• Disease
  • Atopic
  • Atopic Eczema
  • Johnannes Ring

    Prominent publications by Johnannes Ring

    KOL Index score: 18535

    Cultured primary human keratinocytes were screened for their expression of various members of the toll-like receptor (TLR) family. Keratinocytes were found to constitutively express TLR1, TLR2, TLR3, TLR5, and TLR9 but not TLR4, TLR6, TLR7, TLR8, or TLR10 as shown by polymerase chain reaction analysis. The expression of the crucial receptor for signaling of staphylococcal compounds TLR2 was also confirmed by immunohistochemistry, in contrast to TLR4, which showed a negative staining ...

    Also Ranks for: Human Keratinocytes |  tolllike receptor |  staphylococcus aureus |  nuclear factor |  nitric oxide
    KOL Index score: 17485

    BACKGROUND: The role of atopy in the pathophysiology of eczema is still under debate. The concept and analyses of the nonatopic and atopic subtypes of eczema have gained increasing interest in recent studies. The course of these subtypes and differences between boys and girls have not been investigated so far.

    OBJECTIVES: To examine the course of nonatopic and atopic eczema in preschool children from Germany with regard to sex.

    METHODS: Repeated cross-sectional studies were performed in ...

    Also Ranks for: Girls Eczema |  2 years |  age onset |  child preschool |  boys atopic
    KOL Index score: 17162

    BACKGROUND: The atopy patch test (APT) was proposed to evaluate IgE-mediated sensitizations in patients with atopic eczema (AE).

    OBJECTIVE: The prevalence and agreement with clinical history and specific IgE (sIgE) of positive APT reactions was investigated in six European countries using a standardized method.

    METHODS: A total of 314 patients with AE in remission were tested in 12 study centers on clinically uninvolved, non-abraded back skin with 200 index of reactivity (IR)/g of house ...

    Also Ranks for: Atopic Eczema |  positive reactions |  apt spt |  patch test |  preschool dermatitis
    KOL Index score: 15753

    BACKGROUND: Prevalence data for atopic eczema based on a dermatological examination have not so far been available for East and West Germany. Possible differences in the proportions of extrinsic and intrinsic types of eczema, and how far these could explain differences in the prevalence of eczema, need to be clarified.

    OBJECTIVES: To compare the prevalence of atopic eczema in pre-school children between different locations in East and West Germany, and over a period of 7 years, at three ...

    Also Ranks for: Atopic Eczema |  east germany |  intrinsic type |  differences prevalence |  95 children
    KOL Index score: 14326

    BACKGROUND: A subgroup of patients with atopic eczema exhibits aggravation through contact with aeroallergens. Little is known from population-based studies, however, about the association between the severity of eczematous skin disease and the degree of aeroallergen sensitization.

    OBJECTIVE: We sought to investigate the relationship between IgE-mediated allergic sensitization to aeroallergens and severity of atopic eczema in schoolchildren.

    METHODS: A nested case-control analysis on ...

    Also Ranks for: Atopic Eczema |  allergen prevalence |  preschool dermatitis |  sensitization severity |  child child
    KOL Index score: 14212

    BACKGROUND: East-West comparison studies in Europe find higher prevalences of infectious airway diseases and lower prevalences of allergies in eastern areas. Pollution from sulphur dioxide (SO2) or total suspended particles (TSP) are discussed as causes of this difference.

    METHODS: In four differently polluted areas of East Germany where pollution decreased dramatically between 1989 and 1995 cross-sectional studies in about 7-year-old children were repeated every year between 1991 and ...

    Also Ranks for: East Germany |  time trends |  total suspended particles |  west german children |  5 years
    KOL Index score: 14191

    Components of the renin angiotensin system, namely renin, angiotensinogen, angiotensin I and II and aldosterone were measured in plasma of patients with hymenoptera venom anaphylaxis (n = 50) and healthy non-allergic controls (n = 25). Patients with a history of anaphylactic reactions to hymenoptera venom who did not undergo immunotherapy showed significantly reduced renin, angiotensinogen, angiotensin I and angiotensin II in plasma as compared with controls (P < 0.05). There was no ...

    Also Ranks for: Renin Angiotensin |  hymenoptera venom |  patients immunotherapy |  living insect |  healthy nonallergic controls
    KOL Index score: 14167

    BACKGROUND: Short-term immunotherapy (STI) can be beneficial for patients who are noncompliant with long-term specific immunotherapy.

    OBJECTIVE: The efficacy and tolerance of STI with seven preseasonal injections of molecular standardized allergens from grass and rye pollen has been investigated in a double-blind, placebo-controlled multicenter study with 87 patients at 12 German University hospitals.

    METHODS: Symptoms of the eyes, nose, and bronchi and use of symptomatic drugs were ...

    Also Ranks for: Grass Pollen |  molecular standardized |  allergic rhinitis |  sti placebo |  term immunotherapy
    KOL Index score: 13970

    BACKGROUND: Following vaccination with traditional smallpox vaccines or after exposure to vaccinated individuals, subjects with atopic dermatitis (AD) can develop eczema vaccinatum, a severe disease with disseminated eruption of pustular contagious lesions. Alternative smallpox vaccines with an improved safety profile would address this unmet medical need.

    METHODS: An open-label controlled Phase I clinical trial was conducted to investigate the safety and immunogenicity of modified ...

