• atrial fibrillation
    • Andreas A Laupacis

      Andreas A Laupacis

      Boursier en rédaction, JAMC (McRae); Départements de médecine d'urgence et des sciences de la santé communautaire (McRae), Université de Calgary, Calgary, Alb.; rédacteur ...



      KOL Resume for Andreas A Laupacis


      Boursier en rédaction, JAMC (McRae); Départements de médecine d'urgence et des sciences de la santé communautaire (McRae), Université de Calgary, Calgary, Alb.; rédacteur adjoint principal, JAMC (Laupacis).

      University of Toronto, Toronto, ON, Canada; Li Ka Shing Knowledge Institute St. Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada


      Departments of Medicine, and Laboratory Medicine and Pathobiology (Sholzberg), St. Michael’s Hospital, University of Toronto; Department of Medicine (Arnold), McMaster University, Toronto, Ont.; Senior Deputy Editor (Laupacis), CMAJ, Ottawa, Ont.

      Institute of Health Policy, Management and Evaluation, University of Toronto, Canada.

      Department of Medicine, University of Toronto, Toronto, Ontario, Canada


      Institute of Health Policy, Management and Evaluation (M.V.V., A.L., P.C.A., M.K.K.), University of Toronto, Canada

      Départements de médecine et de sciences de la santé communautaire (Holroyd-Leduc), Université de Calgary, Calgary, Alta.; rédacteur en chef (Laupacis), CMAJ.

      Executive editor, CMAJ (Patrick); deputy editor, CMAJ (Stanbrook); Department of Medicine (Stanbrook), University of Toronto, Toronto, Ont.; editor-in-chief, CMAJ (Laupacis).

      Editor-in-Chief, CMAJ (Laupacis); Dalla Lana School of Public Health (Boozary), University of Toronto, Toronto, Ont.; Health and Social Policy (Boozary), University Health Network, Toronto, Ont.; and Harvard T.H. Chan School of Public Health (Boozary), Boston, Mass.


      Department of Palliative Care, St. Michael's Hospital, Toronto, Ontario, Canada

      Faculty of Medicine, University of Toronto.

      Editor-in-Chief, CMAJ

      The Li Ka Shing Knowledge Institute of St. Michael's Hospital.


      Li Ka Shing Knowledge Institute, St. Michael's Hospital

      Department of Medicine, University of Toronto, ON, Canada

      Institute of Health Policy, Management and Evaluation, University of Toronto

      Advisory Committee


      St Michael's Hospital, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada

      Institute of Health Policy, Management and Evaluation, University of Toronto.

      Department of Medicine, University of Toronto



      Andreas A Laupacis: Influence Statistics

      Sample of concepts for which Andreas A Laupacis is among the top experts in the world.
      Concept World rank
      relative risk operation #1
      95 cls differences #1
      patients cafa study #1
      erythropoietin autologous donation #1
      stroke warfarin therapy #1
      250 osteoarthritic patients #1
      3 cohorts magnitude #1
      incidental sequencing #1
      discharge summaries physicians #1
      extent current clinical #1
      devices salvaged blood #1
      anesthesia purpose #1
      advances clinical medicine #1
      health biomedical child #1
      transplant success patients #1
      provincial formulary #1
      n3660 #1
      comparative effects txa #1
      ontario physicians attitudes #1
      outcomes assessor #1
      funded clinical studies #1
      ptot patients values #1
      gdm clinicians #1
      life medical guidelines #1
      charlson risk adjustment #1
      older ontarians anticoagulation #1
      antibiotic prescriptions standarddose #1
      canada priority #1
      fields clinical medicine #1
      switchers higher ses #1
      ecg chest radiography #1
      transfusion uncertain patients #1
      provincial legislatures #1
      transfusionrelated diseases costs #1
      provincial elections decisions #1
      atrial fibrillation factors #1
      groups secondary outcome #1
      canadian cancer population #1
      4 scales testing #1
      effects medications #1
      95 randomized participants #1
      patient hospitalization factors #1
      canadian hospital costs #1
      0 clinicians p005 #1
      physicians discharge summary #1
      incidental adoption #1
      aprotinin tranexamic acid #1
      validation published cprs #1
      statistical databases charlson #1
      treatment thresholds ptot #1


      Prominent publications by Andreas A Laupacis

      KOL-Index: 23109

      BACKGROUND: Concerns regarding the safety of transfused blood have led to the development of a range of interventions to minimise blood loss during major surgery. Anti-fibrinolytic drugs are widely used, particularly in cardiac surgery and previous reviews have found them to be effective in reducing blood loss and the need for transfusion. Recently, questions have been raised regarding the comparative performance of the drugs and the safety of the most popular agent, ...

