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    • Tamotsu Yoshimori
    • Tamotsu Yoshimori

      Tamotsu Yoshimori

      Department of Genetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan | Integrated Frontier Research for Medical Science Division, ...



      KOL Resume for Tamotsu Yoshimori


      Department of Genetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan


      Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan


      Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan


      Department of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, 565-0871 Japan


      Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan; Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, View further author information


      Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan;

      Graduate School of Frontier Biosciences Osaka University Laboratory of Intracellular Membrane Dynamics Osaka Japan


      b Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, Osaka University , Osaka , Japan.

      Department of Genetics Osaka University Graduate School of Medicine Osaka Japan

      Research Center for Autophagy


      Osaka University Department of Genetics Graduate School of Medicine Japan


      Osaka University Graduate School of Medicine Department of Genetics Osaka Japan


      Japan Science and Technology Agency CREST Tokyo Japan


      Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan


      Department of Cellular Regulation, Research Institute for Microbial Disease, Osaka University, Suita‐Osaka 565‐0871, Japan


      Department of Genetics, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan; and



      Tamotsu Yoshimori: Influence Statistics

      Sample of concepts for which Tamotsu Yoshimori is among the top experts in the world.
      Concept World rank
      transgolgi area acrosome #1
      inpp5e genes #1
      gtr2 npr2npr3 #1
      pi3phosphatase developments #1
      recognition ubiquitinated target #1
      progress hepacivirus hepatocytes #1
      skd1e235q accumulation #1
      autophagosome apg8 aut7p #1
      nutrients catabolites #1
      gas xenophagy #1
      essential proteins studies #1
      lap bacterial infection #1
      helixloophelix knockout mice #1
      mitophagy autophagosome #1
      protein skd1 #1
      snapin endosome maturation #1
      typhimurium spi1 ttss #1
      pikfyve aaa atpase #1
      egf fluorescence microscopy #1
      inpp5e lysosomes #1
      atg9l1 #1
      npc2 npc1 ubiquitylation #1
      hsp90 signaling peptides #1
      ultimately fuse #1
      lysophagy lysosomal damage #1
      lc3 accumulation #1
      iron‐induced ubiquitylation #1
      aps unique organelles #1
      phospholipids autophagosome formation #1
      atg12–516l1 complex #1
      npr3 mutants #1
      mature fimbriae vds #1
      doublemembrane organelles #1
      transmembrane protein snare #1
      appearance endocytosed hrp #1
      major resident protein #1
      ubiquitin xenophagy #1
      protein beclin1 protein #1
      mvps2 skd1 #1
      50 ptdins #1
      skd1 membrane transport #1
      embryo atg5 #1
      expanded lysosomes #1
      atg16l2 phagophores #1
      tscassociated hypopigmentation #1
      gingipain cysteine electron #1
      atpase activity skd1 #1
      autophagy biomarkers blotting #1
      cells lysotracker #1
      lysosomes autophagic degradation #1


      Prominent publications by Tamotsu Yoshimori

      KOL-Index: 19483

      Alix (ALG-2-interacting protein X) is a 95-kDa protein that interacts with an EF-hand type Ca(2+)-binding protein, ALG-2 (apoptosis-linked gene 2), through its C-terminal proline-rich region. In this study, we searched for proteins that interact with human AlixDeltaC (a truncated form not containing the C-terminal region) by using a yeast two-hybrid screen, and we identified two similar human proteins, CHMP4a and CHMP4b (chromatin-modifying protein; charged multivesicular body protein), ...

      Known for Protein Alix | Multivesicular Body | Diverse Cellular Activities | Hela Cells | Fluorescence Models
      KOL-Index: 15522

      Autophagy plays a crucial role in host defense, termed antimicrobial autophagy (xenophagy), as it functions to degrade intracellular foreign microbial invaders such as group A Streptococcus (GAS). Xenophagosomes undergo a stepwise maturation process consisting of a fusion event with lysosomes, after which the cargoes are degraded. However, the molecular mechanism underlying xenophagosome/lysosome fusion remains unclear. We examined the involvement of endocytic soluble ...

      Known for Vti1b Vamp8 | Canonical Autophagosomes | Antimicrobial Autophagy | Snare Proteins | Sensitive Factor
      KOL-Index: 14680

      Ligand-activated receptor tyrosine kinases undergo endocytosis and are transported via endosomes to lysosomes for degradation. This "receptor down-regulation" process is crucial to terminate the cell proliferation signals produced by activated receptors. During the process, ubiquitination of the receptors serves as a sorting signal for their trafficking from endosomes to lysosomes. Here, we describe the role of a deubiquitinating enzyme UBPY/USP8 in the down-regulation of epidermal ...

