• Atopic Dermatitis
    • Donald Y M Leung
    • Donald Y M Leung: Influence Statistics

      Donald Y M Leung

      Donald Y M Leung

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      Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health Hospital, Denver, CO 80206, USA;, leungd@njhealth.org, (D.Y.M.L.);, golevae@njhealth.org, ...

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      Donald Y M Leung:Expert Impact

      Concepts for whichDonald Y M Leunghas direct influence:Atopic dermatitis,Eczema herpeticum,Food allergy,Ige synthesis,Staphylococcus aureus,Kawasaki disease,Patients atopic dermatitis,Kawasaki syndrome.

      Donald Y M Leung:KOL impact

      Concepts related to the work of other authors for whichfor which Donald Y M Leung has influence:Atopic dermatitis,Kawasaki disease,Food allergy,Staphylococcus aureus,Severe asthma,Allergic rhinitis,Mast cells.

      KOL Resume for Donald Y M Leung


      Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health Hospital, Denver, CO 80206, USA;, (D.Y.M.L.);, (E.G.)

      Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA, .

      National Jewish Health, Denver, Colorado, USA


      Division of Allergy/Immunology, Department of Pediatrics, National Jewish Health, Denver, Colorado, USA

      National Jewish Health, Denver, CO;


      Department of Pediatrics, National Jewish Health, Denver, CO 80206

      National Jewish Health, Denver, CO, USA


      Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and

      Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206


      Department of Pediatrics, National Jewish Health, Denver, Colo; University of Colorado School of Medicine, Aurora, Colo. Electronic address:

      National Jewish Health, Denver, Colorado, USA.


      Department of Pediatrics, Division of Allergy and Clinical Immunology, National Jewish Health, 1400 Jackson St, J322, 80206, Denver, CO, USA

      Clinical Professor of Immunopharmacology and Honorary Consultant Physician, Clinical and Experimental Sciences Faculty of Medicine Southampton University and Hospital Trust, Southampton, United Kingdom

      National Jewish Health, Denver, CO, U.S.A.

      Director, Asthma UK Centre for Applied Research


      a Division of Pediatric Allergy-Immunology, Department of Pediatrics , National Jewish Health , Denver , CO , USA.


      Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health and the University of Colorado School of Medicine, Denver, Colo


      Division of Allergy, Department of Pediatrics, National Jewish Health, Denver, Colorado

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      Sample of concepts for which Donald Y M Leung is among the top experts in the world.
      Concept World rank
      hsv1 stimulation #1
      tnx901 450 #1
      asthma type asthma #1
      permanova egg allergy #1
      6 gene stat6 #1
      satellite pox lesions #1
      keratinocyte host defense #1
      granulocyte contamination #1
      epitope library sesigg4 #1
      vitd receptor med14 #1
      grβ expression #1
      spei alpha3beta8 loop #1
      staphylococcus aureus skin #1
      potential role sags #1
      pollen allergen tsst1 #1
      glucocorticoid rhinitis leukocytes #1
      rifngamma study #1
      rifngammatreated patients 21 #1
      skin acute #1
      hdacs bronchoalveolar lavage #1
      aureus colonization skin #1
      tsst1 hsv #1
      pha superantigens #1
      atopic enterotoxins humans #1
      tight junction gene #1
      cd4cd25 cells seb #1
      production streptococcus pyogenes #1
      biologic agents disease #1
      treatment groups cent #1
      il10 iad #1
      steroid therapy expression #1
      skin superantigens #1
      mcls patients #1
      lymphocytes monocytesmacrophages #1
      inhaled rifngamma #1
      atopic gene #1
      lpsinduced pp38 monocytes #1
      eczema herpeticum subjects #1
      adeh patients #1
      pharmacokinetic abnormalities #1
      allergen polysensitization #1
      allergen gcr #1
      ivig reductions #1
      ifns keratinocytes #1
      manner new insights #1
      potentiating factors supernatants #1
      potential toxin neutralization #1
      phosphorylation receptors cd28 #1
      insensitive asthma #1
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      Prominent publications by Donald Y M Leung

      KOL-Index: 32624

      OBJECTIVE: In a prospective study of children with a family history of asthma, asthma onset by 3 years of age was found previously to be positively associated with variables from the first year of life, including elevated total immunoglobulin E (IgE), frequent respiratory infections, and parenting difficulties. We followed this cohort of genetically at-risk children to investigate the relationship between factors assessed in infancy and asthma, allergy, and psychological status at school ...

