 | Isabelle C Van Gelder |
Prominent publications by Isabelle C Van Gelder
BACKGROUND: The combination of left bundle branch block (LBBB) morphology and QRS duration is currently used to select patients for cardiac resynchronization therapy (CRT). These parameters, however, have limitations. This study evaluates the value of QRS area compared with that of QRS duration and morphology in the association with clinical and echocardiographic outcomes in a large cohort of CRT patients.
METHODS: A retrospective multicentre study was conducted in 1492 CRT patients. ...
| Also Ranks for: Qrs Area | cardiac resynchronization | patients crt | bundle branch | echocardiographic response |
BACKGROUND: One quarter of strokes are of unknown cause, and subclinical atrial fibrillation may be a common etiologic factor. Pacemakers can detect subclinical episodes of rapid atrial rate, which correlate with electrocardiographically documented atrial fibrillation. We evaluated whether subclinical episodes of rapid atrial rate detected by implanted devices were associated with an increased risk of ischemic stroke in patients who did not have other evidence of atrial ...
| Also Ranks for: Atrial Fibrillation | systemic embolism | 3 months | hazard ratio | ischemic stroke patients |
OBJECTIVES: We studied the influence of rate control or rhythm control in patients with persistent atrial fibrillation (AF) on quality of life (QoL).
BACKGROUND: Atrial fibrillation may cause symptoms like fatigue and dyspnea. This can impair QoL. Treatment of AF with either rate or rhythm control may influence QoL.
METHOD: Quality of life was assessed in patients included in the Rate Control Versus Electrical Cardioversion for Persistent Atrial Fibrillation (RACE) study (rate vs. rhythm ...
| Also Ranks for: Rhythm Control | life qol | persistent atrial | baseline study | electrical cardioversion |
OBJECTIVES: The purpose of this study was to evaluate left ventricular function and atrial and ventricular diameters in patients with persistent atrial fibrillation (AF) treated with rate or rhythm control.
BACKGROUND: Restoration of sinus rhythm in patients with persistent AF may improve left ventricular function and reduce atrial dimensions. Adequate rate control in AF may preserve ventricular function.
METHODS: In 335 patients included in the RAte Control versus Electrical ...
| Also Ranks for: Ventricular Function | rate control | persistent atrial fibrillation | electrical cardioversion | sinus rhythm patients |
A Comparison of Rate Control and Rhythm Control in Patients with Recurrent Persistent Atrial Fibrillation
[ PUBLICATION ]
BACKGROUND: Maintenance of sinus rhythm is the main therapeutic goal in patients with atrial fibrillation. However, recurrences of atrial fibrillation and side effects of antiarrhythmic drugs offset the benefits of sinus rhythm. We hypothesized that ventricular rate control is not inferior to the maintenance of sinus rhythm for the treatment of atrial fibrillation.
METHODS: We randomly assigned 522 patients who had persistent atrial fibrillation after a previous electrical cardioversion ...
| Also Ranks for: Rhythm Control | atrial fibrillation | primary point | patients rate | death cardiovascular |
BACKGROUND: Despite improvements in the management of atrial fibrillation, patients with this condition remain at increased risk for cardiovascular complications. It is unclear whether early rhythm-control therapy can reduce this risk.
METHODS: In this international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial, we randomly assigned patients who had early atrial fibrillation (diagnosed ≤1 year before enrollment) and cardiovascular conditions to receive ...
| Also Ranks for: Early Rhythm | atrial fibrillation | control therapy | patients usual | ventricular function |
OBJECTIVES: This study sought to study the association of atrial fibrillation (AF) with exercise capacity, left ventricular filling pressure, natriuretic peptides, and left atrial size in heart failure with preserved ejection fraction (HFpEF).
BACKGROUND: The diagnosis of HFpEF in patients with AF remains a challenge because both contribute to impaired exercise capacity, and increased natriuretic peptides and left atrial volume.
METHODS: We studied 94 patients with symptomatic heart ...
| Also Ranks for: Atrial Volume | natriuretic peptides | heart failure | exercise capacity | sinus rhythm |
Abnormalities in intracellular Ca2+ handling play a crucial role in the pathogenesis of heart failure. The reduced capacity of failing human myocardium to restore low resting Ca2+ levels during diastole has been explained by the impairment of Ca2+ uptake into the sarcoplasmic reticulum (SR) via the SR Ca2+ATPase. It is unclear whether Ca2+ATPase function, protein levels, and mRNA steady-state levels correspond to one other, and whether the cause of heart failure, namely idiopathic ...
| Also Ranks for: Protein Levels | sarcoplasmic reticulum | heart failure | dilated cardiomyopathy | patients dcm |
Aims: Atrial fibrillation (AF) is a progressive disease. Targeted therapy of underlying conditions refers to interventions aiming to modify risk factors in order to prevent AF. We hypothesised that targeted therapy of underlying conditions improves sinus rhythm maintenance in patients with persistent AF.
