Prominent publications by Andrew Bruce Onderdonk

KOL Index score: 14661

Enzyme-linked immunosorbent assay (ELISA), indirect immunofluorescent-antibody assay (IFA), and Western immunoblot were used to test serum samples from 128 dogs for the presence of antibody to Borrelia burgdorferi. Sera included 72 samples from dogs suspected of having Lyme disease, 32 samples from dogs residing in areas in which Lyme disease was not considered endemic, and 24 samples from dogs with clinical and serologic evidence of immune-mediated disease (n = 10), Rocky Mountain ...

Also Ranks for: Lyme Disease |  western immunoblot |  immunosorbent assay |  elisa ifa |  bacterial blotting
KOL Index score: 13847

OBJECTIVES: To evaluate the adequacy of discharge room cleaning and the impact of a cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) on environmental surfaces in intensive care unit (ICU) rooms.

DESIGN: Prospective environmental study.

SETTING AND SAMPLE: Convenience sample of ICU rooms in an academic hospital. METHODS AND INTERVENTION: The intervention consisted of (1) a change from the use of pour ...

Also Ranks for: Cleaning Intervention |  staphylococcus aureus |  environmental surfaces |  mrsa vre |  icu rooms
KOL Index score: 13381

The rate of methicillin-resistant Staphylococcus aureus (MRSA) infection continues to rise in many health care settings. Rapid detection of MRSA colonization followed by appropriate isolation can reduce transmission and infection. We compared the performance of the new Roche LightCycler MRSA advanced test to that of the BD GeneOhm MRSA test and culture. Double-headed swabs were used to collect anterior nasal specimens from each subject. For both tests, DNA was extracted and real-time PCR ...

Also Ranks for: Advanced Test |  resistant staphylococcus |  multicenter evaluation |  lightcycler mrsa |  relative sensitivity
KOL Index score: 12138

Autism Spectrum Disorder (ASD) is a complex neurological and developmental disorder characterized by behavioral and social impairments as well as multiple co-occurring conditions, such as gastrointestinal abnormalities, dental/periodontal diseases, and allergies. The etiology of ASD likely involves interaction between genetic and environmental factors. Recent studies suggest that oral and gut microbiome play important roles in the pathogenesis of inflammation, immune dysfunction, and ...

Also Ranks for: Gut Microbiota |  autism spectrum disorder |  asd diagnosis |  neurotypical individuals |  microbiome clinical
KOL Index score: 10261

Bacteroides fragilis is the anaerobe most commonly isolated from clinical cases of intra-abdominal sepsis. In a rodent model of this disease process, intraperitoneal injection of the capsular polysaccharide complex (CPC) from B. fragilis provokes abscess formation, while subcutaneous administration of this complex confers protection against B. fragilis-induced intra-abdominal abscesses. The CPC consists of two discrete polysaccharides, polysaccharides A and B (PS A and PS B), each ...

Also Ranks for: Abscess Formation |  cpc fragilis |  intraabdominal sepsis |  bacterial polysaccharides |  pneumoniae type
KOL Index score: 10195

Carbapenem-resistant Enterobacteriaceae (CRE) are an urgent public health concern. Rapid identification of the resistance genes, their mobilization capacity, and strains carrying them is essential to direct hospital resources to prevent spread and improve patient outcomes. Whole-genome sequencing allows refined tracking of both chromosomal traits and associated mobile genetic elements that harbor resistance genes. To enhance surveillance of CREs, clinical isolates with phenotypic ...

Also Ranks for: Resistance Genes |  bacterial enterobacter |  klebsiella pneumoniae |  wholegenome sequencing |  sequence analysis
KOL Index score: 9997

Epidemiologists have grouped the multiple disorders that lead to preterm delivery before the 28th week of gestation in a variety of ways. The authors sought to identify characteristics that would help guide how to classify disorders that lead to such preterm delivery. They enrolled 1,006 women who delivered a liveborn singleton infant of less than 28 weeks' gestation at 14 centers in the United States between 2002 and 2004. Each delivery was classified by presentation: preterm labor ...

Also Ranks for: 28th Week |  pregnancy disorders |  united states |  preterm delivery |  placental abruption
KOL Index score: 9869

BACKGROUND: Wound infection is a common complication in diabetic patients. The progressive spread of infections and development of drug-resistant strains underline the need for further insights into bacterial behavior in the host in order to develop new therapeutic strategies. The aim of our study was to develop a large animal model suitable for monitoring the development and effect of bacterial infections in diabetic wounds.

METHODS: Fourteen excisional wounds were created on the dorsum ...

