Prominent publications by Peter M Elias

KOL Index score: 20290

BACKGROUND AND OBJECTIVES: Evidence suggests the importance of skin biophysical properties in predicting diseases and in developing appropriate skin care. The results to date of studies on skin surface pH, stratum corneum (SC) hydration and sebum content in both genders and at various ages have been inconclusive, which was in part due to small sample size. Additionally, little is known about the skin physical properties of Asian, especially Chinese, subjects. In the present study, we ...

Also Ranks for: Sebum Content |  skin surface |  stratum corneum hydration |  females age |  chinese population
KOL Index score: 17604

Activators of peroxisome proliferator activated receptor-alpha, a nuclear hormone receptor that heterodimerizes with retinoid X receptor, stimulate epidermal differentiation and inhibit proliferation. Here we determined the anti-inflammatory effects of peroxisome proliferator activated receptor-alpha agonists in models of irritant and allergic contact dermatitis produced in mouse ears by topical treatment with 12-O-tetradecanoylphorbol-13-acetate and oxazalone, respectively. As expected, ...

Also Ranks for: Peroxisome Proliferator |  activated receptor |  contact dermatitis |  ear thickness |  topical treatment
KOL Index score: 16297

The pathological scaling in recessive x-linked ichthyosis is associated with accumulation of abnormal quantities of cholesterol sulfate in stratum corneum (J. Clin. Invest. 68:1404-1410, 1981). To determine whether or not cholesterol sulfate accumulates in recessive x-linked ichthyosis as a direct result of the missing enzyme, steroid sulfatase, we quantitated both steroid sulfatase and its substrate, we quantitated both steroid sulfatase and its substrate, cholesterol sulfate, in ...

Also Ranks for: Cholesterol Sulfate |  steroid sulfatase |  stratum corneum |  linked ichthyosis |  normal desquamation
KOL Index score: 16177

The extracellular lipids of the stratum corneum, which are comprised mainly of cholesterol, fatty acids, and ceramides, are essential for epidermal permeability barrier function. Moreover, disruption of the permeability barrier results in an increased cholesterol, fatty acid, and ceramide synthesis in the underlying epidermis. This increase in lipid synthesis has been shown previously to be due to increased activities of HMG-CoA reductase, acetyl-CoA carboxylase, fatty acid synthase and ...

Also Ranks for: Fatty Acid |  permeability barrier |  ceramide synthesis |  mrna levels |  enzymes cholesterol
KOL Index score: 15814

BACKGROUND: We previously showed that the number of publications in dermatology is increasing year by year, and positively correlates with improved economic conditions in mainland China, a still developing Asian country. However, the characteristics of publications in dermatology departments in more developed Asian countries such as Japan and South Korea are unknown.

METHODS: In the present study, publications from 2003 through 2012 in dermatology in Japan, South Korea and mainland China ...

Also Ranks for: South Korea |  mainland china |  publications dermatology |  impact factors |  japan published
KOL Index score: 15200

Epidermal ceramides (Cer) comprise a heterogeneous family of seven species, including two unique omega-hydroxylated Cer, that are key components of the stratum corneum (SC) intercellular lamellar membranes responsible for the epidermal permeability barrier. Although both glucosylceramide (GlcCer) and the phospho-sphingolipid sphingomyelin (SM) are potential precursors of SC Cer, based on reported chemical structures of epidermal GlcCer and SC Cer, it is assumed that all major ...

Also Ranks for: Epidermal Cer |  stratum corneum |  spectrometry mass |  omega hydroxy |  atom bombardment
KOL Index score: 14769

Keratinocytes require abundant cholesterol for cutaneous permeability barrier function; hence, the regulation of cholesterol homeostasis is of great importance. ABCA1 is a membrane transporter responsible for cholesterol efflux and plays a pivotal role in regulating cellular cholesterol levels. We demonstrate that ABCA1 is expressed in cultured human keratinocytes (CHKs) and murine epidermis. Liver X receptor (LXR) activation markedly stimulates ABCA1 mRNA and protein levels in CHKs and ...

Also Ranks for: Abca1 Expression |  murine epidermis |  human keratinocytes |  liver receptors |  lxr activators
KOL Index score: 14631

Members of the superfamily of nuclear hormone receptors which are obligate heterodimeric partners of the retinoid X receptor may be important in epidermal development. Here, we examined the effects of activators of the receptors for vitamin D3 and retinoids, and of the peroxisome proliferator activated receptors (PPARs) and the farnesoid X-activated receptor (FXR), on the development of the fetal epidermal barrier in vitro. Skin explants from gestational day 17 rats (term is 22 d) are ...

