Prominent publications by Ove Bäck

KOL Index score: 10754

BACKGROUND: The yeast Malassezia is considered to be one of the factors that can contribute to atopic dermatitis (AD).

OBJECTIVES: To investigate the reactivity to Malassezia allergens, measured as specific serum IgE, positive skin prick test and positive atopy patch test (APT), in adult patients with AD.

METHODS: In total, 132 adult patients with AD, 14 with seborrhoeic dermatitis (SD) and 33 healthy controls were investigated for their reactions to M. sympodialis extract and three ...

Known for Atopic Dermatitis |  Patch Test |  Seborrheic Diagnosis |  Serum Ige |  Positive Apt
KOL Index score: 9806

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease. The pathogenesis of AD involves skin barrier defects and dysregulation of innate and adaptive immunity. Some environmental factors such as stress, infections, and allergens are associated with aggravation of AD. The aim of the study was to investigate the relationship between skin barrier function, skin colonization of Staphylococcus aureus, and sensitization to antigens of skin-associated microorganisms in adult ...

Known for Staphylococcus Aureus |  Atopic Dermatitis |  Skin Barrier |  Microbial Antigens |  Adaptive Immunity
KOL Index score: 8693

The immunopathology of AD is still unclear, but evidence for an immune response polarized towards Th2 activity has been provided. The CD30 molecule belongs to the tumour necrosis factor (TNF) receptor family and is expressed on activated T cells with a sustained expression in Th2 cells. This molecule also exists in a soluble form (sCD30). Elevated serum levels of sCD30 have been found in patients with Hodgkin's disease, chronic hepatitis B infection and HIV infection. Studies were ...

Known for Atopic Dermatitis |  Serum Levels |  Soluble Cd30 |  Th2 Cells |  Hiv Infection
KOL Index score: 8544

The aim of the present study was to investigate the binding of tissue plasminogen activator (tPA) to cultured endothelial cells and to characterize binding structures present in the cultures. Studies on the binding of 125I-tPA to cultured endothelial cells from human umbilical-cord veins (HUVEC) indicated that the number of sites for specific binding of tPA is 8 x 10(5) per cell. Treatment with an excess of antibodies against plasminogen-activator inhibitor type 1 (PAI-1) caused an 80% ...

Known for Plasminogen Activator |  Endothelial Cells |  Binding Tpa |  Cultured Endothelium |  Cell Surface
KOL Index score: 8029

BACKGROUND: Malassezia yeasts play a role in the pathogenesis of atopic eczema/dermatitis syndrome (AEDS). The revised genus Malassezia includes several species which all are natural habitants of the human skin. In this study, we evaluated the presence of immunoglobulin E (IgE) antibodies to different Malassezia spp. in AEDS patients to allow optimization of the characterization of the IgE antibody profile of IgE-associated AEDS.

METHODS: Ninety-six adult patients, with a clinical ...

Known for Malassezia Species |  Fungal Dermatitis |  Ige Antibodies |  Human Skin |  Atopic Female
KOL Index score: 7859

BACKGROUND: Vitamin D, a common food additive, has been shown to prevent the induction of experimental autoimmune diseases in mice. A possible immune deviation from T(H)1 to T(H)2 responses has been postulated. Although there is no doubt about the beneficial effects of vitamin D, its role in allergy has not been investigated.

OBJECTIVE: To define the role of vitamin D in modulating the development of a T(H)2-mediated disease, we used a murine model of pulmonary eosinophilic ...

Known for Ige Production |  Role Vitamin |  Airway Disease |  Th1 Th2 |  Murine Model
KOL Index score: 7857

The prevalence of specific IgE antibodies to the yeasts Pityrosporum orbiculare and Candida albicans was investigated in adult patients with atopic dermatitis (AD) or with seborrhoeic dermatitis and in healthy controls by means of the radioallergosorbent test (RAST). Of 63 AD patients, 28 (44%) had IgE antibodies to P. orbiculare and 21 (33%) to C. albicans. This is highly significant, since no antibodies were found in sera from other patients or controls. With the intention to treat, 20 ...

Known for Atopic Dermatitis |  Serum Ige |  Fungal Candida |  Clinical Score |  Pityrosporum Orbiculare
KOL Index score: 7582

New methods are described for the separation of the cellular components of human blood. They can be separated into erythrocytes, polymorpho-nuclear leucocytes, mononuclear leucocytes and platelets by centrifugation in density gradients of colloidal silica and polyvinylpyrrolidone. The procedures are simple and the yields and resolution achieved higher than in methods currently available. The fractionations are made in media of physiological pH and osmolality. The cells are intact after ...

Known for Blood Cells |  Colloidal Silica |  Density Gradients |  Cell Populations |  Mononuclear Leucocytes
KOL Index score: 7459

IgE reactivity to the opportunistic yeast Malassezia furfur can be found in patients with atopic dermatitis (AD). We have previously cloned and expressed 6 recombinant allergens (rMal f 1, rMal f 5-9) from M. furfur. In the present study, we used ImmunoCAP to investigate whether these rMal f allergens can be useful in the diagnosis of M. furfur-associated AD compared with the M. furfur extract. A total of 156 adult patients with a clinical diagnosis of AD participated in the study. ...