      Known for Epidermal Growth Factor | Egfr Ubpy | Egf Receptor | Endosomal Sorting | Deubiquitinating Enzyme
      KOL-Index: 14673

      Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) regulates viral replication through its interaction with host and other viral proteins. We have previously shown that FK506-binding protein 8 (FKBP8) binds to NS5A and recruits Hsp90 to form a complex that participates in the replication of HCV. In this study, we examined the biochemical characteristics of the interaction and the intracellular localization of NS5A and FKBP8. Surface plasmon resonance analysis revealed that the ...

      Known for Viral Replication | Ns5a Fkbp8 | Hepatitis Virus | Protein Interaction | Acid Mutation
      KOL-Index: 14382

      Lipomannan (LM) and lipoarabinomannan (LAM) are mycobacterial glycolipids containing a long mannose polymer. While they are implicated in immune modulations, the significance of LM and LAM as structural components of the mycobacterial cell wall remains unknown. We have previously reported that a branch-forming mannosyltransferase plays a critical role in controlling the sizes of LM and LAM and that deletion or overexpression of this enzyme results in gross changes in LM/LAM structures. ...

      Known for Cell Wall | Lm Lam | Critical Roles | Mycobacterium Tuberculosis | Lipomannan Lipoarabinomannan
      KOL-Index: 13882

      Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease worldwide. It encompasses a spectrum ranging from simple steatosis to fatty liver with hepatocellular injury, termed nonalcoholic steatohepatitis. Recent studies have demonstrated hepatic autophagy being impaired in NAFLD. In the present study, we investigated the impact of Rubicon, a Beclin1-interacting negative regulator for autophagosome-lysosome fusion, in the pathogenesis of NAFLD. In HepG2 cells, BNL-CL2 ...

      Known for Fatty Liver | Hepatocyte Apoptosis | Lipid Accumulation | Autophagy Impairment | Rubicon Mice
      KOL-Index: 13657

      The mouse SKD1 is an AAA-type ATPase homologous to the yeast Vps4p implicated in transport from endosomes to the vacuole. To elucidate a possible role of SKD1 in mammalian endocytosis, we generated a mutant SKD1, harboring a mutation (E235Q) that is equivalent to the dominant negative mutation (E233Q) in Vps4p. Overexpression of the mutant SKD1 in cultured mammalian cells caused defect in uptake of transferrin and low-density lipoprotein. This was due to loss of their receptors from the ...

      Known for Yeast Vps4p | Mammalian Cells | Diverse Cellular Activities | Proteins Sequence Homology | Mutant Skd1
      KOL-Index: 13647

      Multikinase inhibitor sorafenib inhibits proliferation and angiogenesis of tumors by suppressing the Raf/MEK/ERK signaling pathway and VEGF receptor tyrosine kinase. It significantly prolongs median survival of patients with advanced hepatocellular carcinoma (HCC) but the response is disease-stabilizing and cytostatic rather than one of tumor regression. To examine the mechanisms underlying the relative resistance in HCC, we investigated the role of autophagy, an evolutionarily conserved ...

      Known for Hepatocellular Carcinoma | Hepatoma Cells | Sorafenib Hcc | Autophagic Flux | Multikinase Inhibitor
      KOL-Index: 13046

      NRAMP2 (natural resistance-associated macrophage protein 2)/DMT1 (divalent metal transporter 1) is a divalent metal transporter conserved from prokaryotes to higher eukaryotes that exhibits an unusually broad substrate range, including Fe(2+), Zn(2+), Mn(2+), Cu(2+), Cd(2+), Co(2+), Ni(2+), and Pb(2+), and mediates active proton-coupled transport. Recently, it has been shown that the microcytic anemia (mk) mouse and the Belgrade (b) rat, which have inherited defects in iron transport ...

      Known for Iron Transport | Late Endosomes | Transferrin Receptor | Membrane Proteins | Microcytic Anemia
      KOL-Index: 12687

      Microbial nucleic acids are critical for the induction of innate immune responses, a host defense mechanism against infection by microbes. Recent studies have indicated that double-stranded DNA (dsDNA) induces potent innate immune responses via the induction of type I IFN (IFN) and IFN-inducible genes. However, the regulatory mechanisms underlying dsDNA-triggered signaling are not fully understood. Here we show that the translocation and assembly of the essential signal transducers, ...

