 | Ilona J Frieden |
Prominent publications by Ilona J Frieden
OBJECTIVES: This study was conducted to determine the prevalence of posterior fossae of the brain, arterial anomalies, cardiac anomalies, and eye anomalies (PHACE) in infants with large facial hemangiomas. The extracutaneous manifestations of PHACE may be associated with significant morbidity, and the prevalence of PHACE in patients with facial hemangiomas has not previously been reported.
METHODS: A multicenter prospective study was conducted with 108 infants who had large facial ...
| Also Ranks for: Facial Hemangiomas | phace syndrome | arterial anomalies | 108 infants | extracutaneous manifestations |
OBJECTIVE: The psychologic, physical, and social impact of atopic dermatitis is complex and varies among children of different ages, and the effects of atopic dermatitis on the quality of life of very young American children and their families are not well understood. This study was conducted to document these effects of atopic dermatitis on young children and their families.
METHODS: Directed focus sessions were performed with parents of 26 young children with atopic dermatitis and 6 ...
| Also Ranks for: Atopic Dermatitis | young children | quality life | conceptual framework | families parents |
OBJECTIVE: In 1940 Kasabach and Merritt described an infant with a vascular anomaly, extensive purpura, and thrombocytopenia; they called his lesion "capillary hemangioma." Hemangioma is a benign tumor that grows in infancy and is characterized by proliferation of endothelial cells and regression during childhood. Although Kasabach-Merritt syndrome (KMS) is frequently mentioned as a possible complication of hemangioma, our experience suggests that the anatomic vascular lesion underlying ...
| Also Ranks for: Hemangioma Infancy | merritt syndrome | 22 patients | vascular lesion | endothelial cells |
A prospective study of PHACE syndrome in infantile hemangiomas: Demographic features, clinical findings, and complications
[ PUBLICATION ]
PHACE (OMIM no. 606519) is a neurocutaneous syndrome that refers to the association of large, plaque-like, "segmental" hemangiomas of the face, with one or more of the following anomalies: posterior fossa brain malformations, arterial cerebrovascular anomalies, cardiovascular anomalies, eye anomalies, and ventral developmental defects, specifically sternal defects and/or supraumbilical raphe. The etiology and pathogenesis of PHACE is unknown, and potential risk factors for the syndrome ...
| Also Ranks for: Phace Syndrome | clinical findings | infantile hemangiomas | cardiovascular anomalies | large cohort |
BACKGROUND AND PURPOSE: PHACE is an acronym for posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. Several case reports of arterial ischemic stroke (AIS) in individuals with PHACE have been published, but risk factors for AIS in PHACE have not been clearly defined. The objective of this article is to review all cases of stroke in PHACE in children and describe clinical characteristics that may be ...
| Also Ranks for: Arterial Anomalies | cardiac defects | ais children | posterior fossa | eye abnormalities |
Genetic Changes in Neoplasms Arising in Congenital Melanocytic Nevi Differences Between Nodular Proliferations and Melanomas
[ PUBLICATION ]
Large congenital melanocytic nevi (CMN) are at an increased risk of developing melanoma. Several forms of secondary proliferations can arise in congenital nevi on rare occasions. Although some of these closely resemble melanoma both clinically and histologically, metastasis is rare. We used comparative genomic hybridization to analyze chromosomal aberrations in different types of proliferations arising in CMN and compared them to typical congenital nevi, clear-cut melanomas arising in ...
| Also Ranks for: Cmn Melanoma | melanocytic nevi | neoplasm diagnosis | preschool dna | arising congenital |
Prospective Study of the Frequency of Hepatic Hemangiomas in Infants with Multiple Cutaneous Infantile Hemangiomas
[ PUBLICATION ]
Multiple cutaneous infantile hemangiomas have been associated with hepatic hemangiomas. Screening of infants with five or more cutaneous infantile hemangiomas with abdominal ultrasound is often recommended. The aim of this study was to determine the frequency with which hepatic hemangiomas occur in infants with five or more cutaneous infantile hemangiomas compared to those with one to four cutaneous infantile hemangiomas and to characterize the clinical features of these hepatic ...
| Also Ranks for: Hepatic Hemangiomas | cutaneous infantile | abdominal ultrasound | prospective study frequency | hemangioma humans |
Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast‐flow vascular anomalies are caused by RASA1 mutations
[ PUBLICATION ]
Capillary malformation-arteriovenous malformation (CM-AVM) is a newly recognized autosomal dominant disorder, caused by mutations in the RASA1 gene in six families. Here we report 42 novel RASA1 mutations and the associated phenotype in 44 families. The penetrance and de novo occurrence were high. All affected individuals presented multifocal capillary malformations (CMs), which represent the hallmark of the disorder. Importantly, one-third had fast-flow vascular lesions. Among them, we ...
| Also Ranks for: Rasa1 Mutations | parkes weber syndrome | galen aneurysmal malformation | flow vascular | neurofibromatosis type |
OBJECTIVES: Infantile hemangiomas often are inapparent at birth and have a period of rapid growth during early infancy followed by gradual involution. More precise information on growth could help predict short-term outcomes and make decisions about when referral or intervention, if needed, should be initiated. The objective of this study was to describe growth characteristics of infantile hemangioma and compare growth with infantile hemangioma referral patterns.
