 | Hideaki HamanoShow email addressDepartment of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan. | Department of Medicine, Division of ... |
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Hideaki Hamano:Expert Impact
Concepts for whichHideaki Hamanohas direct influence:Autoimmune pancreatitis,Sclerosing pancreatitis,Autoimmune pancreatitis aip,3 years,Pancreatic cancer,Steroid therapy,Chronic pancreatitis,Duodenal papilla.
Hideaki Hamano:KOL impact
Concepts related to the work of other authors for whichfor which Hideaki Hamano has influence:Autoimmune pancreatitis,Igg4related disease,Immunoglobulin g4,Pancreatic cancer,Steroid therapy,Sclerosing cholangitis,Retroperitoneal fibrosis.
KOL Resume for Hideaki Hamano
| Year | |
|---|---|
| 2022 | Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan. Nagano Prefectural Kiso Hospital, Kiso, Japan |
| 2020 | Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan. Division of Medical Informatics, Shinshu University Hospital, Matsumoto, Japan |
| 2019 | Department of Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan; |
| 2018 | Department of Medical Information, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan |
| 2017 | Division of Hepatology and Gastroenterology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan |
| 2016 | Medical Informatics Division and Internal Medicine, Gastroenterology, Shinshu University Hospital, Matsumoto, Japan |
| 2015 | From the Department of Gastroenterology, the Endoscopic Examination Center, and the Center for Health, Safety, and Environmental Management, Shinshu University School of Medicine, Matsumoto, Japan.J. Asano, MD, Department of Gastroenterology, Shinshu University School of Medicine; T. Watanabe, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; T. Oguchi, MD, Department of Gastroenterology, Shinshu University School of Medicine; K. Kanai, MD, Department of Gastroenterology, Shinshu University School of Medicine; M. Maruyama, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; T. Ito, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; T. Muraki, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; H. Hamano, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; N. Arakura, MD, PhD, Endoscopic Examination Center, Shinshu University School of Medicine; A. Matsumoto, MD, PhD, Department of Gastroenterology, Shinshu University School of Medicine; S. Kawa, MD, PhD, Center for Health, Safety, and Environmental Management, Shinshu University. Second Dept of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan |
| 2014 | Shinshu University School of Medicine Second Department of Internal Medicine Matsumoto Japan |
| 2013 | Department of Gastroenterology, Shinshu University School of Medicine, Japan Shinshu University Hospital Medical Informatics Division and Internal Medicine, Gastroenterology Matsumoto |
| 2012 | Division of Medical Informatics, Department of Internal Medicine, Gastroenterology; Shinshu University Hospital; Matsumoto Japan |
| 2011 | Second Dept of Internal Medicine |
| 2010 | Second Department of Internal Medicine, Shinshu University School of Medicine |
| 2009 | Department of Gastroenterology, Shinshu University School of Medicine |
| 2008 | Department of Internal Medicine, Division of Gastroenterology and Hepatology, Matsumoto, Japan |
| 2007 | *Department of Internal Medicine and Gastroenterology, †Center for Health, Safety and Environmental Management, and Departments of ‡Surgery and §Biomedical Laboratory Sciences, Shinshu University School of Medicine, Matsumoto, Japan. Department of Internal Medicine, Division of Hepatology and Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan |
| 2006 | From the *Department of Medicine and Gastroenterology; and †Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. the Second Department of Internal Medicine, Shinshu University School of Medicine |
