Prominent publications by Carle F Carle

KOL Index score: 28325

BACKGROUND: Ixekizumab is a humanised monoclonal antibody against the proinflammatory cytokine interleukin 17A. We report two studies of ixekizumab compared with placebo or etanercept to assess the safety and efficacy of specifically targeting interleukin 17A in patients with widespread moderate-to-severe psoriasis.

METHODS: In two prospective, double-blind, multicentre, phase 3 studies (UNCOVER-2 and UNCOVER-3), eligible patients were aged 18 years or older, had a confirmed diagnosis of ...

Known for Placebo Etanercept |  Patients Ixekizumab |  2 Weeks |  Nonsteroidal Antibodies |  Phase 3
KOL Index score: 23063

OBJECTIVE: Pimecrolimus cream (SDZ ASM 981), a nonsteroid inhibitor of inflammatory cytokines, is effective in atopic dermatitis (AD). We assessed whether early treatment of AD signs/symptoms with pimecrolimus could influence long-term outcome by preventing disease flares.

METHODS: Early intervention with pimecrolimus was compared with a conventional AD treatment strategy (ie, emollients and topical corticosteroids). In this 1-year, controlled, double-blind study, 713 AD patients (2-17 ...

Known for Patients Pimecrolimus |  12 Months |  Atopic Dermatitis |  Incidence Adverse Events |  Disease Flares
KOL Index score: 20967

BACKGROUND: Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis.

METHODS: In two phase 3 studies (AMAGINE-2 and AMAGINE-3), patients with moderate-to-severe psoriasis were randomly assigned to receive brodalumab (210 mg or 140 mg every 2 weeks), ustekinumab (45 mg for patients with a body weight ≤100 kg and 90 mg for patients >100 kg), or placebo. At week 12, patients receiving brodalumab were ...

Known for Brodalumab Patients |  Placebo Week |  Phase 3 Studies |  Ustekinumab Psoriasis |  Monoclonal Antibodies
KOL Index score: 18956

BACKGROUND: Apremilast, an oral phosphodiesterase 4 inhibitor, regulates immune responses associated with psoriasis.

OBJECTIVES: ESTEEM 2 evaluated the efficacy and safety of apremilast 30 mg twice daily for moderate-to-severe plaque psoriasis.

METHODS: This phase III, double-blind, placebo-controlled trial randomized adults to apremilast or placebo (2 : 1). At week 16, placebo patients switched to apremilast. At week 32, apremilast patients achieving ≥ 50% reduction in Psoriasis Area ...

Known for 52 Weeks |  4 Inhibitor |  Phase Iii |  Oral Phosphodiesterase |  Esteem 2
KOL Index score: 18853

Previous epidemiological studies have demonstrated a high prevalence of cardiovascular (CV) risk factors in psoriasis patients, including metabolic syndrome, cigarette smoking, obesity, hypertension, diabetes mellitus, insulin resistance and dyslipidaemia. An increase in CV morbidity and mortality attributable to psoriasis is still under question.

PRIMARY OBJECTIVE: to assess CV morbidity and mortality in psoriasis and psoriatic arthritis (PsA) including stroke, coronary artery disease, ...

Known for Psoriatic Arthritis |  Cardiovascular Morbidity |  Psoriasis Mortality |  Risk Stroke |  Coronary Artery Disease
KOL Index score: 17976

BACKGROUND: Psoriasis is an autoimmune disease that affects approximately 100 million people worldwide, and is a disease that can be ameliorated by anti-cytokine treatment. We aimed to compare the efficacy and safety of risankizumab with adalimumab in patients with moderate-to-severe plaque psoriasis.

METHODS: IMMvent was a phase 3, randomised, double-blind, active-comparator-controlled trial completed at 66 clinics in 11 countries. Eligible patients were aged 18 years or older with ...

Known for Patients Risankizumab |  Plaque Psoriasis |  Pasi Week |  Phase 3 |  Blind Treatment
KOL Index score: 16059

BACKGROUND: The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic dermatitis. Data from trials comparing JAK1 inhibitors with monoclonal antibodies, such as dupilumab, that block interleukin-4 receptors are limited.

METHODS: In a phase 3, double-blind trial, we randomly assigned patients with atopic dermatitis that was unresponsive to topical agents or that warranted systemic ...