      Known for Children Asthma | 6 Years Age | Year Life | Parenting Difficulties | Mothers Infants
      KOL-Index: 20524

      Allergen exposure can confound the management of asthma. To understand the potential mechanisms by which allergens increase the steroid requirements in atopic asthmatics, we examined the effects of allergens on glucocorticoid receptor (GCR) binding affinity and glucocorticoid (GC) responsiveness of peripheral blood mononuclear cells (PBMC) from atopic asthmatics. A significant reduction (p < 0.001) in the GCR binding affinity (Kd) was observed in ragweed-allergic asthmatics during ...

      Known for Allergen Exposure | Binding Affinity | Atopic Asthmatics | Glucocorticoid Receptor | Steroid Responsiveness
      KOL-Index: 18128

      Eotaxin is an eosinophil-specific chemokine associated with the recruitment of eosinophils to the site of allergic inflammation. The aims of this study were to determine the expression of eotaxin in nasal biopsies from allergic and nonallergic individuals with chronic severe sinusitis, and to examine whether the expression of this chemokine is upregulated following allergen challenge in the nasal mucosa of patients with allergic rhinitis. We also undertook to phenotype of inflammatory ...

      Known for Chronic Sinusitis | Eotaxin Mrna | Allergic Rhinitis | Nasal Mucosa | Protein Expression
      KOL-Index: 16571

      BACKGROUND: Immune features of infants with food allergy have not been delineated.

      OBJECTIVES: We sought to explore the basic mechanisms responsible for food allergy and identify biomarkers, such as skin prick test (SPT) responses, food-specific IgE levels, and mononuclear cell responses, in a cohort of infants with likely milk/egg allergy at increased risk of peanut allergy.

      METHODS: Infants aged 3 to 15 months were enrolled with a positive SPT response to milk or egg and either a ...

      Known for Egg Allergy | Infants Milk | Specific Ige | Peanut Hypersensitivity | Positive Spt Response
      KOL-Index: 15705

      BACKGROUND: Vitamin D is known for its anti-inflammatory effects.

      OBJECTIVE: Vitamin D regulation of responses in patients with steroid-resistant (SR) versus steroid-sensitive (SS) asthma has not been studied.

      METHODS: Peripheral blood cells from 11 patients with SR asthma and 8 patients with SS asthma were preincubated with 1,25-dihydroxyvitamin D (1,25[OH]2D [VitD]), followed by dexamethasone (DEX) treatment and LPS stimulation. LPS-induced phosphorylated p38 mitogen-activated protein ...

      Known for Asthma Patients | Dex Induced | Anti Inflammatory | Glucocorticoid Receptor | Activated Protein
      KOL-Index: 15534

      BACKGROUND: The innate immune system of human skin contains antimicrobial peptides known as cathelicidins (LL-37) and beta-defensins. In normal skin these peptides are negligible, but they accumulate in skin affected by inflammatory diseases such as psoriasis. We compared the levels of expression of LL-37 and human beta-defensin 2 (HBD-2) in inflamed skin from patients with atopic dermatitis and from those with psoriasis.

      METHODS: The expression of LL-37 and HBD-2 protein in skin-biopsy ...

      Known for Atopic Dermatitis | Antimicrobial Peptides | Patients Psoriasis | Expression Ll37 | Skin Infections
      KOL-Index: 13935

      BACKGROUND: Staphylococcus aureus colonizes the skin lesions of more than 90% of patients with atopic dermatitis (AD). The mechanism for increased S aureus colonization in AD is unknown. However, the initial event in colonization requires adherence of S aureus to the skin.

      OBJECTIVE: The purpose of this study was to examine the roles of various bacterial adhesins on S aureus binding to AD skin.

      METHODS: In an attempt to delineate the mechanism behind this adherence process, an in vitro ...

      Known for Aureus Skin | Patients Atopic Dermatitis | Fibronectin Binding | Bacterial Adhesion | Infections Staphylococcus
      KOL-Index: 13858

      Kawasaki syndrome (KS) is characterized by diffuse vasculitis and marked T cell and B cell activation. In this study, sera from 16 patients with acute KS, 15 patients in the convalescent phase of KS, and 19 age-matched controls were assessed for complement dependent cytotoxic activity against 111In-labeled human umbilical vein endothelial (HUVE) cells, Neither sera from patients with KS nor sera from controls had cytotoxic effects on HUVE cells cultivated under standard conditions. Since ...