| 2005 | Current affiliations: Department of Medicine, Gastroenterology, Department of Laboratory Medicine, Department of Surgery, Gastroenterology, Shinshu University School of Medicine, Matsumoto, Japan |
| 2004 | Current affiliations: Department of Medicine, Department of Laboratory Medicine, and Department of Endoscopy, Shinshu University School of Medicine, Matsumoto, Japan |
| 2003 | *Second Department of Internal Medicine and †Department of Radiology, Shinshu University School of Medicine, Matsumoto, Japan |
| 2002 | Current affiliations: The Second Department of Internal Medicine and the Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan |
| 2001 | From the Second Department of Internal Medicine (H.H., S.K., A.H., H.U., N.F., T.A., K.K.) and the Departments of Laboratory Medicine (M.F.), Obstetrics and Gynecology (T.N.), Organ Generation (T.N.), and Anatomy (K.N.), Shinshu University School of Medicine, Matsumoto, Japan |
| 2000 | Second Department of Internal Medicine and the First Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan |
| Concept | World rank |
|---|---|
| tbs reagent | #1 |
| 3 patients pancreatitis | #1 |
| enlarged lacrimal gland | #1 |
| median igg4rrd patients | #1 |
| eventual treatment volume | #1 |
| enlarged lacrimal | #1 |
| balf igg4 | #1 |
| fundus symptoms | #1 |
| new igg4 | #1 |
| igg4rrd patients median | #1 |
| biopsy specimen pericardium | #1 |
| igg4rrd sarcoidosis | #1 |
| tlymphocyte infiltration papilla | #1 |
| fluid igg4 | #1 |
| enlarged bilateral | #1 |
| glands globes | #1 |
| balf igg4rrd patients | #1 |
| values method comparison | #1 |
| duodenal papilla pancreatitis | #1 |
| patients sclerosing pancreatitis | #1 |
| balf levels ccl1 | #1 |
| pericardium massive infiltration | #1 |
| papilla sclerosing | #1 |
| pericardium biopsy specimen | #1 |
| dacyroadenitis presenting | #1 |
| differential humans immunoglobulin | #1 |
| disease 60yearold woman | #1 |
| igg4 reference interval | #1 |
| ccl1 sarcoidosis patients | #1 |
| duodenal papilla diagnosis | #1 |
| pancreatitis unique | #1 |
| variety extra | #1 |
| ccl1 levels balf | #1 |
| aged autoimmune | #1 |
| globe compression | #1 |
| dacryoadenitis chorioretinal | #1 |
| manifestation igg4related disease | #1 |
| normal ercp findings | #1 |
| igg4 reference | #1 |
| serum igg4 concentrations | #1 |
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Prominent publications by Hideaki Hamano
BACKGROUND: Sclerosing pancreatitis is a unique form of pancreatitis that is characterized by irregular narrowing of the main pancreatic duct, lymphoplasmacytic inflammation of the pancreas, and hypergammaglobulinemia and that responds to glucocorticoid treatment. Preliminary studies suggested that serum IgG4 concentrations are elevated in this disease but not in other diseases of the pancreas or biliary tract.
METHODS: We measured serum IgG4 concentrations using single radial ...
| Known for Sclerosing Pancreatitis | Serum Igg4 Concentrations | Immune Complexes | Igg4 Subclass | Glucocorticoid Therapy |
OBJECTIVE: To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP).
METHODS: A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse.
RESULTS: Of 563 patients with AIP, 459 (82%) received steroid treatment. The remission rate of steroid-treated AIP was 98%, which was significantly higher than that of patients without steroid treatment (74%, 77/104; p<0.001). Steroid ...
| Known for Steroid Treatment | Autoimmune Pancreatitis | Patients Aip | Remission Rate | Maintenance Dose |
BackgroundFluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has been widely used for the diagnosis of pancreatic cancer. Because autoimmune pancreatitis is easily misdiagnosed as pancreatic cancer and can be tested for by FDG-PET analysis based on the presence of suspected pancreatic cancer, we attempted to clarify the differences in FDG-PET findings between the two conditions.MethodsWe compared FDG-PET findings between 15 patients with autoimmune pancreatitis and 26 ...
