• Autoimmune Pancreatitis
    • Kazuichi Okazaki
    • Kazuichi Okazaki: Influence Statistics

      Kazuichi Okazaki

      Kazuichi Okazaki

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      Department of Internal Medicine Kansai Medical University Kori Hospital Neyagawa Japan | Department of Internal Medicine, Kansai Medical University Kori Hospital, Neyagawa, ...

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      Kazuichi Okazaki:Expert Impact

      Concepts for whichKazuichi Okazakihas direct influence:Autoimmune pancreatitis,Chronic pancreatitis,Pancreatic cancer,Autoimmune pancreatitis aip,Acute pancreatitis,Igg4related disease,Ulcerative colitis,Type 1.

      Kazuichi Okazaki:KOL impact

      Concepts related to the work of other authors for whichfor which Kazuichi Okazaki has influence:Autoimmune pancreatitis,Pancreatic cancer,Igg4related disease,Hepatocellular carcinoma,Helicobacter pylori,Ulcerative colitis,Immunoglobulin g4.

      KOL Resume for Kazuichi Okazaki


      Department of Internal Medicine Kansai Medical University Kori Hospital Neyagawa Japan


      Kansai Medical University Kori Hospital, Neyagawa, Japan


      The Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan.

      Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Osaka, Japan


      The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan;, View further author information

      Department of Gastroenterology and Hepatology Kansai Medical University, Hirakata, Japan


      Kansai Medical University, Osaka, Japan


      From the *Clinic of Fukuoka Government Building, Hamanomachi Hospital, Fukuoka; †Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital; ‡Department of Gastroenterology, Tokyo Women's Medical University; §Department of Medical Oncology, Faculty of Medicine, Kyorin University; ∥Department of Radiation Oncology, National Cancer Center Hospital, Tokyo; ¶Department of Gastroenterology, JA Onomichi General Hospital, Onomichi; #Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai; and **Department of Gastroenterology and Hepatology, Kansai Medical University, Hirakata, Japan.

      Third Department of Internal Medicine, Kansai Medical University, Hirakata, Japan


      Third Department of Internal Medicine, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan


      Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka 573-1191, Japan;

      Kansai Medical University, Moriguchi, Japan


      The Third Department of Internal Medicine, Kansai Medical University, Osaka, Japan


      The Third Department of Internal Medicine Division of Gastroenterology and Hepatology, Kansai Medical University, Shinmachi, Hirakata, Osaka 573-1197 Japan

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      Sample of concepts for which Kazuichi Okazaki is among the top experts in the world.
      Concept World rank
      presence naïve papilla #1
      secretion mucinrelated products #1
      mst1 aip patients #1
      serum levels ics #1
      lymphoplasmacytic infiltrations #1
      5 major criteria #1
      linker threonine #1
      short dbe #1
      postes bleeding study #1
      aip hc #1
      28mm channel #1
      appendix priming site #1
      aip tregs #1
      5 region rassf5crapl #1
      patients igg4related aip #1
      pac followup #1
      numbers igg4positive cells #1
      proven lymphoplasmacytic #1
      creactive protein patient #1
      hse solution papilla #1
      net 0000 ± #1
      igg4 “ #1
      easy snare #1
      aip regulatory transforming #1
      biliary stenosis improvement #1
      langerhans lactoferrin #1
      diagnostic algorithm aip #1
      japanese autoimmune pancreatitis #1
      publication dissection endoscopy #1
      decompensated cirrhosis cholangiocarcinoma #1
      antibodies is900gst #1
      cd3 cells uc #1
      gastric inflammatory #1
      murine experimental pancreatitis #1
      developed short‐type #1
      emerging disease entity #1
      serum gammaglobulin #1
      pancreatic biopsy patient #1
      subclinical gastric anisakiasis #1
      autoimmunerelated pancreatitis aip #1
      icdc japan #1
      aip proposed #1
      lps serum levels #1
      appendix apan #1
      mimicking gallbladder #1
      dbercp co2 insufflation #1
      prevalence malignant disease #1
      colon tumours sites #1
      hypermethylation mst1 #1
      rouxeny cholangiopancreatography anastomosis #1
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      Prominent publications by Kazuichi Okazaki

