Carlos A Morillo

Carlos A Morillo

Population Health Research Institute-McMaster University, Hamilton, ON, Canada | University of Calgary Department of Cardiac Sciences | Libin Cardiovascular Institute of ...

KOL Resume for Carlos A Morillo  (paroxysmal atrial fibrillation, atrial fibrillation flutter, disease, flutter, cardiovascular, fibrillation, atrial)


Population Health Research Institute-McMaster University, Hamilton, ON, Canada

University of Calgary Department of Cardiac Sciences


Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

Newmarket, Ontario


Libin Cardiovascular Institute, Calgary, Alberta, Canada.

Southeastern Alberta Region, Alberta Health Services, Foothills Medical Centre, CA

Population Health Research Institute‐McMaster University, Hamilton, ON, Canada


Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Foothills Medical Centre, Room C823, 1403 29th Street Northwest, Calgary, Alberta T2N 2T9, Canada


Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, ON, Canada


Department of Cardiac Sciences, Cumming School of Medicine, Division of Cardiology, Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada


From the Department of Cardiology, Hospital Klinikum Coburg, Teaching Hospital of the University of Würzburg, Coburg, Germany (J.B.); Department of Medicine, Population Health Research Institute, McMaster University, Hamilton, ON, Canada (C.A.M.); Department of Cardiac Intensive Care, Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy (T.S.); Department of Neurology, Institute of Neurology, Università Campus Bio-Medico, Rome, Italy (V.D.L.); Department of Neurology & Stroke Center, University Hospital Essen, Essen, Germany (H.-C.D.); Davee Department of Neurology (R.A.B.) and Bluhm Cardiovascular Institute (R.S.P.), Northwestern University Feinberg School of Medicine, Chicago, IL; University of Kansas Medical Center, Kansas City, KS (M.R.); Departments of Diagnostics and Monitoring Research (P.D.Z.) and Statistics (S.L.), Medtronic, Mounds View, MN; and Bluhm Cardiovascular Institute, Northwestern University Feinberg School of Medicine, Chicago, IL (R.S.P.).

Division of Cardiology, Department of Medicine, McMaster University, 1280 Main Street West, L8S 4L8, Hamilton, ON, Canada


From the Florey Institute of Neuroscience and Mental Health and Austin Health Department of Neurology (V.N.T.), Heidelberg, Australia; Hospital Klinikum Coburg (J.B.), Teaching Hospital of the University of Würzburg, Coburg, Germany; Population Health Research Institute (C.A.M.), McMaster University, Hamilton, Canada; Northwestern University Feinberg School of Medicine (R.S.P.), Chicago, IL; Institute of Cardiology (T.S.), Catholic University of the Sacred Heart, Rome, Italy; Davee Department of Neurology (R.A.B.), Northwestern University, Chicago, IL; Department of Neurology (H.-C.D.), University Hospital Essen University Duisburg-Essen, Germany; Institute of Neurology (V.D.L.), University Campus Bio-Medico of Rome, Rome, Italy; University of Kansas Medical Center (M.M.R.), Kansas City; Medtronic (L.H.), Maastricht, Netherlands; Medtronic (T.B.R., P.D.Z.), Mounds View, Minneapolis, MN; and Baylor University Medical Center (M.D.A.), Dallas, TX.

Cardiology Division, Department of Medicine, Arrhythmia Service, Hamilton Health Sciences, McMaster University, Population Health Research Institute, Hamilton, Ontario, Canada


Eectrophysiology, McMaster University, Hamilton, Canada


Prominent publications by Carlos A Morillo

KOL Index score: 21377

Importance: Catheter ablation of persistent atrial fibrillation (AF) has limited success. Procedural strategies beyond pulmonary vein isolation have failed to consistently improve results. The vein of Marshall contains innervation and AF triggers that can be ablated by retrograde ethanol infusion.

Objective: To determine whether vein of Marshall ethanol infusion could improve ablation results in persistent AF when added to catheter ablation.

Design, Setting, and Participants: The Vein of ...

Known for Catheter Ablation |  Marshall Ethanol Infusion |  Persistent Atrial Fibrillation |  Atrial Tachycardia |  Perimitral Block
KOL Index score: 19610

BACKGROUND: Despite the clinical importance of atrial fibrillation (AF), the development of chronic nonvalvular AF models has been difficult. Animal models of sustained AF have been developed primarily in the short-term setting. Recently, models of chronic ventricular myopathy and fibrillation have been developed after several weeks of continuous rapid ventricular pacing. We hypothesized that chronic rapid atrial pacing would lead to atrial myopathy, yielding a reproducible model of ...

Known for Sustained Atrial |  Chronic Rapid |  6 Weeks |  Posterior Atrium |  11 Dogs
KOL Index score: 15893

IMPORTANCE: Atrial fibrillation (AF) is the most common rhythm disorder seen in clinical practice. Antiarrhythmic drugs are effective for reduction of recurrence in patients with symptomatic paroxysmal AF. Radiofrequency ablation is an accepted therapy in patients for whom antiarrhythmic drugs have failed; however, its role as a first-line therapy needs further investigation.