Known for Atopic Dermatitis |  Abrocitinib Dupilumab |  Placebo Iga Response |  200 100 |  Week 16
KOL Index score: 15951

BACKGROUND: The interleukin-17 cytokine family plays a central role in psoriasis pathogenesis.

OBJECTIVES: To evaluate the efficacy and safety of brodalumab, a human anti-interleukin-17 receptor antibody, in treating patients with moderate-to-severe plaque psoriasis.

METHODS: In this phase III, double-blind, placebo-controlled study (NCT01708590; AMAGINE-1), adult patients in the U.S.A., Canada and Europe were randomized to brodalumab (140 or 210 mg) or placebo every 2 weeks (Q2W), with ...

Known for Brodalumab Patients |  Monoclonal Antibodies |  210 Q2w |  Severe Plaque |  Phase Iii
KOL Index score: 15722

BACKGROUND: It has been shown that the interleukin (IL)-23/IL-17 axis is critical in the pathogenesis of psoriasis.

OBJECTIVES: To present the primary end point (week 12) and safety and efficacy data up to week 24 from a head-to-head trial (IXORA-S) of the IL-17A inhibitor ixekizumab (IXE) vs. the IL-12/23 inhibitor ustekinumab (UST).

METHODS: Randomized patients received IXE (160-mg starting dose, then 80 mg every 2 weeks for 12 weeks, then 80 mg every 4 weeks, n = 136) or UST (45 mg or ...

Known for Pasi Week |  Moderate‐to‐severe Psoriasis |  Ixe Ust |  Primary Point |  Phase Iii
KOL Index score: 15089

BACKGROUND: Oral 8-methoxypsoralen-UV-A (PUVA) and narrowband UV-B (NB-UVB or UVB TL-01) are effective and widely used treatments for chronic plaque psoriasis. Although the role of PUVA therapy in skin carcinogenesis in humans with psoriasis has been clearly demonstrated, there is still controversy regarding the risk of skin cancer with NB-UVB. Furthermore, there is no clear evidence about the maximum cumulative number of sessions not to be exceeded in a lifetime.

OBJECTIVES: To assess ...

Known for Chronic Plaque Psoriasis |  Skin Cancer |  Carcinogenic Risk |  Puva Therapy |  Systematic Literature Review
KOL Index score: 14746

BACKGROUND: Patients with plaque psoriasis treated with biologic therapies need more efficacious, safe and convenient treatments to improve quality of life. Risankizumab and secukinumab inhibit interleukin-23 and interleukin-17A, respectively, and are effective in adult patients with moderate-to-severe plaque psoriasis but have different dosing regimens.

OBJECTIVES: To compare directly the efficacy and safety of risankizumab vs. secukinumab over 52 weeks.

METHODS: IMMerge was an ...

Known for Plaque Psoriasis |  Risankizumab Secukinumab |  Monoclonal Antibodies |  Patients Pasi |  Efficacy Safety
KOL Index score: 14588

BACKGROUND: Tofacitinib is an oral Janus kinase inhibitor that is being investigated for psoriasis. Psoriasis impacts on physical and psychological well-being; improvements in health-related quality of life (HRQoL) with etanercept in psoriasis are well documented.

OBJECTIVE: To evaluate HRQoL with tofacitinib, vs. placebo or etanercept, in the Phase 3, randomized, placebo-controlled, non-inferiority, Oral-treatment Psoriasis Trial (OPT) Compare Study (NCT01241591).

METHODS: Adults with ...

Known for Tofacitinib Placebo |  10 Bid |  Phase 3 Study |  Plaque Psoriasis |  Dlqi Score
KOL Index score: 14536

BACKGROUND: Fixed combination calcipotriol 50 μg/g (Cal) plus betamethasone 0.5 mg/g (BD) foam has been developed as a new treatment option for patients with psoriasis.

METHODS: The randomized, parallel-group, investigator-blinded Phase III, 12-week PSO-ABLE study compared the efficacy and safety of Cal/BD foam with Cal/BD gel. Patients aged ≥18 years with mild-to-severe psoriasis were randomized 4:4:1:1 to once-daily Cal/BD foam, Cal/BD gel, foam vehicle or gel vehicle (NCT02132936). ...