      Known for Lysine Analogues | Txa Eaca | Aprotinin Tranexamic Acid | Rbc Transfusion | Antifibrinolytic Drugs
      KOL-Index: 16555

      Importance: People who immigrate face unique health literacy, communication, and system navigation challenges, and they may have diverse preferences that influence end-of-life care.

      Objective: To examine end-of-life care provided to immigrants to Canada in the last 6 months of their life.

      Design, Setting, and Participants: This population-based cohort study (April 1, 2004, to March 31, 2015) included 967 013 decedents in Ontario, Canada, using validated linkages between health and ...

      Known for Immigrant Status | Ontario Canada | 6 Months | Longstanding Residents | Aged 80
      KOL-Index: 16223

      CONTEXT: Patients with nonvalvular atrial fibrillation (AF) have an increased risk of stroke and other vascular events.

      OBJECTIVE: To compare the risk of vascular and bleeding events in patients with nonvalvular AF treated with vitamin K -inhibiting oral anticoagulants or acetylsalicylic acid (aspirin).

      DESIGN: Pooled analysis of patient-level data from 6 published, randomized clinical trials.

      PATIENTS: A total of 4052 patients with AF randomly assigned to receive therapeutic doses of ...

      Known for Oral Anticoagulant | Nonvalvular Atrial Fibrillation | Cardiovascular Events | Major Bleeding | Ischemic Stroke 95
      KOL-Index: 15556

      Concern about risks of allogeneic transfusion has led to an interest in methods for decreasing perioperative transfusion. To determine whether cell salvage reduces patient exposure to allogeneic blood, we performed meta-analyses of randomized trials, evaluating the effectiveness and safety of cell salvage in cardiac or orthopedic elective surgery. The primary outcome was the proportion of patients who received at least one perioperative allogeneic red cell transfusion. Twenty-seven ...

      Known for Cell Salvage | Orthopedic Surgery | Allogeneic Blood | Transfusion Cardiac | Surgical Procedures
      KOL-Index: 15359

      CONTEXT: Osteoporosis is associated with significant morbidity and mortality. Oral bisphosphonates have become a mainstay of treatment, but concerns have emerged that long-term use of these drugs may suppress bone remodeling, leading to unusual fractures.

      OBJECTIVE: To determine whether prolonged bisphosphonate therapy is associated with an increased risk of subtrochanteric or femoral shaft fracture.

      DESIGN, SETTING, AND PATIENTS: A population-based, nested case-control study to explore ...

      Known for Older Women | Shaft Fractures | 5 Years | Bisphosphonate Therapy | Subtrochanteric Femoral
      KOL-Index: 14676

      CONTEXT: Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community are not well characterized.

      OBJECTIVE: To determine whether elderly patients admitted to hospital with specific drug toxicities were likely to have been prescribed an interacting drug in the week prior to admission.

      DESIGN: Three population-based, nested case-control studies.

      SETTING: Ontario, Canada, from January 1, 1994, to December 31, 2000.

      PATIENTS: All Ontario ...

      Known for Elderly Patients | Drug Toxicity | Ace Inhibitors | 95 Confidence Interval | Hospital Admissions
      KOL-Index: 14476

      CONTEXT: High levels of variation and inefficiency exist in current clinical practice regarding use of cervical spine (C-spine) radiography in alert and stable trauma patients.

      OBJECTIVE: To derive a clinical decision rule that is highly sensitive for detecting acute C-spine injury and will allow emergency department (ED) physicians to be more selective in use of radiography in alert and stable trauma patients.

      DESIGN: Prospective cohort study conducted from October 1996 to April 1999, ...

      Known for Spine Rule | Stable Trauma Patients | Process Assessment | Radiography Alert | Trauma Decision
      KOL-Index: 13783

      OBJECTIVES: The purpose of this study was to present radial and saphenous vein graft (SVG) occlusion results more than 5 years following coronary artery bypass surgery.