      Known for Immune Response | Sting Tbk1 | Autophagy Proteins | Endoplasmic Reticulum | Ifn Genes
      KOL-Index: 12531

      Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular pathogen that causes disease in a variety of hosts. S. Typhimurium actively invade host cells and typically reside within a membrane-bound compartment called the Salmonella-containing vacuole (SCV). The bacteria modify the fate of the SCV using two independent type III secretion systems (TTSS). TTSS are known to damage eukaryotic cell membranes and S. Typhimurium has been suggested to damage the SCV ...

      Known for Salmonella Infection | Autophagy Typhimurium | Fluorescence Models | Confocal Microscopy | Cytosol Bacteria
      KOL-Index: 12313

      BACKGROUND & AIMS: The Helicobacter pylori toxin vacuolating cytotoxin (VacA) promotes gastric colonization, and its presence (VacA(+)) is associated with more-severe disease. The exact mechanisms by which VacA contributes to infection are unclear. We previously found that limited exposure to VacA induces autophagy of gastric cells, which eliminates the toxin; we investigated whether autophagy serves as a defense mechanism against H pylori infection.

      METHODS: We investigated the effect ...

      Known for Pylori Infection | Vacuolating Cytotoxin | Toxin Vaca | Autophagy Gastric | Polymorphisms Atg16l1
      KOL-Index: 12096

      Double membrane structure, autophagosome, is formed de novo in the process of autophagy in the yeast Saccharomyces cerevisiae, and many Apg proteins participate in this process. To further understand autophagy, we analyzed the involvement of factors engaged in the secretory pathway. First, we showed that Sec18p (N-ethylmaleimide-sensitive fusion protein, NSF) and Vti1p (soluble N-ethylmaleimide-sensitive fusion protein attachment protein, SNARE), and soluble N-ethylmaleimide-sensitive ...

      Known for Proteins Autophagy | Process Saccharomyces | Membrane Fusion | Ethylmaleimide Sensitive | Autophagosome Formation
      KOL-Index: 12056

      The gene for Tom1 was initially identified as a specific target of the oncogene v-myb. The Tom1 protein belongs to the VHS domain-containing protein family, and it has a GAT domain in a central part as well as an N-terminal VHS domain. VHS domain-containing proteins, including Hrs/Vps27, STAM, and GGA proteins, have been implicated in intracellular trafficking and sorting, but the role of Tom1 has not yet been elucidated. In this study, we found that Tom1 binds directly with ubiquitin ...

      Known for Vhs Domain | Protein Tom1 | Ubiquitin Chains | Amino Acid | Intracellular Trafficking
      KOL-Index: 11983

      Rat LC3, a homologue of yeast Atg8 (Aut7/Apg8), localizes to autophagosomal membranes after post-translational modifications. The C-terminal fragment of LC3 is cleaved immediately following synthesis to yield a cytosolic form called LC3-I. A subpopulation of LC3-I is further converted to an autophagosome-associating form, LC3-II. Because yeast Atg8 is conjugated with phosphatidylethanolamine (PE) by a ubiquitin-like system, it has been hypothesized that LC3 is modified in a similar ...

      Known for Autophagosomal Membrane | Lc3 Gabarap | Homologue Yeast | 16 Kda | Cytosolic Form

      Key People For Autophagosome Formation

      Top KOLs in the world
      Noboru N Mizushima
      autophagosome formation cell death autophagy protein
      Daniel J Klionsky
      saccharomyces cerevisiae cell death autophagy proteins
      Tamotsu Yoshimori
      autophagosome formation endoplasmic reticulum mammalian cells
      Takeshi Noda
      endothelial cells autophagosome formation endoplasmic reticulum
      Yoshinori Ohsumi
      saccharomyces cerevisiae autophagosome formation vacuolar membrane
      Beth Levine
      beclin 1 cell death sindbis virus

      Tamotsu Yoshimori:Expert Impact

      Concepts for whichTamotsu Yoshimorihas direct influence:Autophagosome formation,  Endoplasmic reticulum,  Damaged lysosomes,  Mammalian cells,  Autophagy proteins,  Plasma membrane,  Acidic organelles.

      Tamotsu Yoshimori:KOL impact

      Concepts related to the work of other authors for whichfor which Tamotsu Yoshimori has influence:Cell death,  Oxidative stress,  Endoplasmic reticulum,  Autophagic flux,  Skeletal muscle,  Breast cancer,  Apoptosis autophagy.



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      Department of Genetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan | Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka

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