    Also Ranks for: Atopic Dermatitis |  smallpox vaccine |  modified vaccinia |  safety immunogenicity |  ankara mva
    KOL Index score: 13877

    Toll-like receptors (TLRs) are important pattern recognition molecules that activate the nuclear factor (NF)-kappaB pathway leading to the production of antimicrobial immune mediators. As keratinocytes represent the first barrier against exogenous pathogens in human skin, we investigated their complete functional TLR1-10 expression profile. First, reverse transcription-polymerase chain reaction (PCR) analysis revealed a very similar pattern of TLR mRNA expression when comparing freshly ...

    Also Ranks for: Tolllike Receptor |  primary keratinocytes |  hacat cells |  human skin |  tlr ligands
    KOL Index score: 13655

    Thyroid hormones have diverse effects on growth and metabolism. Specific "receptor" proteins which bind triiodothyronine and other biologically active analogs and which may be involved in thyroid hormone action have been recently found in nuclei of responsive tissues. This report presents studies of these receptors in rat liver nuclei. Confirming previous reports, a Scatchard analysis of the binding data suggests the reaction, triiodothyronine + specific receptor in equilibrium with ...

    Also Ranks for: Thyroid Hormone |  nuclear localization |  binding characteristics |  receptors chromatin |  triiodothyronine animals
    KOL Index score: 13530

    Emerging evidence suggests an important role for human epidermal keratinocytes in innate immune mechanisms against bacterial and viral skin infections. The proinflammatory effect of viral infections can be mimicked by double-stranded RNA (dsRNA). Herein, we demonstrate that keratinocytes express all known dsRNA sensing receptors at a constitutive and inducible level, and that they use several downstream signaling pathways leading to a broad pattern of gene expression, not only ...

    Also Ranks for: Stranded Rna |  viral infections |  rig mda5 |  pattern recognition receptors |  irf3 activation
    KOL Index score: 13400

    BACKGROUND: Polymorphisms in the serine protease inhibitor gene serine peptidase inhibitor Kazal type 5 (SPINK5) and the serine protease kallikrein-related peptidase 7 gene (KLK7) appear to confer risk to eczema in some cohorts, but these findings have not been widely replicated. These genes encode proteins thought to be involved in the regulation of posttranslation processing of filaggrin (FLG), the strongest identified genetic risk factor for eczema to date.

    OBJECTIVES: We sought to ...

    Also Ranks for: Eczema Risk |  serine peptidase |  kazal type |  spink5 klk7 |  flg polymorphisms


    Johnannes Ring: Influence Statistics

    Sample of concepts for which Johnannes Ring is among the top experts in the world.
    Concept World rank
    atopic diseases sensitization #1
    jeadv #1
    greater itch #1
    indicators atopy #1
    hot spot studies #1
    east germany differences #1
    east germany borken #1
    depot pollen patients #1
    n‐palmitoylethanolamine #1
    loratadine severity #1
    einschränkung lebensqualität #1
    allergischer #1
    indomethacin enhances #1
    prevalence atopic diseases #1
    areas eczema #1
    „ragweed #1
    epicutaneous patch test #1
    psychosomatic counselling #1
    pollen allergies participants #1
    evaluated clinical criteria #1
    aeroallergentriggered #1
    test true #1
    dipyrone ict #1
    anticd203c #1
    radiation icam1 expression #1
    skin prick rast #1
    adaptieren #1
    bat skin tests #1
    living insect #1
    latephasereaction #1
    tests challenge #1
    pyrazolons dipyrone #1
    candidiasis exhibit #1
    test‐induced eczema #1
    flow2 cast #1
    anaphylaktoide reaktionen #1
    eczema atopic #1
    kategorisierung #1
    candida cmc patients #1
    eiq5 #1
    notch ligands myd88 #1
    variable region patients #1
    behandlungsmethode #1
    positive apt reactions #1
    betape induced expression #1
    loratadine crosstalk #1
    quality itch #1
    tcis data #1
    allergies pets #1
    cd4 cd152 #1

    Key People For Atopic Eczema

    Top KOLs in the world
    Hywel C G Williams
    atopic eczema cochrane skin basal cell carcinoma
    Johnannes Ring
    atopic eczema west germany histamine release
    Thomas RM Bieber
    atopic dermatitis dendritic cells lupus erythematosus
    Jon M Hanifin
    atopic dermatitis eczema herpeticum histamine release
    David Peter Strachan
    lung function international study air pollution
    Donald Y M Leung
    atopic dermatitis eczema herpeticum food allergy

    Johnannes Ring:Expert Impact

    Concepts for whichJohnannes Ringhas direct influence:Atopic eczema,  Atopic dermatitis,  West germany,  Histamine release,  Anaphylactoid reactions,  East germany,  Patients atopic eczema,  Atopic diseases.

    Johnannes Ring:KOL impact

    Concepts related to the work of other authors for whichfor which Johnannes Ring has influence:Atopic dermatitis,  Allergic rhinitis,  Food allergy,  Mast cells,  Hypersensitivity reactions,  Skin tests,  Staphylococcus aureus.



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    Department Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany | Department of Dermatology and Allergy Biederstein, Technical University Munich, Munich, Germany | Technical University of Munich, School of Medicine, Depar