| Known for Autoimmune Pancreatitis | Pancreatic Cancer | Emission Tomography | Fluorodeoxyglucose Positron | Fdg Pet |
Prevalence and distribution of extrapancreatic lesions complicating autoimmune pancreatitis
[ PUBLICATION ]
BackgroundAutoimmune pancreatitis is a unique form of chronic pancreatitis characterized by high serum IgG4 concentrations and abundant IgG4-bearing plasma cell infiltration in the pancreatic lesion, and it has been reported to be associated with a variety of extrapancreatic lesions, leading us to postulate the concept of a systemic inflammatory disease. To confirm this, we clarified the exact distribution of these extrapancreatic lesions and provide a panoramic view of them.MethodsThe ...
| Known for Extrapancreatic Lesions | Chronic Pancreatitis | Systemic Inflammatory Disease | Characteristic Findings | Corticosteroid Therapy |
HLA DRB1*0405-DQB1*0401 haplotype is associated with autoimmune pancreatitis in the Japanese population
[ PUBLICATION ]
BACKGROUND & AIMS: Autoimmune pancreatitis is a distinctive disease entity characterized by high serum immunoglobulin G4 concentrations. Because of the close association between some autoimmune diseases and particular alleles of major histocompatibility complex genes, we investigated the association between HLA alleles and autoimmune pancreatitis.
METHODS: HLA-A, -B, -C, -DR, and -DQ gene typing and HLA-DRB1, -DQB1, and -DPB1 allele typing were performed by the polymerase chain reaction ...
| Known for Autoimmune Pancreatitis | Japanese Population | Hla Drb10405 | Dqb10401 Haplotype | 40 Patients |
Immunoglobin G4‐hepatopathy: Association of immunoglobin G4‐bearing plasma cells in liver with autoimmune pancreatitis
[ PUBLICATION ]
Autoimmune pancreatitis (AIP) is characterized by high serum immunoglobin (Ig) G4 concentrations, lymphoplasmacytic inflammation, and a favorable response to corticosteroid treatment. Since liver dysfunction is frequently seen in AIP patients, we investigated hepatic histopathology and its clinical significance in patients with AIP. We examined the clinical features, histology, and immunoglobin G (IgG)4-bearing plasma cell infiltration of liver biopsies from 17 patients with AIP and 63 ...
| Known for Autoimmune Pancreatitis | Aip Patients | Bearing Plasma | Liver Biopsies | Interface Hepatitis |
BACKGROUND: A wide variety of systemic lesions have been seen in patients with autoimmune pancreatitis. The pulmonary involvement of autoimmune pancreatitis was analysed to clarify the clinicopathological features of pulmonary lesions in comparison with pulmonary sarcoidosis.
MATERIALS AND METHODS: Nineteen patients had autoimmune pancreatitis and eight had pulmonary sarcoidosis. The symptoms, laboratory data, chest computed tomography, Gallium-67 scintigraphy, pulmonary function testing ...
| Known for Autoimmune Pancreatitis | Pulmonary Involvement | Chest Computed Tomography | Bronchoalveolar Lavage | Laboratory Data |
Distinct clinicopathological entity ‘autoimmune pancreatitis‐associated sclerosing cholangitis’
[ PUBLICATION ]
Autoimmune pancreatitis (AIP) is a recently proposed disease entity, in which an elevated serum IgG4 is characteristic. This disease is sometimes associated with other inflammatory diseases: Sjögren's disease, or sclerosing cholangitis. The aim of the present paper was to examine the difference in pathophysiology between AIP-associated sclerosing cholangitis (AIP-SC) and primary sclerosing cholangitis (PSC). The clinicopathological findings and the immunohistochemical expressions of IgG ...
| Known for Sclerosing Cholangitis | Autoimmune Pancreatitis | Steroid Therapy | Differential Female Humans | Igg4 Disease |
Establishment of a serum IgG4 cut‐off value for the differential diagnosis of IgG4‐related sclerosing cholangitis: A Japanese cohort
[ PUBLICATION ]
BACKGROUND AND AIM: IgG4-related sclerosing cholangitis (IgG4-SC) must be precisely distinguished from primary sclerosing cholangitis and cholangiocarcinoma (CC) because the treatments are completely different. However, the pathological diagnosis of IgG4-SC is difficult. Therefore, highly specific non-invasive criteria such as serum IgG4 should be established. This study established a cut-off for serum IgG4 to differentiate IgG4-SC from respective controls using serum IgG4 levels ...