OBJECTIVE: To compare radiofrequency ablation with antiarrhythmic drugs (standard therapy) in treating patients ...

Known for Antiarrhythmic Drugs |  Radiofrequency Ablation |  Paroxysmal Atrial |  Recurrence Patients |  Firstline Therapy
KOL Index score: 15399

OBJECTIVES: A double-blind randomized trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally mediated syncope induced by a head-up tilt test.

BACKGROUND: Neurally mediated syncope is a frequent cause of syncope and may be induced by head-up tilt testing. Recent uncontrolled trials have suggested that disopyramide may be an effective therapy in patients with neurally mediated syncope.

METHODS: Twenty-two consecutive patients with ...

Known for Neurally Mediated Syncope |  Headup Tilt Testing |  Head Tilt |  Test Positive |  Uncontrolled Trials
KOL Index score: 15219

Chagas disease caused by Trypanosoma cruzi is a complex disease that is endemic and an important problem in public health in Latin America. The T. cruzi parasite is classified into six discrete taxonomic units (DTUs) based on the recently proposed nomenclature (TcI, TcII, TcIII, TcIV, TcV and TcVI). The discovery of genetic variability within TcI showed the presence of five genotypes (Ia, Ib, Ic, Id and Ie) related to the transmission cycle of Chagas disease. In Colombia, TcI is more ...

Known for Trypanosoma Cruzi |  Tci Tcii |  Chagas Cardiomyopathy |  Disease Colombia |  Genetic Variability
KOL Index score: 15134

CONTEXT: Three previous small randomized trials have reported that pacemaker therapy is beneficial for patients with severe recurrent vasovagal syncope. However, because these trials were not double blind, they may have been biased in their assessment of outcomes and had a placebo effect of surgery.

OBJECTIVE: To determine if pacing therapy reduces the risk of syncope in patients with vasovagal syncope.

DESIGN, SETTING, AND PATIENTS: A randomized double-blind trial of pacemaker therapy ...

Known for Pacemaker Therapy |  Vasovagal Syncope |  6 Months |  Patients Recurrent |  Blind Randomized
KOL Index score: 14341

BACKGROUND: One quarter of strokes are of unknown cause, and subclinical atrial fibrillation may be a common etiologic factor. Pacemakers can detect subclinical episodes of rapid atrial rate, which correlate with electrocardiographically documented atrial fibrillation. We evaluated whether subclinical episodes of rapid atrial rate detected by implanted devices were associated with an increased risk of ischemic stroke in patients who did not have other evidence of atrial ...

Known for Atrial Fibrillation |  Systemic Embolism |  3 Months |  Hazard Ratio |  Ischemic Stroke Patients
KOL Index score: 14236

BACKGROUND: Atrial fibrillation is a common post-operative complication of cardiac surgery and is associated with an increased risk of post-operative stroke, increased length of intensive care unit and hospital stays, healthcare costs and mortality. Numerous trials have evaluated various pharmacological and non-pharmacological prophylactic interventions for their efficacy in preventing post-operative atrial fibrillation. We conducted an update to a 2004 Cochrane systematic review and ...

Known for Atrial Fibrillation |  Heart Surgery |  Supraventricular Tachycardia |  Pharmacological Interventions |  Post Operative
KOL Index score: 14078

This international multidisciplinary document intends to provide clinicians with evidence-based practical patient-centered recommendations for evaluating patients and decedents with (aborted) sudden cardiac arrest and their families. The document includes a framework for the investigation of the family allowing steps to be taken, should an inherited condition be found, to minimize further events in affected relatives. Integral to the process is counseling of the patients and families, ...

Known for Sudden Cardiac |  Patients Families |  Unexplained Death |  Clinicians Document |  Investigation Decedents
KOL Index score: 13598

AIMS: This multicentre, randomized trial compared three strategies of AF ablation: ablation of complex fractionated electrograms (CFE) alone, pulmonary vein isolation (PVI) alone, and combined PVI + CFE ablation, using standardized automated mapping software.

METHODS AND RESULTS: Patients with drug-refractory, high-burden paroxysmal (episodes >6 h, >4 in 6 months) or persistent atrial fibrillation (AF) were enrolled at eight centres. Patients (n = 100) were randomized to one of three ...

Known for Pvi Cfe |  Atrial Fibrillation |  6 Months |  Repeat Procedures |  Trigger Ablation
KOL Index score: 13589

OBJECTIVES: This study was designed to identify all randomized clinical trial data evaluating angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for the prevention of atrial fibrillation (AF), to estimate the magnitude of this effect and to identify patient subgroups most likely to benefit.

BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) reduce morbidity and mortality in patients with heart failure, vascular ...

Known for Angiotensin Receptor Blockers |  Atrial Fibrillation |  Converting Enzyme |  Aceis Arbs |  Patients Hypertension
KOL Index score: 13485

BACKGROUND: Guidelines recommend a trial of one or more antiarrhythmic drugs before catheter ablation is considered in patients with atrial fibrillation. However, first-line ablation may be more effective in maintaining sinus rhythm.

