John L McGuire: Influence Statistics

John L McGuire

John L McGuire

Johnson & Johnson, New Brunswick, New Jersey, United States | Johnson & Johnson, New Brunswick, New Jersey, United States, 08933 | From The R. W. Johnson Pharmaceutical ...

John L McGuire: Expert Impact

Concepts for which John L McGuire has direct influence: Gnrh antagonist , Antifertility activity , Oral administration , Arachidonic acid , Uterine contractions , Uterine contractility , Preterm labor .

John L McGuire: KOL impact

Concepts related to the work of other authors for which for which John L McGuire has influence: Oral contraceptives , Ethinyl estradiol , Preterm labor , Uterine contractions , Contraceptive patch , Ovarian stimulation , Mast cells .

KOL Resume for John L McGuire

Year
2007

Johnson & Johnson, New Brunswick, New Jersey, United States

2000

Johnson & Johnson, New Brunswick, New Jersey, United States, 08933

1992

From The R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey

1990

Ortho Pharmaceutical Corporation Research Laboratories Raritan, New Jersey 08869

R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ 08876.

1988

Ortho Research Laboratories, Ortho Pharmaceutical Corporation, Raritan, New Jersey 08869, U.S.A.

Institute for Biomedical Research, University of Texas Austin, TX, USA

1987

The Reproductive Endocrine Unit and the Vincent Research Laboratories, Massachusetts General Hospital, Boston, MA, USA

Research Laboratories, Ortho Pharmaceutical Corporation, Raritan, New Jersey

1986

Research Laboratories, Ortho Pharmaceutical Corporation Raritan, New Jersey, USA.

1985

Research Laboratories Ortho Pharmaceutical Corporation Raritan, New Jersey 08869 USA

1984

Ortho Pharmaceutical Corporation Research Labs Route 202, Raritan, N.J. 08869, USA

1983

Research Laboratories, Ortho Pharmaceutical Corporation, Raritan, N.J. 08869.

1982

Research Laboratories, Ortho Pharmaceutical Corporation, 08869, Raritan, NJ, USA

1981

Research Laboratories Ortho Pharmaceutical Corporation Raritan, New Jersey

1980

M. S. Hershey Medical Center The Pennsylvania State University Hershey, Pennsylvania 17033 USA

1979

Drug Disposition Section, Ortho Pharmaceutical Corporation, Raritan, NJ 08869

1978

Ortho Pharmaceutical Corporation, Raritan, NJ 08869

1977

Research Lboratories Ortho Pharmaceutical Corporation Raritan, New Jersey 08869 USA