Known for Cal Gel |  Betamethasone Dipropionate |  Aerosol Foam |  Psoriasis Vulgaris |  Treatment Success
KOL Index score: 14256

BACKGROUND: High doses of corticosteroids are considered the standard treatment for pemphigus. Because long-term corticosteroid treatment can cause severe and even life-threatening side-effects in patients with this disease, we assessed whether first-line use of rituximab as adjuvant therapy could improve the proportion of patients achieving complete remission off-therapy, compared with corticosteroid treatment alone, while decreasing treatment side-effects of corticosteroids.


Known for Rituximab Prednisone |  Patients Pemphigus |  Ritux 3 |  Complete Remission |  Combined Short
KOL Index score: 13601

BACKGROUND: Available literature on psoriasis and psoriatic arthritis (PsA) demonstrates a tremendous burden of disease and suggests underdiagnosis and undertreatment.

OBJECTIVE: To obtain real-world physician perspectives on the impact of psoriasis and PsA and its treatment on patients' daily lives, including perceptions of, and satisfaction with, current therapies.

METHODS: The Multinational Assessment of Psoriasis and Psoriatic Arthritis (MAPP) surveyed dermatologists (n = 391) and ...

Known for Psoriatic Arthritis |  Patients Psoriasis |  Dermatologists Rheumatologists |  Cutaneous Administration |  North America


Carle F Carle: Influence Statistics

Sample of concepts for which Carle F Carle is among the top experts in the world.
Concept World rank
patients autoinjection #1
smoking dependency #1
oral pimecrolimus treatment #1
etn ixe #1
corneocyte structural proteins #1
microtubules rhe #1
ointment complete #1
005 doses etanercept #1
mycological cure factors #1
prednisone 36 patients #1
oral tofacitinib improvements #1
pattern psoriasis recurrence #1
nonplaque psoriasis #1
facial psoriasis week #1
oral specialist #1
long‐term continuation #1
pattern psoriasis relapse #1
gel patients #1
pimecrolimus control #1
flg2 calpain #1
staphylococcus aureus density #1
autoinjector week #1
flg gene mutations #1
etanercept pen #1
time disease control #1
moderatetosevere dlqi #1
gorlin syndrome malpdt #1
95 igemediated sensitization #1
abrupt cessation brodalumab #1
recommendations topical #1
cal gel patients #1
flglike proteins #1
itch improvement sleep #1
topic conflict decision #1
patients dlqi score #1
conventional systemic treatments #1
steroid‐sparing #1
calpain proteolytic processing #1
psoriasis severity pasi #1
initial literature search #1
plastic dressing d105 #1
pimecrolimus inflammatory agents #1
alcohol psoriasis #1
foam patients #1
sensitization topical #1
topical steroids tcis #1
melanoma thickness vivo #1
facial psoriasis clearance #1
atopic dermatitis paclitaxel #1
satisfaction piperidines tofacitinib #1

Key People For Atopic Dermatitis

Top KOLs in the world
Donald Y M Leung
atopic dermatitis eczema herpeticum food allergy
Thomas RM Bieber
atopic dermatitis dendritic cells lupus erythematosus
Jon M Hanifin
atopic dermatitis eczema herpeticum histamine release
Mark Boguniewicz
atopic dermatitis eczema herpeticum tacrolimus ointment
Hywel C G Williams
atopic eczema cochrane skin basal cell carcinoma
Johnannes Ring
atopic eczema west germany histamine release

Carle F Carle:Expert Impact

Concepts for whichCarle F Carlehas direct influence:Atopic dermatitis,  Psoriatic arthritis,  Psoriasis patients,  Pimecrolimus cream,  Severe psoriasis,  Plaque psoriasis,  Patients psoriasis,  Cutaneous mastocytosis.

Carle F Carle:KOL impact

Concepts related to the work of other authors for whichfor which Carle F Carle has influence:Atopic dermatitis,  Psoriatic arthritis,  Patients psoriasis,  Pimecrolimus cream,  Monoclonal antibodies,  Quality life,  Toxic epidermal necrolysis.



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CHU de Toulouse, Dermatologie, Toulouse, France | Department of Dermatology, Medical University of Toulouse, Toulouse, France | Department of Dermatology, Toulouse University Hospital, Toulouse, France | . | Dermatologie, CHU

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