• Disease
  • Cholinergic
  • Cholinergic Urticaria
  • Atsushi Fukunaga

    Prominent publications by Atsushi Fukunaga

    KOL Index score: 12315

    CD4(+)CD25(+) T cells are an important population that plays a crucial role in the maintenance of peripheral self-tolerance. Recently, it was shown that the elimination of these cells by in vivo administration of anti-CD25 monoclonal antibody (mAb) caused the regression of highly immunogenic tumors in syngeneic mice. In this study, we examined whether B16F10 melanoma cells regressed with the elimination of CD25(+) regulatory T cells. We found the melanoma cells were not affected at all ...

    Also Ranks for: Tumor Cells |  b16f10 melanoma |  cell depletion |  skin neoplasms |  anticd25 mab
    KOL Index score: 11764

    The UV radiation in sunlight is the primary cause of nonmelanoma skin cancer. Moreover, UV exposure induces immune suppression. Early steps in the cascade of events leading to immune suppression are the binding of UV-induced platelet-activating factor (PAF) to its receptor and the binding of cis-urocanic acid, a photoreceptor for UVB radiation, to the serotonin (5-HT(2A)) receptor. Here, we tested the hypothesis that blocking the binding of PAF and 5-HT(2A) to their receptors would also ...

    Also Ranks for: Receptor Antagonists |  activating factor |  immune suppression |  skin cancer induction |  mice paf
    KOL Index score: 11743

    Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory protein family in which the extracellular region interacts with its ligand, CD47. Recent studies have demonstrated that SHPS-1 plays an important role in cell migration and cell adhesion. We demonstrate in this study, using immunohistochemical and flow cytometric analyses, that murine Langerhans cells (LCs) express SHPS-1. Treatment of mice ears with ...

    Also Ranks for: Langerhans Cells |  lymph nodes |  monoclonal antigens |  tyrosine phosphatase |  src homology
    KOL Index score: 11172

    BACKGROUND: It has been reported that patients with cholinergic urticaria have a type 1 allergy to autologous sweat; however, the pathogenesis of that disorder has not been fully elucidated.

    OBJECTIVE: We investigated the responsiveness to autologous sweat and serum in patients with cholinergic urticaria in relation to their clinical characteristics. We further classified the clinical subtypes that are clearly characterized by responsiveness to in vivo and in vitro tests as well as their ...

    Also Ranks for: Autologous Sweat |  cholinergic urticaria |  serum patients |  positive reactions |  histamine release
    KOL Index score: 10835

    Langerhans cells (LCs) serve as epidermal sentinels of the adaptive immune system. Conventional wisdom suggests that LCs encounter Ag in the skin and then migrate to the draining lymph nodes, where the Ag is presented to T cells, thus initiating an immune response. Platelet-activating factor (PAF) is a phospholipid mediator with potent biological effects. During inflammation, PAF mediates recruitment of leukocytes to inflammatory sites. We herein tested a hypothesis that PAF induces LC ...

    Also Ranks for: Langerhans Cells |  immune response |  dermal dendritic |  lymph nodes |  lcs migration
    KOL Index score: 9916

    UV exposure induces skin cancer, in part, by inducing immune suppression. Repairing DNA damage, neutralizing the activity of cis-urocanic acid, and reversing oxidative stress abrogate UV-induced immune suppression and skin cancer induction, suggesting that DNA, UCA, and lipid photo-oxidation serve as UV photoreceptors. What is not clear is whether signaling through each of these different photoreceptors activates independent pathways to induce biological effects or whether there is a ...

    Also Ranks for: Dna Repair |  immune suppression |  oxidative stress |  skin cancer |  5 ht
    KOL Index score: 8974

    BACKGROUND: Many patients with chronic spontaneous/idiopathic urticaria (CSU/CIU) do not respond adequately to treatment with non-sedating H1 antihistamines (H1AH). There are limited studies on use of omalizumab as add-on therapy for treatment of CSU in an Asian population.

    OBJECTIVE: The POLARIS study (NCT02329223), representing the first randomized, double-blind, placebo-controlled phase III trial of omalizumab for CSU in an Eastern Asian population, evaluated efficacy and safety of ...

    Also Ranks for: Omalizumab Csu |  chronic spontaneous |  polaris study |  h1ah treatment |  addon therapy
    KOL Index score: 8593

    BACKGROUND: The insufficient effect of H1-antihistamine in some patients with chronic spontaneous urticaria (CSU) suggests that factors other than histamine are involved in the pathophysiology of CSU. Moreover, a central role for basophils in the pathophysiology of CSU has been hypothesized. However, few studies have focused on the relationship between basophil reactivity via FcεRI and clinical features in patients with CSU.

    OBJECTIVE: To assess basophil reactivity via FcεRI against ...

    Also Ranks for: Patients Csu |  basophils fcεri |  spontaneous urticaria |  anti ige |  atopic dermatitis
    KOL Index score: 8363

    CD47 is a membrane-associated glycoprotein that suppresses the function of immune cells. We previously reported that Langerhans cells (LCs) express Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1), a ligand for CD47, which plays an important role in the regulation of their motility. In this study, we show that LCs also express CD47, and that ligation of CD47 with SHPS-1-Fc fusion protein in vivo diminishes the development of the contact hypersensitivity ...

    Also Ranks for: Langerhans Cells |  contact hypersensitivity |  lymph nodes |  cd47 antigen |  skin explants
    KOL Index score: 8350

    Signal regulatory protein α (SIRPα), an immunoglobulin superfamily protein that is expressed predominantly in myeloid lineage cells such as dendritic cells (DCs) or macrophages, mediates cell-cell signaling. In the immune system, SIRPα is thought to be important for homeostasis of DCs, but it remains unclear whether SIRPα intrinsic to DCs is indeed indispensable for such functional role. Thus, we here generated the mice, in which SIRPα was specifically ablated in CD11c(+) DCs (Sirpa(Δ) ...