Also Ranks for: Nuclear Hormone |  barrier development |  fetal epidermal |  activators pparalpha |  mature lamellar membranes
KOL Index score: 13801

Activators of liver X receptors (LXR) stimulate epidermal differentiation and development, but inhibit keratinocyte proliferation. In this study, the anti-inflammatory effects of two oxysterols, 22(R)-hydroxy-cholesterol (22ROH) and 25-hydroxycholesterol (25OH), and a nonsterol activator of LXR, GW3965, were examined utilizing models of irritant and allergic contact dermatitis. Irritant dermatitis was induced by applying phorbol 12-myristate-13-acetate (TPA) to the surface of the ears of ...

Also Ranks for: Dermatitis Models |  lxr gw3965 |  receptor activators |  allergic contact |  antiinflammatory effects
KOL Index score: 13560

After permeability barrier perturbation there is an increase in the mRNA levels for key enzymes necessary for lipid synthesis in the epidermis. The mechanism(s) responsible for this regulation is unknown. Sterol regulatory element binding proteins-1a, 1c, and -2 (SREBPs) control the transcription of enzymes required for cholesterol and fatty acid t synthesis in response to modulations of sterol levels. We now demonstrate that SREBP-2 is the predominant SREBP in human keratinocytes and ...

Also Ranks for: Murine Epidermis |  fatty acid |  human keratinocytes |  ceramide synthesis |  sterol regulatory
KOL Index score: 13450

Acute disruption of the permeability barrier by either tape stripping or acetone treatment and chronic disruption by feeding an essential fatty acid-deficient diet increase the mRNA levels of tumor necrosis factor-alpha (TNF alpha), interleukin (IL)-1 alpha, IL-1 beta, IL-1ra, and granulocyte/macrophage-colony-stimulating factor in murine epidermis. Furthermore, epidermal TNF alpha protein levels also are stimulated by barrier disruption. To understand the relation of epidermal cytokine ...

Also Ranks for: Barrier Disruption |  mrna levels |  il1 alpha |  messenger receptors |  essential fatty
KOL Index score: 13369

Ligands and activators of the nuclear hormone receptor superfamily are important in the regulation of epidermal development and differentiation. Previously, we showed that naturally occurring fatty acids, as well as synthetic ligands for the peroxisome proliferator-activated receptor, induce keratinocyte differentiation in vitro. Here we asked whether oxysterols, another class of lipids formed de novo in the epidermis and that activate liver X-activated receptor, regulate keratinocyte ...

Also Ranks for: Involucrin Transcription |  human keratinocytes |  keratinocyte differentiation |  messenger receptors |  ap1 dna
KOL Index score: 13164

ATP-binding cassette (ABC) transporter, family 12 (ABCA12), a member of the ABC superfamily, facilitates the delivery of lipids to lamellar bodies (LB) in keratinocytes, which is critical for permeability barrier function. Recently, gene mutations of ABCA12 were found to underlie Harlequin ichthyosis and lamellar ichthyosis, two devastating skin disorders. Previously we and others have demonstrated that peroxisome proliferators-activated receptors (PPARs) and liver X receptor (LXR) ...

Also Ranks for: Lxr Activators |  abca12 expression |  human keratinocytes |  lamellar ichthyosis |  keratinocyte differentiation
KOL Index score: 13076

Stratum corneum lipids comprise an approximately equimolar mixture of sphingolipids, cholesterol, and free fatty acids, arranged as intercellular membrane bilayers that are presumed to mediate the epidermal permeability barrier. Prior studies have shown that alterations in epidermal barrier function lead to a rapid increase in cholesterol and fatty acid synthesis which parallels the early stages of the repair process. Despite an abundance of indirect evidence for their role in the ...

Also Ranks for: Sphingolipid Synthesis |  barrier recovery |  hairless mice |  epidermal permeability |  prior studies
KOL Index score: 12807

Disruption of the permeability barrier results in an increase in cholesterol synthesis in the epidermis. Inhibition of cholesterol synthesis impairs the repair and maintenance of barrier function. The increase in epidermal cholesterol synthesis after barrier disruption is due to an increase in the activity of epidermal HMG-CoA (3-hydroxy-3-methylglutaryl CoA) reductase. To determine the mechanism for this increase in enzyme activity, in the present study we have shown by Western blot ...

Also Ranks for: Barrier Disruption |  mrna levels |  coa reductase |  hairless mice |  messenger receptors

Key People For Stratum Corneum

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Peter M Elias:Expert Impact

Concepts for whichPeter M Eliashas direct influence:Stratum corneum,  Barrier function,  Permeability barrier,  Atopic dermatitis,  Barrier recovery,  Barrier disruption,  Barrier homeostasis,  Epidermal differentiation.

Peter M Elias:KOL impact

Concepts related to the work of other authors for whichfor which Peter M Elias has influence:Atopic dermatitis,  Stratum corneum,  Human skin,  Barrier function,  Wound healing,  Fatty acids,  Gene expression.



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Department of Dermatology, UC San Francisco and VA Medical Center, San Francisco, CA. Electronic address: | Dermatology Service Veterans Affairs Medical Center, Department of Dermatology, University of California, San Francisco,