Pankaj Jay Pasricha

Pankaj Jay Pasricha

Division Of Gastroenterology And Hepatology, Johns Hopkins University School Of Medicine, Baltimore, Maryland, Usa; The Solomon H. Snyder Department Of Neuroscience, Johns ...

Direct Impact

Concepts for which Pankaj Jay Pasricha has direct influence:

intraoperative hypotension
postoperative major
duration threstholds
cardiac surgery
threshold relationship

External impact

Concepts related to the work of other authors for which Pankaj Jay Pasricha has influence:

chronic pancreatitis
enteric nervous
gastric emptying
botulinum toxin
proximal jejunum
bacterial overgrowth
stem cells

Prominent publications by Pankaj Jay Pasricha

KOL-Index: 128 Achalasia is a relatively rare primary motor esophageal disorder, characterized by absence of relaxations of the lower esophageal sphincter and of peristalsis along the esophageal body. As a result, patients typically present with dysphagia, regurgitation and occasionally chest pain, pulmonary complication and malnutrition. New diagnostic methodologies and therapeutic techniques have been ...
Known for
Definition | Esophageal Achalasia
KOL-Index: 82 BACKGROUND & AIMS: Chronic nausea and vomiting with normal gastric emptying is a poorly understood syndrome; we analyzed its characteristics. METHODS: We collected and analyzed data from 425 patients with chronic nausea and vomiting, enrolled at 6 centers by the ...
Known for
2 4 Hours | Chronic Idiopathic Nausea | Delayed Gastric Emptying | Gastroparesis Cardinal Symptom Scores
KOL-Index: 77 Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreatic intraepithelial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine ...
Known for
Sensory Neurons | Genetically Engineered Mouse Model | Panin Organoid Growth | Pancreatic Ductal Adenocarcinoma
KOL-Index: 60 BACKGROUND: Wireless motility capsule (WMC) findings are incompletely defined in suspected gastroparesis. We aimed to characterize regional WMC transit and contractility in relation to scintigraphy, etiology, and symptoms in patients undergoing gastric emptying testing. METHODS: A total of 209 patients with ...
Known for
Validated Questionnaires | 209 | Gastroparesis Abstracttext | Wmcs
KOL-Index: 52 Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and ...
Known for
Neuropathies | Nervous Stem | Cells Transplant
KOL-Index: 46 OBJECTIVES: Diabetic gastroparesis (Gp) occurs more often in type 1 diabetes mellitus (T1DM) than in type 2 diabetes mellitus (T2DM). Other diabetic end-organ complications include peripheral neuropathy, nephropathy, and retinopathy (together termed triopathy). This study determines the prevalence of diabetic complications (retinopathy, nephropathy, and peripheral neuropathy) in diabetic ...
Known for
Diabetic Symptoms | Complications Retinopathy | Electrogastrography | Emptying Associates
KOL-Index: 45 BACKGROUND: Gastric electrical stimulation (GES) for treating gastroparesis symptoms is controversial. METHODS: We studied 319 idiopathic or diabetic gastroparesis symptom patients from the Gastroparesis Clinical Research Consortium (GpCRC) observational studies: 238 without GES and 81 with GES. We assessed the effects of GES using change in GCSI total score and nausea/vomiting subscales ...
Known for
1 Point | Inferences | Gcsi Nausea | Larger Sample
KOL-Index: 45 The cellular and molecular understanding of human gastroparesis has markedly improved due to studies on full-thickness gastric biopsies. A decrease in the number of interstitial cells of Cajal (ICC) and functional changes in ICC constitutes the hallmark cellular feature of gastroparesis. More recently, in animal models, macrophages have also been identified to play a central role in ...
Known for
Gastroparesis Loss | Macrophages Identified
KOL-Index: 45 ABSTRACT The enteric nervous system (ENS), a collection of neurons contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cells migrating from the embryonic neural crest and remains largely unchanged thereafter. Here, we show that the composition of maturing ENS ...
Known for
Mesoderm Derived | Functional Effects | Dynamic Balance | Distinct Expression Profile
KOL-Index: 42 Current advances in our understanding of stem and precursor cell biology and in the protocols of stem cell isolation and transplantation have opened up the possibility of transplanting neural stem cells for the treatment of gastrointestinal motility disorders. This review summarises the current status of research in this field, identifies the major gaps in our knowledge and discusses the ...
Known for
Disorders Gastrointestinal

Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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