      KOL-Index: 17659

      Although hepatocyte growth factor (HGF) can act synergistically or antagonistically with transforming growth factor-β (TGF-β) signaling, molecular mechanism of their crosstalk remains unknown. Using antibodies which selectively distinguished receptor-regulated Smads (R-Smads) phosphorylated at linker regions from those at C-terminal regions, we herein showed that either HGF or TGF-β treatment of normal stomach-origin cells activated the JNK pathway, thereafter inducing endogenous R-Smads ...

      Known for Linker Regions | Tgf Β | Protein Kinase | Jnk Pathway | Hepatocyte Growth Factor
      KOL-Index: 16429

      Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis B progression. Transforming growth factor beta (TGF-beta) signaling involves both tumor suppression and oncogenesis. TGF-beta activates TGF-beta type I receptor (TbetaRI) and c-Jun N-terminal kinase (JNK), which differentially phosphorylate the mediator Smad3 to become C-terminally phosphorylated Smad3 (pSmad3C) and linker-phosphorylated Smad3 (pSmad3L). Reversible shifting of ...

      Known for Tumor Suppression | Growth Factor | Chronic Hepatitis | Hepatocellular Carcinoma Hcc | Smad3 Protein
      KOL-Index: 14903

      After liver injury, transforming growth factor-beta (TGF-beta) and platelet-derived growth factor (PDGF) regulate the activation of hepatic stellate cells (HSCs) and tissue remodeling. Mechanisms of PDGF signaling in the TGF-beta-triggered cascade are not completely understood. TGF-beta signaling involves phosphorylation of Smad2 and Smad3 at linker and C-terminal regions. Using antibodies to distinguish Smad2/3 phosphorylated at linker regions from those phosphorylated at C-terminal ...

      Known for Growth Factor | Liver Injury | Smad2 3 | Linker Regions | Stellate Cells
      KOL-Index: 14591

      Many patients with chronic hepatitis caused by hepatitis C virus (HCV) infection develop liver fibrosis with high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear. Conversely, transforming growth factor beta (TGF-beta) activates not only TGF-beta type I receptor (TbetaRI) but also c-Jun N-terminal kinase (JNK), which convert the mediator Smad3 into two distinctive phosphoisoforms: C-terminally phosphorylated Smad3 (pSmad3C) and ...

      Known for Chronic Inflammation | Growth Factor | Hepatocellular Carcinoma | Cirrhosis Hcc | Virus Infection
      KOL-Index: 13774

      ObjectivesPatients with autoimmune pancreatitis (AIP) characteristically show elevated serum levels of immunoglobulin G4 (IgG4) and abundant infiltration of IgG4-positive plasmacytes in the involved organs. The most common involved organ showing extrapancreatic lesions is the bile duct, which exhibits sclerosing cholangitis (SC). However, the role of IgG4 in the development of IgG4-related SC (IgG4-SC) remains unclear. To clarify the role of IgG4 in IgG4-SC, we have performed an ...

      Known for Liver Diseases | Plasma Cells | Sclerosing Cholangitis | Patients Psc | Igg4 Igg4sc
      KOL-Index: 13639

      BACKGROUND: The aims of this study were to characterize the features of the biliary strictures that occur after duct-to-duct biliary reconstruction during right-lobe living-donor liver transplantation (LDLT) and to evaluate the feasibility of correcting such stricture endoscopically by inserting an "inside stent," that is, a short internal stent, above the sphincter of Oddi.

      METHODS: Biliary stricture occurred in 26 (35.6%) of 73 consecutive patients who underwent right-lobe LDLT with ...

      Known for Biliary Stricture | Endoscopic Management | Lobe Living | Inside Stent | Liver Transplantation
      KOL-Index: 13087

      BACKGROUND AND STUDY AIMS: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) with 25-gauge needles yields small volume samples that are mainly processed for cytology. Using 25-gauge needles with a core trap may overcome this limitation. This trial compared 25-gauge needles with and without a core trap in terms of their ability to obtain histologic samples from solid pancreatic masses.