    Also Ranks for: Dendritic Cells |  knockout receptors |  sirpα dcs |  inbred c57bl mice |  secondary lymphoid organs
    KOL Index score: 7692

    Thioredoxin (TRX) is a small ubiquitous protein, which regulates cellular redox status and scavenges reactive oxygen species. The present study was conducted to investigate the effect of TRX on ultraviolet (UV)-B-mediated inflammatory and apoptotic responses. Ear swelling after UV-B irradiation was significantly reduced in TRX-transgenic mice compared to wild-type mice. Administration i.p. of recombinant human TRX also reduced acute skin inflammatory reaction, such as skin erythema and ...

    Also Ranks for: Recombinant Human |  apoptotic keratinocytes |  mice mice |  inflammatory cells |  map kinase
    KOL Index score: 7374

    Ultraviolet exposure alters the morphology and function of epidermal Langerhans cells (LCs), which play a role in UV-induced immune suppression. It is generally believed that UV exposure triggers the migration of immature LCs from the skin to the draining lymph nodes (LNs), where they induce tolerance. However, because most of the previous studies employed in vitro UV-irradiated LCs, the data generated may not adequately reflect what is happening in vivo. In this study, we isolated ...

    Also Ranks for: Nkt Cells |  immune suppression |  uv exposure |  irradiated mice |  draining lymph nodes
    KOL Index score: 6586

    BACKGROUND: The majority of patients with cholinergic urticaria presents with strong hypersensitivity to autologous sweat. Patients with severe cholinergic urticaria are frequently resistant to H(1) antagonists which are used in conventional therapies for various types of urticaria. It has been reported that desensitization using partially purified sweat antigen was effective in a patient with cholinergic urticaria.

    METHODS: The aim of this study is to determine the usefulness of rapid ...

    Also Ranks for: Autologous Sweat |  cholinergic urticaria |  h1 antagonists |  skin tests |  histamine release
    KOL Index score: 6103

    BACKGROUND: The rate at which patients are accurately diagnosed with hereditary angioedema (HAE), as well as diagnosed patients access to modern treatments differs greatly among countries. Moreover, the severity and burden of HAE on patients have been reported mostly on the basis of physician-reported surveys. To gain insight into the real-world conditions of patients with HAE through a patient-reported survey in Japan and identify any unmet needs.

    METHODS: A questionnaire was ...

    Also Ranks for: Hereditary Angioedema |  patients hae |  questionnaire distributed


    Atsushi Fukunaga: Influence Statistics

    Sample of concepts for which Atsushi Fukunaga is among the top experts in the world.
    Concept World rank
    eluted hemodialysis #2
    spts priming fluid #2
    hemodialysis membranes hypotension #2
    bioincompatible patients #2
    bioincompatibility eluted substances #2
    pectin nutallergic child #2
    povidone predictive tests #2
    spt pvp #2
    bioincompatibility membranes #2
    malaise hemodialysis #2
    pvp priming fluid #2
    shock pvp #2
    nutallergic child #2
    hypotension malaise #2
    bioincompatibility eluted #2
    eluted substances pvp #2
    anaphylaxis benzhydryl #2
    membraneincompatible cases #2
    hemodialysis membranes spt #2
    citrus bath #2
    hemodialysis membranes bioincompatibility #2
    pvp hemodialysis membranes #2
    spts priming #2
    pvp priming #2
    surfacebound ige basophils #3
    adapalene prophylaxis #3
    langerin lymph #3
    clotiazepam adrenergic urticaria #3
    dmin interquartile #3
    photosensitivity pirfenidone #3
    action mechanism tolerance #3
    anhd enrolled #3
    csu 250 #3
    ige phototherapy #3
    angioedema web‐based #3
    clotiazepam anxiolytic #3
    sat choluanhd #3
    patients topical moisturizer #3
    fcεri stimulation frs #3
    n11 cholu #3
    moisturizer oral #3
    humans vulgaris adapalene #3
    omalizumab treatment therapeutic #3
    include sat #3
    hcs serum ige #3
    improved fcεri #3
    substances hemodialysis #3
    activated steady status #3
    low reactivity basophils #3
    lesions beta blockers #3

    Key People For Cholinergic Urticaria

    Top KOLs in the world
    Allen P Kaplan
    factor xii chronic urticaria histamine release
    Malcolm Watson Greaves
    chronic urticaria human skin arachidonic acid
    Atsushi Fukunaga
    cholinergic urticaria autologous sweat atopic dermatitis
    Frances Lawlor
    chronic urticaria reticulate acropigmentation symptomatic dermographism
    Michihiro Michihiro
    atopic dermatitis mast cells histamine release
    Torsten Zuberbier
    allergic rhinitis chronic urticaria mast cells

    Atsushi Fukunaga:Expert Impact

    Concepts for whichAtsushi Fukunagahas direct influence:Cholinergic urticaria,  Autologous sweat,  Hereditary angioedema,  Langerhans cells,  Atopic dermatitis,  Rapid desensitization,  Solar urticaria,  Hemodialysis membranes.

    Atsushi Fukunaga:KOL impact

    Concepts related to the work of other authors for whichfor which Atsushi Fukunaga has influence:Atopic dermatitis,  Cholinergic urticaria,  Dendritic cells,  Uv radiation,  Contact hypersensitivity,  Chemokine receptors,  Autologous sweat.



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    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Hyogo, Japan | Division of Medicine for Function and Morphology of Sensory Organs, Department of Dermatology, Faculty of Medicine, Osaka Medical and