Methods and results: We randomized patients with early persistent AF and mild-to-moderate heart failure (HF) to targeted therapy of underlying conditions or conventional therapy. Both ...
| Also Ranks for: Underlying Conditions | sinus rhythm | atrial fibrillation | race 3 trial | cardiac rehabilitation |
BACKGROUND: There is a marked lack of evidence on the optimal prevention of ischaemic stroke and other thromboembolic events in patients with non-valvular atrial fibrillation and a recent intracerebral haemorrhage during treatment with oral anticoagulation. These patients are currently treated with oral anticoagulants, antiplatelet drugs, or no antithrombotic treatment, depending on personal and institutional preferences. Compared with warfarin, the direct oral anticoagulant apixaban ...
| Also Ranks for: Intracerebral Haemorrhage | patients atrial fibrillation | oral anticoagulation | antithrombotic drugs | risk stroke |
Comparison of strain imaging techniques in CRT candidates: CMR tagging, CMR feature tracking and speckle tracking echocardiography
[ PUBLICATION ]
Parameters using myocardial strain analysis may predict response to cardiac resynchronization therapy (CRT). As the agreement between currently available strain imaging modalities is unknown, three different modalities were compared. Twenty-seven CRT-candidates, prospectively included in the MARC study, underwent cardiac magnetic resonance (CMR) imaging and echocardiographic examination. Left ventricular (LV) circumferential strain was analysed with CMR tagging (CMR-TAG), CMR feature ...
| Also Ranks for: Strain Imaging | cmrft ste | tracking echocardiography | cmr tagging | dyssynchrony discoordination |
OBJECTIVES: The aim of this study was to investigate the influence of rate control on quality of life (QOL).
BACKGROUND: The RACE II (Rate Control Efficacy in Permanent Atrial Fibrillation II) trial showed that lenient rate control is not inferior to strict rate control in terms of cardiovascular morbidity and mortality. The influence of stringency of rate control on QOL is unknown.
METHODS: In RACE II, a total of 614 patients with permanent atrial fibrillation (AF) were randomized to ...
| Also Ranks for: Rate Control | atrial fibrillation | life qol | cardiovascular morbidity | severity scale |
BACKGROUND: Among patients with implantable pacemakers and defibrillators, subclinical atrial fibrillation (SCAF) is associated with an increased risk of stroke; however, there is limited understanding of their temporal relationship.
METHODS AND RESULTS: The Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT) enrolled 2580 pacemaker and defibrillator patients aged ≥65 years with a history of ...
| Also Ranks for: Temporal Relationship | atrial fibrillation | scaf stroke | systemic embolism | pacemaker patients |
Human SCN5A gene mutations alter cardiac sodium channel kinetics and are associated with the Brugada syndrome
[ PUBLICATION ]
BACKGROUND: Primary dysrhythmias other than those associated with the long QT syndrome, are increasingly recognized. One of these are represented by patients with a history of resuscitation from cardiac arrest but without any structural heart disease. These patients exhibit a distinct electrocardiographic (ECG) pattern consisting of a persistent ST-segment elevation in the right precordial leads often but not always accompanied by a right bundle branch block (Brugada syndrome). This ...
| Also Ranks for: Sodium Channel | brugada syndrome | scn5a gene | missense mutations | xenopus oocytes |
Isabelle C Van Gelder: Influence Statistics
| Concept | World rank |
|---|---|
| p002 shocks | #1 |
| atrial preventive | #1 |
| fallot icd therapy | #1 |
| atrial arrhythmias complications | #1 |
| hspb1 hspb6 hspb7 | #1 |
| function emptying fraction | #1 |
| surgical symptomatic patients | #1 |
| maze surgery patients | #1 |
| laaa atrial | #1 |
| control inferior | #1 |
| atrial remodeling induction | #1 |
| adjustment hasbled score | #1 |
| protective hspb1 | #1 |
| procedurerelated complications 14 | #1 |
| aads pvi | #1 |
| hspb mice myocytes | #1 |
| atriumenriched genes | #1 |
| transcatheter pvi | #1 |
| atrial remodeling tac | #1 |
| subclinical ait | #1 |
| absence antiarrhythmic drug | #1 |
| inadequate inr | #1 |
| nidcm ventricular remodeling | #1 |
| 96hour holter monitoring | #1 |
| fair icc comparisons | #1 |
| increased cimt cacs | #1 |
| systolic stretch icc | #1 |
| dyssynchronopathy | #1 |
| khairy colleagues | #1 |
| srssept ssi | #1 |
| magnitude echocardiographic remodelling | #1 |
| increased cimt association | #1 |
| patients ait aih | #1 |
| 48 adults chd | #1 |
| acwas | #1 |
| comparisons cmrft | #1 |
| antiarrhythmic drugs women | #1 |
| hspb8 tachycardia | #1 |
| positive spect cad | #1 |
| hspb1 tachycardia | #1 |
| sinus rhythm baseline | #1 |
| paroxysmal drug | #1 |
| complications surgical pvi | #1 |
| sex differences pharmacodynamics | #1 |
| ecv reason | #1 |
| stroke developments | #1 |
| ecv therapy | #1 |
| ultracinch | #1 |
| 67 male qrsduration | #1 |
| fibrillation progression | #1 |
Key People For Atrial Fibrillation
Isabelle C Van Gelder:Expert Impact
Concepts for whichIsabelle C Van Gelderhas direct influence:Atrial fibrillation, Heart failure, Rate control, Sinus rhythm, Rhythm control, Heart rate, Patients atrial fibrillation, Persistent atrial fibrillation.
Isabelle C Van Gelder:KOL impact
Concepts related to the work of other authors for whichfor which Isabelle C Van Gelder has influence:Atrial fibrillation, Heart failure, Catheter ablation, Sinus rhythm, Ischemic stroke, Oral anticoagulants, Major bleeding.
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