METHODS: A prospective ...
| Also Ranks for: Infantile Hemangiomas | growth characteristics | 5 months | early infancy | gradual involution |
BACKGROUND: Atopic dermatitis is a common skin disorder that most often begins in infancy. Sleep disturbances in children with atopic dermatitis are likely due to itching and scratching and not only impact the afflicted child but may also affect the entire family. Sleep characteristics in young children with atopic dermatitis and their families have not been thoroughly investigated.
OBJECTIVE: To evaluate sleep disturbance and cosleeping in young children with atopic dermatitis and ...
| Also Ranks for: Atopic Dermatitis | sleep disturbance | young children | life illness | parents reported |
BACKGROUND: Oral propranolol has been used to treat complicated infantile hemangiomas, although data from randomized, controlled trials to inform its use are limited.
METHODS: We performed a multicenter, randomized, double-blind, adaptive, phase 2-3 trial assessing the efficacy and safety of a pediatric-specific oral propranolol solution in infants 1 to 5 months of age with proliferating infantile hemangioma requiring systemic therapy. Infants were randomly assigned to receive placebo or ...
| Also Ranks for: Infantile Hemangioma | oral propranolol | 6 months | controlled trial | drug administration |
To measure the effects of atopic dermatitis (AD) on the quality of life of affected young children and their families, we developed a prototype 62-item instrument, the Childhood Atopic Dermatitis Impact Scale (CADIS). The prototype CADIS was developed from a comprehensive conceptual framework based on data from parents and clinicians. The instrument had eight subscales (four each for child and parent): physical health, emotional health, physical functioning, and social functioning. The ...
| Also Ranks for: Atopic Dermatitis | young children | impact scale | content validity | prototype cadis |
Congenital Cardiac, Aortic Arch, and Vascular Bed Anomalies in PHACE Syndrome (from the International PHACE Syndrome Registry)
[ PUBLICATION ]
PHACE syndrome represents the association of large infantile hemangiomas of the head and neck with brain, cerebrovascular, cardiac, ocular, and ventral or midline defects. Cardiac and cerebrovascular anomalies are the most common extracutaneous features of PHACE, and they also constitute the greatest source of potential morbidity. Congenital heart disease in PHACE is incompletely described, and this study was conducted to better characterize its features. This study of the International ...
| Also Ranks for: Aortic Arch | phace syndrome | cardiovascular anomalies | head neck | congenital heart disease |
Ilona J Frieden: Influence Statistics
| Concept | World rank |
|---|---|
| clinicians3evaluating infants | #1 |
| telemedicine infantile hemangiomas | #1 |
| representation rapamycin | #1 |
| birth ihs | #1 |
| pustular psoriasis children | #1 |
| hemangioma investigator | #1 |
| ncm dandywalker | #1 |
| diagnosis phace | #1 |
| reduction stridor | #1 |
| xlinked inheritance study | #1 |
| conditions masquerading | #1 |
| prevention disfigurement | #1 |
| clinical description evidence | #1 |
| scalp midline | #1 |
| neurocutaneous melanosis | #1 |
| facial limb asymmetry | #1 |
| physicians propranolol sarcoma | #1 |
| diaper screening test | #1 |
| mixed management accuracy | #1 |
| hemangiomas mapped | #1 |
| cohort inclusive | #1 |
| infants diaper | #1 |
| infants hepatic hemangiomas | #1 |
| phace syndrome mothers | #1 |
| patients orbital ihs | #1 |
| hepatic hemangiomas treatment | #1 |
| multidisciplinary vascular | #1 |
| differences clinical recognition | #1 |
| facial segmental hemangioma | #1 |
| vascular anomalies mosaic | #1 |
| breast hypoplasia complication | #1 |
| eventual selfinvolution | #1 |
| presence hemangioma | #1 |
| cadis prototype cadis | #1 |
| vegfr proliferation | #1 |
| neural melanosis | #1 |
| hss hdcs | #1 |
| concordance dizygotic twins | #1 |
| risk neurologic assessment | #1 |
| prolonged growth | #1 |
| hemangiomas minimal | #1 |
| sparing distal digits | #1 |
| pneumoniaeinduced rash mucositis | #1 |
| profiler pathway analysis | #1 |
| images recorded video | #1 |
| pik3r1 variants | #1 |
| wound approaches | #1 |
| segmental indeterminate | #1 |
| intervention detailed knowledge | #1 |
| segmental morphologic type | #1 |
Key People For Infantile Hemangiomas
Ilona J Frieden:Expert Impact
Concepts for whichIlona J Friedenhas direct influence:Infantile hemangiomas, Phace syndrome, Atopic dermatitis, Infantile hemangioma, Vascular malformations, Vascular anomalies, Airway hemangiomas, Tinea capitis.
Ilona J Frieden:KOL impact
Concepts related to the work of other authors for whichfor which Ilona J Frieden has influence:Atopic dermatitis, Infantile hemangiomas, Vascular anomalies, Phace syndrome, Tinea capitis, Oral propranolol, Neurocutaneous melanosis.
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