      BACKGROUND: In the RAPS (Radial Artery Patency Study) study, complete graft occlusion was less frequent in radial artery compared with SVG 1 year post-operatively while functional occlusion (Thrombolysis In Myocardial Infarction flow grade 0, 1, 2) was similar.

      METHODS: A total of 510 patients <80 years of age undergoing ...

      Known for Radial Artery | 5 Years | Bypass Surgery | Patency Study | Saphenous Vein
      KOL-Index: 13555

      CONTEXT: Decision aids are tools designed to help patients participate in the clinical decision-making process.

      OBJECTIVE: To determine whether use of an audiobooklet (AB) decision aid explaining the results of a clinical trial affected the decision-making process of study participants.

      DESIGN: Randomized controlled trial conducted from May 1997 to April 1998.

      SETTING: Fourteen centers that participated in the Stroke Prevention in Atrial Fibrillation (SPAF) III trial.


      Known for Antithrombotic Therapy | Atrial Fibrillation | Stroke Prevention | Randomized Controlled Trial | Decision Aid
      KOL-Index: 13388

      BACKGROUND: Despite the use of warfarin, major systemic embolism remains an important complication in patients with heart-valve replacement. Although the addition of antiplatelet agents has the potential to reduce this complication, their efficacy and safety when given in combination with warfarin are uncertain.

      METHODS: In a randomized, double-blind, placebo-controlled trial, we assessed the efficacy and safety of adding aspirin (100 mg per day) to warfarin treatment (target ...

      Known for Aspirin Placebo | Patients Warfarin | Valve Replacement | Efficacy Safety | Systemic Embolism
      KOL-Index: 13257

      BACKGROUND: Atrial fibrillation is a leading preventable cause of recurrent stroke for which early detection and treatment are critical. However, paroxysmal atrial fibrillation is often asymptomatic and likely to go undetected and untreated in the routine care of patients with ischemic stroke or transient ischemic attack (TIA).

      METHODS: We randomly assigned 572 patients 55 years of age or older, without known atrial fibrillation, who had had a cryptogenic ischemic stroke or TIA within ...

      Known for Atrial Fibrillation | Cryptogenic Stroke | Patients Intervention | Absolute Difference | 30 Seconds
      KOL-Index: 13122

      BACKGROUND: Recent debate has emerged regarding the cardiovascular safety of selective cyclooxygenase 2 inhibitors and the possible cardioprotective effect of naproxen sodium. We compared the rates of acute myocardial infarction (AMI) among elderly patients dispensed selective cyclooxygenase 2 inhibitors, naproxen, and nonselective nonnaproxen nonsteroidal anti-inflammatory drugs (NSAIDs).

      METHODS: We conducted a population-based retrospective cohort study using administrative health ...

      Known for 2 Inhibitors | Selective Cyclooxygenase | Acute Myocardial Infarction | 95 Naproxen | Nsaids Inflammatory Agents
      KOL-Index: 13057

      Importance: Trauma of hospitalization refers to the depersonalizing and stressful experience of a hospital admission and is hypothesized to increase the risk of readmission after discharge.

      Objectives: To characterize the trauma of hospitalization by measuring patient-reported disturbances in sleep, mobility, nutrition, and mood among medical inpatients, and to examine the association between these disturbances and the risk of unplanned return to hospital after discharge.

      Design, ...

      Known for Trauma Hospitalization | Mobility Nutrition | Emergency Department | Medical Inpatients | Disturbances Sleep

      Key People For Atrial Fibrillation

      Top KOLs in the world
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      Harry J G M C Crijns
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      Andreas A Laupacis:Expert Impact

      Concepts for whichAndreas A Laupacishas direct influence:Atrial fibrillation,  Cardiac surgery,  Blood transfusion,  Decision aid,  Essential medicines,  1 trials,  Antithrombotic therapy,  Mechanical ventilation.

      Andreas A Laupacis:KOL impact

      Concepts related to the work of other authors for whichfor which Andreas A Laupacis has influence:Atrial fibrillation,  Heart failure,  Study protocol,  Controlled trial,  Tranexamic acid,  Breast cancer,  Cardiac surgery.



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      Boursier en rédaction, JAMC (McRae); Départements de médecine d'urgence et des sciences de la santé communautaire (McRae), Université de Calgary, Calgary, Alb.; rédacteur adjoint principal, JAMC (Laupacis). | University of Toronto, Toronto, ON, Canad

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