Prominent publications by John L McGuire

KOL-Index: 10585 . The progestational and androgenic in vitro receptor binding affinity and the in vivo activity of norgestimate was compared with that of its metabolites and other progestins. The relative binding affinities (RBAs) of norgestimate and its 17-deacetylated metabolite for rabbit uterine progestin receptors were similar to that of progesterone (P); those of 3-keto norgestimate and levonorgestrel ...
Known for Androgen Receptors | Norgestimate Progestins | Receptor Binding | Gestodene Levonorgestrel
KOL-Index: 9333 . Pituitary sensitivity to a gonadotropin-releasing hormone (GnRH) challenge test before, during, and after GnRH antagonist administration was compared in four ovariectomized female monkeys receiving GnRH antagonist intramuscularly (IM) at increasing doses of 0.3, 1.0, and 3.0 mg/kg/day over 9 days. Three days before and 3 days after treatment, monkeys received vehicle alone. On experiment ...
Known for Gnrh Antagonist | Releasing Hormone | Fsh Lh | Pituitary Suppression
KOL-Index: 6732 . The potencies and activities of six progestational agents, norethindrone, levonorgestrel, desogestrel, medroxyprogesterone acetate (MPA), progesterone (P) and norgestimate have been evaluated using standard laboratory bioassays. The endocrine activities measured are those most closely related to the clinically important actions of contraceptives. Relative potencies varied with parameter ...
Known for Norethindrone Levonorgestrel | Ovulation Inhibition | Oral Administration | Target Organs
KOL-Index: 6237 . An in situ model for studying factors related to dysmenorrhea and for evaluating drugs for their inhibitory effects on uterine contractility induced by arachidonic acid and prostaglandins has been developed. Intravenous administration of arachidonic acid and PGF2 alpha to guinea pigs during the late stage of the estrous cycle, induced dose related uterine contractions and an elevation in ...
Known for Arachidonic Acid | Uterine Contractions | Pgf2 Alpha | Animal Doseresponse Relationship
KOL-Index: 5996 . The relative binding affinity of norgestimate for human sex hormone-binding globulin was compared with that of its metabolites and other progestins by measuring their abilities to displace [3H]testosterone from this carrier protein in vitro. Norgestimate and its 17-deacetylated and 3-keto metabolites did not significantly displace [3H]testosterone from sex hormone-binding globulin at ...
Known for Binding Globulin | Sex Hormone | Levonorgestrel Norgestrel | Norgestimate Metabolites
KOL-Index: 5409 . Studies with an in situ preparation of guinea pig uterus suggest the possible involvement of the lipoxygenase pathway of arachidonic acid (AA) metabolism in myometrial contractions. Female guinea pigs were sensitized to ovalbumin (OA) on day one of their estrous cycle. On day 14, these pigs were anesthetized and the uterus was cannulated for measuring contractions. OA challenge, with ...
Known for Lipoxygenase Products | Antigen Challenge | Uterine Contractions | Guinea Pigs
KOL-Index: 5105 . In the lung, the contraction of smooth muscle, or bronchospasm, is generally caused by an immunologic insult resulting in mast cell degranulation and the release of histamine, slow reacting substances, and other mediators of inflammation (1). Although the immediate response is bronchospasm, continued activation of this sequence of events results in a chronic inflammatory disease. In the ...
Known for Arachidonic Acid | Smooth Muscle | Uterine Contraction | Guinea Pigs
KOL-Index: 4986 . Terconazole is a new triazole ketal derivative with broad-spectrum in vitro and in vivo antifungal activities. This study further characterizes the effects of terconazole in vitro on yeast cell growth, viability, and morphology. Terconazole inhibited the growth of Candida albicans ATCC 44859 in a concentration-related manner, but with modest effects noted at levels from 10(-8) to 10(-5) M ...
Known for Effects Terconazole | Electron Microscopy | Antifungal Agents | Candida Albicans
KOL-Index: 4815 . The effect of endometriosis on pregnancy, from ovulation through day 14 of pregnancy, was studied in an animal model previously developed and validated with the use of the rabbit. Endometrial tissue was implanted surgically in rabbits and allowed to grow for 11 weeks without hormonal supplementation. The animals were artificially inseminated with semen from bucks with established fertility ...
Known for Infertility Endometriosis | Endometrial Tissue | Animal Model | Embryo Implantation
KOL-Index: 4751 . Norgestimate is a novel progestin with highly selective progestational activity and minimal androgenicity. In rabbits, norgestimate binds to uterine progestin receptors, stimulates the endometrium, and inhibits ovulation. Norgestimate acts directly on target organs, stimulating rabbit endometrium when injected into the uterine cavity and inhibiting luteinizing hormone-releasing ...
Known for Androgenic Activity | Norgestimate Progestin | Androgen Receptors | Rabbits Rats
KOL-Index: 4672 . Biotransformation, pharmacologic, and pharmacokinetic studies of norgestimate and its metabolites indicate that 17-deacetyl norgestimate, along with the parent drug, contributes to the biologic response. The postulated metabolic pathway, which is based on the identification of urinary products had indicated that three metabolites of norgestimate, 17-deacetyl norgestimate, 3-keto ...
Known for Metabolites Norgestimate | Parent Drug | 17 Deacetyl | Serum Women
KOL-Index: 4159 . We attempted to characterize the ability of a new oxytocin derivative, 1-deamino[D-Tyr(Oethyl)2,Thr4,Orn8] vasotocin (ORF 22164), to antagonize the action of oxytocin in several in vitro and in vivo animal models of uterine hyperactivity. In these studies, the derivative was found to be a specific competitive inhibitor of oxytocin-induced contractions of pregnant guinea pig uterus in ...
Known for Preterm Labor | Uterine Contractility | Oxytocin Antagonist | Animal Models

Key People For Gnrh Antagonist

Top KOLs in the world
#1
Paul Devroey
ovarian stimulation embryo transfer intracytoplasmic sperm injection
#2
Klaus Diedrich
ovarian stimulation embryo transfer vitro fertilization
#3
Efstratios M Kolibianakis
ovarian stimulation gnrh antagonist poor responders
#4
Hesham Gaber Al‐Inany
embryo transfer pregnancy rate culture media
#5
Basil C Tarlatzis
ovarian stimulation vitro fertilization oocyte maturation
#6
André C Van Steirteghem
intracytoplasmic sperm injection embryo transfer vitro fertilization

Johnson & Johnson, New Brunswick, New Jersey, United States | Johnson & Johnson, New Brunswick, New Jersey, United States, 08933 | From The R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey | Ortho Pharmaceutical Corporation Resear