METHODS: We randomly assigned 303 patients with symptomatic, paroxysmal, untreated atrial fibrillation to undergo catheter ablation with a cryothermy balloon or to receive antiarrhythmic drug therapy for initial rhythm control. All the patients received an ...

Known for Atrial Fibrillation |  Initial Treatment |  Drug Therapy |  Catheter Ablation Patients |  Hazard Ratio
KOL Index score: 13466

BACKGROUND: Catheter ablation is less successful for persistent atrial fibrillation than for paroxysmal atrial fibrillation. Guidelines suggest that adjuvant substrate modification in addition to pulmonary-vein isolation is required in persistent atrial fibrillation.

METHODS: We randomly assigned 589 patients with persistent atrial fibrillation in a 1:4:4 ratio to ablation with pulmonary-vein isolation alone (67 patients), pulmonary-vein isolation plus ablation of electrograms showing ...

Known for Atrial Fibrillation |  Catheter Ablation |  Patients Pulmonary |  Atria Humans |  18 Months
KOL Index score: 13243

Quantitative real-time PCR (qPCR) is an accurate method to quantify Trypanosoma cruzi DNA and can be used to follow-up parasitemia in Chagas disease (CD) patients undergoing chemotherapy. The Benznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) study is an international, multicenter, randomized, double-blinded and placebo-controlled clinical trial to evaluate the efficacy of benznidazole (BZ) treatment in patients with chronic Chagas cardiomyopathy (CCC). One important ...

Known for Chronic Chagas Disease |  Parasite Load |  Cruzi Dna |  Sybr Green |  Ccc Patients
KOL Index score: 13069

BACKGROUND: Current guidelines recommend at least 24 hours of electrocardiographic (ECG) monitoring after an ischemic stroke to rule out atrial fibrillation. However, the most effective duration and type of monitoring have not been established, and the cause of ischemic stroke remains uncertain despite a complete diagnostic evaluation in 20 to 40% of cases (cryptogenic stroke). Detection of atrial fibrillation after cryptogenic stroke has therapeutic implications.

METHODS: We conducted a ...

Known for Atrial Fibrillation |  Cryptogenic Stroke |  Patients Icm |  12 Months |  Hazard Ratio


Carlos A Morillo: Influence Statistics

Sample of concepts for which Carlos A Morillo is among the top experts in the world.
Concept World rank
ccc bzn #1
reflex vasovagal syncope #1
167–295 #1
symptom score csss #1
vvs measures #1
csss vvs score #1
ablation postablation state #1
pacing recording #1
larger international issues #1
1 syncope episode #1
trypanosomiasis parasite #1
updated evidence metaanalysis #1
atrial fibrillation ccssaf #1
ablation cfae ablation #1
afeqt ccssaf #1
bpv brg #1
reduced procedural time #1
microg ncs #1
patients recurrent ncs #1
patients judicious #1
population sensitivity specificity #1
reflex vasovagal #1
capcost #1
strongest predictor asymptomatic #1
aging subjects trial #1
normal physiologic demand #1
cfe procedures #1
microg prolactin #1
iasc roadmap #1
syncope guidelines #1
cardioneuroablation vasovagal #1
vagal baroreflex slopes #1
americas current migration #1
ventricular tachycardia shocks #1
nonmetabolic model #1
physicians 89 #1
dbt cpt #1
pvac control groups #1
orthostatic syncope intervals #1
infrahisian heart block #1
star randomized trial #1
35 diagnostic approach #1
brg sinus adaptation #1
recurrence vasovagal #1
single egm #1
recurrent syncope patients #1
2 baroreflex gain #1
analysis roadblocks #1
syncope frequency vvs #1
chagas disease light #1

Key People For Atrial Fibrillation

Top KOLs in the world
Gregory Yoke Hong Lip
atrial fibrillation heart failure stroke prevention
John Camm MD John Camm
atrial fibrillation myocardial infarction heart rate
Emelia J Benjamin
atrial fibrillation framingham heart study heart failure
Harry J G M C Crijns
atrial fibrillation heart failure sinus rhythm
Isabelle C Van Gelder
atrial fibrillation heart failure rate control
Stefan Hans Hohnloser
atrial fibrillation myocardial infarction sinus rhythm

Carlos A Morillo:Expert Impact

Concepts for whichCarlos A Morillohas direct influence:Atrial fibrillation,  Chagas disease,  Vasovagal syncope,  Catheter ablation,  Cryptogenic stroke,  Pacemaker patients,  Antiarrhythmic medications,  Chagas cardiomyopathy.

Carlos A Morillo:KOL impact

Concepts related to the work of other authors for whichfor which Carlos A Morillo has influence:Atrial fibrillation,  Chagas disease,  Catheter ablation,  Trypanosoma cruzi,  Heart failure,  Vasovagal syncope,  Cryptogenic stroke.



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Population Health Research Institute-McMaster University, Hamilton, ON, Canada | University of Calgary Department of Cardiac Sciences | Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Alberta

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