJECTIVES: To determine the rate of documented infections and prevalence of antimicrobial use among pediatric patients admitted to the PICU. To assess the appropriateness of antimicrobial prescribing according to clinical and microbiological findings, Infectious Disease Consult recommendations, and formulary guidelines.

DESIGN: Prospective point prevalence study.

SETTING: Cardiac and medical-surgical critical care units (CCCU-PICU) in a tertiary care pediatric teaching hospital in ...

Also Ranks for: Antimicrobial Utilization |  point prevalence survey |  pediatric patients |  newborn intensive units |  bacterial infections
KOL Index score: 9304

The genetics of renal cancer is dominated by inactivation of the VHL tumour suppressor gene in clear cell carcinoma (ccRCC), the commonest histological subtype. A recent large-scale screen of ∼3,500 genes by PCR-based exon re-sequencing identified several new cancer genes in ccRCC including UTX (also known as KDM6A), JARID1C (also known as KDM5C) and SETD2 (ref. 2). These genes encode enzymes that demethylate (UTX, JARID1C) or methylate (SETD2) key lysine residues of histone H3. ...

Also Ranks for: Renal Carcinoma |  frequent mutation |  exome sequencing |  snf complex |  setd2 histone
KOL Index score: 9032

The relationships between cerebral blood flow (CBF), arterial oxygen content, whole blood viscosity and the transport of oxygen to the brain have been studied in 54 subjects with variations in arterial oxygen content resulting from alterations in haemoglobin concentration ranging from 5.7 to 19.1 g/dl. A highly significant relationship was found between CBF and arterial oxygen content, CBF altering to maintain the rate of transport of oxygen to the brain within certain limits. No ...

Also Ranks for: Arterial Oxygen Content |  cerebral blood flow |  blood viscosity |  oxygen brain |  haemoglobin concentration
KOL Index score: 8949

All cancers carry somatic mutations. The patterns of mutation in cancer genomes reflect the DNA damage and repair processes to which cancer cells and their precursors have been exposed. To explore these mechanisms further, we generated catalogs of somatic mutation from 21 breast cancers and applied mathematical methods to extract mutational signatures of the underlying processes. Multiple distinct single- and double-nucleotide substitution signatures were discernible. Cancers with BRCA1 ...

Also Ranks for: 21 Breast Cancers |  mutational processes |  humans mutation |  female genes |  regions kataegis

Key People For New Zealand

Top KOLs in the world
Matt * *******
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Kelvin * ********
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Nick ********
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Rupert **********
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Brent * *******
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Bruce * ********
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John Marshall:Expert Impact

Concepts for whichJohn Marshallhas direct influence:New zealand,  Ulcerative colitis,  Convalescent plasma,  Intestinal permeability,  Southern ocean,  Traumatic brain injury,  Peer support,  Disc degeneration.

John Marshall:KOL impact

Concepts related to the work of other authors for whichfor which John Marshall has influence:Breast cancer,  Chronic lymphocytic leukemia,  North atlantic,  Somatic mutations,  Deep convection,  Photorefractive keratectomy,  Southern ocean.



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Colorado Mesa University, Grand Junction, CO, 81501, USA | Colorado Mesa University, Grand Junction, CO 81501, USA | Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. | Department of Surgery, St. Michael’s Hos