      PATIENTS AND METHODS: Consecutive patients with solid pancreatic masses who presented to ...

      Known for Core Trap | Pancreatic Masses | Endoscopic Ultrasound | Histologic Diagnosis | Multicenter Randomized Trial
      KOL-Index: 12728

      Transforming growth factor (TGF)-beta initially inhibits growth of mature epithelial cells. Later, however, autocrine TGF-beta signaling acts in concert with the Ras pathway to induce a proliferative and invasive phenotype. TGF-beta activates not only TGF-beta type I receptor (TbetaRI) but also Ras-associated kinases, which differentially phosphorylate the mediators Smad2 and Smad3 to create distinct phosphorylated forms: COOH-terminally phosphorylated Smad2/3 (pSmad2C and pSmad3C) and ...

      Known for Colorectal Cancer | Smad2 Smad3 | Tgf Beta | Neoplastic Genes | Cell Growth
      KOL-Index: 12609

      OBJECTIVE: To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP).

      METHODS: A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse.

      RESULTS: Of 563 patients with AIP, 459 (82%) received steroid treatment. The remission rate of steroid-treated AIP was 98%, which was significantly higher than that of patients without steroid treatment (74%, 77/104; p<0.001). Steroid ...

      Known for Steroid Treatment | Autoimmune Pancreatitis | Patients Aip | Remission Rate | Maintenance Dose
      KOL-Index: 12085

      BACKGROUND: This study assessed the risk of recurrence of esophageal varices by evaluating the severity of cardia vascular structures in patients with portal hypertension by EUS with a catheter US probe before endoscopic variceal ligation.

      METHODS: Thirty consecutive patients with esophageal varices at high risk for bleeding were studied. Simultaneous conventional endoscopy and EUS with a 20 MHz catheter US probe were performed before endoscopic variceal ligation. By catheter US probe ...

      Known for Gastric Cardia | Variceal Recurrence | Esophageal Varices | Patients Portal Hypertension | Vascular Structures
      KOL-Index: 12027

      Autoimmune pancreatitis (AIP) has been characterized by unique clinical imaging, immunological findings, and the effectiveness of steroid therapy. A set of clinicopathological criteria for AIP was proposed by the Japan Pancreatic Society in 2002, and AIP has come to be widely recognized among general digestive clinicians. However, the indication of steroid therapy for AIP is still not well established, and furthermore the therapeutic doses and method of administration of steroid therapy ...

      Known for Autoimmune Pancreatitis | Steroid Therapy | Clinical Manifestations | Aip Japan | Complete Remission
      KOL-Index: 11924

      BackgroundEpinephrine sprayed on the papilla may reduce papillary edema and thus prevent acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to determine the efficacy of this technique for prevention of post- ERCP pancreatitis.MethodsPatients scheduled for ERCP were recruited into this study. We randomized the patients to have 10 ml of either 0.02% epinephrine (epinephrine group) or saline (control group) sprayed on the papilla after ...

      Known for Ercp Pancreatitis | Epinephrine Sprayed | Pancreatic Duct | Papilla Prevention | Vater Cholangiopancreatography
      KOL-Index: 11610

      Chronic infection with hepatitis B virus (HBV) is strongly associated with hepatocellular carcinoma (HCC), and the viral HBx protein plays a crucial role in the pathogenesis of liver tumors. Because the protooncogene pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in HCC, we investigated the regulation of this protein by HBx. We analyzed PTTG1 expression levels in liver biopsies from patients chronically infected with HBV, presenting different disease stages, and from HBx ...

      Known for Pituitary Tumor | Hepatitis Virus | Transforming Gene | Hbv Hcc | Protein Hbx

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      Department of Internal Medicine Kansai Medical University Kori Hospital Neyagawa Japan | Department of Internal Medicine, Kansai Medical University Kori Hospital, Neyagawa, Osaka, Japan. | The Third Department of Internal Medicine, Division of Gastro

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