      Known for Endothelial Cell | Kawasaki Syndrome | Acute Ks | Gamma Interferon | Sera Patients
      KOL-Index: 13354

      BACKGROUND: The purpose of this study was to characterize the relationship between tissue cytokine expression and the cellular infiltrate present in chronic hyperplastic sinusitis with nasal polyposis (CHS/NP) and to compare the immunopathology and cytokine profile of patients with allergy versus patients without allergy.

      METHODS: Nasal polyp tissue samples from 12 patients with CHS/NP and nasal turbinate biopsy specimens from 10 normal control patients were examined for the expression ...

      Known for Chs Np | Patients Allergy | Gmcsf Ifngamma | Cytokine Expression | Allergic Nonallergic
      KOL-Index: 13240

      BACKGROUND: Corticosteroid insensitivity in asthmatics is associated with an increased expression of glucocorticoid receptor-beta (GR-beta) in many cell types. T-helper type 17 (Th17) cytokine (IL-17A and F) expressions increase in mild and in difficult-to-treat asthma. We hypothesize that IL-17A and F cytokines alone or in combination, induce the expression of GR-beta in bronchial epithelial cells.

      OBJECTIVES: To confirm the expression of the GR-beta and IL-17 cytokines in the airways ...

      Known for Epithelial Cells | Expression Il17a | Asthmatic Airways | Glucocorticoid Receptor | Il17 Cytokines
      KOL-Index: 13145

      Atopic dermatitis (AD) and psoriasis are the two most common chronic skin diseases. However patients with AD, but not psoriasis, suffer from frequent skin infections. To understand the molecular basis for this phenomenon, skin biopsies from AD and psoriasis patients were analyzed using GeneChip microarrays. The expression of innate immune response genes, human beta defensin (HBD)-2, IL-8, and inducible NO synthetase (iNOS) was found to be decreased in AD, as compared with psoriasis, skin ...

      Known for Atopic Dermatitis | Psoriasis Skin | Th2 Cytokines | Cytokine Milieu | Innate Immune
      KOL-Index: 13014

      BACKGROUND: Atopic dermatitis is characterized by immunologic abnormalities including evidence for reduced interferon gamma production. Therapeutic options for treatment of atopic dermatitis are limited and unsatisfactory. Previous open trials have suggested efficacy for recombinant interferon-gamma (rIFN-gamma) in treatment of severe atopic dermatitis. We describe the results of treatment with rIFN-gamma, assessing clinical, immunologic, and laboratory safety parameters in 83 patients ...

      Known for Atopic Dermatitis | Interferon Gamma | Treatment Rifn | Therapeutic Options | 12 Weeks
      KOL-Index: 12960

      Kawasaki syndrome (KS) is an acute febrile illness of early childhood characterized by diffuse vasculitis and marked immune activation. The present study was undertaken to determine whether the acute phase of KS is associated with circulating cytotoxic antibodies directed to target antigens induced on vascular endothelium by the monokines, IL-1, or tumor necrosis factor (TNF). Sera from 20 patients with acute KS, 11 patients in the convalescent phase of KS, and 17 age-matched controls ...

      Known for Kawasaki Syndrome | Endothelial Cells | Tumor Necrosis Factor | Vascular Endothelium | Cell Antigens
      KOL-Index: 12701

      Genome sequences are available for many bacterial strains, but there has been little progress in using these data to understand the molecular basis of pathogen emergence and differences in strain virulence. Serotype M3 strains of group A Streptococcus (GAS) are a common cause of severe invasive infections with unusually high rates of morbidity and mortality. To gain insight into the molecular basis of this high-virulence phenotype, we sequenced the genome of strain MGAS315, an organism ...

      Known for Serotype M3 | Genome Sequence | Bacterial Humans | Strain Mgas315 | Molecular Basis

      Key People For Atopic Dermatitis

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      Division of Allergy-Immunology, Department of Pediatrics, National Jewish Health Hospital, Denver, CO 80206, USA;, leungd@njhealth.org, (D.Y.M.L.);, golevae@njhealth.org, (E.G.) | Department of Pediatrics, National Jewish Health, Denver, CO 80206, US

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