Also Ranks for: Diabetic Wound |  bacterial infections |  staphylococcus aureus |  blood glucose |  common complication
KOL Index score: 9751

Six strains of Prevotella bivia and 4 of Gardnerella vaginalis were examined for nutrient substrate utilization as part of ongoing studies on the pathogenesis of bacterial vaginosis. Addition of single amino acids to vaginal defined medium (VDM) was stimulatory to the growth of P. bivia but not to G. vaginalis. However, peptides significantly promoted the growth of both organisms. Growth of P. bivia in VDM and VDM supplemented with either amino acids or peptone was accompanied by net ...

Also Ranks for: Prevotella Bivia |  gardnerella vaginalis |  symbiotic relationship |  amino acids |  bacterial vaginosis
KOL Index score: 9741

Menstrual toxic shock syndrome (mTSS) is thought to be associated with colonization with toxic shock syndrome toxin 1 (TSST-1)-producing Staphylococcus aureus in women with insufficient antibody titers. mTSS has been associated with menstruation and tampon use, and although it is rare, the effects can be life threatening. It remains of interest because of the widespread use of tampons, reported to be about 70% of women in the United States, Canada, and much of Western Europe. This ...

Also Ranks for: Toxic Shock |  staphylococcus aureus |  antibody titers |  black women |  syndrome toxin
KOL Index score: 9305

The accumulation of certain species of bacteria in the intestine is involved in both tissue homeostasis and immune-mediated pathologies. The host mechanisms involved in controlling intestinal colonization with commensal bacteria are poorly understood. We observed that under specific pathogen-free or germ-free conditions, intragastric administration of Pseudomonas aeruginosa, E. coli, Staphylococcus aureus, or Lactobacillus gasseri resulted in increased colonization of the small intestine ...

Also Ranks for: Bacterial Colonization |  cd1d mice |  small intestine |  staphylococcus aureus |  pseudomonas aeruginosa
KOL Index score: 9106

Bacterial vaginosis (BV) is a prevalent multifactorial disease of women in their reproductive years characterized by a shift from the Lactobacillus species-dominated microbial community toward a taxonomically diverse anaerobic community. For unknown reasons, some women do not respond to therapy. In our recent clinical study, among 37 women diagnosed with BV, 31 were successfully treated with metronidazole, while 6 still had BV after treatment. To discover possible reasons for the lack of ...

Also Ranks for: Bacterial Vaginosis |  vaginal microbiota |  bv women |  female gardnerella |  anti infective
KOL Index score: 9040

Macrolide (including erythromycin and azithromycin) and lincosamide (including clindamycin) antibiotics are recommended for treatment of penicillin-allergic patients with Streptococcus pyogenes pharyngitis. Resistance to erythromycin in S. pyogenes can be as high as 48% in specific populations in the United States. Macrolide and lincosamide resistance in S. pyogenes is mediated by several different genes. Expression of the erm(A) or erm(B) genes causes resistance to erythromycin and ...

Also Ranks for: Streptococcus Pyogenes |  resistance erythromycin |  united states |  bacterial proteins |  resistant strains
KOL Index score: 8895

PURPOSE: To test the hypothesis that the presence of bacteria and/or histologic inflammation in the placenta of infants born preterm is associated with an increased risk for severe retinopathy of prematurity (ROP).

METHODS: This was a prospective cohort study. Exploratory and multivariable data analyses were used, including logistic regression models with interaction terms. Main outcomes were four definitions of severe ROP: stage 3 or higher, any ROP in zone I, prethreshold/threshold, ...

Also Ranks for: Severe Retinopathy |  gestational age |  prematurity rop |  newborn infant |  inflammation increased risk

Key People For Bacteroides Fragilis

Top KOLs in the world
Sydney * ********
anaerobic bacteria bacteroides fragilis vitro activity
Sherwood * *******
bacteroides fragilis anaerobic infections clostridium difficile
Dennis *** ******
bacteroides fragilis capsular polysaccharide abscess formation
Francis * *****
bacteroides fragilis anaerobic bacteria united states
John * ********
clostridium difficile african americans anaerobic bacteria
Hannah * ******
anaerobic bacteria bacteroides fragilis vitro activity

Andrew Bruce Onderdonk:Expert Impact

Concepts for whichAndrew Bruce Onderdonkhas direct influence:Bacteroides fragilis,  Vaginal microflora,  Abscess formation,  Intraabdominal sepsis,  Bacterial vaginosis,  Staphylococcus aureus,  Ulcerative colitis,  Axonal necrosis.

Andrew Bruce Onderdonk:KOL impact

Concepts related to the work of other authors for whichfor which Andrew Bruce Onderdonk has influence:Clostridium difficile,  Bacterial vaginosis,  Gut microbiota,  Preterm birth,  Bacteroides fragilis,  Staphylococcus aureus,  Inflammatory bowel disease.



Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA. | Massachusetts Host-Microb