Known for Atopic Dermatitis |  Ige Reactivity |  Malassezia Furfur |  Recombinant Proteins |  Allergens Rmal
KOL Index score: 7270

Bone marrow of chickens of different ages was labelled locally in vivo with small amounts of 3H-thymidine directly into the bone marrow. Using autoradiography and a radiochemical technique, bone marrow-derived cells were demonstrated in the thymic medulla, the bursa of Fabricius, the splenic red pulp, and the cecal tonsil and in the bone marrow from locations other than the labelled ones. Considerable numbers of bone marrow cells were found in the bursa of chickens labelled on the day of ...

Known for Bone Marrow |  Bursa Fabricius |  Progenitor Cells |  Thymus Gland |  3h Thymidine
KOL Index score: 7107

The binding of 125I-labelled tissue plasminogen activator (tPA), the tPA A- or B-chain to endothelial cells (EC) were studied in suspensions of cultured human umbilical vein EC (HUVEC) or immortalized microvascular EC (HMEC). By determinations of the concentration-dependent binding it was shown that both the A-chain and the B-chain, which were isolated after partial reduction of two-chain tPA, contain ligands for binding to EC. The affinity for the B-chain was much higher than for the ...

Known for Plasminogen Activator |  Endothelial Cells |  Tpa Binding |  Inhibitor 1 |  Enzyme Activation
KOL Index score: 6373

A technique has been devised to isolate the thin papillary part of the dermis from punch biopsies. Papillary dermis has been treated with various proteolytic enzymes in order to release or solubilize the granular IgA deposits from the papillary dermis of patients with dermatitis herpetiformis. Incubation of the thin skin preparations with pepsin caused a disappearance of the specific fluorescence with antibodies to human IgA. After peptic digestion small amounts of IgA could be detected ...

Known for Papillary Dermis |  Dermatitis Herpetiformis |  Iga Deposits |  Proteolytic Enzymes |  Peptic Digestion
KOL Index score: 6294

Granular deposits of IgA in radioactively labeled thin slices of papillary dermis from 4-mm punch biopsies of clinically normal skin from patients with dermatitis herpetiformis were solubilized with sodium dodecyl sulfate (SDS) or peptic digestion at pH 4.5. Solubilized IgA-like material was isolated by immunoprecipitation and analyzed by electrophoresis in one and two dimensions in polyacrylamide gels containing SDS followed by autoradiography. SDS extracts contained IgA-like components ...

Known for Dermatitis Herpetiformis |  Papillary Dermis |  Granular Deposits |  Peptic Digestion |  Iga Fragments


Ove Bäck: Influence Statistics

Sample of concepts for which Ove Bäck is among the top experts in the world.
Concept World rank
controls ltt #1
furfur orbiculare #1
test site inhibition #1
sensitized mice suppression #1
edema formation ear #1
yeast allergic patients #1
mouse reserpine treatment #1
suppression edema formation #1
consumption clinical score #1
headneck distribution #1
reserpine treatment doses #1
yeast allergic #1
formation cellular infiltrate #1
nitrofurantoin antibody #1
antibody titre drug #1
eighteen sensitive patients #1
eighteen sensitive #1
ltt elisa #1
200 ketoconazole daily #1
hypersensitivity nitrofurantoin #1
inbred cba reserpine #1
antibodies nitrofurantoin #1
oral therapeutic singledose #2
isoproterenol skin adult #2
dilutions steroid formulations #2
mitosis labelled #2
therapeutic peroral singledose #2
controls blanching #2
rhinoconjunctivitis 21 #2
cell suspension serum #2
resistant chemotaxis #2
blanching response alpha #2
caseininduced pmn migration #2
labelled epithelial lymphocytes #2
random pmn #2
pmn publication administration #2
topical glucocorticoids suppression #2
peroral griseofulvin #2
α‐adrenoceptor response #2
antitubulinresistant chemotaxis #2
griseofulvin serum #2
tetracyclines vitro migration #2
pmn vinca #2
doxycycline casein gradient #2
caseininduced pmn chemotaxis #2
thymic medulla bursa #2
presence griseofulvincontaining serum #2
neglibible pmn chemotaxis #2
allergic asthma adrenergic #2
labelling base regions #2

Key People For Atopic Dermatitis

Top KOLs in the world
Donald Y M Leung
atopic dermatitis eczema herpeticum food allergy
Thomas RM Bieber
atopic dermatitis dendritic cells lupus erythematosus
Jon M Hanifin
atopic dermatitis eczema herpeticum histamine release
Mark Boguniewicz
atopic dermatitis eczema herpeticum tacrolimus ointment
Hywel C G Williams
atopic eczema cochrane skin basal cell carcinoma
Johnannes Ring
atopic eczema west germany histamine release

Ove Bäck:Expert Impact

Concepts for whichOve Bäckhas direct influence:Atopic dermatitis,  Papillary dermis,  Pityrosporum folliculitis,  Intestinal epithelium,  Patients atopic dermatitis,  Seborrhoeic dermatitis,  Dermatitis herpetiformis,  Tissue plasminogen activator.

Ove Bäck:KOL impact

Concepts related to the work of other authors for whichfor which Ove Bäck has influence:Atopic dermatitis,  Malassezia species,  Allergic rhinitis,  Vitamin deficiency,  Skin diseases,  Pityriasis versicolor,  Pityrosporum folliculitis.



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Lund University Division of Dermatology and Venereology Department of Clinical Sciences Lund Sweden | Dermatology & Venereology, Department of Clinical Sciences-Division III Lund University; Lund, Sweden | Department of Clinical sciences, Dermatology

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