| Known for Serum Igg4 | Differential Diagnosis | Sclerosing Cholangitis | Pancreatic Cancer | Sensitivity Specificity |
Association of Autoimmune Pancreatitis With Cytotoxic T-lymphocyte Antigen 4 Gene Polymorphisms in Japanese Patients
[ PUBLICATION ]
OBJECTIVES: Autoimmune pancreatitis (AIP) is characterized by high serum IgG4 concentrations, lymphoplasmacytic inflammation, and a favorable response to corticosteroid treatment. Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors is largely unknown. As cytotoxic T-lymphocyte antigen 4 (CTLA4) polymorphisms have recently been linked with several autoimmune diseases, we sought to determine if ...
| Known for Autoimmune Pancreatitis | Japanese Patients | Chronic Polymorphism | Antigen 4 | Aip Genetic |
BackgroundIgG4-related disease (IgG4-RD) is a novel clinical disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4+ plasma cells. Although IgG4-RD is not rare and is clinically important, its clinical diagnostic criteria have not been established. Comprehensive diagnostic criteria for IgG4-RD, including the involvement of various organs, are intended for the practical use of general physicians and nonspecialists.MethodsTwo ...
| Known for Diagnostic Criteria Igg4rd | General Physicians | Cells Igg4 | Tissue Infiltration | Autoimmune Diseases |
Randomised controlled trial of long-term maintenance corticosteroid therapy in patients with autoimmune pancreatitis
[ PUBLICATION ]
OBJECTIVE: Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP.
DESIGN: We conducted a multicentre, tertiary setting, randomised controlled trial. After the induction of remission with the initial oral prednisolone (PSL) treatment, maintenance ...
| Known for Maintenance Therapy | Autoimmune Pancreatitis | Randomised Controlled Trial | 3 Years | Patients Aip |
Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis
[ PUBLICATION ]
We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet to be established. To dissect the genetic contribution of the incriminated haplotype, we have now performed an association analysis within the human leukocyte antigen (HLA) ...
| Known for Autoimmune Pancreatitis | Hla Region | Association Analysis | Genes Aip | Genetic Contribution |
Usefulness of endoscopic observation of the main duodenal papilla in the diagnosis of sclerosing pancreatitis
[ PUBLICATION ]
BACKGROUND: There are no descriptions of the appearance of the main duodenal papilla in sclerosing pancreatitis. The intent of the present study was to clarify the characteristics of the main duodenal papilla in patients with sclerosing pancreatitis.
METHODS: Macroscopic findings at ERCP with reference to the main duodenal papilla of 17 patients with sclerosing pancreatitis were compared with those of 24 patients with normal ERCP findings, 11 with chronic pancreatitis, 13 with primary ...
| Known for Duodenal Papilla | Pancreatic Cancer | Chronic Pancreatitis | 3 Patients | Primary Sclerosing Cholangitis |
Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis
[ PUBLICATION ]
PURPOSE: Autoimmune pancreatitis is a unique form of chronic pancreatitis characterized by a variety of extra-pancreatic involvements which are frequently misdiagnosed as lesions of corresponding organs. The purpose of this study was to clarify the diagnostic imaging features of extra-pancreatic lesions associated with autoimmune pancreatitis.
MATERIALS AND METHODS: We retrospectively analyzed diagnostic images of 90 patients with autoimmune pancreatitis who underwent computer-assisted ...
| Known for Autoimmune Pancreatitis | Characteristic Findings | Pancreatic Lesions | Wall Thickening | Steroid Therapy |
